PROSITE documentation PDOC51792
Yippee domain profile


The Yippee-like (YPEL) family proteins share homology to drosophila Yippee, a zinc finger binding protein. YPEL proteins are found in essentiallly all the eukaryotes and hence they must play important roles in the maintenance of life. Subcellular localization of all YPEL proteins to the centrosomes and the mitotic apparatus suggest their role in the mitosis-associated function. YPEL proteins contain a Yippee domain, which is a putative zinc-finger-like, metal-binding domain [1,2,3,4].

The Yippee domain contains two cysteine pairs that are fifty-two amino acids appart (C-X(2)-C-X(52)-C-X(2)-C) and could be part of a metal (zinc) binding pocket [1].

The profile we developed covers the entire Yippee domain.

Last update:

February 2016 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

YIPPEE, PS51792; Yippee domain profile  (MATRIX)


1AuthorsRoxstroem-Lindquist K. Faye I.
TitleThe Drosophila gene Yippee reveals a novel family of putative zinc binding proteins highly conserved among eukaryotes.
SourceInsect Mol. Biol. 10:77-86(2001).
PubMed ID11240639

2AuthorsHosono K. Sasaki T. Minoshima S. Shimizu N.
TitleIdentification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species.
SourceGene 340:31-43(2004).
PubMed ID15556292

3AuthorsLiang P. Wan Y. Yan Y. Wang Y. Luo N. Deng Y. Fan X. Zhou J. Li Y. Wang Z. Yuan W. Tang M. Mo X. Wu X.
TitleMVP interacts with YPEL4 and inhibits YPEL4-mediated activities of the ERK signal pathway.
SourceBiochem. Cell Biol. 88:445-450(2010).
PubMed ID20555386

4AuthorsTan T.Y. Gordon C.T. Miller K.A. Amor D.J. Farlie P.G.
TitleYPEL1 overexpression in early avian craniofacial mesenchyme causes mandibular dysmorphogenesis by up-regulating apoptosis.
SourceDev. Dyn. 244:1022-1030(2015).
PubMed ID26061551

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