PROSITE documentation PDOC52001
AD domain profile


The AD domain, which may function in RNA-binding based on its predicted anticodon-binding fold, is found in the Hezron/Gemin6/Lsm12 protein family. Members of this eukaryotic protein family have an N-terminal Sm domain (see <PDOC52002>) followed by an AD domain and are involved in RNA metabolism [1,2,3].

The profile we developed covers the entire AD domain.

Last update:

June 2022 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

AD, PS52001; AD domain profile  (MATRIX)


1AuthorsAlbrecht M. Lengauer T.
TitleNovel Sm-like proteins with long C-terminal tails and associated methyltransferases.
SourceFEBS. Lett. 569:18-26(2004).
PubMed ID15225602

2AuthorsMatera A.G. Raimer A.C. Schmidt C.A. Kelly J.A. Droby G.N. Baillat D. Ten Have S. Lamond A.I. Wagner E.J. Gray K.M.
TitleComposition of the Survival Motor Neuron (SMN) Complex in Drosophila melanogaster.
SourceG3. (Bethesda). 9:491-503(2019).
PubMed ID30563832

3AuthorsPatel S. Gunaratne G.S. Marchant J.S. Biggin P.C. Rahman T.
TitleNAADP receptors: A one-two.
SourceCell. Calcium. 100:102478-102478(2021).
PubMed ID34600271

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