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| Entry: PS00068 |
General information about the entry
| Entry name [info] | MDH |
| Accession [info] | PS00068 |
| Entry type [info] | PATTERN |
| Date [info] |
01-APR-1990 CREATED;
01-OCT-1993 DATA UPDATE; 13-NOV-2019 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00066 |
| Associated ProRule [info] | PRU10004 |
Name and characterization of the entry
| Description [info] | Malate dehydrogenase active site signature. |
| Pattern [info] |
[LIVM]-T-[TRKMN]-L-D-x(2)-R-[STA]-x(3)-[LIVMFY]. |
Numerical results [info]
| Total number of hits | 233 in 233 different sequences |
| Number of true positive hits | 229 in 229 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 4 in 4 different sequences |
| Number of false negative sequences | 115 |
| Number of 'partial' sequences | 21 |
| Precision (true positives / (true positives + false positives)) | 98.28 % |
| Recall (true positives / (true positives + false negatives)) | 66.57 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 1 |
| Site [info] | active_site at position 5 |
| Site [info] | active_site at position 7 |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
229 sequences
MDHA_DICDI (Q54GE6 ), MDHC1_ARATH (P93819 ), MDHC2_ARATH (P57106 ), MDHC3_ARATH (Q9FJU0 ), MDHC_BETVU (Q9SML8 ), MDHC_BOVIN (Q3T145 ), MDHC_CANAL (P83778 ), MDHC_CHICK (Q5ZME2 ), MDHC_DICDI (Q54VM2 ), MDHC_ECHGR (Q04820 ), MDHC_FELCA (Q7YRU4 ), MDHC_HUMAN (P40925 ), MDHC_MAIZE (Q08062 ), MDHC_MEDSA (O48905 ), MDHC_MESCR (O24047 ), MDHC_MOUSE (P14152 ), MDHC_ORYSJ (Q7XDC8 ), MDHC_PIG (P11708 ), MDHC_RAT (O88989 ), MDHC_XENLA (Q6PAB3 ), MDHC_XENTR (Q6DIY9 ), MDHC_YEAST (P22133 ), MDHG1_BRANA (Q43743 ), MDHG2_BRANA (Q9XFW3 ), MDHG_CITLA (P19446 ), MDHG_CUCSA (P46488 ), MDHG_ORYSJ (Q42972 ), MDHG_SOYBN (P37228 ), MDHM1_ARATH (Q9ZP06 ), MDHM2_ARATH (Q9LKA3 ), MDHM_BOVIN (Q32LG3 ), MDHM_CAEEL (O02640 ), MDHM_CHLRE (Q42686 ), MDHM_CITLA (P17783 ), MDHM_EUCGU (P46487 ), MDHM_FELCA (K0J107 ), MDHM_FRAAN (P83373 ), MDHM_HUMAN (P40926 ), MDHM_MACFA (Q4R568 ), MDHM_MOUSE (P08249 ), MDHM_PIG (P00346 ), MDHM_PONAB (Q5NVR2 ), MDHM_RAT (P04636 ), MDHM_YEAST (P17505 ), MDHNP_ARATH (Q8H1E2 ), MDHP1_SORBI (P17606 ), MDHP2_SORBI (P37229 ), MDHP_ARATH (Q9SN86 ), MDHP_FLABI (P46489 ), MDHP_MAIZE (P15719 ), MDHP_MEDSA (O48902 ), MDHP_MESCR (Q05145 ), MDHP_PEA (P21528 ), MDHP_SPIOL (P52426 ), MDHP_YEAST (P32419 ), MDHX1_ARATH (O82399 ), MDHX2_ARATH (Q9ZP05 ), MDH_ACTSZ (Q5U907 ), MDH_AERHH (A0KG16 ), MDH_AERS4 (A4SIV0 ), MDH_AKKM8 (B2UKY5 ), MDH_ALCBS (Q0VQ52 ), MDH_ALIF1 (Q5E875 ), MDH_ALIFM (B5FGF5 ), MDH_ALISL (B6EL39 ), MDH_ALKEH (Q0ABE6 ), MDH_CELJU (B3PHI3 ), MDH_CITK8 (A8AQC8 ), MDH_COLP3 (Q47VL0 ), MDH_COXB1 (B6J7Q0 ), MDH_COXB2 (B6IZN7 ), MDH_COXBN (A9KFT9 ), MDH_COXBR (A9NDV1 ), MDH_COXBU (Q83C87 ), MDH_CROS8 (A7MNR3 ), MDH_CUTAK (Q6A6Z5 ), MDH_ECO24 (A7ZSD0 ), MDH_ECO27 (B7UJW8 ), MDH_ECO45 (B7MBZ7 ), MDH_ECO55 (B7LHU4 ), MDH_ECO57 (P61891 ), MDH_ECO5E (B5YSW2 ), MDH_ECO7I (B7NKU9 ), MDH_ECO81 (B7N0M1 ), MDH_ECO8A (B7M0U8 ), MDH_ECOBW (C4ZSX4 ), MDH_ECODH (B1XHK9 ), MDH_ECOHS (A8A545 ), MDH_ECOK1 (A1AGC9 ), MDH_ECOL5 (Q0TCN0 ), MDH_ECOL6 (P61890 ), MDH_ECOLC (B1IQP3 ), MDH_ECOLI (P61889 ), MDH_ECOLU (B7NDL4 ), MDH_ECOSE (B6I1V4 ), MDH_ECOSM (B1LGK2 ), MDH_ECOUT (Q1R6A3 ), MDH_EDWI9 (C5BF98 ), MDH_ENT38 (A4WF48 ), MDH_ERWT9 (B2VGW7 ), MDH_ESCF3 (B7LRL0 ), MDH_FRAAA (Q0RE66 ), MDH_FRACC (Q2J7E7 ), MDH_HAEDU (Q7VP41 ), MDH_HAEI8 (Q4QL89 ), MDH_HAEIE (A5UCQ1 ), MDH_HAEIG (A5UIX3 ), MDH_HAEIN (P44427 ), MDH_HAES1 (Q0I491 ), MDH_HALHL (A1WV94 ), MDH_HISS2 (B0UUR6 ), MDH_IDILO (Q5R030 ), MDH_KLEOX (P61894 ), MDH_KLEP3 (B5XSQ7 ), MDH_KLEP7 (A6TEQ3 ), MDH_KLEVA (P61896 ), MDH_KOCRD (B2GKC8 ), MDH_LEGPA (Q5X2T6 ), MDH_LEGPC (A5IEF4 ), MDH_LEGPH (Q5ZT13 ), MDH_LEGPL (Q5WU94 ), MDH_LEPBJ (Q04RS5 ), MDH_LEPBL (Q051U6 ), MDH_LEPIC (P61975 ), MDH_LEPIN (Q8F4A2 ), MDH_MANSM (Q65T37 ), MDH_METCA (Q60B71 ), MDH_MORJA (Q6AW21 ), MDH_MORMI (Q6AW23 ), MDH_MORS2 (Q7X3X5 ), MDH_MORS5 (P48364 ), MDH_MYCA1 (A0QCI6 ), MDH_MYCBO (P0A5J7 ), MDH_MYCBP (A1KI28 ), MDH_MYCBT (C1AMN4 ), MDH_MYCLE (P50917 ), MDH_MYCMM (B2HRH5 ), MDH_MYCPA (P61976 ), MDH_MYCTA (A5U1T8 ), MDH_MYCTO (P9WK12 ), MDH_MYCTU (P9WK13 ), MDH_MYCUA (A0PVV1 ), MDH_NOCFA (Q5YTI1 ), MDH_NOCSJ (A1SMP3 ), MDH_PAEAT (A1R2B5 ), MDH_PARUW (Q6MAA3 ), MDH_PASMU (Q9CN86 ), MDH_PECAS (Q6D9D1 ), MDH_PECCC (P61897 ), MDH_PECCP (C6DKH1 ), MDH_PHOLL (Q7MYW9 ), MDH_PHOPR (P37226 ), MDH_PROMH (B4F2A1 ), MDH_PSEA6 (Q15YH0 ), MDH_PSEHT (Q3IFH4 ), MDH_PSYA2 (Q4FQU7 ), MDH_PSYCK (Q1Q932 ), MDH_PSYIN (A1SRP8 ), MDH_RAOTE (P61895 ), MDH_RHOJR (Q0S365 ), MDH_RHOOB (C1B155 ), MDH_RUBXD (Q1AWH4 ), MDH_SACEN (A4FFX3 ), MDH_SALA4 (B5F7L9 ), MDH_SALAR (A9MNX5 ), MDH_SALCH (Q57JA9 ), MDH_SALDC (B5FIT7 ), MDH_SALEP (B5R0N2 ), MDH_SALG2 (B5REV7 ), MDH_SALHS (B4TJT3 ), MDH_SALMU (Q59838 ), MDH_SALNS (B4T769 ), MDH_SALPA (Q7WS85 ), MDH_SALPB (A9N855 ), MDH_SALPC (C0PZQ4 ), MDH_SALPK (B5BGR3 ), MDH_SALSV (B4TWK9 ), MDH_SALTI (Q8Z3E0 ), MDH_SALTY (P25077 ), MDH_SHEAM (A1S3C4 ), MDH_SHEB2 (B8EB55 ), MDH_SHEB5 (A3D075 ), MDH_SHEB8 (A6WSM1 ), MDH_SHEB9 (A9L340 ), MDH_SHEDO (Q12R11 ), MDH_SHEFN (Q07YA5 ), MDH_SHEHH (B0TUH8 ), MDH_SHELP (A3QB91 ), MDH_SHEON (P82177 ), MDH_SHEPA (A8H0U0 ), MDH_SHEPC (A4YAE8 ), MDH_SHEPW (B8CSY7 ), MDH_SHESA (A0L113 ), MDH_SHESH (A8FRU0 ), MDH_SHESM (Q0HEW2 ), MDH_SHESR (Q0HZ38 ), MDH_SHESW (A1RFX8 ), MDH_SHEWM (B1KGG7 ), MDH_SHIB3 (B2U1U9 ), MDH_SHIBS (Q31WA4 ), MDH_SHIDS (Q32BA3 ), MDH_SHIF8 (Q0T052 ), MDH_SHIFL (Q83Q04 ), MDH_SHISS (Q3YX11 ), MDH_STRAW (Q82HS2 ), MDH_STRCO (Q9K3J3 ), MDH_STRGG (B1W3N4 ), MDH_THEFY (Q47TT4 ), MDH_THET2 (P61977 ), MDH_THET8 (Q5SKV7 ), MDH_THETH (P10584 ), MDH_TOBAC (Q9FSF0 ), MDH_VIBCB (A7MWD3 ), MDH_VIBCH (Q9KUT3 ), MDH_VIBMI (Q9L8F6 ), MDH_VIBPA (Q87SU7 ), MDH_VIBTL (B7VID0 ), MDH_VIBVU (Q8DEC2 ), MDH_VIBVY (Q7MP97 ), MDH_YERE8 (A1JIV0 ), MDH_YERP3 (A7FMU2 ), MDH_YERPA (Q1CBY7 ), MDH_YERPB (B2K2N5 ), MDH_YERPE (P61892 ), MDH_YERPG (A9R584 ), MDH_YERPN (Q1CEJ3 ), MDH_YERPP (A4TRK3 ), MDH_YERPS (P0C7R5 ), MDH_YERPY (B1JMK1 )» more
|
| UniProtKB/Swiss-Prot False negative sequences |
115 sequences
MDH1_BURTA (Q2T7J2 ), MDH1_BURVG (A4JKE6 ), MDH1_RHOFT (Q21XH1 ), MDH2_BURTA (Q2T4T8 ), MDH2_BURVG (A4JM71 ), MDH2_RHOFT (Q21VT3 ), MDHM_BRANA (Q43744 ), MDH_ACIAC (A1TP96 ), MDH_ACIAD (Q6F7X1 ), MDH_ACIB3 (B7GW58 ), MDH_ACIB5 (B7I9D2 ), MDH_ACIBC (B2HZ52 ), MDH_ACIBS (B0VQX5 ), MDH_ACIBT (A3M928 ), MDH_ACIBY (B0V6R7 ), MDH_ACICJ (A5G320 ), MDH_ACIET (B9MBP0 ), MDH_ACISJ (A1W9K7 ), MDH_ACTP2 (A3N1U6 ), MDH_ACTP7 (B3H269 ), MDH_ACTPJ (B0BQN0 ), MDH_AQUAR (Q9ZF99 ), MDH_AROAE (Q5NYA9 ), MDH_AZOSB (A1K5Q9 ), MDH_BDEBA (P61973 ), MDH_BORA1 (Q2L068 ), MDH_BORBR (Q7WD94 ), MDH_BORPA (Q7W5Q8 ), MDH_BORPD (A9IIS3 ), MDH_BORPE (Q7VW97 ), MDH_BURCA (Q1BM38 ), MDH_BURCC (B1K394 ), MDH_BURCH (A0AZ43 ), MDH_BURCJ (B4EFB0 ), MDH_BURCM (Q0BAF9 ), MDH_BURL3 (Q393V1 ), MDH_BURM1 (A9AMD5 ), MDH_BURM7 (A3MBR2 ), MDH_BURM9 (A2S105 ), MDH_BURMA (Q62AG8 ), MDH_BURMS (A1UZ10 ), MDH_BURP0 (A3P7Q9 ), MDH_BURP1 (Q3JKE9 ), MDH_BURP6 (A3NM97 ), MDH_BURPS (P80536 ), MDH_CHLAB (Q5L5E3 ), MDH_CHLCV (Q822E9 ), MDH_CHLFF (Q255I4 ), MDH_CHLMU (Q9PK18 ), MDH_CHLPN (Q9Z6N1 ), MDH_CHLT2 (B0B7U5 ), MDH_CHLTA (Q3KLX8 ), MDH_CHLTB (B0BC10 ), MDH_CHLTR (O84381 ), MDH_CHRVO (Q7NZ60 ), MDH_CORDI (P61974 ), MDH_COREF (Q8FN62 ), MDH_CORGB (A4QGA0 ), MDH_CORGL (Q8NN33 ), MDH_CORJK (Q4JWV0 ), MDH_CUPMC (Q1LKG0 ), MDH_CUPNH (Q0K8F5 ), MDH_CUPPJ (Q46YU4 ), MDH_CUPTR (B3R570 ), MDH_DECAR (Q47C34 ), MDH_DEIDV (C1CY73 ), MDH_DEIGD (Q1IWC9 ), MDH_DEIRA (Q9RXI8 ), MDH_DELAS (A9BVK0 ), MDH_DESPS (Q6AQI3 ), MDH_EHRRG (Q5FGT9 ), MDH_HAEPS (B8F5K4 ), MDH_HERAR (A4G5Z9 ), MDH_JANMA (A6SY47 ), MDH_LARHH (C1DB66 ), MDH_LEPBA (B0SF41 ), MDH_LEPBP (B0SN74 ), MDH_LEPCP (B1Y8A3 ), MDH_MAGMM (A0L5T9 ), MDH_METPP (A2SHT9 ), MDH_MYCVP (A1T9L9 ), MDH_NITEC (Q0AFK6 ), MDH_NITEU (Q82WB9 ), MDH_NITMU (Q2YAQ4 ), MDH_PARP8 (B2JQD2 ), MDH_PARPJ (B2T9P8 ), MDH_PARXL (Q13S42 ), MDH_POLAQ (A4SWW0 ), MDH_POLNA (A1VRQ1 ), MDH_POLNS (B1XV63 ), MDH_POLSJ (Q126N9 ), MDH_PSYWF (A5WGM2 ), MDH_RALPJ (B2U705 ), MDH_RALSO (Q8XXW5 ), MDH_SACD2 (Q21K60 ), MDH_SERP5 (A8G8Y7 ), MDH_STRM5 (B4SLI5 ), MDH_STRMK (B2FQL8 ), MDH_SYNFM (A0LFF8 ), MDH_TERTT (C5BU70 ), MDH_VARPS (C5CSI5 ), MDH_VEREI (A1WR02 ), MDH_WOLTR (Q5GT41 ), MDH_XANAC (Q8PNP8 ), MDH_XANC5 (Q3BWU8 ), MDH_XANC8 (Q4URH2 ), MDH_XANCB (B0RU49 ), MDH_XANCP (Q8PC25 ), MDH_XANOM (Q2P736 ), MDH_XANOP (B2SMP6 ), MDH_XANOR (Q5H496 ), MDH_XYLF2 (B2I8M1 ), MDH_XYLFA (Q9PE17 ), MDH_XYLFM (B0U5Q1 ), MDH_XYLFT (Q87E35 )» more |
| UniProtKB/Swiss-Prot 'Partial' sequences |
21 sequences
MDHM_CAPAA (P86074 ), MDHM_IMPCY (P84209 ), MDHM_SCHMA (P37227 ), MDHM_TOBAC (P82816 ), MDH_ACIDE (P80540 ), MDH_ACTMI (P19977 ), MDH_BURCE (P80537 ), MDH_DELAC (P80539 ), MDH_KIBAR (P19978 ), MDH_KLEPN (P0C1G4 ), MDH_KLEPR (P0C1G5 ), MDH_MICGL (P19979 ), MDH_NITAL (P10887 ), MDH_PHEIM (P19980 ), MDH_PLAVE (P19981 ), MDH_PSEMZ (P85920 ), MDH_STEMA (P80541 ), MDH_STRAR (P19982 ), MDH_STRRS (P19983 ), MDH_THEAL (P33163 ), MDH_VOGIN (P80538 )» more |
| UniProtKB/Swiss-Prot False positive sequences |
4 sequences
HIS4_CHRVO (Q7P0F0 ), HIS4_HYDCU (Q31E65 ), PX11E_ARATH (Q84JW1 ), TLR3_BOSTR (Q0PV50 )» more |
| PDB [Detailed view] |
40 PDB
1BDM; 1BMD; 1CIV; 1EMD; 1IZ9; 1MLD; 1SEV; 1SMK; 1WZE; 1WZI; 1Y7T; 2CMD; 2CVQ; 2DFD; 2PWZ; 3HHP; 4E0B; 4KDE; 4KDF; 4MDH; 4TVO; 4WLE; 4WLF; 4WLN; 4WLO; 4WLU; 4WLV; 5KKA; 5KVV; 5MDH; 5NUE; 5NUF; 5Z3W; 5ZI2; 5ZI3; 5ZI4; 6AOO; 6BAL; 6PBL; 7MDH » more |
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