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PROSITE documentation PDOC51674

4Fe-4S WhiB-like (Wbl)-type iron-sulfur binding domain profile





Description

Members of the WhiB-like (Wbl) family are found exclusively in actinobacteria and are implicated in the regulation of developmental processes. All WhiB-like proteins have four conserved cysteine residues where two of them are in a C-X-X-C motif. The four cysteine residues are proposed to act as the ligands for a [4Fe-4S] cluster. Wbl-mediated transcription regulation is dependent upon the presence or absence and state (nitrosylated or non-nitrosylated) of the [4Fe-4S] cluster [1,2,3].

The profile we developed covers the entire Wbl-type 4Fe-4S domain.

Last update:

May 2013 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

4FE4S_WBL, PS51674; 4Fe-4S WhiB-like (Wbl)-type iron-sulfur binding domain profile  (MATRIX)


References

1AuthorsGarg S.K. Suhail Alam M. Soni V. Radha Kishan K.V. Agrawal P.
TitleCharacterization of Mycobacterium tuberculosis WhiB1/Rv3219 as a protein disulfide reductase.
SourceProtein Expr. Purif. 52:422-432(2007).
PubMed ID17157031
DOI10.1016/j.pep.2006.10.015

2Authorsden Hengst C.D. Buttner M.J.
TitleRedox control in actinobacteria.
SourceBiochim. Biophys. Acta 1780:1201-1216(2008).
PubMed ID18252205
DOI10.1016/j.bbagen.2008.01.008

3AuthorsSmith L.J. Stapleton M.R. Buxton R.S. Green J.
TitleStructure-function relationships of the Mycobacterium tuberculosis transcription factor WhiB1.
SourcePLoS ONE 7:E40407-E40407(2012).
PubMed ID22792304
DOI10.1371/journal.pone.0040407



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