PROSITE documentation PDOC51879RST domain profiles
The RST (for RCD1 SRO TAF4) domain is a plant-specific domain found in WWE-PARPs (poly(ADP-ribose) polymerase) (see <PDOC50918> and <PDOC51059>) and TAF4s (TBP-Associated Factor 4), a component of several multimeric protein complexes including primarily the general transcription factor TFIID involved in transcriptional initiation. The RST domain is a protein-protein interaction domain suggested to be critical for the interaction with several, mostly plant-specific transcription factors [1,2].
The RST domain structure has a unique helical arrangement composed of four α helices flanked by disordered termini (see <PDB:5OAO>). The four-helix fold of the RST domain organizes in an open, hydrophobic L-shape with room for catching the ligand [3]. A strong conservation of a large number of aliphatic amino acids in the N- and C-termini of the RST domain, with a conserved tyrosine in the middle of the domain and two conserved positively charged amino acids in the second half of the domain, is striking [1].
The profile we developed covers the entire RST domain.
Last update:November 2018 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Jaspers P. Overmyer K. Wrzaczek M. Vainonen J.P. Blomster T. Salojaervi J. Reddy R.A. Kangasjaervi J. |
| Title | The RST and PARP-like domain containing SRO protein family: analysis of protein structure, function and conservation in land plants. | |
| Source | BMC Genomics 11:170-170(2010). | |
| PubMed ID | 20226034 | |
| DOI | 10.1186/1471-2164-11-170 |
| 2 | Authors | Jaspers P. Blomster T. Brosche M. Salojaervi J. Ahlfors R. Vainonen J.P. Reddy R.A. Immink R. Angenent G. Turck F. Overmyer K. Kangasjaervi J. |
| Title | Unequally redundant RCD1 and SRO1 mediate stress and developmental responses and interact with transcription factors. | |
| Source | Plant J. 60:268-279(2009). | |
| PubMed ID | 19548978 | |
| DOI | 10.1111/j.1365-313X.2009.03951.x |
| 3 | Authors | Bugge K. Staby L. Kemplen K.R. O'Shea C. Bendsen S.K. Jensen M.K. Olsen J.G. Skriver K. Kragelund B.B. |
| Title | Structure of Radical-Induced Cell Death1 Hub Domain Reveals a Common alphaalpha-Scaffold for Disorder in Transcriptional Networks. | |
| Source | Structure 26:734-746.e7(2018). | |
| PubMed ID | 29657132 | |
| DOI | 10.1016/j.str.2018.03.013 |
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