The peptidase family M60 domain belongs to the zincin superfamily of zinc-requiring metalloproteases (clan MA, subclan MA(E)) [E1]. The peptidase family
M60 domain contains the metal-binding consensus motif HExxH. The two histidine
residues are ligands of the catalytic Zn(2+) and the glutamic acid residue is
involved in nucleophilic attack. An additional conserved glutamic acid is
found approximately 20 residues from the first histidine within the metal-binding motif. The second conserved glutamic acid potentially acts as a third
proteous Zn(2+) ligand. The peptidase family M60 domain targets complex host
glycoproteins, such as mucins [1,2,3,4,5].
Some proteins known to contain a peptidase family M60 domain are listed below:
Baculovirus viral enhancing factor (VEF), also known as Enhancin, a
metalloprotease that enhances viral infection by degrading the peritrophic
membrane (PM) of the insect midgut.
Bacteria enhancin-like metalloproteases.
Mammalian FAM115 family proteins.
The profile we developed covers the entire peptidase family M60 domain.
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