We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE entry PS00068
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PURL: https://purl.expasy.org/prosite/signature/PS00068
Direct ScanProsite submission
General information about the entry
| Entry name [info] | MDH |
| Accession [info] | PS00068 |
| Entry type [info] | PATTERN |
| Date [info] |
01-APR-1990 CREATED;
01-OCT-1993 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00066 |
| Associated ProRule [info] | PRU10004 |
Name and characterization of the entry
| Description [info] | Malate dehydrogenase active site signature. |
| Pattern [info] |
[LIVM]-T-[TRKMN]-L-D-x(2)-R-[STA]-x(3)-[LIVMFY]. |
Numerical results [info]
| Total number of hits | 236 in 236 different sequences |
| Number of true positive hits | 230 in 230 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 6 in 6 different sequences |
| Number of false negative sequences | 115 |
| Number of 'partial' sequences | 21 |
| Precision (true positives / (true positives + false positives)) | 97.46 % |
| Recall (true positives / (true positives + false negatives)) | 66.67 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 1 |
| Site [info] | active_site at position 5 |
| Site [info] | active_site at position 7 |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
230 sequences
MDHA_DICDI (Q54GE6), MDHC1_ARATH (P93819), MDHC2_ARATH (P57106), MDHC3_ARATH (Q9FJU0), MDHC_BETVU (Q9SML8), MDHC_BOVIN (Q3T145), MDHC_CAEEL (Q9UAV5), MDHC_CANAL (P83778), MDHC_CHICK (Q5ZME2), MDHC_DICDI (Q54VM2), MDHC_ECHGR (Q04820), MDHC_FELCA (Q7YRU4), MDHC_HUMAN (P40925), MDHC_MAIZE (Q08062), MDHC_MEDSA (O48905), MDHC_MESCR (O24047), MDHC_MOUSE (P14152), MDHC_ORYSJ (Q7XDC8), MDHC_PIG(P11708), MDHC_RAT(O88989), MDHC_XENLA (Q6PAB3), MDHC_XENTR (Q6DIY9), MDHC_YEAST (P22133), MDHG1_BRANA (Q43743), MDHG2_BRANA (Q9XFW3), MDHG_CITLA (P19446), MDHG_CUCSA (P46488), MDHG_ORYSJ (Q42972), MDHG_SOYBN (P37228), MDHM1_ARATH (Q9ZP06), MDHM2_ARATH (Q9LKA3), MDHM_BOVIN (Q32LG3), MDHM_CAEEL (O02640), MDHM_CHLRE (Q42686), MDHM_CITLA (P17783), MDHM_EUCGU (P46487), MDHM_FELCA (K0J107), MDHM_FRAAN (P83373), MDHM_HUMAN (P40926), MDHM_MACFA (Q4R568), MDHM_MOUSE (P08249), MDHM_PIG(P00346), MDHM_PONAB (Q5NVR2), MDHM_RAT(P04636), MDHM_YEAST (P17505), MDHNP_ARATH (Q8H1E2), MDHP1_SORBI (P17606), MDHP2_SORBI (P37229), MDHP_ARATH (Q9SN86), MDHP_FLABI (P46489), MDHP_MAIZE (P15719), MDHP_MEDSA (O48902), MDHP_MESCR (Q05145), MDHP_PEA(P21528), MDHP_SPIOL (P52426), MDHP_YEAST (P32419), MDHX1_ARATH (O82399), MDHX2_ARATH (Q9ZP05), MDH_ACTSZ (Q5U907), MDH_AERHH (A0KG16), MDH_AERS4 (A4SIV0), MDH_AKKM8 (B2UKY5), MDH_ALCBS (Q0VQ52), MDH_ALIF1 (Q5E875), MDH_ALIFM (B5FGF5), MDH_ALISL (B6EL39), MDH_ALKEH (Q0ABE6), MDH_CELJU (B3PHI3), MDH_CITK8 (A8AQC8), MDH_COLP3 (Q47VL0), MDH_COXB1 (B6J7Q0), MDH_COXB2 (B6IZN7), MDH_COXBN (A9KFT9), MDH_COXBR (A9NDV1), MDH_COXBU (Q83C87), MDH_CROS8 (A7MNR3), MDH_CUTAK (Q6A6Z5), MDH_ECO24 (A7ZSD0), MDH_ECO27 (B7UJW8), MDH_ECO45 (B7MBZ7), MDH_ECO55 (B7LHU4), MDH_ECO57 (P61891), MDH_ECO5E (B5YSW2), MDH_ECO7I (B7NKU9), MDH_ECO81 (B7N0M1), MDH_ECO8A (B7M0U8), MDH_ECOBW (C4ZSX4), MDH_ECODH (B1XHK9), MDH_ECOHS (A8A545), MDH_ECOK1 (A1AGC9), MDH_ECOL5 (Q0TCN0), MDH_ECOL6 (P61890), MDH_ECOLC (B1IQP3), MDH_ECOLI (P61889), MDH_ECOLU (B7NDL4), MDH_ECOSE (B6I1V4), MDH_ECOSM (B1LGK2), MDH_ECOUT (Q1R6A3), MDH_EDWI9 (C5BF98), MDH_ENT38 (A4WF48), MDH_ERWT9 (B2VGW7), MDH_ESCF3 (B7LRL0), MDH_FRAAA (Q0RE66), MDH_FRACC (Q2J7E7), MDH_HAEDU (Q7VP41), MDH_HAEI8 (Q4QL89), MDH_HAEIE (A5UCQ1), MDH_HAEIG (A5UIX3), MDH_HAEIN (P44427), MDH_HALHL (A1WV94), MDH_HISS1 (Q0I491), MDH_HISS2 (B0UUR6), MDH_IDILO (Q5R030), MDH_KLEOX (P61894), MDH_KLEP3 (B5XSQ7), MDH_KLEP7 (A6TEQ3), MDH_KLEVA (P61896), MDH_KOCRD (B2GKC8), MDH_LEGPA (Q5X2T6), MDH_LEGPC (A5IEF4), MDH_LEGPH (Q5ZT13), MDH_LEGPL (Q5WU94), MDH_LEPBJ (Q04RS5), MDH_LEPBL (Q051U6), MDH_LEPIC (P61975), MDH_LEPIN (Q8F4A2), MDH_MANSM (Q65T37), MDH_METCA (Q60B71), MDH_MORJA (Q6AW21), MDH_MORMI (Q6AW23), MDH_MORS2 (Q7X3X5), MDH_MORS5 (P48364), MDH_MYCA1 (A0QCI6), MDH_MYCBO (P0A5J7), MDH_MYCBP (A1KI28), MDH_MYCBT (C1AMN4), MDH_MYCLE (P50917), MDH_MYCMM (B2HRH5), MDH_MYCPA (P61976), MDH_MYCTA (A5U1T8), MDH_MYCTO (P9WK12), MDH_MYCTU (P9WK13), MDH_MYCUA (A0PVV1), MDH_NOCFA (Q5YTI1), MDH_NOCSJ (A1SMP3), MDH_PAEAT (A1R2B5), MDH_PARUW (Q6MAA3), MDH_PASMU (Q9CN86), MDH_PECAS (Q6D9D1), MDH_PECCC (P61897), MDH_PECCP (C6DKH1), MDH_PHOLL (Q7MYW9), MDH_PHOPR (P37226), MDH_PROMH (B4F2A1), MDH_PSEA6 (Q15YH0), MDH_PSET1 (Q3IFH4), MDH_PSYA2 (Q4FQU7), MDH_PSYCK (Q1Q932), MDH_PSYIN (A1SRP8), MDH_RAOTE (P61895), MDH_RHOJR (Q0S365), MDH_RHOOB (C1B155), MDH_RUBXD (Q1AWH4), MDH_SACEN (A4FFX3), MDH_SALA4 (B5F7L9), MDH_SALAR (A9MNX5), MDH_SALCH (Q57JA9), MDH_SALDC (B5FIT7), MDH_SALEP (B5R0N2), MDH_SALG2 (B5REV7), MDH_SALHS (B4TJT3), MDH_SALMU (Q59838), MDH_SALNS (B4T769), MDH_SALPA (Q7WS85), MDH_SALPB (A9N855), MDH_SALPC (C0PZQ4), MDH_SALPK (B5BGR3), MDH_SALSV (B4TWK9), MDH_SALTI (Q8Z3E0), MDH_SALTY (P25077), MDH_SHEAM (A1S3C4), MDH_SHEB2 (B8EB55), MDH_SHEB5 (A3D075), MDH_SHEB8 (A6WSM1), MDH_SHEB9 (A9L340), MDH_SHEDO (Q12R11), MDH_SHEFN (Q07YA5), MDH_SHEHH (B0TUH8), MDH_SHELP (A3QB91), MDH_SHEON (P82177), MDH_SHEPA (A8H0U0), MDH_SHEPC (A4YAE8), MDH_SHEPW (B8CSY7), MDH_SHESA (A0L113), MDH_SHESH (A8FRU0), MDH_SHESM (Q0HEW2), MDH_SHESR (Q0HZ38), MDH_SHESW (A1RFX8), MDH_SHEWM (B1KGG7), MDH_SHIB3 (B2U1U9), MDH_SHIBS (Q31WA4), MDH_SHIDS (Q32BA3), MDH_SHIF8 (Q0T052), MDH_SHIFL (Q83Q04), MDH_SHISS (Q3YX11), MDH_STRAW (Q82HS2), MDH_STRCO (Q9K3J3), MDH_STRGG (B1W3N4), MDH_THEFY (Q47TT4), MDH_THET2 (P61977), MDH_THET8 (Q5SKV7), MDH_THETH (P10584), MDH_TOBAC (Q9FSF0), MDH_VIBA3 (B7VID0), MDH_VIBC1 (A7MWD3), MDH_VIBCH (Q9KUT3), MDH_VIBMI (Q9L8F6), MDH_VIBPA (Q87SU7), MDH_VIBVU (Q8DEC2), MDH_VIBVY (Q7MP97), MDH_YERE8 (A1JIV0), MDH_YERP3 (A7FMU2), MDH_YERPA (Q1CBY7), MDH_YERPB (B2K2N5), MDH_YERPE (P61892), MDH_YERPG (A9R584), MDH_YERPN (Q1CEJ3), MDH_YERPP (A4TRK3), MDH_YERPS (P0C7R5), MDH_YERPY (B1JMK1)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
115 sequences
MDH1_ALBFT (Q21XH1), MDH1_BURTA (Q2T7J2), MDH1_BURVG (A4JKE6), MDH2_ALBFT (Q21VT3), MDH2_BURTA (Q2T4T8), MDH2_BURVG (A4JM71), MDHM_BRANA (Q43744), MDH_ACIAD (Q6F7X1), MDH_ACIB3 (B7GW58), MDH_ACIB5 (B7I9D2), MDH_ACIBC (B2HZ52), MDH_ACIBS (B0VQX5), MDH_ACIBT (A3M928), MDH_ACIBY (B0V6R7), MDH_ACICJ (A5G320), MDH_ACIET (B9MBP0), MDH_ACISJ (A1W9K7), MDH_ACTP2 (A3N1U6), MDH_ACTP7 (B3H269), MDH_ACTPJ (B0BQN0), MDH_AQUAR (Q9ZF99), MDH_AROAE (Q5NYA9), MDH_AZOSB (A1K5Q9), MDH_BDEBA (P61973), MDH_BORA1 (Q2L068), MDH_BORBR (Q7WD94), MDH_BORPA (Q7W5Q8), MDH_BORPD (A9IIS3), MDH_BORPE (Q7VW97), MDH_BURCH (A0AZ43), MDH_BURCJ (B4EFB0), MDH_BURCM (Q0BAF9), MDH_BURL3 (Q393V1), MDH_BURM1 (A9AMD5), MDH_BURM7 (A3MBR2), MDH_BURM9 (A2S105), MDH_BURMA (Q62AG8), MDH_BURMS (A1UZ10), MDH_BURO0 (B1K394), MDH_BURO1 (Q1BM38), MDH_BURP0 (A3P7Q9), MDH_BURP1 (Q3JKE9), MDH_BURP6 (A3NM97), MDH_BURPS (P80536), MDH_CHLAB (Q5L5E3), MDH_CHLCV (Q822E9), MDH_CHLFF (Q255I4), MDH_CHLMU (Q9PK18), MDH_CHLPN (Q9Z6N1), MDH_CHLT2 (B0B7U5), MDH_CHLTA (Q3KLX8), MDH_CHLTB (B0BC10), MDH_CHLTR (O84381), MDH_CHRVO (Q7NZ60), MDH_CORDI (P61974), MDH_COREF (Q8FN62), MDH_CORGB (A4QGA0), MDH_CORGL (Q8NN33), MDH_CORJK (Q4JWV0), MDH_CUPMC (Q1LKG0), MDH_CUPNH (Q0K8F5), MDH_CUPPJ (Q46YU4), MDH_CUPTR (B3R570), MDH_DECAR (Q47C34), MDH_DEIDV (C1CY73), MDH_DEIGD (Q1IWC9), MDH_DEIRA (Q9RXI8), MDH_DELAS (A9BVK0), MDH_DESPS (Q6AQI3), MDH_EHRRG (Q5FGT9), MDH_GLAP5 (B8F5K4), MDH_HERAR (A4G5Z9), MDH_JANMA (A6SY47), MDH_LARHH (C1DB66), MDH_LEPBA (B0SF41), MDH_LEPBP (B0SN74), MDH_LEPCP (B1Y8A3), MDH_MAGMM (A0L5T9), MDH_METPP (A2SHT9), MDH_MYCVP (A1T9L9), MDH_NITEC (Q0AFK6), MDH_NITEU (Q82WB9), MDH_NITMU (Q2YAQ4), MDH_PARC0 (A1TP96), MDH_PARP8 (B2JQD2), MDH_PARPJ (B2T9P8), MDH_PARXL (Q13S42), MDH_POLAQ (A4SWW0), MDH_POLNA (A1VRQ1), MDH_POLNS (B1XV63), MDH_POLSJ (Q126N9), MDH_PSYWF (A5WGM2), MDH_RALN1 (Q8XXW5), MDH_RALPJ (B2U705), MDH_SACD2 (Q21K60), MDH_SERP5 (A8G8Y7), MDH_STRM5 (B4SLI5), MDH_STRMK (B2FQL8), MDH_SYNFM (A0LFF8), MDH_TERTT (C5BU70), MDH_VARPS (C5CSI5), MDH_VEREI (A1WR02), MDH_WOLTR (Q5GT41), MDH_XANAC (Q8PNP8), MDH_XANC8 (Q4URH2), MDH_XANCB (B0RU49), MDH_XANCP (Q8PC25), MDH_XANE5 (Q3BWU8), MDH_XANOM (Q2P736), MDH_XANOP (B2SMP6), MDH_XANOR (Q5H496), MDH_XYLF2 (B2I8M1), MDH_XYLFA (Q9PE17), MDH_XYLFM (B0U5Q1), MDH_XYLFT (Q87E35)» more |
| UniProtKB/Swiss-Prot 'Partial' sequences |
21 sequences
MDHM_CAPAA (P86074), MDHM_IMPCY (P84209), MDHM_SCHMA (P37227), MDHM_TOBAC (P82816), MDH_ACIDE (P80540), MDH_ACTMI (P19977), MDH_BURCE (P80537), MDH_DELAC (P80539), MDH_KIBAR (P19978), MDH_KLEPN (P0C1G4), MDH_KLEPR (P0C1G5), MDH_MICGL (P19979), MDH_NITAL (P10887), MDH_PHEIM (P19980), MDH_PLAVE (P19981), MDH_PSEMZ (P85920), MDH_STEMA (P80541), MDH_STRAR (P19982), MDH_STRRS (P19983), MDH_THEAL (P33163), MDH_VOGIN (P80538)» more |
| UniProtKB/Swiss-Prot False positive sequences |
6 sequences
HIS4_CHRVO (Q7P0F0), HIS4_HYDCU (Q31E65), MYCA_THET4 (G2Q9A5), PX11E_ARATH (Q84JW1), SDGA_EMENI (A0A1U8QN18), TLR3_BOSTR (Q0PV50)» more |
| PDB [Detailed view] |
51 PDB
pdb_00001bdm; pdb_00001bmd; pdb_00001civ; pdb_00001emd; pdb_00001iz9; pdb_00001mld; pdb_00001sev; pdb_00001smk; pdb_00001wze; pdb_00001wzi; pdb_00001y7t; pdb_00002cmd; pdb_00002cvq; pdb_00002dfd; pdb_00002pwz; pdb_00003hhp; pdb_00004e0b; pdb_00004kde; pdb_00004kdf; pdb_00004mdh; pdb_00004tvo; pdb_00004wle; pdb_00004wlf; pdb_00004wln; pdb_00004wlo; pdb_00004wlu; pdb_00004wlv; pdb_00005kka; pdb_00005kvv; pdb_00005mdh; pdb_00005nue; pdb_00005nuf; pdb_00005z3w; pdb_00005zi2; pdb_00005zi3; pdb_00005zi4; pdb_00006aoo; pdb_00006bal; pdb_00006itl; pdb_00006ka0; pdb_00006ka1; pdb_00006pbl; pdb_00007cgc; pdb_00007cgd; pdb_00007mdh; pdb_00007rm9; pdb_00007rrl; pdb_00007xqn; pdb_00008j5d; pdb_00008xku; pdb_00008xkv » more |