PROSITE entry PS00137
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Direct ScanProsite submission
General information about the entry
| PURL [info] | https://purl.expasy.org/prosite/signature/PS00137 |
| Entry name [info] | SUBTILASE_HIS |
| Accession [info] | PS00137 |
| Entry type [info] | PATTERN |
| Date [info] |
01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00125 |
| Associated ProRule [info] | PRU10081 |
Name and characterization of the entry
| Description [info] | Serine proteases, subtilase family, histidine active site. |
| Pattern [info] |
H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-[SAGM]. |
Numerical results [info]
| Total number of hits | 249 in 249 different sequences |
| Number of true positive hits | 234 in 234 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 15 in 15 different sequences |
| Number of false negative sequences | 8 |
| Number of 'partial' sequences | 7 |
| Precision (true positives / (true positives + false positives)) | 93.98 % |
| Recall (true positives / (true positives + false negatives)) | 96.69 % |
Comments [info]
| Taxonomic range [info] | Archaea, Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 1 |
| Site [info] | active_site at position 1 |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
234 sequences
AEP_YARLI (P09230), AEX5_CAEEL (P91863), ALP2_ASPFC (B0Y473), ALP2_ASPFU (P87184), ALP_HAPCH (P29118), ALP_HYPAT (Q03420), ALP_LECPS (Q68GV9), APRX_BACSU (O31788), AQL1_THEAQ (P08594), ASES_SARSR (R4IR27), ASP_AERSO (Q9L5A4), BLI4_CAEEL (P51559), BLI_ONCVO (A0A044RE18), BPRV_DICNO (P42779), BPRX_DICNO (P42780), C5AP_STRP1 (P58099), C5AP_STRP3 (P0DD34), C5AP_STRP6 (Q5X9R0), C5AP_STRP8 (Q8NZ80), C5AP_STRPQ (P0DD35), C5AP_STRPY (P15926), CH901_DAVTA (B7ZK61), CL401_COCLU (B3V0K8), CRSP_ARATH (Q9LNU1), CUDP_METAN (P29138), ELYA_ALKAL (P27693), ELYA_BACYA (P20724), ELYA_HALH5 (P41363), ELYA_SHOCL (P41362), EPIP_STAEP (P30199), EXPR_XANCP (P23314), FKPC1_CAEEL (O17798), FLS_FERPE (Q93LQ6), FUR11_DROME (P26016), FUR1C_DROME (P30430), FUR2_DROME (P30432), FURI1_XENLA (P29119), FURIN_BOVIN (Q28193), FURIN_HUMAN (P09958), FURIN_MOUSE (P23188), FURIN_RAT (P23377), HLY_HALMT (I3R794), HLY_NATA1 (P29143), ISP1_BACSU (P11018), ISP6_SCHPO (P40903), ISP_PAEPO (P29139), ISP_SHOCL (P29140), KEX1A_KLULA (P09231), KEX2_CANAW (O13359), KEX2_YEAST (P13134), KRP1_SCHPO (Q09175), MBTP1_CRIGR (Q9Z2A8), MBTP1_HUMAN (Q14703), MBTP1_MOUSE (Q9WTZ2), MBTP1_RAT (Q9WTZ3), MYCP2_MYCTU (O05458), MYCP3_MYCTU (O53695), MYCP4_MYCTU (I6YC58), MYCP5_MYCTU (O53945), NEC1_BOVIN (Q9GLR1), NEC1_HUMAN (P29120), NEC1_MOUSE (P63239), NEC1_MUSCO (P63240), NEC1_RAT(P28840), NEC2_BOVIN (Q9GLR0), NEC2_CAEEL (G5ECN9), NEC2_DROME (Q9VBC7), NEC2_HUMAN (P16519), NEC2_MOUSE (P21661), NEC2_PIG(Q03333), NEC2_PONAB (Q5REC2), NEC2_RAT(P28841), NECA_HYDVU (P29146), NECB_HYDVU (P29145), NEP_NATMA (Q5RLZ1), NISP_LACLL (Q07596), ORYZ_ASPCL (A1CIA7), ORYZ_ASPFC (B0Y708), ORYZ_ASPFL (P35211), ORYZ_ASPFN (B8N106), ORYZ_ASPFU (P28296), ORYZ_ASPOR (P12547), ORYZ_EMENI (Q00208), ORYZ_NEOFI (A1CWF3), P1P_LACLC (P16271), P2P_LACLC (P15293), P2P_LACPA (Q02470), P3P_LACLS (P15292), PCH18_PENCH (P9WEW6), PCH18_PENRB (P9WEW5), PCSK4_HUMAN (Q6UW60), PCSK4_MOUSE (P29121), PCSK4_RAT (Q78EH2), PCSK5_BRACL (Q9NJ15), PCSK5_HUMAN (Q92824), PCSK5_MOUSE (Q04592), PCSK5_RAT (P41413), PCSK6_HUMAN (P29122), PCSK6_RAT (Q63415), PCSK7_HUMAN (Q16549), PCSK7_MOUSE (Q61139), PCSK7_RAT (Q62849), PEN18_PENRB (Q9P8G3), PENC2_PENCI (Q9Y755), PEPC_ASPNG (P33295), PLS_PYRFU (P72186), POPC_MYXXD (Q1DFT5), PRCA_NOSS1 (Q59149), PRCA_TRIV2 (P23916), PROA_VIBAL (P16588), PRTB_YEAST (P09232), PRTK_PARAQ (P06873), PRTM_SHOC1 (Q99405), PRTR_PARAQ (P23653), PRTS_SERMA (P09489), PRTT_PARAQ (P20015), PRTT_SERMA (P29805), PSP3_SCHPO (Q9UTS0), RM201_RHOMI (Q32ZM1), RRT12_YEAST (P25381), SBT24_ARATH (F4HYR6), SBT31_ARATH (F4JJH4), SBT33_ARATH (Q9MAP5), SBT34_ARATH (F4HPF1), SBT39_ARATH (Q9ZSB0), SBT3A_ARATH (Q9ZSB1), SBT3B_ARATH (Q1PDX5), SBT3C_ARATH (F4JJH5), SBT3G_ARATH (Q8GWX9), SBT41_ARATH (F4IG09), SBT51_ARATH (F4HSQ2), SBT61_ARATH (Q0WUG6), SEPR_THESR (P80146), SMP1_MAGPO (Q9Y778), SPAZ_ARTOA (G1X8P8), SPAZ_ORBOL (G3FNQ9), SPL1_ENCCU (Q8SQJ3), SPM1_PYRO7 (P58371), SUB10_ARTBC (D4AQG0), SUB10_TRIVH (D4DIS6), SUB1_PLABA (A0A509AM03), SUB1_PLAF7 (Q8I0V0), SUB1_PLAFA (O61142), SUB1_PLAFO (W7K9M0), SUB1_PLAVI (E6Y8B9), SUB1_PSED2 (L8G6I7), SUB2A_COCP7 (C5P6D1), SUB2C_COCP7 (C5NZ70), SUB2_ARTBC (D4AZ75), SUB2_ARTBE (Q64K35), SUB2_ARTGP (E4UZP9), SUB2_ARTOC (C5G168), SUB2_ARTOT (Q8J0D8), SUB2_DEIRA (Q9RYM8), SUB2_PLAF7 (Q8IHZ5), SUB2_PLAFA (O97364), SUB2_PLAFP (Q9Y008), SUB2_PSED2 (L8FSM5), SUB2_TRIEQ (B6VA85), SUB2_TRIRU (Q69F57), SUB2_TRITO (B8XGQ5), SUB2_TRIVC (Q5VJ76), SUB2_TRIVH (D4DLI5), SUB3_PLAF7 (Q8I430), SUB3_PSED2 (L8GD75), SUB4B_COCP7 (C5NZT2), SUB5_ARTBC (D4B194), SUB5_ARTBE (Q64K32), SUB5_ARTGP (E4V2L6), SUB5_ARTOC (C5G1D1), SUB5_TRIEQ (B6VA87), SUB5_TRIRU (Q69F34), SUB5_TRITO (B8XGQ8), SUB5_TRIVC (Q5VJ73), SUB5_TRIVH (D4D0F5), SUB6_ARTBC (D4ALV9), SUB6_ARTBE (Q64K31), SUB6_ARTGP (E4V4J8), SUB6_ARTOC (C5FQI3), SUB6_TRIEQ (A1XIH0), SUB6_TRIRU (Q9UW97), SUB6_TRISD (A1XIH1), SUB6_TRISH (Q8J077), SUB6_TRITO (Q3ZEJ8), SUB6_TRIVC (Q5VJ72), SUB6_TRIVH (D4D5H3), SUB7B_COCP7 (C5PCX1), SUB7C_COCP7 (C5NZ69), SUB7_ARTBC (D4APA9), SUB7_ARTBE (Q64K36), SUB7_ARTGP (E4V2V9), SUB7_ARTOC (C5FJA5), SUB7_TRIEQ (A1XIH3), SUB7_TRIRU (Q8NID9), SUB7_TRISD (A1XIH5), SUB7_TRITO (A1XIH4), SUB7_TRIVC (Q5VJ71), SUB7_TRIVH (D4CZQ4), SUB7_TRIVO (A1XIH6), SUB8_ARTBC (D4AX50), SUB8_ARTOC (C5FII2), SUB8_COCP7 (C5P4Z8), SUB8_TRIVH (D4DKQ4), SUBB_LEDLE (P29599), SUBC_BACLI (P00780), SUBD_BACLI (P00781), SUBE_BACSU (P16396), SUBF_BACSU (P16397), SUBN_BACNA (P35835), SUBS_LEDLE (P29600), SUBT_BACAM (P00782), SUBT_BACPU (P07518), SUBT_BACS9 (P28842), SUBT_BACSA (P00783), SUBT_BACSU (P04189), SUBT_GEOSE (P29142), SUBV_BACSU (P29141), TAGB_DICDI (P54683), TAGC_DICDI (Q23868), TAGD_DICDI (Q8T9W1), THES_BACSJ (Q45670), THET_THEVU (P04072), TKSP_THEKO (Q5JIZ5), TPP2_BOVIN (A5PK39), TPP2_CAEEL (Q09541), TPP2_DROME (Q9V6K1), TPP2_HUMAN (P29144), TPP2_MOUSE (Q64514), TPP2_RAT(Q64560), TPP2_SCHPO (Q9UT05), TPPII_ARATH (F4JVN6), WPRA_BACSU (P54423), XPR6_YARLI (P42781), YSP3_YEAST (P25036)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
8 sequences
NALP_NEIMB (Q9JXM7), NALP_NEIMH (E6MVD9), SBT1_LOTJA (A9QY40), SBT3_LOTJA (A9QY39), SBT4_LOTJA (A9QY38), SBTS_LOTJA (A9JQS7), SBT_MEDTR (G7KEU7), SBT_PETHY (A0A0M3R8G2)» more |
| UniProtKB/Swiss-Prot 'Partial' sequences |
7 sequences
ASE2_ACRSP (P85157), CUDP_METCM (P80406), NCP3_COPCM (P83454), NVSP_ALIVI (P83433), PRTE_HALME (P28308), SP01_SCEBO (Q10721), THEM_MALCI (P13858)» more |
| UniProtKB/Swiss-Prot False positive sequences |
15 sequences
ADCY8_HUMAN (P40145), ADCY8_MOUSE (P97490), ADCY8_RAT (P40146), DGGGP_METTH (O27170), KTNB1_XENTR (Q6NVM2), PSBA3_GLOVI (Q7NH81), PSBA_ALETA (Q9TM69), PSBA_AMPCA (Q9BBC1), PSBA_AMPOP (Q7HP56), PSBA_HETNI (Q9MSC0), PSBA_HETPY (Q9MSC1), PSBA_HETRO (Q9MSC2), PSBA_HETTR (Q9XQV1), PSBA_PROMC (Q9TM72), TM241_MOUSE (Q3UME2)» more |
| PDB [Detailed view] |
449 PDB
1A2Q; 1AF4; 1AH2; 1AK9; 1AQN; 1AU9; 1AV7; 1AVT; 1BE6; 1BE8; 1BFK; 1BFU; 1BH6; 1BJR; 1C3L; 1C9J; 1C9M; 1C9N; 1CNM; 1CSE; 1DBI; 1DUI; 1EGQ; 1GCI; 1GNS; 1GNV; 1HT3; 1IAV; 1IC6; 1JEA; 1LW6; 1MEE; 1MPT; 1NDQ; 1NDU; 1OT5; 1OYO; 1OYV; 1P7V; 1P7W; 1P8J; 1PEK; 1PFG; 1PJ8; 1PTK; 1Q5P; 1R0R; 1R64; 1S01; 1S02; 1SBC; 1SBH; 1SBI; 1SBN; 1SBT; 1SCA; 1SCB; 1SCD; 1SCJ; 1SCN; 1SEL; 1SIB; 1SPB; 1ST2; 1ST3; 1SUA; 1SUB; 1SUC; 1SUD; 1SUE; 1SUP; 1SVN; 1TEC; 1THM; 1TK2; 1TM1; 1TM3; 1TM4; 1TM5; 1TM7; 1TMG; 1TO1; 1TO2; 1UBN; 1V5I; 1VSB; 1WSD; 1XF1; 1Y1K; 1Y33; 1Y34; 1Y3B; 1Y3C; 1Y3D; 1Y3F; 1Y48; 1Y4A; 1Y4D; 1YJA; 1YJB; 1YJC; 1YU6; 2DP4; 2DQK; 2DUJ; 2G4V; 2HD4; 2HPZ; 2ID4; 2ID8; 2PKC; 2PQ2; 2PRK; 2PWA; 2PWB; 2PYZ; 2SBT; 2SEC; 2SIC; 2SNI; 2ST1; 2TEC; 2V8B; 2WUV; 2WUW; 3AFG; 3AJ8; 3AJ9; 3BGO; 3BX1; 3CNQ; 3CO0; 3D9Q; 3DDZ; 3DE0; 3DE1; 3DE2; 3DE3; 3DE4; 3DE5; 3DE6; 3DE7; 3DVQ; 3DVR; 3DVS; 3DW1; 3DW3; 3DWE; 3DYB; 3EIF; 3F49; 3F7M; 3GT3; 3GT4; 3HJR; 3I2Y; 3I30; 3I34; 3I37; 3L1K; 3LXU; 3OSZ; 3PRK; 3PTL; 3Q40; 3Q5G; 3QMP; 3SIC; 3TEC; 3UNX; 3VSB; 3VYV; 3WHI; 3WQB; 4B5L; 4C3U; 4C3V; 4CFY; 4CFZ; 4CG0; 4DJ5; 4DWW; 4DZT; 4FON; 4LVN; 4LVO; 4MZD; 4OMC; 4OMD; 4RYD; 4TR2; 4WOB; 4WOC; 4Z2A; 4ZAR; 5AMX; 5AQE; 5ARB; 5ARC; 5ARD; 5AVJ; 5AVK; 5B1D; 5B1E; 5CW1; 5GL8; 5I9S; 5JMO; 5JXG; 5JXH; 5JXI; 5JXJ; 5K7S; 5KXU; 5KXV; 5MIM; 5MJL; 5OX2; 5ROC; 5ROD; 5ROE; 5ROF; 5ROG; 5ROH; 5ROI; 5ROJ; 5ROK; 5ROL; 5ROM; 5RON; 5ROO; 5ROP; 5ROQ; 5ROR; 5ROS; 5ROT; 5ROU; 5ROV; 5ROW; 5ROX; 5ROY; 5ROZ; 5RP0; 5RP1; 5RP2; 5RP3; 5RP4; 5RP5; 5RP6; 5RP7; 5RP8; 5RP9; 5RPA; 5RPB; 5RPC; 5RPD; 5RPE; 5RPF; 5RPG; 5RPH; 5RPI; 5RPJ; 5RPK; 5RPL; 5RPM; 5RPN; 5RPO; 5RPP; 5RPQ; 5RPR; 5RPS; 5RPT; 5RPU; 5RPV; 5RPW; 5RPX; 5RPY; 5RPZ; 5SIC; 5UVL; 5WHW; 5WJG; 5WJH; 5WRC; 6CL7; 6CL8; 6CL9; 6CLA; 6CLB; 6DWQ; 6EQV; 6EQW; 6EQX; 6FJS; 6HLB; 6HLD; 6HLE; 6HZA; 6HZB; 6HZC; 6HZD; 6J43; 6K2P; 6K2R; 6K2S; 6K2T; 6K2V; 6K2W; 6K2X; 6K8M; 6KKF; 6LAW; 6MH6; 6N4U; 6O44; 6PAK; 6PKJ; 6PKK; 6PKL; 6PKM; 6PKN; 6PKO; 6PKP; 6PKQ; 6PKR; 6PKS; 6PKT; 6PQ0; 6PQ4; 6PU4; 6PU5; 6QF1; 6QXV; 6RUG; 6RUH; 6RUK; 6RUN; 6RUW; 6RVE; 6RVG; 6RZP; 6TXG; 6V8R; 6Y5S; 6Y5T; 6YD2; 6YD3; 6YD4; 6YD7; 6ZET; 6ZEU; 6ZEV; 7A68; 7A9F; 7A9K; 7A9M; 7AM3; 7AM4; 7AM5; 7AM6; 7AM7; 7AM8; 7BJ3; 7C0P; 7JSY; 7LCU; 7LN7; 7LPT; 7LPU; 7LPV; 7LQ8; 7LQ9; 7LQA; 7LQB; 7LQC; 7LTD; 7LTI; 7LTV; 7LU0; 7LU1; 7LU2; 7LU3; 7NJJ; 7NP7; 7NPR; 7NPS; 7NUY; 7NUZ; 7O1U; 7O1W; 7O1Y; 7O20; 7O22; 7QXY; 7QXZ; 7QY0; 7QY1; 7QY2; 7S4Z; 7SKX; 7SVY; 7SVZ; 7SW0; 7SW1; 7SW2; 7SW3; 7SW4; 7SW5; 7SW6; 7SW7; 7SW8; 7SW9; 7SWA; 7SWB; 7SWC; 7YZX; 8B4V; 8B4W; 8B4X; 8COY; 8COZ; 8CP0; 8E52; 8E53; 8E7F; 8F05; 8F06; 8F07; 8FYO; 8FYP; 8FYQ; 8FYR; 8FYS; 8OYH; 8POL; 8QKE; 8QKG; 8QKJ; 8RSE; 8RSF; 8RSG; 8SDK; 8SOG; 8SOU; 8SOV; 8SPL; 8SQV; 8UW8; 8UWC » more |