PROSITE documentation PDOC51433Pointed (PNT) domain profile
Description
The highly conserved PNT (or Pointed) domain is found within a subset of the Ets transcription factors (see <PDOC00374>), including mammalian Ets-1, Ets-2, Erg, Fli-1, GABPα, and Tel, as well as Drosophila Pnt-P2 and Yan. The PNT domain is structurally related to the larger group of SAM domains (see <PDOC50105>) through a common tertiary arrangement of four α-helices (see <PDB:1SXE>). A role in protein-protein association has been established for the PNT domain [1,2].
The profiles we developed cover the entire PNT domain.
Last update:January 2009 / First entry.
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Technical section
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References
| 1 | Authors | Potter M.D. Buijs A. Kreider B. van Rompaey L. Grosveld G.C. |
| Title | Identification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1/ETV6. | |
| Source | Blood 95:3341-3348(2000). | |
| PubMed ID | 10828014 |
| 2 | Authors | Mackereth C.D. Schaerpf M. Gentile L.N. MacIntosh S.E. Slupsky C.M. McIntosh L.P. |
| Title | Diversity in structure and function of the Ets family PNT domains. | |
| Source | J. Mol. Biol. 342:1249-1264(2004). | |
| PubMed ID | 15351649 | |
| DOI | 10.1016/j.jmb.2004.07.094 |
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