PROSITE documentation PDOC51801Zinc finger CCHC NOA-type profile
The regulatory NEMO (NF-kappaB essential modulator) protein has a crucial role in the canonical NF-kappaB signaling pathway notably involved in immune and inflammatory responses, apoptosis and oncogenesis. The regulatory domain is located in the C-terminal half of NEMO and contains a CCHC-type zinc finger (ZF). A similar CCHC-type zinc finger is also found in other regulators of NF-kappaB, such as Optineurin and ABIN2. The CCHC NOA (NEMO Optineurin ABIN2)-type zinc finger has been shown to function as an ubiquitin-binding domain (UBD) [1,2].
The CCHC NOA-type zinc finger consists of a short antiparallel β-sheet, where β1 and β2 strands are connected by a type IV β-turn, and an α-helix (see <PDB:2JVX>). This ββα fold is stabilized by tetrahedral coordination to a zinc ion [1].
The profile we developed covers the entire CCHC NOA-type zinc finger.
Last update:June 2016 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Cordier F. Vinolo E. Veron M. Delepierre M. Agou F. |
| Title | Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation. | |
| Source | J. Mol. Biol. 377:1419-1432(2008). | |
| PubMed ID | 18313693 | |
| DOI | 10.1016/j.jmb.2008.01.048 |
| 2 | Authors | Laplantine E. Fontan E. Chiaravalli J. Lopez T. Lakisic G. Veron M. Agou F. Israel A. |
| Title | NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain. | |
| Source | EMBO J. 28:2885-2895(2009). | |
| PubMed ID | 19763089 | |
| DOI | 10.1038/emboj.2009.241 |
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