PROSITE logo

PROSITE entry PS00068


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] MDH
Accession [info] PS00068
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-OCT-1993 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00066
Associated ProRule [info] PRU10004

Name and characterization of the entry

Description [info] Malate dehydrogenase active site signature.
Pattern [info]
[LIVM]-T-[TRKMN]-L-D-x(2)-R-[STA]-x(3)-[LIVMFY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 236 in 236 different sequences
Number of true positive hits 230 in 230 different sequences
Number of 'unknown' hits 0
Number of false positive hits 6 in 6 different sequences
Number of false negative sequences 115
Number of 'partial' sequences 21
Precision (true positives / (true positives + false positives)) 97.46 %
Recall (true positives / (true positives + false negatives)) 66.67 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Site [info] active_site at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
230 sequences

MDHA_DICDI  (Q54GE6), MDHC1_ARATH (P93819), MDHC2_ARATH (P57106), 
MDHC3_ARATH (Q9FJU0), MDHC_BETVU  (Q9SML8), MDHC_BOVIN  (Q3T145), 
MDHC_CAEEL  (Q9UAV5), MDHC_CANAL  (P83778), MDHC_CHICK  (Q5ZME2), 
MDHC_DICDI  (Q54VM2), MDHC_ECHGR  (Q04820), MDHC_FELCA  (Q7YRU4), 
MDHC_HUMAN  (P40925), MDHC_MAIZE  (Q08062), MDHC_MEDSA  (O48905), 
MDHC_MESCR  (O24047), MDHC_MOUSE  (P14152), MDHC_ORYSJ  (Q7XDC8), 
MDHC_PIG(P11708), MDHC_RAT(O88989), MDHC_XENLA  (Q6PAB3), 
MDHC_XENTR  (Q6DIY9), MDHC_YEAST  (P22133), MDHG1_BRANA (Q43743), 
MDHG2_BRANA (Q9XFW3), MDHG_CITLA  (P19446), MDHG_CUCSA  (P46488), 
MDHG_ORYSJ  (Q42972), MDHG_SOYBN  (P37228), MDHM1_ARATH (Q9ZP06), 
MDHM2_ARATH (Q9LKA3), MDHM_BOVIN  (Q32LG3), MDHM_CAEEL  (O02640), 
MDHM_CHLRE  (Q42686), MDHM_CITLA  (P17783), MDHM_EUCGU  (P46487), 
MDHM_FELCA  (K0J107), MDHM_FRAAN  (P83373), MDHM_HUMAN  (P40926), 
MDHM_MACFA  (Q4R568), MDHM_MOUSE  (P08249), MDHM_PIG(P00346), 
MDHM_PONAB  (Q5NVR2), MDHM_RAT(P04636), MDHM_YEAST  (P17505), 
MDHNP_ARATH (Q8H1E2), MDHP1_SORBI (P17606), MDHP2_SORBI (P37229), 
MDHP_ARATH  (Q9SN86), MDHP_FLABI  (P46489), MDHP_MAIZE  (P15719), 
MDHP_MEDSA  (O48902), MDHP_MESCR  (Q05145), MDHP_PEA(P21528), 
MDHP_SPIOL  (P52426), MDHP_YEAST  (P32419), MDHX1_ARATH (O82399), 
MDHX2_ARATH (Q9ZP05), MDH_ACTSZ   (Q5U907), MDH_AERHH   (A0KG16), 
MDH_AERS4   (A4SIV0), MDH_AKKM8   (B2UKY5), MDH_ALCBS   (Q0VQ52), 
MDH_ALIF1   (Q5E875), MDH_ALIFM   (B5FGF5), MDH_ALISL   (B6EL39), 
MDH_ALKEH   (Q0ABE6), MDH_CELJU   (B3PHI3), MDH_CITK8   (A8AQC8), 
MDH_COLP3   (Q47VL0), MDH_COXB1   (B6J7Q0), MDH_COXB2   (B6IZN7), 
MDH_COXBN   (A9KFT9), MDH_COXBR   (A9NDV1), MDH_COXBU   (Q83C87), 
MDH_CROS8   (A7MNR3), MDH_CUTAK   (Q6A6Z5), MDH_ECO24   (A7ZSD0), 
MDH_ECO27   (B7UJW8), MDH_ECO45   (B7MBZ7), MDH_ECO55   (B7LHU4), 
MDH_ECO57   (P61891), MDH_ECO5E   (B5YSW2), MDH_ECO7I   (B7NKU9), 
MDH_ECO81   (B7N0M1), MDH_ECO8A   (B7M0U8), MDH_ECOBW   (C4ZSX4), 
MDH_ECODH   (B1XHK9), MDH_ECOHS   (A8A545), MDH_ECOK1   (A1AGC9), 
MDH_ECOL5   (Q0TCN0), MDH_ECOL6   (P61890), MDH_ECOLC   (B1IQP3), 
MDH_ECOLI   (P61889), MDH_ECOLU   (B7NDL4), MDH_ECOSE   (B6I1V4), 
MDH_ECOSM   (B1LGK2), MDH_ECOUT   (Q1R6A3), MDH_EDWI9   (C5BF98), 
MDH_ENT38   (A4WF48), MDH_ERWT9   (B2VGW7), MDH_ESCF3   (B7LRL0), 
MDH_FRAAA   (Q0RE66), MDH_FRACC   (Q2J7E7), MDH_HAEDU   (Q7VP41), 
MDH_HAEI8   (Q4QL89), MDH_HAEIE   (A5UCQ1), MDH_HAEIG   (A5UIX3), 
MDH_HAEIN   (P44427), MDH_HALHL   (A1WV94), MDH_HISS1   (Q0I491), 
MDH_HISS2   (B0UUR6), MDH_IDILO   (Q5R030), MDH_KLEOX   (P61894), 
MDH_KLEP3   (B5XSQ7), MDH_KLEP7   (A6TEQ3), MDH_KLEVA   (P61896), 
MDH_KOCRD   (B2GKC8), MDH_LEGPA   (Q5X2T6), MDH_LEGPC   (A5IEF4), 
MDH_LEGPH   (Q5ZT13), MDH_LEGPL   (Q5WU94), MDH_LEPBJ   (Q04RS5), 
MDH_LEPBL   (Q051U6), MDH_LEPIC   (P61975), MDH_LEPIN   (Q8F4A2), 
MDH_MANSM   (Q65T37), MDH_METCA   (Q60B71), MDH_MORJA   (Q6AW21), 
MDH_MORMI   (Q6AW23), MDH_MORS2   (Q7X3X5), MDH_MORS5   (P48364), 
MDH_MYCA1   (A0QCI6), MDH_MYCBO   (P0A5J7), MDH_MYCBP   (A1KI28), 
MDH_MYCBT   (C1AMN4), MDH_MYCLE   (P50917), MDH_MYCMM   (B2HRH5), 
MDH_MYCPA   (P61976), MDH_MYCTA   (A5U1T8), MDH_MYCTO   (P9WK12), 
MDH_MYCTU   (P9WK13), MDH_MYCUA   (A0PVV1), MDH_NOCFA   (Q5YTI1), 
MDH_NOCSJ   (A1SMP3), MDH_PAEAT   (A1R2B5), MDH_PARUW   (Q6MAA3), 
MDH_PASMU   (Q9CN86), MDH_PECAS   (Q6D9D1), MDH_PECCC   (P61897), 
MDH_PECCP   (C6DKH1), MDH_PHOLL   (Q7MYW9), MDH_PHOPR   (P37226), 
MDH_PROMH   (B4F2A1), MDH_PSEA6   (Q15YH0), MDH_PSET1   (Q3IFH4), 
MDH_PSYA2   (Q4FQU7), MDH_PSYCK   (Q1Q932), MDH_PSYIN   (A1SRP8), 
MDH_RAOTE   (P61895), MDH_RHOJR   (Q0S365), MDH_RHOOB   (C1B155), 
MDH_RUBXD   (Q1AWH4), MDH_SACEN   (A4FFX3), MDH_SALA4   (B5F7L9), 
MDH_SALAR   (A9MNX5), MDH_SALCH   (Q57JA9), MDH_SALDC   (B5FIT7), 
MDH_SALEP   (B5R0N2), MDH_SALG2   (B5REV7), MDH_SALHS   (B4TJT3), 
MDH_SALMU   (Q59838), MDH_SALNS   (B4T769), MDH_SALPA   (Q7WS85), 
MDH_SALPB   (A9N855), MDH_SALPC   (C0PZQ4), MDH_SALPK   (B5BGR3), 
MDH_SALSV   (B4TWK9), MDH_SALTI   (Q8Z3E0), MDH_SALTY   (P25077), 
MDH_SHEAM   (A1S3C4), MDH_SHEB2   (B8EB55), MDH_SHEB5   (A3D075), 
MDH_SHEB8   (A6WSM1), MDH_SHEB9   (A9L340), MDH_SHEDO   (Q12R11), 
MDH_SHEFN   (Q07YA5), MDH_SHEHH   (B0TUH8), MDH_SHELP   (A3QB91), 
MDH_SHEON   (P82177), MDH_SHEPA   (A8H0U0), MDH_SHEPC   (A4YAE8), 
MDH_SHEPW   (B8CSY7), MDH_SHESA   (A0L113), MDH_SHESH   (A8FRU0), 
MDH_SHESM   (Q0HEW2), MDH_SHESR   (Q0HZ38), MDH_SHESW   (A1RFX8), 
MDH_SHEWM   (B1KGG7), MDH_SHIB3   (B2U1U9), MDH_SHIBS   (Q31WA4), 
MDH_SHIDS   (Q32BA3), MDH_SHIF8   (Q0T052), MDH_SHIFL   (Q83Q04), 
MDH_SHISS   (Q3YX11), MDH_STRAW   (Q82HS2), MDH_STRCO   (Q9K3J3), 
MDH_STRGG   (B1W3N4), MDH_THEFY   (Q47TT4), MDH_THET2   (P61977), 
MDH_THET8   (Q5SKV7), MDH_THETH   (P10584), MDH_TOBAC   (Q9FSF0), 
MDH_VIBA3   (B7VID0), MDH_VIBC1   (A7MWD3), MDH_VIBCH   (Q9KUT3), 
MDH_VIBMI   (Q9L8F6), MDH_VIBPA   (Q87SU7), MDH_VIBVU   (Q8DEC2), 
MDH_VIBVY   (Q7MP97), MDH_YERE8   (A1JIV0), MDH_YERP3   (A7FMU2), 
MDH_YERPA   (Q1CBY7), MDH_YERPB   (B2K2N5), MDH_YERPE   (P61892), 
MDH_YERPG   (A9R584), MDH_YERPN   (Q1CEJ3), MDH_YERPP   (A4TRK3), 
MDH_YERPS   (P0C7R5), MDH_YERPY   (B1JMK1)
» more

UniProtKB/Swiss-Prot
False negative sequences
115 sequences

MDH1_ALBFT  (Q21XH1), MDH1_BURTA  (Q2T7J2), MDH1_BURVG  (A4JKE6), 
MDH2_ALBFT  (Q21VT3), MDH2_BURTA  (Q2T4T8), MDH2_BURVG  (A4JM71), 
MDHM_BRANA  (Q43744), MDH_ACIAD   (Q6F7X1), MDH_ACIB3   (B7GW58), 
MDH_ACIB5   (B7I9D2), MDH_ACIBC   (B2HZ52), MDH_ACIBS   (B0VQX5), 
MDH_ACIBT   (A3M928), MDH_ACIBY   (B0V6R7), MDH_ACICJ   (A5G320), 
MDH_ACIET   (B9MBP0), MDH_ACISJ   (A1W9K7), MDH_ACTP2   (A3N1U6), 
MDH_ACTP7   (B3H269), MDH_ACTPJ   (B0BQN0), MDH_AQUAR   (Q9ZF99), 
MDH_AROAE   (Q5NYA9), MDH_AZOSB   (A1K5Q9), MDH_BDEBA   (P61973), 
MDH_BORA1   (Q2L068), MDH_BORBR   (Q7WD94), MDH_BORPA   (Q7W5Q8), 
MDH_BORPD   (A9IIS3), MDH_BORPE   (Q7VW97), MDH_BURCH   (A0AZ43), 
MDH_BURCJ   (B4EFB0), MDH_BURCM   (Q0BAF9), MDH_BURL3   (Q393V1), 
MDH_BURM1   (A9AMD5), MDH_BURM7   (A3MBR2), MDH_BURM9   (A2S105), 
MDH_BURMA   (Q62AG8), MDH_BURMS   (A1UZ10), MDH_BURO0   (B1K394), 
MDH_BURO1   (Q1BM38), MDH_BURP0   (A3P7Q9), MDH_BURP1   (Q3JKE9), 
MDH_BURP6   (A3NM97), MDH_BURPS   (P80536), MDH_CHLAB   (Q5L5E3), 
MDH_CHLCV   (Q822E9), MDH_CHLFF   (Q255I4), MDH_CHLMU   (Q9PK18), 
MDH_CHLPN   (Q9Z6N1), MDH_CHLT2   (B0B7U5), MDH_CHLTA   (Q3KLX8), 
MDH_CHLTB   (B0BC10), MDH_CHLTR   (O84381), MDH_CHRVO   (Q7NZ60), 
MDH_CORDI   (P61974), MDH_COREF   (Q8FN62), MDH_CORGB   (A4QGA0), 
MDH_CORGL   (Q8NN33), MDH_CORJK   (Q4JWV0), MDH_CUPMC   (Q1LKG0), 
MDH_CUPNH   (Q0K8F5), MDH_CUPPJ   (Q46YU4), MDH_CUPTR   (B3R570), 
MDH_DECAR   (Q47C34), MDH_DEIDV   (C1CY73), MDH_DEIGD   (Q1IWC9), 
MDH_DEIRA   (Q9RXI8), MDH_DELAS   (A9BVK0), MDH_DESPS   (Q6AQI3), 
MDH_EHRRG   (Q5FGT9), MDH_GLAP5   (B8F5K4), MDH_HERAR   (A4G5Z9), 
MDH_JANMA   (A6SY47), MDH_LARHH   (C1DB66), MDH_LEPBA   (B0SF41), 
MDH_LEPBP   (B0SN74), MDH_LEPCP   (B1Y8A3), MDH_MAGMM   (A0L5T9), 
MDH_METPP   (A2SHT9), MDH_MYCVP   (A1T9L9), MDH_NITEC   (Q0AFK6), 
MDH_NITEU   (Q82WB9), MDH_NITMU   (Q2YAQ4), MDH_PARC0   (A1TP96), 
MDH_PARP8   (B2JQD2), MDH_PARPJ   (B2T9P8), MDH_PARXL   (Q13S42), 
MDH_POLAQ   (A4SWW0), MDH_POLNA   (A1VRQ1), MDH_POLNS   (B1XV63), 
MDH_POLSJ   (Q126N9), MDH_PSYWF   (A5WGM2), MDH_RALN1   (Q8XXW5), 
MDH_RALPJ   (B2U705), MDH_SACD2   (Q21K60), MDH_SERP5   (A8G8Y7), 
MDH_STRM5   (B4SLI5), MDH_STRMK   (B2FQL8), MDH_SYNFM   (A0LFF8), 
MDH_TERTT   (C5BU70), MDH_VARPS   (C5CSI5), MDH_VEREI   (A1WR02), 
MDH_WOLTR   (Q5GT41), MDH_XANAC   (Q8PNP8), MDH_XANC8   (Q4URH2), 
MDH_XANCB   (B0RU49), MDH_XANCP   (Q8PC25), MDH_XANE5   (Q3BWU8), 
MDH_XANOM   (Q2P736), MDH_XANOP   (B2SMP6), MDH_XANOR   (Q5H496), 
MDH_XYLF2   (B2I8M1), MDH_XYLFA   (Q9PE17), MDH_XYLFM   (B0U5Q1), 
MDH_XYLFT   (Q87E35)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
21 sequences

MDHM_CAPAA  (P86074), MDHM_IMPCY  (P84209), MDHM_SCHMA  (P37227), 
MDHM_TOBAC  (P82816), MDH_ACIDE   (P80540), MDH_ACTMI   (P19977), 
MDH_BURCE   (P80537), MDH_DELAC   (P80539), MDH_KIBAR   (P19978), 
MDH_KLEPN   (P0C1G4), MDH_KLEPR   (P0C1G5), MDH_MICGL   (P19979), 
MDH_NITAL   (P10887), MDH_PHEIM   (P19980), MDH_PLAVE   (P19981), 
MDH_PSEMZ   (P85920), MDH_STEMA   (P80541), MDH_STRAR   (P19982), 
MDH_STRRS   (P19983), MDH_THEAL   (P33163), MDH_VOGIN   (P80538)
» more

UniProtKB/Swiss-Prot
False positive sequences
6 sequences

HIS4_CHRVO  (Q7P0F0), HIS4_HYDCU  (Q31E65), MYCA_THET4  (G2Q9A5), 
PX11E_ARATH (Q84JW1), SDGA_EMENI  (A0A1U8QN18), TLR3_BOSTR  (Q0PV50)
» more

PDB
[Detailed view]
49 PDB

1BDM; 1BMD; 1CIV; 1EMD; 1IZ9; 1MLD; 1SEV; 1SMK; 1WZE; 1WZI; 1Y7T; 2CMD; 2CVQ; 2DFD; 2PWZ; 3HHP; 4E0B; 4KDE; 4KDF; 4MDH; 4TVO; 4WLE; 4WLF; 4WLN; 4WLO; 4WLU; 4WLV; 5KKA; 5KVV; 5MDH; 5NUE; 5NUF; 5Z3W; 5ZI2; 5ZI3; 5ZI4; 6AOO; 6BAL; 6ITL; 6KA0; 6KA1; 6PBL; 7CGC; 7CGD; 7MDH; 7RM9; 7RRL; 7XQN; 8J5D
» more