|PROSITE documentation PDOC51775|
The GTD-binding domain is a plant-specific protein-protein interaction domain. It emerged in primitive land plants and founded a multigene family that is conserved in all flowering plants. Proteins with GTD-binding domains fall into four groups, where group 1-3 contain the GTD-binding domain at the C-terminal half of the protein and one (group 2) or more (group1) predicted transmembrane domains, or an endoplasmic reticulum signal peptide (group 3) at the N-terminus, whereas group 4 contains the GTD-binding domain near the N-terminus. GTD-binding domain proteins may constitute a family of myosin receptors, which are associated with the surface of specific plant organelles, bind to the globular tail domain (GTD) of myosin motor proteins, and thereby promote actin-dependent organelle motility. It seems likely that myosin binding is a common property of the GTD-binding domain, whereas the ability of FLOURY1 to bind maize-specific zeins is a specific feature of this endoplasmic reticulum (ER)-associated protein.
The GTD-binding domain is predicted to adopt a coiled-coil structure.
Some proteins known to contain a GTD-binding domain are listed below:
The profile we developed covers the entire GTD-binding domain.Last update:
September 2015 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Holding D.R. Otegui M.S. Li B. Meeley R.B. Dam T. Hunter B.G. Jung R. Larkins B.A.|
|Title||The maize floury1 gene encodes a novel endoplasmic reticulum protein involved in zein protein body formation.|
|Source||Plant Cell 19:2569-2582(2007).|
|2||Authors||Peremyslov V.V. Morgun E.A. Kurth E.G. Makarova K.S. Koonin E.V. Dolja V.V.|
|Title||Identification of myosin XI receptors in Arabidopsis defines a distinct class of transport vesicles.|
|Source||Plant Cell 25:3022-3038(2013).|
|3||Authors||Stephan O. Cottier S. Fahlen S. Montes-Rodriguez A. Sun J. Eklund D.M. Klahre U. Kost B.|
|Title||RISAP is a TGN-associated RAC5 effector regulating membrane traffic during polar cell growth in tobacco.|
|Source||Plant Cell 26:4426-4447(2014).|
|4||Authors||Wang B.-J. Hsu Y.-F. Chen Y.-C. Wang C.-S.|
|Title||Characterization of a lily anther-specific gene encoding cytoskeleton-binding glycoproteins and overexpression of the gene causes severe inhibition of pollen tube growth.|