PROSITE documentation PDOC52027
Zinc finger C2HC/C3H-type profile


The C2HC/C3H-type zinc finger has first been identified in four copies in Zfp474, a protein exclusively found in testis and ovary and thought to function as a germ cell specific transcription factor that plays important roles in spermatid differentiation and oocyte development [1]. It is also found in:

  • Animal proteins of the ZC2HC1 family.
  • Bryophyte SOSEKI proteins that locally interpret global polarity cues and can influence cell division orientation to coordinate cell polarization relative to body axes.

The profile we developed covers the entire C2HC/C3H-type zinc finger.

Last update:

June 2023 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

ZF_C2HC_C3H, PS52027; Zinc finger C2HC/C3H-type profile  (MATRIX)


1AuthorsZhou C. Li L.Y. Lu G.X.
TitleMolecular cloning and character analysis of the mouse zinc finger protein gene Zfp474 exclusively expressed in testis and ovary.
SourceYi. Chuan. Xue. Bao. 32:155-162(2005).
PubMed ID15759862

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