PROSITE documentation PDOC51800Zinc finger CHHC U11-48K-type profile
The CHHC U11-48K-type zinc finger is found only in eukaryotes. It has been identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors (GTSF). The CHHC U11-48K-type zinc finger (~30 residues) is present in a single copy in U11-48k AND TRM13, whereas GTSF contains two repeats separated by a short linker. The CHHC U11-48K-type zinc finger may function as a RNA recognition and binding module [1,2].
The CHHC U11-48K-type zinc finger contains four invariant Cys and His residues with a consensus sequence of C-x(5,7)-H-x(7,9)-H-x(3,4)-C. It stochiometrically binds zinc ions in a one-to-one ratio. The structure of the CHHC U11-48K-type zinc finger consists of a β hairpin followed by a helix (see <PDB:2VY4>). the zinc ion is coordinated by Cys and His residues from the β hairpin and by His and Cys residues from the helix, respectively. The helical region has an α-helical conformation that is interrupted in the middle by a single pi-helical turn [2].
The profile we developed covers the entire CHHC U11-48K-type zinc finger.
Last update:May 2016 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Andreeva A. Tidow H. |
| Title | A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes. | |
| Source | Bioinformatics 24:2277-2280(2008). | |
| PubMed ID | 18703587 | |
| DOI | 10.1093/bioinformatics/btn431 |
| 2 | Authors | Tidow H. Andreeva A. Rutherford T.J. Fersht A.R. |
| Title | Solution structure of the U11-48K CHHC zinc-finger domain that specifically binds the 5' splice site of U12-type introns. | |
| Source | Structure 17:294-302(2009). | |
| PubMed ID | 19217400 | |
| DOI | 10.1016/j.str.2008.11.013 |
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