PROSITE documentation PDOC51791
hSac2 domain profile


Sac2 is an evolutionarily conserved protein in multicellular organisms from nematode to human. Sac2 orthologues are also found in fungi genera such as Aspergillus species and Yarrowia lipolytica, but is absent in Saccharomyces cerevisiae. Sac2 is a phosphatidylinositol (PI) 4-phosphatase that specifically hydrolyzes phosphatidylinositol 4-phosphate (PI(4)P) to phosphatidylinositol. Besides the conserved N-terminal Sac1 domain (see <PDOC00978>), Sac2 contains a unique homology domain, homology Sac2 (hSac2), followed by a proline-rich C-terminal portion with various lengths in different species. The hSac2 domain plays a role in Sac2 dimerization and intracellular localization. The hSac2 domain is also found in proteins encoded by the transformation-related protein 63 regulated 1 (TPRG1) and the tumor protein p63 regulated gene 1-like genes (TPRGl) [1,2,3,4].

The hSac2 domain has a PH domain-like (see <PDOC50003>) fold and consists of a core of two perpendicularly apposed β sheets with a C-terminal α helix that seals the gap between the two sheets. In addition to the core, hSac2 has an extra N-terminal α helix and a short β strand in the C-terminal end (see <PDB:4XUU>) [1].

The profile we developed covers the entire hSac2 domain.

Last update:

February 2016 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

HSAC2, PS51791; hSac2 domain profile  (MATRIX)


1AuthorsHsu F. Hu F. Mao Y.
TitleSpatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling.
SourceJ. Cell Biol. 209:97-110(2015).
PubMed ID25869669

2AuthorsMinagawa T. Ijuin T. Mochizuki Y. Takenawa T.
TitleIdentification and characterization of a sac domain-containing phosphoinositide 5-phosphatase.
SourceJ. Biol. Chem. 276:22011-22015(2001).
PubMed ID11274189

3AuthorsAntonini D. Dentice M. Mahtani P. De Rosa L. Della Gatta G. Mandinova A. Salvatore D. Stupka E. Missero C.
TitleTprg, a gene predominantly expressed in skin, is a direct target of the transcription factor p63.
SourceJ. Invest. Dermatol. 128:1676-1685(2008).
PubMed ID18256694

4AuthorsKremer T. Kempf C. Wittenmayer N. Nawrotzki R. Kuner T. Kirsch J. Dresbach T.
TitleMover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses.
SourceFEBS Lett. 581:4727-4733(2007).
PubMed ID17869247

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