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PROSITE entry PS00068


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00068
Entry name [info] MDH
Accession [info] PS00068
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-OCT-1993 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00066
Associated ProRule [info] PRU10004

Name and characterization of the entry

Description [info] Malate dehydrogenase active site signature.
Pattern [info] 
[LIVM]-T-[TRKMN]-L-D-x(2)-R-[STA]-x(3)-[LIVMFY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 236 in 236 different sequences
Number of true positive hits 230 in 230 different sequences
Number of 'unknown' hits 0
Number of false positive hits 6 in 6 different sequences
Number of false negative sequences 115
Number of 'partial' sequences 21
Precision (true positives / (true positives + false positives)) 97.46 %
Recall (true positives / (true positives + false negatives)) 66.67 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Site [info] active_site at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 230 sequences 

MDHA_DICDI  (Q54GE6), MDHC1_ARATH (P93819), MDHC2_ARATH (P57106), 

MDHC3_ARATH (Q9FJU0), MDHC_BETVU  (Q9SML8), MDHC_BOVIN  (Q3T145), 
MDHC_CAEEL  (Q9UAV5), MDHC_CANAL  (P83778), MDHC_CHICK  (Q5ZME2), 
MDHC_DICDI  (Q54VM2), MDHC_ECHGR  (Q04820), MDHC_FELCA  (Q7YRU4), 
MDHC_HUMAN  (P40925), MDHC_MAIZE  (Q08062), MDHC_MEDSA  (O48905), 
MDHC_MESCR  (O24047), MDHC_MOUSE  (P14152), MDHC_ORYSJ  (Q7XDC8), 
MDHC_PIG(P11708), MDHC_RAT(O88989), MDHC_XENLA  (Q6PAB3), 
MDHC_XENTR  (Q6DIY9), MDHC_YEAST  (P22133), MDHG1_BRANA (Q43743), 
MDHG2_BRANA (Q9XFW3), MDHG_CITLA  (P19446), MDHG_CUCSA  (P46488), 
MDHG_ORYSJ  (Q42972), MDHG_SOYBN  (P37228), MDHM1_ARATH (Q9ZP06), 
MDHM2_ARATH (Q9LKA3), MDHM_BOVIN  (Q32LG3), MDHM_CAEEL  (O02640), 
MDHM_CHLRE  (Q42686), MDHM_CITLA  (P17783), MDHM_EUCGU  (P46487), 
MDHM_FELCA  (K0J107), MDHM_FRAAN  (P83373), MDHM_HUMAN  (P40926), 
MDHM_MACFA  (Q4R568), MDHM_MOUSE  (P08249), MDHM_PIG(P00346), 
MDHM_PONAB  (Q5NVR2), MDHM_RAT(P04636), MDHM_YEAST  (P17505), 
MDHNP_ARATH (Q8H1E2), MDHP1_SORBI (P17606), MDHP2_SORBI (P37229), 
MDHP_ARATH  (Q9SN86), MDHP_FLABI  (P46489), MDHP_MAIZE  (P15719), 
MDHP_MEDSA  (O48902), MDHP_MESCR  (Q05145), MDHP_PEA(P21528), 
MDHP_SPIOL  (P52426), MDHP_YEAST  (P32419), MDHX1_ARATH (O82399), 
MDHX2_ARATH (Q9ZP05), MDH_ACTSZ   (Q5U907), MDH_AERHH   (A0KG16), 
MDH_AERS4   (A4SIV0), MDH_AKKM8   (B2UKY5), MDH_ALCBS   (Q0VQ52), 
MDH_ALIF1   (Q5E875), MDH_ALIFM   (B5FGF5), MDH_ALISL   (B6EL39), 
MDH_ALKEH   (Q0ABE6), MDH_CELJU   (B3PHI3), MDH_CITK8   (A8AQC8), 
MDH_COLP3   (Q47VL0), MDH_COXB1   (B6J7Q0), MDH_COXB2   (B6IZN7), 
MDH_COXBN   (A9KFT9), MDH_COXBR   (A9NDV1), MDH_COXBU   (Q83C87), 
MDH_CROS8   (A7MNR3), MDH_CUTAK   (Q6A6Z5), MDH_ECO24   (A7ZSD0), 
MDH_ECO27   (B7UJW8), MDH_ECO45   (B7MBZ7), MDH_ECO55   (B7LHU4), 
MDH_ECO57   (P61891), MDH_ECO5E   (B5YSW2), MDH_ECO7I   (B7NKU9), 
MDH_ECO81   (B7N0M1), MDH_ECO8A   (B7M0U8), MDH_ECOBW   (C4ZSX4), 
MDH_ECODH   (B1XHK9), MDH_ECOHS   (A8A545), MDH_ECOK1   (A1AGC9), 
MDH_ECOL5   (Q0TCN0), MDH_ECOL6   (P61890), MDH_ECOLC   (B1IQP3), 
MDH_ECOLI   (P61889), MDH_ECOLU   (B7NDL4), MDH_ECOSE   (B6I1V4), 
MDH_ECOSM   (B1LGK2), MDH_ECOUT   (Q1R6A3), MDH_EDWI9   (C5BF98), 
MDH_ENT38   (A4WF48), MDH_ERWT9   (B2VGW7), MDH_ESCF3   (B7LRL0), 
MDH_FRAAA   (Q0RE66), MDH_FRACC   (Q2J7E7), MDH_HAEDU   (Q7VP41), 
MDH_HAEI8   (Q4QL89), MDH_HAEIE   (A5UCQ1), MDH_HAEIG   (A5UIX3), 
MDH_HAEIN   (P44427), MDH_HALHL   (A1WV94), MDH_HISS1   (Q0I491), 
MDH_HISS2   (B0UUR6), MDH_IDILO   (Q5R030), MDH_KLEOX   (P61894), 
MDH_KLEP3   (B5XSQ7), MDH_KLEP7   (A6TEQ3), MDH_KLEVA   (P61896), 
MDH_KOCRD   (B2GKC8), MDH_LEGPA   (Q5X2T6), MDH_LEGPC   (A5IEF4), 
MDH_LEGPH   (Q5ZT13), MDH_LEGPL   (Q5WU94), MDH_LEPBJ   (Q04RS5), 
MDH_LEPBL   (Q051U6), MDH_LEPIC   (P61975), MDH_LEPIN   (Q8F4A2), 
MDH_MANSM   (Q65T37), MDH_METCA   (Q60B71), MDH_MORJA   (Q6AW21), 
MDH_MORMI   (Q6AW23), MDH_MORS2   (Q7X3X5), MDH_MORS5   (P48364), 
MDH_MYCA1   (A0QCI6), MDH_MYCBO   (P0A5J7), MDH_MYCBP   (A1KI28), 
MDH_MYCBT   (C1AMN4), MDH_MYCLE   (P50917), MDH_MYCMM   (B2HRH5), 
MDH_MYCPA   (P61976), MDH_MYCTA   (A5U1T8), MDH_MYCTO   (P9WK12), 
MDH_MYCTU   (P9WK13), MDH_MYCUA   (A0PVV1), MDH_NOCFA   (Q5YTI1), 
MDH_NOCSJ   (A1SMP3), MDH_PAEAT   (A1R2B5), MDH_PARUW   (Q6MAA3), 
MDH_PASMU   (Q9CN86), MDH_PECAS   (Q6D9D1), MDH_PECCC   (P61897), 
MDH_PECCP   (C6DKH1), MDH_PHOLL   (Q7MYW9), MDH_PHOPR   (P37226), 
MDH_PROMH   (B4F2A1), MDH_PSEA6   (Q15YH0), MDH_PSET1   (Q3IFH4), 
MDH_PSYA2   (Q4FQU7), MDH_PSYCK   (Q1Q932), MDH_PSYIN   (A1SRP8), 
MDH_RAOTE   (P61895), MDH_RHOJR   (Q0S365), MDH_RHOOB   (C1B155), 
MDH_RUBXD   (Q1AWH4), MDH_SACEN   (A4FFX3), MDH_SALA4   (B5F7L9), 
MDH_SALAR   (A9MNX5), MDH_SALCH   (Q57JA9), MDH_SALDC   (B5FIT7), 
MDH_SALEP   (B5R0N2), MDH_SALG2   (B5REV7), MDH_SALHS   (B4TJT3), 
MDH_SALMU   (Q59838), MDH_SALNS   (B4T769), MDH_SALPA   (Q7WS85), 
MDH_SALPB   (A9N855), MDH_SALPC   (C0PZQ4), MDH_SALPK   (B5BGR3), 
MDH_SALSV   (B4TWK9), MDH_SALTI   (Q8Z3E0), MDH_SALTY   (P25077), 
MDH_SHEAM   (A1S3C4), MDH_SHEB2   (B8EB55), MDH_SHEB5   (A3D075), 
MDH_SHEB8   (A6WSM1), MDH_SHEB9   (A9L340), MDH_SHEDO   (Q12R11), 
MDH_SHEFN   (Q07YA5), MDH_SHEHH   (B0TUH8), MDH_SHELP   (A3QB91), 
MDH_SHEON   (P82177), MDH_SHEPA   (A8H0U0), MDH_SHEPC   (A4YAE8), 
MDH_SHEPW   (B8CSY7), MDH_SHESA   (A0L113), MDH_SHESH   (A8FRU0), 
MDH_SHESM   (Q0HEW2), MDH_SHESR   (Q0HZ38), MDH_SHESW   (A1RFX8), 
MDH_SHEWM   (B1KGG7), MDH_SHIB3   (B2U1U9), MDH_SHIBS   (Q31WA4), 
MDH_SHIDS   (Q32BA3), MDH_SHIF8   (Q0T052), MDH_SHIFL   (Q83Q04), 
MDH_SHISS   (Q3YX11), MDH_STRAW   (Q82HS2), MDH_STRCO   (Q9K3J3), 
MDH_STRGG   (B1W3N4), MDH_THEFY   (Q47TT4), MDH_THET2   (P61977), 
MDH_THET8   (Q5SKV7), MDH_THETH   (P10584), MDH_TOBAC   (Q9FSF0), 
MDH_VIBA3   (B7VID0), MDH_VIBC1   (A7MWD3), MDH_VIBCH   (Q9KUT3), 
MDH_VIBMI   (Q9L8F6), MDH_VIBPA   (Q87SU7), MDH_VIBVU   (Q8DEC2), 
MDH_VIBVY   (Q7MP97), MDH_YERE8   (A1JIV0), MDH_YERP3   (A7FMU2), 
MDH_YERPA   (Q1CBY7), MDH_YERPB   (B2K2N5), MDH_YERPE   (P61892), 
MDH_YERPG   (A9R584), MDH_YERPN   (Q1CEJ3), MDH_YERPP   (A4TRK3), 
MDH_YERPS   (P0C7R5), MDH_YERPY   (B1JMK1)
» more

UniProtKB/Swiss-Prot
False negative sequences		 115 sequences 

MDH1_ALBFT  (Q21XH1), MDH1_BURTA  (Q2T7J2), MDH1_BURVG  (A4JKE6), 

MDH2_ALBFT  (Q21VT3), MDH2_BURTA  (Q2T4T8), MDH2_BURVG  (A4JM71), 
MDHM_BRANA  (Q43744), MDH_ACIAD   (Q6F7X1), MDH_ACIB3   (B7GW58), 
MDH_ACIB5   (B7I9D2), MDH_ACIBC   (B2HZ52), MDH_ACIBS   (B0VQX5), 
MDH_ACIBT   (A3M928), MDH_ACIBY   (B0V6R7), MDH_ACICJ   (A5G320), 
MDH_ACIET   (B9MBP0), MDH_ACISJ   (A1W9K7), MDH_ACTP2   (A3N1U6), 
MDH_ACTP7   (B3H269), MDH_ACTPJ   (B0BQN0), MDH_AQUAR   (Q9ZF99), 
MDH_AROAE   (Q5NYA9), MDH_AZOSB   (A1K5Q9), MDH_BDEBA   (P61973), 
MDH_BORA1   (Q2L068), MDH_BORBR   (Q7WD94), MDH_BORPA   (Q7W5Q8), 
MDH_BORPD   (A9IIS3), MDH_BORPE   (Q7VW97), MDH_BURCH   (A0AZ43), 
MDH_BURCJ   (B4EFB0), MDH_BURCM   (Q0BAF9), MDH_BURL3   (Q393V1), 
MDH_BURM1   (A9AMD5), MDH_BURM7   (A3MBR2), MDH_BURM9   (A2S105), 
MDH_BURMA   (Q62AG8), MDH_BURMS   (A1UZ10), MDH_BURO0   (B1K394), 
MDH_BURO1   (Q1BM38), MDH_BURP0   (A3P7Q9), MDH_BURP1   (Q3JKE9), 
MDH_BURP6   (A3NM97), MDH_BURPS   (P80536), MDH_CHLAB   (Q5L5E3), 
MDH_CHLCV   (Q822E9), MDH_CHLFF   (Q255I4), MDH_CHLMU   (Q9PK18), 
MDH_CHLPN   (Q9Z6N1), MDH_CHLT2   (B0B7U5), MDH_CHLTA   (Q3KLX8), 
MDH_CHLTB   (B0BC10), MDH_CHLTR   (O84381), MDH_CHRVO   (Q7NZ60), 
MDH_CORDI   (P61974), MDH_COREF   (Q8FN62), MDH_CORGB   (A4QGA0), 
MDH_CORGL   (Q8NN33), MDH_CORJK   (Q4JWV0), MDH_CUPMC   (Q1LKG0), 
MDH_CUPNH   (Q0K8F5), MDH_CUPPJ   (Q46YU4), MDH_CUPTR   (B3R570), 
MDH_DECAR   (Q47C34), MDH_DEIDV   (C1CY73), MDH_DEIGD   (Q1IWC9), 
MDH_DEIRA   (Q9RXI8), MDH_DELAS   (A9BVK0), MDH_DESPS   (Q6AQI3), 
MDH_EHRRG   (Q5FGT9), MDH_GLAP5   (B8F5K4), MDH_HERAR   (A4G5Z9), 
MDH_JANMA   (A6SY47), MDH_LARHH   (C1DB66), MDH_LEPBA   (B0SF41), 
MDH_LEPBP   (B0SN74), MDH_LEPCP   (B1Y8A3), MDH_MAGMM   (A0L5T9), 
MDH_METPP   (A2SHT9), MDH_MYCVP   (A1T9L9), MDH_NITEC   (Q0AFK6), 
MDH_NITEU   (Q82WB9), MDH_NITMU   (Q2YAQ4), MDH_PARC0   (A1TP96), 
MDH_PARP8   (B2JQD2), MDH_PARPJ   (B2T9P8), MDH_PARXL   (Q13S42), 
MDH_POLAQ   (A4SWW0), MDH_POLNA   (A1VRQ1), MDH_POLNS   (B1XV63), 
MDH_POLSJ   (Q126N9), MDH_PSYWF   (A5WGM2), MDH_RALN1   (Q8XXW5), 
MDH_RALPJ   (B2U705), MDH_SACD2   (Q21K60), MDH_SERP5   (A8G8Y7), 
MDH_STRM5   (B4SLI5), MDH_STRMK   (B2FQL8), MDH_SYNFM   (A0LFF8), 
MDH_TERTT   (C5BU70), MDH_VARPS   (C5CSI5), MDH_VEREI   (A1WR02), 
MDH_WOLTR   (Q5GT41), MDH_XANAC   (Q8PNP8), MDH_XANC8   (Q4URH2), 
MDH_XANCB   (B0RU49), MDH_XANCP   (Q8PC25), MDH_XANE5   (Q3BWU8), 
MDH_XANOM   (Q2P736), MDH_XANOP   (B2SMP6), MDH_XANOR   (Q5H496), 
MDH_XYLF2   (B2I8M1), MDH_XYLFA   (Q9PE17), MDH_XYLFM   (B0U5Q1), 
MDH_XYLFT   (Q87E35)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 21 sequences 

MDHM_CAPAA  (P86074), MDHM_IMPCY  (P84209), MDHM_SCHMA  (P37227), 

MDHM_TOBAC  (P82816), MDH_ACIDE   (P80540), MDH_ACTMI   (P19977), 
MDH_BURCE   (P80537), MDH_DELAC   (P80539), MDH_KIBAR   (P19978), 
MDH_KLEPN   (P0C1G4), MDH_KLEPR   (P0C1G5), MDH_MICGL   (P19979), 
MDH_NITAL   (P10887), MDH_PHEIM   (P19980), MDH_PLAVE   (P19981), 
MDH_PSEMZ   (P85920), MDH_STEMA   (P80541), MDH_STRAR   (P19982), 
MDH_STRRS   (P19983), MDH_THEAL   (P33163), MDH_VOGIN   (P80538)
» more

UniProtKB/Swiss-Prot
False positive sequences		 6 sequences 

HIS4_CHRVO  (Q7P0F0), HIS4_HYDCU  (Q31E65), MYCA_THET4  (G2Q9A5), 

PX11E_ARATH (Q84JW1), SDGA_EMENI  (A0A1U8QN18), TLR3_BOSTR  (Q0PV50)
» more

PDB
[Detailed view]		 51 PDB

1BDM; 1BMD; 1CIV; 1EMD; 1IZ9; 1MLD; 1SEV; 1SMK; 1WZE; 1WZI; 1Y7T; 2CMD; 2CVQ; 2DFD; 2PWZ; 3HHP; 4E0B; 4KDE; 4KDF; 4MDH; 4TVO; 4WLE; 4WLF; 4WLN; 4WLO; 4WLU; 4WLV; 5KKA; 5KVV; 5MDH; 5NUE; 5NUF; 5Z3W; 5ZI2; 5ZI3; 5ZI4; 6AOO; 6BAL; 6ITL; 6KA0; 6KA1; 6PBL; 7CGC; 7CGD; 7MDH; 7RM9; 7RRL; 7XQN; 8J5D; 8XKU; 8XKV
» more