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PROSITE documentation PDOC51750

Bro-N domain profile





Description

The baculovirus Bro proteins are encoded by a multigene family. The typical Bro proteins that have been experimentally investigated are BroA, BroC and BroD from Bombyx mori uclear polyhedrosis virus (BmNV). They contain distinct amino- and carboxy-terminal domains (Bro-N and Bro-C, respectively) that are present independently of each other and in distinct contexts in a variety of other viral proteins. The Bro-N domain occurs in a stand-alone form or combined with other domains in proteins from temperate phages that infect Gram-positive bacteria and Myxococcus xanthus, and proteins encoded in the genomes of proteobacteria and Gram positive bacteria. The Bro-N domain appears to define a distinct superfamily of widespread viral DNA-binding domains [1].

Multiple alignment-based secondary-structure prediction of the Bro-N domain reveals a core with two head-to-tail units of a β-hairpin followed by an α-helix. The multiple alignment shows that the Bro-N domains contain two highly conserved aromatic or hydrophobic residues at the end of the second and forth conserved strands [1].

The profile we developed covers the entire Bro-N domain.

Last update:

March 2015 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

BRO_N, PS51750; Bro-N domain profile  (MATRIX)


Reference

1AuthorsIyer L.M. Koonin E.V. Aravind L.
TitleExtensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors.
SourceGenome Biol. 3:RESEARCH0012-RESEARCH0012(2002).
PubMed ID11897024



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