We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC516744Fe-4S WhiB-like (Wbl)-type iron-sulfur binding domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51674
Description
Members of the WhiB-like (Wbl) family are found exclusively in actinobacteria and are implicated in the regulation of developmental processes. All WhiB-like proteins have four conserved cysteine residues where two of them are in a C-X-X-C motif. The four cysteine residues are proposed to act as the ligands for a [4Fe-4S] cluster. Wbl-mediated transcription regulation is dependent upon the presence or absence and state (nitrosylated or non-nitrosylated) of the [4Fe-4S] cluster [1,2,3].
The profile we developed covers the entire Wbl-type 4Fe-4S domain.
Last update:May 2013 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Garg S.K. Suhail Alam M. Soni V. Radha Kishan K.V. Agrawal P. |
| Title | Characterization of Mycobacterium tuberculosis WhiB1/Rv3219 as a protein disulfide reductase. | |
| Source | Protein Expr. Purif. 52:422-432(2007). | |
| PubMed ID | 17157031 | |
| DOI | 10.1016/j.pep.2006.10.015 |
| 2 | Authors | den Hengst C.D. Buttner M.J. |
| Title | Redox control in actinobacteria. | |
| Source | Biochim. Biophys. Acta 1780:1201-1216(2008). | |
| PubMed ID | 18252205 | |
| DOI | 10.1016/j.bbagen.2008.01.008 |
| 3 | Authors | Smith L.J. Stapleton M.R. Buxton R.S. Green J. |
| Title | Structure-function relationships of the Mycobacterium tuberculosis transcription factor WhiB1. | |
| Source | PLoS ONE 7:E40407-E40407(2012). | |
| PubMed ID | 22792304 | |
| DOI | 10.1371/journal.pone.0040407 |
Copyright
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