We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51532PITH domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51532
Description
The proteasome-interacting thioredoxin (PITH) domain is a general proteasome-interacting module [1].
The PITH domain is dominated by a jelly roll β-sandwich structure (see <PDB:1XOY>). The β-sandwich is formed by face-to-face packing of two anti-parallel β-sheets. Another two-stranded β-sheet seals off one end of the β-barrel [2,3].
Some proteins known to contain a PITH domain are listed below:
- Human Txnl1 or TRP32, a thioredoxin-like protein implicated in endocytosis and in protection against glucose deprivation-induced cytotoxicity.
- Human C1ORF28, an uncharacterized protein that does not contain any other known protein domains, but has been found to associate with 26S proteasomes.
- Arabidopsis thaliana At3g04780, a single domain protein.
The profile we developed covers the entire PITH domain.
Last update:March 2011 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Andersen K.M. Madsen L. Prag S. Johnsen A.H. Semple C.A. Hendil K.B. Hartmann-Petersen R. |
| Title | Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome. | |
| Source | J. Biol. Chem. 284:15246-15254(2009). | |
| PubMed ID | 19349277 | |
| DOI | 10.1074/jbc.M900016200 |
| 2 | Authors | Song J. Tyler R.C. Wrobel R.L. Frederick R.O. Vojtek F.C. Jeon W.B. Lee M.S. Markley J.L. |
| Title | Solution structure of At3g04780.1-des15, an Arabidopsis thaliana ortholog of the C-terminal domain of human thioredoxin-like protein. | |
| Source | Protein Sci. 14:1059-1063(2005). | |
| PubMed ID | 15741346 | |
| DOI | 10.1110/ps.041246805 |
| 3 | Authors | Goroncy A.K. Koshiba S. Tochio N. Tomizawa T. Inoue M. Tanaka A. Sugano S. Kigawa T. Yokoyama S. |
| Title | Solution structure of the C-terminal DUF1000 domain of the human thioredoxin-like 1 protein. | |
| Source | Proteins 78:2176-2180(2010). | |
| PubMed ID | 20455272 | |
| DOI | 10.1002/prot.22719 |
Copyright
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