We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC52001AD domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC52001
Description
The AD domain, which may function in RNA-binding based on its predicted anticodon-binding fold, is found in the Hezron/Gemin6/Lsm12 protein family. Members of this eukaryotic protein family have an N-terminal Sm domain (see <PDOC52002>) followed by an AD domain and are involved in RNA metabolism [1,2,3].
The profile we developed covers the entire AD domain.
Last update:June 2022 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Albrecht M. Lengauer T. |
| Title | Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. | |
| Source | FEBS. Lett. 569:18-26(2004). | |
| PubMed ID | 15225602 | |
| DOI | 10.1016/j.febslet.2004.03.126 |
| 2 | Authors | Matera A.G. Raimer A.C. Schmidt C.A. Kelly J.A. Droby G.N. Baillat D. Ten Have S. Lamond A.I. Wagner E.J. Gray K.M. |
| Title | Composition of the Survival Motor Neuron (SMN) Complex in Drosophila melanogaster. | |
| Source | G3. (Bethesda). 9:491-503(2019). | |
| PubMed ID | 30563832 | |
| DOI | 10.1534/g3.118.200874 |
| 3 | Authors | Patel S. Gunaratne G.S. Marchant J.S. Biggin P.C. Rahman T. |
| Title | NAADP receptors: A one-two. | |
| Source | Cell. Calcium. 100:102478-102478(2021). | |
| PubMed ID | 34600271 | |
| DOI | 10.1016/j.ceca.2021.102478 |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.