PROSITE documentation PDOC51839His(Cys)3-ligated-type [4Fe-4S] domain profile
Description
The following proteins contain a His(Cys)3-ligated-type [4Fe-4S] domain that consists of just two α helices separated by a loop region that coordinates a [4Fe-4S] cluster through an unusual H-x(3)-C-x(2)-C-x(5)-C motif that includes one His and three Cys residues (see <PDB:1FEH>) [1,2,3,4,5,6]:
- Prokaryotic and mitochondrial NuoG/Nqo3 subunit (75 kDa) of NADH:ubiquinone oxidoreductase (complex I) (see <PDOC00554>).
- Clostridium pasteurianum of the iron-only hydrogenase (CpI) (EC:1.12.7.2).
- Ralstonia eutropha NAD-dependent formate dehydrogenase α subunit (FdsA).
- Moorella thermoacetica formate dehydrogenase α subunit (FdhA).
- Desulfovibrio fructosivorans NADP-reducing hydrogenase subunit HndD.
- Clostridium pasteurianum
- Ralstonia eutropha NAD-reducing [Ni-Fe] hydrogenase (H2:NAD oxidoreductase) (HoxU). Its motif for the [4Fe-4S] cluster is G-x-H-x-C-x(2)-C-x(5)-C.
The profile we developed covers the entire His(Cys)3-ligated-type [4Fe-4S] domain.
Last update:July 2017 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Oh J.-I. Bowien B. |
| Title | Structural analysis of the fds operon encoding the NAD+-linked formate dehydrogenase of Ralstonia eutropha. | |
| Source | J. Biol. Chem. 273:26349-26360(1998). | |
| PubMed ID | 9756865 |
| 2 | Authors | Peters J.W. Lanzilotta W.N. Lemon B.J. Seefeldt L.C. |
| Title | X-ray crystal structure of the Fe-only hydrogenase (CpI) from Clostridium pasteurianum to 1.8 angstrom resolution. | |
| Source | Science 282:1853-1858(1998). | |
| PubMed ID | 9836629 |
| 3 | Authors | Nicolet Y. Lemon B.J. Fontecilla-Camps J.C. Peters J.W. |
| Title | A novel FeS cluster in Fe-only hydrogenases. | |
| Source | Trends Biochem. Sci. 25:138-143(2000). | |
| PubMed ID | 10694885 |
| 4 | Authors | Yano T. Sklar J. Nakamaru-Ogiso E. Takahashi Y. Yagi T. Ohnishi T. |
| Title | Characterization of cluster N5 as a fast-relaxing [4Fe-4S] cluster in the Nqo3 subunit of the proton-translocating NADH-ubiquinone oxidoreductase from Paracoccus denitrificans. | |
| Source | J. Biol. Chem. 278:15514-15522(2003). | |
| PubMed ID | 12600982 | |
| DOI | 10.1074/jbc.M212275200 |
| 5 | Authors | Sazanov L.A. Hinchliffe P. |
| Title | Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus. | |
| Source | Science 311:1430-1436(2006). | |
| PubMed ID | 16469879 | |
| DOI | 10.1126/science.1123809 |
| 6 | Authors | Nakamaru-Ogiso E. Matsuno-Yagi A. Yoshikawa S. Yagi T. Ohnishi T. |
| Title | Iron-sulfur cluster N5 is coordinated by an HXXXCXXCXXXXXC motif in the NuoG subunit of Escherichia coli NADH:quinone oxidoreductase (complex I). | |
| Source | J. Biol. Chem. 283:25979-25987(2008). | |
| PubMed ID | 18603533 | |
| DOI | 10.1074/jbc.M804015200 |
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