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PROSITE entry PS00137


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PURL: https://purl.expasy.org/prosite/signature/PS00137

Direct ScanProsite submission
General information about the entry

Entry name [info] SUBTILASE_HIS
Accession [info] PS00137
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00125
Associated ProRule [info] PRU10081

Name and characterization of the entry

Description [info] Serine proteases, subtilase family, histidine active site.
Pattern [info]
H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-[SAGM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 249 in 249 different sequences
Number of true positive hits 234 in 234 different sequences
Number of 'unknown' hits 0
Number of false positive hits 15 in 15 different sequences
Number of false negative sequences 8
Number of 'partial' sequences 7
Precision (true positives / (true positives + false positives)) 93.98 %
Recall (true positives / (true positives + false negatives)) 96.69 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
234 sequences

AEP_YARLI   (P09230), AEX5_CAEEL  (P91863), ALP2_ASPFC  (B0Y473), 
ALP2_ASPFU  (P87184), ALP_CORPA   (Q68GV9), ALP_HAPCH   (P29118), 
ALP_HYPAT   (Q03420), APRX_BACSU  (O31788), AQL1_THEAQ  (P08594), 
ASES_SARSR  (R4IR27), ASP_AERSO   (Q9L5A4), BLI4_CAEEL  (P51559), 
BLI_ONCVO   (A0A044RE18), BPRV_DICNO  (P42779), BPRX_DICNO  (P42780), 
C5AP_STRP1  (P58099), C5AP_STRP3  (P0DD34), C5AP_STRP6  (Q5X9R0), 
C5AP_STRP8  (Q8NZ80), C5AP_STRPQ  (P0DD35), C5AP_STRPY  (P15926), 
CH901_DAVTA (B7ZK61), CL401_COCLU (B3V0K8), CRSP_ARATH  (Q9LNU1), 
CUDP_METAN  (P29138), ELYA_ALKAL  (P27693), ELYA_BACYA  (P20724), 
ELYA_HALH5  (P41363), ELYA_SHOCL  (P41362), EPIP_STAEP  (P30199), 
EXPR_XANCP  (P23314), FKPC1_CAEEL (O17798), FLS_FERPE   (Q93LQ6), 
FUR11_DROME (P26016), FUR1C_DROME (P30430), FUR2_DROME  (P30432), 
FURI1_XENLA (P29119), FURIN_BOVIN (Q28193), FURIN_HUMAN (P09958), 
FURIN_MOUSE (P23188), FURIN_RAT   (P23377), HLY_HALMT   (I3R794), 
HLY_NATA1   (P29143), ISP1_BACSU  (P11018), ISP6_SCHPO  (P40903), 
ISP_PAEPO   (P29139), ISP_SHOCL   (P29140), KEX1A_KLULA (P09231), 
KEX2_CANAW  (O13359), KEX2_YEAST  (P13134), KRP1_SCHPO  (Q09175), 
MBTP1_CRIGR (Q9Z2A8), MBTP1_HUMAN (Q14703), MBTP1_MOUSE (Q9WTZ2), 
MBTP1_RAT   (Q9WTZ3), MYCP2_MYCTU (O05458), MYCP3_MYCTU (O53695), 
MYCP4_MYCTU (I6YC58), MYCP5_MYCTU (O53945), NEC1_BOVIN  (Q9GLR1), 
NEC1_HUMAN  (P29120), NEC1_MOUSE  (P63239), NEC1_MUSCO  (P63240), 
NEC1_RAT(P28840), NEC2_BOVIN  (Q9GLR0), NEC2_CAEEL  (G5ECN9), 
NEC2_DROME  (Q9VBC7), NEC2_HUMAN  (P16519), NEC2_MOUSE  (P21661), 
NEC2_PIG(Q03333), NEC2_PONAB  (Q5REC2), NEC2_RAT(P28841), 
NECA_HYDVU  (P29146), NECB_HYDVU  (P29145), NEP_NATMA   (Q5RLZ1), 
NISP_LACLL  (Q07596), ORYZ_ASPCL  (A1CIA7), ORYZ_ASPFC  (B0Y708), 
ORYZ_ASPFL  (P35211), ORYZ_ASPFN  (B8N106), ORYZ_ASPFU  (P28296), 
ORYZ_ASPOR  (P12547), ORYZ_EMENI  (Q00208), ORYZ_NEOFI  (A1CWF3), 
P1P_LACLC   (P16271), P2P_LACLC   (P15293), P2P_LACPA   (Q02470), 
P3P_LACLS   (P15292), PCH18_PENCH (P9WEW6), PCH18_PENRB (P9WEW5), 
PCSK4_HUMAN (Q6UW60), PCSK4_MOUSE (P29121), PCSK4_RAT   (Q78EH2), 
PCSK5_BRACL (Q9NJ15), PCSK5_HUMAN (Q92824), PCSK5_MOUSE (Q04592), 
PCSK5_RAT   (P41413), PCSK6_HUMAN (P29122), PCSK6_RAT   (Q63415), 
PCSK7_HUMAN (Q16549), PCSK7_MOUSE (Q61139), PCSK7_RAT   (Q62849), 
PEN18_PENRB (Q9P8G3), PENC2_PENCI (Q9Y755), PEPC_ASPNG  (P33295), 
PLS_PYRFU   (P72186), POPC_MYXXD  (Q1DFT5), PRCA_NOSS1  (Q59149), 
PRCA_TRIV2  (P23916), PROA_VIBAL  (P16588), PRTB_YEAST  (P09232), 
PRTK_PARAQ  (P06873), PRTM_SHOC1  (Q99405), PRTR_PARAQ  (P23653), 
PRTS_SERMA  (P09489), PRTT_PARAQ  (P20015), PRTT_SERMA  (P29805), 
PSP3_SCHPO  (Q9UTS0), RM201_RHOMI (Q32ZM1), RRT12_YEAST (P25381), 
SBT24_ARATH (F4HYR6), SBT31_ARATH (F4JJH4), SBT33_ARATH (Q9MAP5), 
SBT34_ARATH (F4HPF1), SBT39_ARATH (Q9ZSB0), SBT3A_ARATH (Q9ZSB1), 
SBT3B_ARATH (Q1PDX5), SBT3C_ARATH (F4JJH5), SBT3G_ARATH (Q8GWX9), 
SBT41_ARATH (F4IG09), SBT51_ARATH (F4HSQ2), SBT61_ARATH (Q0WUG6), 
SEPR_THESR  (P80146), SMP1_MAGPO  (Q9Y778), SPAZ_ARTOA  (G1X8P8), 
SPAZ_ORBOL  (G3FNQ9), SPL1_ENCCU  (Q8SQJ3), SPM1_PYRO7  (P58371), 
SUB10_ARTBC (D4AQG0), SUB10_TRIVH (D4DIS6), SUB1_PLABA  (A0A509AM03), 
SUB1_PLAF7  (Q8I0V0), SUB1_PLAFA  (O61142), SUB1_PLAFO  (W7K9M0), 
SUB1_PLAVI  (E6Y8B9), SUB1_PSED2  (L8G6I7), SUB2A_COCP7 (C5P6D1), 
SUB2C_COCP7 (C5NZ70), SUB2_ARTBC  (D4AZ75), SUB2_ARTBE  (Q64K35), 
SUB2_ARTGP  (E4UZP9), SUB2_ARTOC  (C5G168), SUB2_ARTOT  (Q8J0D8), 
SUB2_DEIRA  (Q9RYM8), SUB2_PLAF7  (Q8IHZ5), SUB2_PLAFA  (O97364), 
SUB2_PLAFP  (Q9Y008), SUB2_PSED2  (L8FSM5), SUB2_TRIEQ  (B6VA85), 
SUB2_TRIRU  (Q69F57), SUB2_TRITO  (B8XGQ5), SUB2_TRIVC  (Q5VJ76), 
SUB2_TRIVH  (D4DLI5), SUB3_PLAF7  (Q8I430), SUB3_PSED2  (L8GD75), 
SUB4B_COCP7 (C5NZT2), SUB5_ARTBC  (D4B194), SUB5_ARTBE  (Q64K32), 
SUB5_ARTGP  (E4V2L6), SUB5_ARTOC  (C5G1D1), SUB5_TRIEQ  (B6VA87), 
SUB5_TRIRU  (Q69F34), SUB5_TRITO  (B8XGQ8), SUB5_TRIVC  (Q5VJ73), 
SUB5_TRIVH  (D4D0F5), SUB6_ARTBC  (D4ALV9), SUB6_ARTBE  (Q64K31), 
SUB6_ARTGP  (E4V4J8), SUB6_ARTOC  (C5FQI3), SUB6_TRIEQ  (A1XIH0), 
SUB6_TRIRU  (Q9UW97), SUB6_TRISD  (A1XIH1), SUB6_TRISH  (Q8J077), 
SUB6_TRITO  (Q3ZEJ8), SUB6_TRIVC  (Q5VJ72), SUB6_TRIVH  (D4D5H3), 
SUB7B_COCP7 (C5PCX1), SUB7C_COCP7 (C5NZ69), SUB7_ARTBC  (D4APA9), 
SUB7_ARTBE  (Q64K36), SUB7_ARTGP  (E4V2V9), SUB7_ARTOC  (C5FJA5), 
SUB7_TRIEQ  (A1XIH3), SUB7_TRIRU  (Q8NID9), SUB7_TRISD  (A1XIH5), 
SUB7_TRITO  (A1XIH4), SUB7_TRIVC  (Q5VJ71), SUB7_TRIVH  (D4CZQ4), 
SUB7_TRIVO  (A1XIH6), SUB8_ARTBC  (D4AX50), SUB8_ARTOC  (C5FII2), 
SUB8_COCP7  (C5P4Z8), SUB8_TRIVH  (D4DKQ4), SUBB_LEDLE  (P29599), 
SUBC_BACLI  (P00780), SUBD_BACLI  (P00781), SUBE_BACSU  (P16396), 
SUBF_BACSU  (P16397), SUBN_BACNA  (P35835), SUBS_LEDLE  (P29600), 
SUBT_BACAM  (P00782), SUBT_BACPU  (P07518), SUBT_BACS9  (P28842), 
SUBT_BACSA  (P00783), SUBT_BACSU  (P04189), SUBT_GEOSE  (P29142), 
SUBV_BACSU  (P29141), TAGB_DICDI  (P54683), TAGC_DICDI  (Q23868), 
TAGD_DICDI  (Q8T9W1), THES_BACSJ  (Q45670), THET_THEVU  (P04072), 
TKSP_THEKO  (Q5JIZ5), TPP2_BOVIN  (A5PK39), TPP2_CAEEL  (Q09541), 
TPP2_DROME  (Q9V6K1), TPP2_HUMAN  (P29144), TPP2_MOUSE  (Q64514), 
TPP2_RAT(Q64560), TPP2_SCHPO  (Q9UT05), TPPII_ARATH (F4JVN6), 
WPRA_BACSU  (P54423), XPR6_YARLI  (P42781), YSP3_YEAST  (P25036)
» more

UniProtKB/Swiss-Prot
False negative sequences
8 sequences

NALP_NEIMB  (Q9JXM7), NALP_NEIMH  (E6MVD9), SBT1_LOTJA  (A9QY40), 
SBT3_LOTJA  (A9QY39), SBT4_LOTJA  (A9QY38), SBTS_LOTJA  (A9JQS7), 
SBT_MEDTR   (G7KEU7), SBT_PETHY   (A0A0M3R8G2)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
7 sequences

ASE2_ACRSP  (P85157), CUDP_METCM  (P80406), NCP3_COPCM  (P83454), 
NVSP_ALIVI  (P83433), PRTE_HALME  (P28308), SP01_SCEBO  (Q10721), 
THEM_MALCI  (P13858)
» more

UniProtKB/Swiss-Prot
False positive sequences
15 sequences

ADCY8_HUMAN (P40145), ADCY8_MOUSE (P97490), ADCY8_RAT   (P40146), 
DGGGP_METTH (O27170), KTNB1_XENTR (Q6NVM2), PSBA3_GLOVI (Q7NH81), 
PSBA_ALETA  (Q9TM69), PSBA_AMPCA  (Q9BBC1), PSBA_AMPOP  (Q7HP56), 
PSBA_HETNI  (Q9MSC0), PSBA_HETPY  (Q9MSC1), PSBA_HETRO  (Q9MSC2), 
PSBA_HETTR  (Q9XQV1), PSBA_PROMC  (Q9TM72), TM241_MOUSE (Q3UME2)
» more

PDB
[Detailed view]
452 PDB

pdb_00001a2q; pdb_00001af4; pdb_00001ah2; pdb_00001ak9; pdb_00001aqn; pdb_00001au9; pdb_00001av7; pdb_00001avt; pdb_00001be6; pdb_00001be8; pdb_00001bfk; pdb_00001bfu; pdb_00001bh6; pdb_00001bjr; pdb_00001c3l; pdb_00001c9j; pdb_00001c9m; pdb_00001c9n; pdb_00001cnm; pdb_00001cse; pdb_00001dbi; pdb_00001dui; pdb_00001egq; pdb_00001gci; pdb_00001gns; pdb_00001gnv; pdb_00001ht3; pdb_00001iav; pdb_00001ic6; pdb_00001jea; pdb_00001lw6; pdb_00001mee; pdb_00001mpt; pdb_00001ndq; pdb_00001ndu; pdb_00001ot5; pdb_00001oyo; pdb_00001oyv; pdb_00001p7v; pdb_00001p7w; pdb_00001p8j; pdb_00001pek; pdb_00001pfg; pdb_00001pj8; pdb_00001ptk; pdb_00001q5p; pdb_00001r0r; pdb_00001r64; pdb_00001s01; pdb_00001s02; pdb_00001sbc; pdb_00001sbh; pdb_00001sbi; pdb_00001sbn; pdb_00001sbt; pdb_00001sca; pdb_00001scb; pdb_00001scd; pdb_00001scj; pdb_00001scn; pdb_00001sel; pdb_00001sib; pdb_00001spb; pdb_00001st2; pdb_00001st3; pdb_00001sua; pdb_00001sub; pdb_00001suc; pdb_00001sud; pdb_00001sue; pdb_00001sup; pdb_00001svn; pdb_00001tec; pdb_00001thm; pdb_00001tk2; pdb_00001tm1; pdb_00001tm3; pdb_00001tm4; pdb_00001tm5; pdb_00001tm7; pdb_00001tmg; pdb_00001to1; pdb_00001to2; pdb_00001ubn; pdb_00001v5i; pdb_00001vsb; pdb_00001wsd; pdb_00001xf1; pdb_00001y1k; pdb_00001y33; pdb_00001y34; pdb_00001y3b; pdb_00001y3c; pdb_00001y3d; pdb_00001y3f; pdb_00001y48; pdb_00001y4a; pdb_00001y4d; pdb_00001yja; pdb_00001yjb; pdb_00001yjc; pdb_00001yu6; pdb_00002dp4; pdb_00002dqk; pdb_00002duj; pdb_00002g4v; pdb_00002hd4; pdb_00002hpz; pdb_00002id4; pdb_00002id8; pdb_00002pkc; pdb_00002pq2; pdb_00002prk; pdb_00002pwa; pdb_00002pwb; pdb_00002pyz; pdb_00002sbt; pdb_00002sec; pdb_00002sic; pdb_00002sni; pdb_00002st1; pdb_00002tec; pdb_00002v8b; pdb_00002wuv; pdb_00002wuw; pdb_00003afg; pdb_00003aj8; pdb_00003aj9; pdb_00003bgo; pdb_00003bx1; pdb_00003cnq; pdb_00003co0; pdb_00003d9q; pdb_00003ddz; pdb_00003de0; pdb_00003de1; pdb_00003de2; pdb_00003de3; pdb_00003de4; pdb_00003de5; pdb_00003de6; pdb_00003de7; pdb_00003dvq; pdb_00003dvr; pdb_00003dvs; pdb_00003dw1; pdb_00003dw3; pdb_00003dwe; pdb_00003dyb; pdb_00003eif; pdb_00003f49; pdb_00003f7m; pdb_00003gt3; pdb_00003gt4; pdb_00003hjr; pdb_00003i2y; pdb_00003i30; pdb_00003i34; pdb_00003i37; pdb_00003l1k; pdb_00003lxu; pdb_00003osz; pdb_00003prk; pdb_00003ptl; pdb_00003q40; pdb_00003q5g; pdb_00003qmp; pdb_00003sic; pdb_00003tec; pdb_00003unx; pdb_00003vsb; pdb_00003vyv; pdb_00003whi; pdb_00003wqb; pdb_00004b5l; pdb_00004c3u; pdb_00004c3v; pdb_00004cfy; pdb_00004cfz; pdb_00004cg0; pdb_00004dj5; pdb_00004dww; pdb_00004dzt; pdb_00004fon; pdb_00004lvn; pdb_00004lvo; pdb_00004mzd; pdb_00004omc; pdb_00004omd; pdb_00004ryd; pdb_00004tr2; pdb_00004wob; pdb_00004woc; pdb_00004z2a; pdb_00004zar; pdb_00005amx; pdb_00005aqe; pdb_00005arb; pdb_00005arc; pdb_00005ard; pdb_00005avj; pdb_00005avk; pdb_00005b1d; pdb_00005b1e; pdb_00005cw1; pdb_00005gl8; pdb_00005i9s; pdb_00005jmo; pdb_00005jxg; pdb_00005jxh; pdb_00005jxi; pdb_00005jxj; pdb_00005k7s; pdb_00005kxu; pdb_00005kxv; pdb_00005mim; pdb_00005mjl; pdb_00005ox2; pdb_00005roc; pdb_00005rod; pdb_00005roe; pdb_00005rof; pdb_00005rog; pdb_00005roh; pdb_00005roi; pdb_00005roj; pdb_00005rok; pdb_00005rol; pdb_00005rom; pdb_00005ron; pdb_00005roo; pdb_00005rop; pdb_00005roq; pdb_00005ror; pdb_00005ros; pdb_00005rot; pdb_00005rou; pdb_00005rov; pdb_00005row; pdb_00005rox; pdb_00005roy; pdb_00005roz; pdb_00005rp0; pdb_00005rp1; pdb_00005rp2; pdb_00005rp3; pdb_00005rp4; pdb_00005rp5; pdb_00005rp6; pdb_00005rp7; pdb_00005rp8; pdb_00005rp9; pdb_00005rpa; pdb_00005rpb; pdb_00005rpc; pdb_00005rpd; pdb_00005rpe; pdb_00005rpf; pdb_00005rpg; pdb_00005rph; pdb_00005rpi; pdb_00005rpj; pdb_00005rpk; pdb_00005rpl; pdb_00005rpm; pdb_00005rpn; pdb_00005rpo; pdb_00005rpp; pdb_00005rpq; pdb_00005rpr; pdb_00005rps; pdb_00005rpt; pdb_00005rpu; pdb_00005rpv; pdb_00005rpw; pdb_00005rpx; pdb_00005rpy; pdb_00005rpz; pdb_00005sic; pdb_00005uvl; pdb_00005whw; pdb_00005wjg; pdb_00005wjh; pdb_00005wrc; pdb_00006cl7; pdb_00006cl8; pdb_00006cl9; pdb_00006cla; pdb_00006clb; pdb_00006dwq; pdb_00006eqv; pdb_00006eqw; pdb_00006eqx; pdb_00006fjs; pdb_00006hlb; pdb_00006hld; pdb_00006hle; pdb_00006hza; pdb_00006hzb; pdb_00006hzc; pdb_00006hzd; pdb_00006j43; pdb_00006k2p; pdb_00006k2r; pdb_00006k2s; pdb_00006k2t; pdb_00006k2v; pdb_00006k2w; pdb_00006k2x; pdb_00006k8m; pdb_00006kkf; pdb_00006law; pdb_00006mh6; pdb_00006n4u; pdb_00006o44; pdb_00006pak; pdb_00006pkj; pdb_00006pkk; pdb_00006pkl; pdb_00006pkm; pdb_00006pkn; pdb_00006pko; pdb_00006pkp; pdb_00006pkq; pdb_00006pkr; pdb_00006pks; pdb_00006pkt; pdb_00006pq0; pdb_00006pq4; pdb_00006pu4; pdb_00006pu5; pdb_00006qf1; pdb_00006qxv; pdb_00006rug; pdb_00006ruh; pdb_00006ruk; pdb_00006run; pdb_00006ruw; pdb_00006rve; pdb_00006rvg; pdb_00006rzp; pdb_00006txg; pdb_00006v8r; pdb_00006y5s; pdb_00006y5t; pdb_00006yd2; pdb_00006yd3; pdb_00006yd4; pdb_00006yd7; pdb_00006zet; pdb_00006zeu; pdb_00006zev; pdb_00007a68; pdb_00007a9f; pdb_00007a9k; pdb_00007a9m; pdb_00007am3; pdb_00007am4; pdb_00007am5; pdb_00007am6; pdb_00007am7; pdb_00007am8; pdb_00007bj3; pdb_00007c0p; pdb_00007jsy; pdb_00007lcu; pdb_00007ln7; pdb_00007lpt; pdb_00007lpu; pdb_00007lpv; pdb_00007lq8; pdb_00007lq9; pdb_00007lqa; pdb_00007lqb; pdb_00007lqc; pdb_00007ltd; pdb_00007lti; pdb_00007ltv; pdb_00007lu0; pdb_00007lu1; pdb_00007lu2; pdb_00007lu3; pdb_00007njj; pdb_00007np7; pdb_00007npr; pdb_00007nps; pdb_00007nuy; pdb_00007nuz; pdb_00007o1u; pdb_00007o1w; pdb_00007o1y; pdb_00007o20; pdb_00007o22; pdb_00007qxy; pdb_00007qxz; pdb_00007qy0; pdb_00007qy1; pdb_00007qy2; pdb_00007s4z; pdb_00007skx; pdb_00007svy; pdb_00007svz; pdb_00007sw0; pdb_00007sw1; pdb_00007sw2; pdb_00007sw3; pdb_00007sw4; pdb_00007sw5; pdb_00007sw6; pdb_00007sw7; pdb_00007sw8; pdb_00007sw9; pdb_00007swa; pdb_00007swb; pdb_00007swc; pdb_00007yzx; pdb_00008b4v; pdb_00008b4w; pdb_00008b4x; pdb_00008coy; pdb_00008coz; pdb_00008cp0; pdb_00008e52; pdb_00008e53; pdb_00008e7f; pdb_00008f05; pdb_00008f06; pdb_00008f07; pdb_00008fyo; pdb_00008fyp; pdb_00008fyq; pdb_00008fyr; pdb_00008fys; pdb_00008oyh; pdb_00008pol; pdb_00008qke; pdb_00008qkg; pdb_00008qkj; pdb_00008rse; pdb_00008rsf; pdb_00008rsg; pdb_00008sdk; pdb_00008sog; pdb_00008sou; pdb_00008sov; pdb_00008spl; pdb_00008sqv; pdb_00008uw8; pdb_00008uwc; pdb_00009ftx; pdb_00009fty; pdb_00009fu1
» more