PROSITE documentation PDOC51433
Pointed (PNT) domain profile


The highly conserved PNT (or Pointed) domain is found within a subset of the Ets transcription factors (see <PDOC00374>), including mammalian Ets-1, Ets-2, Erg, Fli-1, GABPα, and Tel, as well as Drosophila Pnt-P2 and Yan. The PNT domain is structurally related to the larger group of SAM domains (see <PDOC50105>) through a common tertiary arrangement of four α-helices (see <PDB:1SXE>). A role in protein-protein association has been established for the PNT domain [1,2].

The profiles we developed cover the entire PNT domain.

Last update:

January 2009 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

PNT, PS51433; Pointed (PNT) domain profile  (MATRIX)


1AuthorsPotter M.D. Buijs A. Kreider B. van Rompaey L. Grosveld G.C.
TitleIdentification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1/ETV6.
SourceBlood 95:3341-3348(2000).
PubMed ID10828014

2AuthorsMackereth C.D. Schaerpf M. Gentile L.N. MacIntosh S.E. Slupsky C.M. McIntosh L.P.
TitleDiversity in structure and function of the Ets family PNT domains.
SourceJ. Mol. Biol. 342:1249-1264(2004).
PubMed ID15351649

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