The peptidase family M60 domain belongs to the zincin superfamily of zinc-requiring metalloproteases (clan MA, subclan MA(E)) [E1]. The peptidase family
M60 domain contains the metal-binding consensus motif HExxH. The two histidine
residues are ligands of the catalytic Zn(2+) and the glutamic acid residue is
involved in nucleophilic attack. An additional conserved glutamic acid is
found approximately 20 residues from the first histidine within the metal-binding motif. The second conserved glutamic acid potentially acts as a third
proteous Zn(2+) ligand. The peptidase family M60 domain targets complex host
glycoproteins, such as mucins [1,2,3,4,5].
Some proteins known to contain a peptidase family M60 domain are listed below:
Baculovirus viral enhancing factor (VEF), also known as Enhancin, a
metalloprotease that enhances viral infection by degrading the peritrophic
membrane (PM) of the insect midgut.
Bacteria enhancin-like metalloproteases.
Mammalian FAM115 family proteins.
The profile we developed covers the entire peptidase family M60 domain.
Hajaij-Ellouze M. Fedhila S. Lereclus D. Nielsen-LeRoux C.
Title
The enhancin-like metalloprotease from the Bacillus cereus group is regulated by the pleiotropic transcriptional activator PlcR but is not essential for larvicidal activity.
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see prosite_license.html.