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PROSITE documentation PDOC51775 |
The GTD-binding domain is a plant-specific protein-protein interaction domain. It emerged in primitive land plants and founded a multigene family that is conserved in all flowering plants. Proteins with GTD-binding domains fall into four groups, where group 1-3 contain the GTD-binding domain at the C-terminal half of the protein and one (group 2) or more (group1) predicted transmembrane domains, or an endoplasmic reticulum signal peptide (group 3) at the N-terminus, whereas group 4 contains the GTD-binding domain near the N-terminus. GTD-binding domain proteins may constitute a family of myosin receptors, which are associated with the surface of specific plant organelles, bind to the globular tail domain (GTD) of myosin motor proteins, and thereby promote actin-dependent organelle motility. It seems likely that myosin binding is a common property of the GTD-binding domain, whereas the ability of FLOURY1 to bind maize-specific zeins is a specific feature of this endoplasmic reticulum (ER)-associated protein.
The GTD-binding domain is predicted to adopt a coiled-coil structure.
Some proteins known to contain a GTD-binding domain are listed below:
The profile we developed covers the entire GTD-binding domain.
Last update:September 2015 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Holding D.R. Otegui M.S. Li B. Meeley R.B. Dam T. Hunter B.G. Jung R. Larkins B.A. |
Title | The maize floury1 gene encodes a novel endoplasmic reticulum protein involved in zein protein body formation. | |
Source | Plant Cell 19:2569-2582(2007). | |
PubMed ID | 17693529 | |
DOI | 10.1105/tpc.107.053538 |
2 | Authors | Peremyslov V.V. Morgun E.A. Kurth E.G. Makarova K.S. Koonin E.V. Dolja V.V. |
Title | Identification of myosin XI receptors in Arabidopsis defines a distinct class of transport vesicles. | |
Source | Plant Cell 25:3022-3038(2013). | |
PubMed ID | 23995081 | |
DOI | 10.1105/tpc.113.113704 |
3 | Authors | Stephan O. Cottier S. Fahlen S. Montes-Rodriguez A. Sun J. Eklund D.M. Klahre U. Kost B. |
Title | RISAP is a TGN-associated RAC5 effector regulating membrane traffic during polar cell growth in tobacco. | |
Source | Plant Cell 26:4426-4447(2014). | |
PubMed ID | 25387880 | |
DOI | 10.1105/tpc.114.131078 |
4 | Authors | Wang B.-J. Hsu Y.-F. Chen Y.-C. Wang C.-S. |
Title | Characterization of a lily anther-specific gene encoding cytoskeleton-binding glycoproteins and overexpression of the gene causes severe inhibition of pollen tube growth. | |
Source | Planta 240:525-537(2014). | |
PubMed ID | 24944111 | |
DOI | 10.1007/s00425-014-2099-x |