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| Entry: PS00137 |
General information about the entry
| Entry name [info] | SUBTILASE_HIS |
| Accession [info] | PS00137 |
| Entry type [info] | PATTERN |
| Date [info] |
01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE; 22-FEB-2023 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00125 |
| Associated ProRule [info] | PRU10081 |
Name and characterization of the entry
| Description [info] | Serine proteases, subtilase family, histidine active site. |
| Pattern [info] |
H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-[SAGM]. |
Numerical results [info]
| Total number of hits | 246 in 246 different sequences |
| Number of true positive hits | 231 in 231 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 15 in 15 different sequences |
| Number of false negative sequences | 8 |
| Number of 'partial' sequences | 7 |
| Precision (true positives / (true positives + false positives)) | 93.90 % |
| Recall (true positives / (true positives + false negatives)) | 96.65 % |
Comments [info]
| Taxonomic range [info] | Archaea, Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 1 |
| Site [info] | active_site at position 1 |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
231 sequences
AEP_YARLI (P09230 ), AEX5_CAEEL (P91863 ), ALP2_ASPFC (B0Y473 ), ALP2_ASPFU (P87184 ), ALP_ACRCH (P29118 ), ALP_HYPAT (Q03420 ), ALP_LECPS (Q68GV9 ), APRX_BACSU (O31788 ), AQL1_THEAQ (P08594 ), ASES_SARSR (R4IR27 ), ASP_AERSO (Q9L5A4 ), BLI4_CAEEL (P51559 ), BLI_ONCVO (A0A044RE18), BPRV_DICNO (P42779 ), BPRX_DICNO (P42780 ), C5AP_STRP1 (P58099 ), C5AP_STRP3 (P0DD34 ), C5AP_STRP6 (Q5X9R0 ), C5AP_STRP8 (Q8NZ80 ), C5AP_STRPQ (P0DD35 ), C5AP_STRPY (P15926 ), CH901_DAVTA (B7ZK61 ), CL401_COCLU (B3V0K8 ), CRSP_ARATH (Q9LNU1 ), CUDP_METAN (P29138 ), ELYA_ALKAL (P27693 ), ELYA_ALKCL (P41362 ), ELYA_BACYA (P20724 ), ELYA_HALH5 (P41363 ), EPIP_STAEP (P30199 ), EXPR_XANCP (P23314 ), FKPC1_CAEEL (O17798 ), FLS_FERPE (Q93LQ6 ), FUR11_DROME (P26016 ), FUR1C_DROME (P30430 ), FUR2_DROME (P30432 ), FURI1_XENLA (P29119 ), FURIN_BOVIN (Q28193 ), FURIN_HUMAN (P09958 ), FURIN_MOUSE (P23188 ), FURIN_RAT (P23377 ), HLY_HALMT (I3R794 ), HLY_NATA1 (P29143 ), ISP1_BACSU (P11018 ), ISP6_SCHPO (P40903 ), ISP_ALKCL (P29140 ), ISP_PAEPO (P29139 ), KEX1A_KLULC (P09231 ), KEX2_CANAW (O13359 ), KEX2_YEAST (P13134 ), KRP1_SCHPO (Q09175 ), MBTP1_CRIGR (Q9Z2A8 ), MBTP1_HUMAN (Q14703 ), MBTP1_MOUSE (Q9WTZ2 ), MBTP1_RAT (Q9WTZ3 ), MYCP2_MYCTU (O05458 ), MYCP3_MYCTU (O53695 ), MYCP4_MYCTU (I6YC58 ), MYCP5_MYCTU (O53945 ), NEC1_BOVIN (Q9GLR1 ), NEC1_HUMAN (P29120 ), NEC1_MOUSE (P63239 ), NEC1_MUSCO (P63240 ), NEC1_RAT (P28840 ), NEC2_BOVIN (Q9GLR0 ), NEC2_CAEEL (G5ECN9 ), NEC2_DROME (Q9VBC7 ), NEC2_HUMAN (P16519 ), NEC2_MOUSE (P21661 ), NEC2_PIG (Q03333 ), NEC2_PONAB (Q5REC2 ), NEC2_RAT (P28841 ), NECA_HYDVU (P29146 ), NECB_HYDVU (P29145 ), NEP_NATMA (Q5RLZ1 ), NISP_LACLL (Q07596 ), ORYZ_ASPCL (A1CIA7 ), ORYZ_ASPFC (B0Y708 ), ORYZ_ASPFL (P35211 ), ORYZ_ASPFN (B8N106 ), ORYZ_ASPFU (P28296 ), ORYZ_ASPOR (P12547 ), ORYZ_EMENI (Q00208 ), ORYZ_NEOFI (A1CWF3 ), P1P_LACLC (P16271 ), P2P_LACLC (P15293 ), P2P_LACPA (Q02470 ), P3P_LACLS (P15292 ), PCH18_PENCH (P9WEW6 ), PCH18_PENRB (P9WEW5 ), PCSK4_HUMAN (Q6UW60 ), PCSK4_MOUSE (P29121 ), PCSK4_RAT (Q78EH2 ), PCSK5_BRACL (Q9NJ15 ), PCSK5_HUMAN (Q92824 ), PCSK5_MOUSE (Q04592 ), PCSK5_RAT (P41413 ), PCSK6_HUMAN (P29122 ), PCSK6_RAT (Q63415 ), PCSK7_HUMAN (Q16549 ), PCSK7_MOUSE (Q61139 ), PCSK7_RAT (Q62849 ), PEN18_PENRB (Q9P8G3 ), PENC2_PENCI (Q9Y755 ), PEPC_ASPNG (P33295 ), PLS_PYRFU (P72186 ), PRCA_NOSS1 (Q59149 ), PRCA_TRIV2 (P23916 ), PROA_VIBAL (P16588 ), PRTB_YEAST (P09232 ), PRTK_PARAQ (P06873 ), PRTM_ALKCK (Q99405 ), PRTR_PARAQ (P23653 ), PRTS_SERMA (P09489 ), PRTT_PARAQ (P20015 ), PRTT_SERMA (P29805 ), PSP3_SCHPO (Q9UTS0 ), RM201_RHOMI (Q32ZM1 ), RRT12_YEAST (P25381 ), SBT24_ARATH (F4HYR6 ), SBT31_ARATH (F4JJH4 ), SBT33_ARATH (Q9MAP5 ), SBT34_ARATH (F4HPF1 ), SBT39_ARATH (Q9ZSB0 ), SBT3A_ARATH (Q9ZSB1 ), SBT3B_ARATH (Q1PDX5 ), SBT3C_ARATH (F4JJH5 ), SBT3G_ARATH (Q8GWX9 ), SBT41_ARATH (F4IG09 ), SBT51_ARATH (F4HSQ2 ), SBT61_ARATH (Q0WUG6 ), SEPR_THESR (P80146 ), SMP1_MAGPO (Q9Y778 ), SPAZ_ARTOA (G1X8P8 ), SPAZ_ORBOL (G3FNQ9 ), SPL1_ENCCU (Q8SQJ3 ), SPM1_MAGO7 (P58371 ), SUB10_ARTBC (D4AQG0 ), SUB10_TRIVH (D4DIS6 ), SUB1_PLAF7 (Q8I0V0 ), SUB1_PLAFA (O61142 ), SUB1_PLAFO (W7K9M0 ), SUB1_PSED2 (L8G6I7 ), SUB2A_COCP7 (C5P6D1 ), SUB2C_COCP7 (C5NZ70 ), SUB2_ARTBC (D4AZ75 ), SUB2_ARTBE (Q64K35 ), SUB2_ARTGP (E4UZP9 ), SUB2_ARTOC (C5G168 ), SUB2_ARTOT (Q8J0D8 ), SUB2_DEIRA (Q9RYM8 ), SUB2_PLAF7 (Q8IHZ5 ), SUB2_PLAFA (O97364 ), SUB2_PLAFP (Q9Y008 ), SUB2_PSED2 (L8FSM5 ), SUB2_TRIEQ (B6VA85 ), SUB2_TRIRU (Q69F57 ), SUB2_TRITO (B8XGQ5 ), SUB2_TRIVC (Q5VJ76 ), SUB2_TRIVH (D4DLI5 ), SUB3_PLAF7 (Q8I430 ), SUB3_PSED2 (L8GD75 ), SUB4B_COCP7 (C5NZT2 ), SUB5_ARTBC (D4B194 ), SUB5_ARTBE (Q64K32 ), SUB5_ARTGP (E4V2L6 ), SUB5_ARTOC (C5G1D1 ), SUB5_TRIEQ (B6VA87 ), SUB5_TRIRU (Q69F34 ), SUB5_TRITO (B8XGQ8 ), SUB5_TRIVC (Q5VJ73 ), SUB5_TRIVH (D4D0F5 ), SUB6_ARTBC (D4ALV9 ), SUB6_ARTBE (Q64K31 ), SUB6_ARTGP (E4V4J8 ), SUB6_ARTOC (C5FQI3 ), SUB6_TRIEQ (A1XIH0 ), SUB6_TRIRU (Q9UW97 ), SUB6_TRISD (A1XIH1 ), SUB6_TRISH (Q8J077 ), SUB6_TRITO (Q3ZEJ8 ), SUB6_TRIVC (Q5VJ72 ), SUB6_TRIVH (D4D5H3 ), SUB7B_COCP7 (C5PCX1 ), SUB7C_COCP7 (C5NZ69 ), SUB7_ARTBC (D4APA9 ), SUB7_ARTBE (Q64K36 ), SUB7_ARTGP (E4V2V9 ), SUB7_ARTOC (C5FJA5 ), SUB7_TRIEQ (A1XIH3 ), SUB7_TRIRU (Q8NID9 ), SUB7_TRISD (A1XIH5 ), SUB7_TRITO (A1XIH4 ), SUB7_TRIVC (Q5VJ71 ), SUB7_TRIVH (D4CZQ4 ), SUB7_TRIVO (A1XIH6 ), SUB8_ARTBC (D4AX50 ), SUB8_ARTOC (C5FII2 ), SUB8_COCP7 (C5P4Z8 ), SUB8_TRIVH (D4DKQ4 ), SUBB_LEDLE (P29599 ), SUBC_BACLI (P00780 ), SUBD_BACLI (P00781 ), SUBE_BACSU (P16396 ), SUBF_BACSU (P16397 ), SUBN_BACNA (P35835 ), SUBS_LEDLE (P29600 ), SUBT_BACAM (P00782 ), SUBT_BACPU (P07518 ), SUBT_BACS9 (P28842 ), SUBT_BACSA (P00783 ), SUBT_BACSU (P04189 ), SUBT_GEOSE (P29142 ), SUBV_BACSU (P29141 ), TAGB_DICDI (P54683 ), TAGC_DICDI (Q23868 ), TAGD_DICDI (Q8T9W1 ), THES_BACSJ (Q45670 ), THET_THEVU (P04072 ), TKSP_THEKO (Q5JIZ5 ), TPP2_BOVIN (A5PK39 ), TPP2_CAEEL (Q09541 ), TPP2_DROME (Q9V6K1 ), TPP2_HUMAN (P29144 ), TPP2_MOUSE (Q64514 ), TPP2_RAT (Q64560 ), TPP2_SCHPO (Q9UT05 ), TPPII_ARATH (F4JVN6 ), WPRA_BACSU (P54423 ), XPR6_YARLI (P42781 ), YSP3_YEAST (P25036 )» more
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| UniProtKB/Swiss-Prot False negative sequences |
8 sequences
NALP_NEIMB (Q9JXM7 ), NALP_NEIMH (E6MVD9 ), SBT1_LOTJA (A9QY40 ), SBT3_LOTJA (A9QY39 ), SBT4_LOTJA (A9QY38 ), SBTS_LOTJA (A9JQS7 ), SBT_MEDTR (G7KEU7 ), SBT_PETHY (A0A0M3R8G2)» more |
| UniProtKB/Swiss-Prot 'Partial' sequences |
7 sequences
ASE2_ACRSP (P85157 ), CUDP_METCM (P80406 ), NCP3_COPCM (P83454 ), NVSP_ALIVI (P83433 ), PRTE_HALME (P28308 ), SP01_SCEBO (Q10721 ), THEM_MALCI (P13858 )» more |
| UniProtKB/Swiss-Prot False positive sequences |
15 sequences
ADCY8_HUMAN (P40145 ), ADCY8_MOUSE (P97490 ), ADCY8_RAT (P40146 ), DGGGP_METTH (O27170 ), KTNB1_XENTR (Q6NVM2 ), PSBA3_GLOVI (Q7NH81 ), PSBA_ALETA (Q9TM69 ), PSBA_AMPCA (Q9BBC1 ), PSBA_AMPOP (Q7HP56 ), PSBA_HETNI (Q9MSC0 ), PSBA_HETPY (Q9MSC1 ), PSBA_HETRO (Q9MSC2 ), PSBA_HETTR (Q9XQV1 ), PSBA_PROMC (Q9TM72 ), TM241_MOUSE (Q3UME2 )» more |
| PDB [Detailed view] |
416 PDB
1A2Q; 1AF4; 1AH2; 1AK9; 1AQN; 1AU9; 1AV7; 1AVT; 1BE6; 1BE8; 1BFK; 1BFU; 1BH6; 1BJR; 1C3L; 1C9J; 1C9M; 1C9N; 1CNM; 1CSE; 1DBI; 1DUI; 1EGQ; 1GCI; 1GNS; 1GNV; 1HT3; 1IAV; 1IC6; 1JEA; 1LW6; 1MEE; 1MPT; 1NDQ; 1NDU; 1OT5; 1OYO; 1OYV; 1P7V; 1P7W; 1P8J; 1PEK; 1PFG; 1PJ8; 1PTK; 1Q5P; 1R0R; 1R64; 1S01; 1S02; 1SBC; 1SBH; 1SBI; 1SBN; 1SBT; 1SCA; 1SCB; 1SCD; 1SCJ; 1SCN; 1SEL; 1SIB; 1SPB; 1ST2; 1ST3; 1SUA; 1SUB; 1SUC; 1SUD; 1SUE; 1SUP; 1SVN; 1TEC; 1THM; 1TK2; 1TM1; 1TM3; 1TM4; 1TM5; 1TM7; 1TMG; 1TO1; 1TO2; 1UBN; 1V5I; 1VSB; 1WSD; 1XF1; 1Y1K; 1Y33; 1Y34; 1Y3B; 1Y3C; 1Y3D; 1Y3F; 1Y48; 1Y4A; 1Y4D; 1YJA; 1YJB; 1YJC; 1YU6; 2DP4; 2DQK; 2DUJ; 2G4V; 2HD4; 2HPZ; 2ID4; 2ID8; 2PKC; 2PQ2; 2PRK; 2PWA; 2PWB; 2PYZ; 2SBT; 2SEC; 2SIC; 2SNI; 2ST1; 2TEC; 2V8B; 2WUV; 2WUW; 3AFG; 3AJ8; 3AJ9; 3BGO; 3BX1; 3CNQ; 3CO0; 3D9Q; 3DDZ; 3DE0; 3DE1; 3DE2; 3DE3; 3DE4; 3DE5; 3DE6; 3DE7; 3DVQ; 3DVR; 3DVS; 3DW1; 3DW3; 3DWE; 3DYB; 3EIF; 3F49; 3F7M; 3GT3; 3GT4; 3HJR; 3I2Y; 3I30; 3I34; 3I37; 3L1K; 3LXU; 3OSZ; 3PRK; 3PTL; 3Q40; 3Q5G; 3QMP; 3SIC; 3TEC; 3UNX; 3VSB; 3VYV; 3WHI; 3WQB; 4B5L; 4C3U; 4C3V; 4CFY; 4CFZ; 4CG0; 4DJ5; 4DWW; 4DZT; 4FON; 4LVN; 4LVO; 4MZD; 4OMC; 4OMD; 4RYD; 4WOB; 4WOC; 4Z2A; 4ZAR; 5AMX; 5AQE; 5ARB; 5ARC; 5ARD; 5AVJ; 5AVK; 5B1D; 5B1E; 5CW1; 5GL8; 5I9S; 5JMO; 5JXG; 5JXH; 5JXI; 5JXJ; 5K7S; 5KXU; 5KXV; 5MIM; 5MJL; 5OX2; 5ROC; 5ROD; 5ROE; 5ROF; 5ROG; 5ROH; 5ROI; 5ROJ; 5ROK; 5ROL; 5ROM; 5RON; 5ROO; 5ROP; 5ROQ; 5ROR; 5ROS; 5ROT; 5ROU; 5ROV; 5ROW; 5ROX; 5ROY; 5ROZ; 5RP0; 5RP1; 5RP2; 5RP3; 5RP4; 5RP5; 5RP6; 5RP7; 5RP8; 5RP9; 5RPA; 5RPB; 5RPC; 5RPD; 5RPE; 5RPF; 5RPG; 5RPH; 5RPI; 5RPJ; 5RPK; 5RPL; 5RPM; 5RPN; 5RPO; 5RPP; 5RPQ; 5RPR; 5RPS; 5RPT; 5RPU; 5RPV; 5RPW; 5RPX; 5RPY; 5RPZ; 5SIC; 5UVL; 5WHW; 5WJG; 5WJH; 5WRC; 6CL7; 6CL8; 6CL9; 6CLA; 6CLB; 6DWQ; 6EQV; 6EQW; 6EQX; 6FJS; 6HLB; 6HLD; 6HLE; 6HZA; 6HZB; 6HZC; 6HZD; 6J43; 6K2P; 6K2R; 6K2S; 6K2T; 6K2V; 6K2W; 6K2X; 6K8M; 6KKF; 6LAW; 6MH6; 6N4U; 6O44; 6PAK; 6PKJ; 6PKK; 6PKL; 6PKM; 6PKN; 6PKO; 6PKP; 6PKQ; 6PKR; 6PKS; 6PKT; 6PQ0; 6PQ4; 6PU4; 6PU5; 6QF1; 6QXV; 6RUG; 6RUH; 6RUK; 6RUN; 6RUW; 6RVE; 6RVG; 6RZP; 6TXG; 6V8R; 6Y5S; 6Y5T; 6YD2; 6YD3; 6YD4; 6YD7; 6ZET; 6ZEU; 6ZEV; 7A68; 7A9F; 7A9K; 7A9M; 7AM3; 7AM4; 7AM5; 7AM6; 7AM7; 7AM8; 7BJ3; 7C0P; 7JSY; 7LCU; 7LN7; 7LPT; 7LPU; 7LPV; 7LQ8; 7LQ9; 7LQA; 7LQB; 7LQC; 7LTD; 7LTI; 7LTV; 7LU0; 7LU1; 7LU2; 7LU3; 7NJJ; 7NP7; 7NPR; 7NPS; 7NUY; 7NUZ; 7O1U; 7O1W; 7O1Y; 7O20; 7O22; 7QXY; 7QXZ; 7QY0; 7QY1; 7QY2; 7S4Z; 7SKX; 7SVY; 7SVZ; 7SW0; 7SW1; 7SW2; 7SW3; 7SW4; 7SW5; 7SW6; 7SW7; 7SW8; 7SW9; 7SWA; 7SWB; 7SWC; 8E52; 8E53 » more |
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