PROSITE documentation PDOC51775
GTD-binding domain profile


The GTD-binding domain is a plant-specific protein-protein interaction domain. It emerged in primitive land plants and founded a multigene family that is conserved in all flowering plants. Proteins with GTD-binding domains fall into four groups, where group 1-3 contain the GTD-binding domain at the C-terminal half of the protein and one (group 2) or more (group1) predicted transmembrane domains, or an endoplasmic reticulum signal peptide (group 3) at the N-terminus, whereas group 4 contains the GTD-binding domain near the N-terminus. GTD-binding domain proteins may constitute a family of myosin receptors, which are associated with the surface of specific plant organelles, bind to the globular tail domain (GTD) of myosin motor proteins, and thereby promote actin-dependent organelle motility. It seems likely that myosin binding is a common property of the GTD-binding domain, whereas the ability of FLOURY1 to bind maize-specific zeins is a specific feature of this endoplasmic reticulum (ER)-associated protein.

The GTD-binding domain is predicted to adopt a coiled-coil structure.

Some proteins known to contain a GTD-binding domain are listed below:

  • Maize FLOURY1 (FL1), which belongs to group 1. Its GTD-binding domain facilitates the localization of 22-kD α-zein [1].
  • Arabidopsis myosin binding (MyoB) proteins 1-6 and 7, which belong respectively to group 3 and 4. They bind to myosin XI [2].
  • Tobacco RAC5 interacting subapical pollen tube protein (RISAP), which belongs to group 3. It binds via its GTD-binding domain to the GTD domain of a pollen tube myosin XI [3].
  • Lily LLP13, which belongs to group 3. It is likely a cytoskeleton-binding protein that binds with intermediate filaments (IFs) that potentially exist in pollen tubes [4].

The profile we developed covers the entire GTD-binding domain.

Last update:

September 2015 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

GTD_BINDING, PS51775; GTD-binding domain profile  (MATRIX)


1AuthorsHolding D.R. Otegui M.S. Li B. Meeley R.B. Dam T. Hunter B.G. Jung R. Larkins B.A.
TitleThe maize floury1 gene encodes a novel endoplasmic reticulum protein involved in zein protein body formation.
SourcePlant Cell 19:2569-2582(2007).
PubMed ID17693529

2AuthorsPeremyslov V.V. Morgun E.A. Kurth E.G. Makarova K.S. Koonin E.V. Dolja V.V.
TitleIdentification of myosin XI receptors in Arabidopsis defines a distinct class of transport vesicles.
SourcePlant Cell 25:3022-3038(2013).
PubMed ID23995081

3AuthorsStephan O. Cottier S. Fahlen S. Montes-Rodriguez A. Sun J. Eklund D.M. Klahre U. Kost B.
TitleRISAP is a TGN-associated RAC5 effector regulating membrane traffic during polar cell growth in tobacco.
SourcePlant Cell 26:4426-4447(2014).
PubMed ID25387880

4AuthorsWang B.-J. Hsu Y.-F. Chen Y.-C. Wang C.-S.
TitleCharacterization of a lily anther-specific gene encoding cytoskeleton-binding glycoproteins and overexpression of the gene causes severe inhibition of pollen tube growth.
SourcePlanta 240:525-537(2014).
PubMed ID24944111

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