PROSITE entry PS50049

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS50049
Entry name [info]	THD_2
Accession [info]	PS50049
Entry type [info]	MATRIX
Date [info]	01-NOV-1997 CREATED; 29-MAY-2024 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00224
Associated ProRule [info]	PRU01387

Name and characterization of the entry

Description [info]

Tumor necrosis factor (TNF) homology domain (THD) profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=149;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=144;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3899584; R2=0.0082396; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1045; N_SCORE=11.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=499; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-39; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='P';  M= -22, -80,  22, -58, -68, -72,   6,  33, -27, -48,  -1, -65,  87, -18, -70, -13, -57,  23, -80, -20;
/M: SY='A';  M=  61,  13, -73, -68,  28, -65, -73,  -2, -67, -23, -52, -41, -73, -67, -31, -14,   0,  47, -75, -59;
/M: SY='A';  M=  81, -64, -65, -27, -71, -56, -67, -36,   9,  -6, -57, -61, -37,  -5, -61,  -8,  -3, -26, -76, -68;
/M: SY='H';  M= -67, -81, -51,  21, -70, -71, 134, -82, -17, -45, -56, -14, -68,  28, -12, -58, -66, -82,  -7, -43;
/M: SY='L';  M= -65, -70, -82, -51,   1, -85, -69,   8, -38,  76, -33, -80, -82, -70, -30, -74, -61,  29, -70,  -7;
/M: SY='T';  M= -16, -71, -63,   0, -60, -73,  17,  36, -29,  -9,  -3,  18, -25,  29, -17, -56,  39,  39, -79, -14;
/M: SY='G';  M=  36, -70, -65, -66, -70,  59, -68, -16, -11,   4, -59,   4,   6, -62, -68,  -1,   4, -21, -76, -69;
/M: SY='N';  M=  13, -72,  32,   7, -71, -62,   2, -16,  11, -68, -62,  61, -28,  29, -23, -13,  18,  -1, -81,  -6;
/I:         I=-6; DM=-14;
/M: SY='P';  M=   7, -75, -60, -40, -69, -23,  39,  -6,  31, -12, -59,  36,  59, -18, -19,  -2, -13, -24,  12, -23; D=-6;
/I:         I=-6; DM=-14;
/M: SY='Q';  M=  -7, -74, -13,   8, -76, -41, -36, -42, -31, -31, -12,  13, -69,  48,   7,  47,  33, -32, -84, -69; D=-6;
/I:         I=-6; DM=-14;
/M: SY='S';  M=  21, -73, -21,  -6, -76, -15,  -7, -32,   4, -41, -47,   7,   1, -57,   5,  45,  20, -13, -85, -70; D=-6;
/I:         I=-6; MI=0; MD=-14; IM=0; DM=-14;
/M: SY='C';  M= -62, 115, -26,   5, -46,  -8, -67,   2, -16,  -2, -63, -18,  42,  27,   3,  28,  -5, -65, -83, -71; D=-6;
/I:         I=-13; MD=-32;
/M: SY='Q';  M= -31, -77, -26,  10, -77,   5,  10, -18,  -5, -36,  12,  31,  -6,  40,   7, -12,  38, -67, -85, -69; D=-13;
/I:         I=-13; MD=-32;
/M: SY='Q';  M=  -3,   8,  14, -41, -78,  13, -68,  -4, -15, -69,  -5, -59, -41,  57, -65,  26, -14,  13, -85, -72; D=-13;
/I:         I=-13; MD=-32;
/M: SY='D';  M= -31, -94,  31, -68, -95,  18,  -9, -53,  -3, -43, -84, -13,  -6,   8,   2,   1, -75, -89, -99, -85; D=-13;
/I:         I=-13; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='V';  M= -49,-101,-102, -95, -17,-106,-100,  -5, -88, -25, -77, -97,  11, -35,   4, -89,   0,  20,-105, -88; D=-13;
/I:         I=-13; DM=-32;
/M: SY='L';  M= -35, -68, -73, -45, -48, -45, -66, -29, -71,  74, -37,  -6, -78, -65, -71,  29, -24,   7, -75, -57;
/M: SY='Q';  M= -58, -75, -21,  16, -69, -11,  33, -68,  13,  -3,  22,  -8,   9,  40,  33,  39, -29, -58, -76,  -6;
/M: SY='W';  M= -73, -98, -96, -36, -41, -40, -95, -73, -71, -71, -73, -91, -78, -70, -74, -44, -84, -86, 175,  11;
/I:         I=-16; MD=-41;
/M: SY='E';  M=  -6,  -4, -54,  46, -66, -23,  25, -66,   6,  -9,  19,  18, -69,  41,  11, -27, -27, -30, -23,  26; D=-16;
/I:         I=-16; MD=-41;
/M: SY='H';  M=  19, -73,   4,  21, -77,   1,  37, -73,  12, -73,  11,  24, -14, -53, -23,  29,  16, -38, -85, -68; D=-16;
/I:         I=-16; MD=-41;
/M: SY='D';  M= -13, -75,  41,  13, -80,  16, -61, -36,  15, -77, -70,  17, -68,  15,  10,  17,  34, -71, -85, -71; D=-16;
/I:         I=-16; MD=-41;
/M: SY='Y';  M= -79, -69,  10, -68, -56, -74, -71, -81,   4, -20, -74, -72,  37, -12,  32, -36,  17, -81, -82,  38; D=-16;
/I:         I=-16; MI=0; MD=-41; IM=0; DM=-41;
/M: SY='G';  M= -43,-111,   8,  -5,-117,  52, -99,-121, -96,-117,-109, -83,-100, -93,-104, -85, -98,-115,-112,-110; D=-16;
/I:         I=-16; DM=-41;
/M: SY='R';  M= -82, -98, -76, -13, -84, -21,  -4, -95, -66, -70, -11,  31, -93,  -7,  38,   1, -79, -94,  27,  20; D=-16;
/I:         I=-16; DM=-41;
/M: SY='A';  M=  44, -83, -34, -77,  -6, -73, -79, -79, -79, -82, -78, -75,   2, -75, -83,  38, -35, -29, -84,  21; D=-16;
/I:         I=-16; DM=-41;
/M: SY='F';  M= -54, -85, -88, -85,  70, -91, -76, -13,  -6,   8, -61, -30, -92, -83, -79, -34,   4, -41, -67,  29; D=-16;
/I:         I=-16; DM=-41;
/M: SY='L';  M= -11, -78, -86, -39, -57, -58, -77,   6, -72,  58,  39, -83, -30, -76, -81, -75,   4,  -9, -83, -66; D=-16;
/I:         I=-16; DM=-41;
/M: SY='H';  M=  12, -79, -65, -61, -82, -68,  60, -82,   1, -81, -71,   4,  16,  -4,  34,  39,  12, -76, -90, -69; D=-16;
/I:         I=-16; DM=-41;
/M: SY='N';  M= -60,  -8, -31, -65,   7,  34,  28, -79, -61, -48, -71,  64, -22,  -6, -20,  36,   0, -77, -85, -67; D=-16;
/I:         I=-16; DM=-41;
/M: SY='G';  M= -61, -82, -67, -37, -46,  63, -72, -83,  -5, -44, -76,  15, -76,   4, -30,  14,   9, -45, -86, -78; D=-16;
/I:         I=-16; MI=0; MD=-41; IM=0; DM=-41;
/M: SY='H';  M= -91,   0, -89, -21, -34, -27,  36,-113, -86,-108,-101,  -6,-104, -38,  -3,  22, -88,-109,-115, -54; D=-16;
/I:         I=-16; DM=-41;
/M: SY='G';  M= -35,-102, -97, -98, -94,  32,   4, -41, -41,   0, -83, -88, -24, -94, -98, -84,  -7, -49,-106, -94; D=-16;
/I:         I=-16; DM=-41;
/M: SY='M';  M= -38, -70, -77, -72,  31, -78, -67,  -2, -69,  36,  75,  -7,  28, -68, -31, -66,  -2,  39, -72, -52;
/M: SY='E';  M= -46, -75, -21,  52, -75, -58,  16, -21,  25, -48, -33, -17, -21,  38,  27,  34,  24, -52, -80, -65;
/M: SY='Y';  M= -30, -72, -74, -21,  26, -80, -57, -42, -70,  53, -41, -74, -22, -66, -69, -66,   3,  11, -52,  83;
/M: SY='Q';  M= -57, -75,  16,  34, -75, -66,  40, -41,  23, -32, -38, -10, -66,  59,  17,  37,  -4, -18, -81, -62;
/M: SY='N';  M= -62, -75,  69,  39, -81,  -4, -51, -81,   6, -82, -74,  79, -38, -48, -19, -24, -24, -78, -90, -71;
/M: SY='N';  M= -21, -74,  20, -60, -78,  71, -57, -82, -18, -82, -72,  75, -70, -11, -28, -49, -39, -79,  11, -31;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='Q';  M= -27, -75, -52,  30, -28,   9,  27, -44,  36, -52, -63,  19, -65,  71, -47,  34, -55, -39, -77, -63;
/M: SY='L';  M= -65, -69, -84, -77, -10, -86, -71,   3, -78,  83, -30, -82, -83, -72, -75, -76, -61,  23, -72, -53;
/M: SY='V';  M=   4, -70, -70, -12, -59, -77,  -8,  20,   4,   4, -47, -66, -73, -61,  35, -60,  10,  63, -80, -61;
/M: SY='V';  M= -58, -71, -84, -79, -51, -87, -84,  72, -76,   1, -38, -77, -77, -76, -78, -69, -30,  76, -80, -59;
/M: SY='P';  M= -33, -80, -13,   2, -75, -67,  51, -45,  17, -17, -17,  33,  75,  49, -30, -56,  -5, -71,   4, -64;
/M: SY='Q';  M= -23,  43,  -5,  23,  13, -69,  15, -71,  13, -64, -62, -19, -68,  61,  40,  11,  17, -35, -76, -59;
/M: SY='D';  M=  17, -72,  71,  -8, -79, -61, -59, -73, -32, -75, -70, -12,  38,  11, -62,  25,  47, -67, -87, -70;
/M: SY='G';  M= -49, -77, -64, -76, -83, 103, -71, -91, -70, -86, -75, -50, -68, -67, -77, -49, -68, -84, -74, -78;
/M: SY='L';  M= -66, -71, -19, -74,  28, -84, -67,  25, -75,  70, -22, -76, -81, -71, -74, -71,  -8,   5, -65,  22;
/M: SY='Y';  M= -71, -82, -71, -74,   7, -78, -37, -56, -66, -53, -50, -72, -83, -61, -63, -66, -66, -61, -27, 133;
/M: SY='Y';  M= -71, -75, -79, -75,  73, -81, -53, -30, -67,  38,   8, -75, -83, -68,   5, -71, -65, -52, -43,  90;
/M: SY='I';  M= -61, -72, -85, -80, -48, -87, -81,  75, -77,  35, -36, -79, -78, -75, -79, -72, -57,  60, -77, -57;
/M: SY='Y';  M= -68, -80, -69, -71,  16, -76,  57, -16, -65, -53, -50, -67, -80, -60, -63, -13, -63, -20, -36, 121;
/M: SY='C';  M=   8,  75, -66, -66, -20,  -8, -67,  13, -65,   3, -58, -56, -71, -60, -69,  74, -20, -30, -80, -64;
/M: SY='Q';  M= -60, -82, -53,  -9, -85, -67,  16, -75,  32, -49, -58,  -2, -66, 119, -39, -50, -61, -76, -74, -61;
/I:         I=-6; MI=0; MD=-14; IM=0; DM=-14;
/M: SY='V';  M= -22, -69, -80, -76, -56,  -3, -81,  18, -74,  13, -44, -75, -13, -75, -77, -65, -17,  82, -83, -63; D=-6;
/I:         I=-6; DM=-14;
/M: SY='T';  M= -58,  27, -64, -26, -55,  -8,   1, -29, -62,  21, -52, -17, -72,  36, -65,  14,  53,   0, -70,  48; D=-6;
/I:         I=-6; DM=-14;
/M: SY='F';  M= -74, -74, -84, -81, 104, -83, -62, -48, -77,  18, -48, -78, -30, -81, -74, -74, -67, -54, -42,  62; D=-6;
/I:         I=-6; MI=0; MD=-14; IM=0; DM=-14;
/M: SY='R';  M= -10, -78, -22, -62, -17, -49, -16, -33,   2, -12, -64,  -3, -76, -26,  58,  28,  26, -38, -83, -67; D=-6;
/I:         I=-6; DM=-14;
/M: SY='G';  M= -63, -81,  25, -26, -21,  57,   3, -28, -64, -77, -71,  43, -76,  23, -26, -59, -66,   4, -86, -72; D=-6;
/I:         I=-6; DM=-14;
/M: SY='Q';  M= -57, -89, -67,  26, -29, -38,   9, -73,  -5, -66, -32, -67, -35,  66,   7, -24,  -3,   8, -89, -73; D=-6;
/I:         I=-6; DM=-14;
/M: SY='T';  M=  -3, -89, -56,  -6, -91,  16, -87, -46, -33, -85, -82, -75, -86, -35, -65,   3,  26,   7,-100, -58; D=-6;
/I:         I=-6; DM=-14;
/M: SY='C';  M=-234, 156,-254,-254,-244,-250,-254,-251,-250,-242,-242,-240,-265,-257,-256,-237,-234,-239,-274,-255; D=-6;
/I:         I=-6; DM=-14;
/M: SY='S';  M= -80,-102, -88, -87, -59, -43, -92,-103, -89,-108,-100, -27,  52, -85, -96,  53, -50,-100,-110,-100; D=-6;
/I:         I=-6; DM=-14;
/M: SY='N';  M= -89,-105, -13, -59,-114, -52, -88,-113, -89,-117,-107,  49, -50, -35, -95,  34, -80,-110,-124,-106; D=-6;
/I:         I=-6; MI=0; MD=-14; IM=0; DM=-14;
/M: SY='Q';  M= -48,-113, -37, -85,-115, -39,   0,-113, -18,-112,-101, -20,  11,  14,  14, -23, -40,-109,-115,-101; D=-6;
/I:         I=-6; DM=-14;
/M: SY='H';  M= -55,-102, -19,   9,-103, -16,  39,-104, -26, -70, -93,  -1, -94, -79, -18, -49,  21, -99,-114, -92; D=-6;
/I:         I=-6; DM=-14;
/M: SY='P';  M= -17,-106, -44, -87, -61, -55, -16, -97, -87, -54, -91, -77,  53, -53, -25,   5, -66, -97,  30,  11; D=-6;
/I:         I=-6; DM=-14;
/M: SY='V';  M= -28, -92, -22, -87, -38, -96, -91, -23, -49,  15, -51, -87, -59, -19, -90,  -7,  -7,  22, -98, -27; D=-6;
/I:         I=-6; DM=-14;
/M: SY='T';  M= -31, -90, -84, -81, -21, -66, -81, -79, -81, -17, -77, -77,  16,   2, -85,  28,  34, -51, -88,  23; D=-6;
/I:         I=-6; DM=-14;
/M: SY='L';  M= -86, -92,-101, -91, -50,-104, -86,  -1, -92,  57,  23, -97,-101,  17, -90, -93, -83, -61, -92, -74; D=-6;
/I:         I=-6; DM=-14;
/M: SY='T';  M=  31, -85, -84, -82, -90, -30, -87, -78, -78, -61,  -1, -42, -86, -80, -14,  -8,  48, -18,-102, -87; D=-6;
/I:         I=-6; DM=-14;
/M: SY='H';  M= -83, -97, -84, -80, -83, -94,  96, -74, -84,  -7, -70, -76,  13, -31, -82, -24, -81,  15,-110, -69; D=-6;
/I:         I=-6; DM=-14;
/M: SY='G';  M= -78, -94, -80,   2,   9,  15,  -4, -83,  -9, -55, -80, -76, -89, -10, -25, -26,  14, -20, -88,   6; D=-6;
/I:         I=-6; DM=-14;
/M: SY='I';  M= -35, -93,-105,-100, -71,-106,-103,  60, -97,  -1, -58, -98, -97, -95, -99, -90, -77,  36, -98, -79; D=-6;
/I:         I=-6; DM=-14;
/M: SY='C';  M= -17,  52, -77, -73, -73, -80, -71, -79, -25, -66, -75,  -9, -86,  42, -73,  23,  16, -29, -82,  44; D=-6;
/I:         I=-6; DM=-14;
/M: SY='R';  M= -67, -46, -71, -64, -81, -59, -69, -79,  39, -15,   6, -22,  14, -58,  47,  43, -49, -77, -88, -75; D=-6;
/I:         I=-6; DM=-14;
/M: SY='F';  M=  -2, -84, -84, -76,  33, -85, -77,  18, -23,   3, -59, -80,  32, -10,   6, -73, -23,   4, -76,  -3; D=-6;
/I:         I=-6; DM=-14;
/M: SY='A';  M=  39,  28,  -2, -68, -84, -23, -74, -78, -21, -81, -76,   9, -78, -67, -27,  33,  22, -29,   5, -78; D=-6;
/I:         I=-6; DM=-14;
/M: SY='S';  M=   2, -77,  12, -39, -49, -17, -75, -17, -74,  25, -59, -67, -31, -70, -78,  42, -15,  13, -88, -72; D=-6;
/I:         I=-6; DM=-14;
/M: SY='H';  M=  -3, -79, -15, -55, -75, -68,  88, -82,  37, -77, -67, -52, -72,  20,  17,  43, -59, -78, -84,   2; D=-6;
/I:         I=-6; DM=-14;
/M: SY='Y';  M=  -5, -77, -30, -71,  14, -28, -53, -23, -68, -27, -13, -67,  -5, -64, -69,  37, -59, -23, -49,  98; D=-6;
/I:         I=-6; MI=0; MD=-14; IM=0; DM=-14;
/M: SY='P';  M= -38, -94,   3,  16,  -1,  -3, -72, -86, -66, -87, -79, -52,  80,  37, -34, -31, -70, -86, -86, -79; D=-6;
/I:         I=-6; DM=-14;
/M: SY='E';  M= -13, -79,  25,  36,  26,  10, -68, -26, -23, -17, -68, -20, -73, -12, -45,   0,  19, -54, -81, -65; D=-6;
/I:         I=-6; DM=-14;
/M: SY='H';  M= -28, -82,  32,  21, -22, -73,  37, -38,  27, -76,   1, -10,  33, -57, -27,   9,   6, -42, -88, -69; D=-6;
/I:         I=-6; DM=-14;
/M: SY='V';  M= -30, -74, -78, -39,  -8, -34,   2,  30, -69,  34, -45, -73,  12, -69,   1, -34, -18,  47, -77, -12; D=-6;
/I:         I=-6; DM=-14;
/M: SY='P';  M= -11, -75, -17,  37, -26, -65, -22, -31, -53, -12, -61,  33,  46,  35,  -4,  30, -19,  -7,  16, -64;
/M: SY='L';  M= -65, -70, -83, -75, -16, -85, -69,  12, -75,  81,  24, -80, -82, -19, -44, -75, -62,   7, -72, -53;
/M: SY='L';  M= -64, -69, -81, -75, -43, -83, -65, -21, -73,  74,  70, -77, -79, -68, -53, -71,   1,  10, -71,   5;
/I:         I=-10; MD=-25;
/M: SY='S';  M= -33, -73, -64, -12, -67, -70,  -6,   5,  42,  -2, -25, -10, -71, -54,  28,  44, -22,  21, -81, -65; D=-10;
/I:         I=-10; MD=-25;
/M: SY='N';  M=  34, -74,  14,  15, -77,  29, -62, -75,   1, -12, -67,  42, -71, -55,   8,   6, -58, -70, -83, -72; D=-10;
/I:         I=-10; MD=-25;
/M: SY='Q';  M=  -3, -80, -67,  -5, -75,  19, -69,  16,  14,   0, -62,  -3, -75,  29,   3,   6,  -9, -63, -83, -72; D=-10;
/I:         I=-10; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='F';  M= -89, -99,-101, -99,  22,-101, -97, -82, -97,  -4,  -6, -92, -28, -96, -72,  16,  20, -46,-101, -81; D=-10;
/I:         I=-10; DM=-25;
/M: SY='H';  M= -28, -89, -82, -75, -28, -34,  31, -72,  26,  -3,  -3, -74, -88, -34,  10, -16,  -2,  -4, -94, -75; D=-10;
/I:         I=-10; DM=-25;
/M: SY='S';  M= -20, -83, -74, -71,  22, -76,   7, -78,  -5, -15, -72,   6, -83,  20, -71,  46,   9, -76, -88, -68; D=-10;
/I:         I=-10; DM=-25;
/M: SY='P';  M= -47, -91, -20, -71, -79, -35, -77, -67, -69, -18, -70, -76,  60,  17,  15, -16, -18,  18, -88,   1; D=-10;
/I:         I=-10; DM=-25;
/M: SY='C';  M=-222, 148,-242,-242,-232,-237,-242,-239,-238,-230,-230,-228,-253,-245,-244,-225,-222,-227,-262,-243; D=-10;
/I:         I=-10; DM=-25;
/M: SY='E';  M= -44, -96, -73,  36, -89,  -2, -10,  -6, -74, -30, -79, -77,  -3,  18, -44, -20,   1, -80,  27, -83; D=-10;
/I:         I=-10; DM=-25;
/M: SY='Q';  M= -76, -93, -76, -28, -90, -33, -74, -39,  -8, -29,   2,  -8, -87,  47,  32,  14, -11, -59, -95, -81; D=-10;
/I:         I=-10; DM=-25;
/M: SY='E';  M= -22, -89, -47,  39, -96,  22, -75, -94, -40, -94, -86,   5, -31,  -7, -76,  31,  -3, -88, -97, -88; D=-10;
/I:         I=-10; DM=-25;
/M: SY='M';  M= -33, -87, -16, -78, -10, -86, -80, -33, -78, -72,  53,   7, -87,  17, -82, -10,  40,  -7, -98, -77; D=-10;
/I:         I=-10; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='P';  M= -18,-114, -51, -65,-107, -10, -34, -36,-101, -62, -99, -98,  30, -31,-107, -16, -95, -61, -20, -35; D=-10;
/I:         I=-10; DM=-25;
/M: SY='S';  M=  -4,-103, -91, -25,-112,  17, -96,-109, -89,-109,-101, -84, -98,   3, -40,  17, -13,-101,-111,-103; D=-10;
/I:         I=-10; DM=-25;
/M: SY='Q';  M= -82, -98,  -6,  24, -90, -90, -23, -92, -57, -32, -85,   1, -13,  28, -80,   4,   0, -91, -97,   6; D=-10;
/I:         I=-10; DM=-25;
/M: SY='P';  M=   1, -94, -83, -16, -71,   5, -85, -88, -46, -21, -14, -79,  21,   3, -48,  11, -12, -85, -99, -90; D=-10;
/I:         I=-10; DM=-25;
/M: SY='K';  M= -40, -97, -21,   4, -97,  -3, -57, -44,  35, -93, -10, -61,  16, -70,  -8, -25,  -5, -88, -98, -89; D=-10;
/I:         I=-10; DM=-25;
/M: SY='P';  M= -49, -92, -31, -76, -20, -50,  27, -46, -74,  -4,  -4,  31,  56, -75,  -4, -75, -30, -34, -91, -10; D=-10;
/I:         I=-10; DM=-25;
/M: SY='W';  M= -37,-100, -37, -78, -68, -35,   0, -24,  10, -82, -80,  -1, -12, -16, -75, -80, -83, -30, 134, -56; D=-10;
/I:         I=-10; DM=-25;
/M: SY='Y';  M= -27, -87, -85, -85,  21, -86, -65, -60, -80,   1, -34, -14, -29, -78, -80, -17, -72,   5,  30,  84; D=-10;
/I:         I=-10; DM=-25;
/M: SY='Q';  M= -24, -83, -15,  23, -77, -73,  32, -77,  -9, -76, -67,  38, -74,  68,  33, -58,  -5, -31, -80,  16; D=-10;
/I:         I=-10; DM=-25;
/M: SY='S';  M= -51, -69, -14, -58,  -2, -59, -60, -18, -56, -40, -64,  19,  42, -54,   6,  77,  34, -62, -80, -63;
/M: SY='C';  M= -55,  80,-226,-222,-203, -48,-223,  72,-218,   3,  29,-217,-224, -29, -24,   4,-203,  47,-227,-209;
/M: SY='Y';  M=   5, -75, -62, -64,  20,  -7,  47, -63, -59, -61, -57,  26, -27, -11,  -5,  17, -58, -27, -51,  93;
/M: SY='Q';  M= -58, -72, -66,  -7,  24, -71, -15, -26, -60,  42, -47, -62, -72,  64, -61,  39,  -6,   2,  32, -52;
/M: SY='G';  M=  16, -73, -63, -66,  13,  80, -66, -76, -64, -45, -67, -17, -69,  33, -69,   9, -17, -72, -72, -66;
/M: SY='G';  M=  30, -73, -67, -67, -74,  77, -67, -69, -59, -12,  -7, -56, -70,  -6,  28, -51, -63, -12, -75, -70;
/M: SY='V';  M= -22, -67, -83, -76, -10, -83, -76,   8, -75,  49,  13, -78, -79, -73, -75, -68, -27,  74, -78, -56;
/M: SY='F';  M=  -2,  -1, -15, -72,  90, -76,  12, -24, -72,  12, -49, -68, -78, -74, -72, -63,  25,   5, -56,  10;
/M: SY='Q';  M= -44, -78, -53,  42, -24, -69,  53, -67,   5,   3, -57,  -2,  21,  63, -28,  10, -59, -68, -69,  40;
/M: SY='L';  M= -67, -69, -85, -77, -40, -86, -68, -32, -78,  92, -28, -84, -84, -71, -75, -77, -63, -39, -71, -53;
/M: SY='Q';  M=   5, -75, -37,  41, -77, -36,  44, -72,  21, -71, -63, -23, -65,  52,  42,  -2,  27, -27, -80, -63;
/M: SY='Q';  M=  29, -74, -59,  18, -16, -44,   8, -64,  38, -67, -60, -57,  18,  39,  28,   0, -57,   9, -72,   7;
/M: SY='G';  M= -20, -75, -42, -68, -81,  91, -65, -86,   5, -84, -73,  38, -68, -61, -26, -49, -54, -81, -76, -75;
/M: SY='D';  M=  -6, -77,  99,  34, -84, -64,   9, -82, -53, -79, -76, -41, -65,  10, -60,   1, -11, -76, -93, -68;
/M: SY='R';  M= -59, -75, -57,  17, -72, -71,  17, -25,  35, -59,  19, -20, -67,  24,  63,  14,  29,  -5, -79, -62;
/M: SY='L';  M= -62, -70, -85, -79, -32, -87, -76,  54, -77,  63, -33, -80, -80, -74, -77, -73, -58,  50, -75, -56;
/M: SY='Y';  M= -16,  53, -30, -36,  41, -32,  -6, -61, -62, -60,   7, -58, -73,  -3, -23,  59, -29, -17, -59,  65;
/M: SY='V';  M=   5, -65, -76, -72, -55, -77, -77,   1, -70,  22, -43, -70, -74, -71, -73, -58,  46,  76, -83, -61;
/M: SY='N';  M= -25, -73, -16,  25, -75, -24,  47, -26,  11, -75, -65,  88, -69, -17,  27, -19, -15, -72, -86, -41;
/M: SY='V';  M= -57, -68, -32, -73,  -4, -81, -76,  40, -72,  19,   1, -25, -75, -72, -74, -62,  35,  70, -80, -57;
/M: SY='T';  M= -56, -69,  39, -54, -72, -62,   1, -34, -55, -30, -64,  56,  22, -56, -17,  36,  65, -32, -88, -67;
/M: SY='H';  M=   1, -73,  39,  -9, -68,  16,  53, -67, -55,   9, -38,  29, -13,   4,   6, -13,  23, -66, -81, -14;
/M: SY='P';  M=  -5, -78,  -4,  24,  14, -37, -65,  12, -32, -11, -59,  -7,  78, -59, -67,   0, -14, -48,  24,  -4;
/M: SY='S';  M=  -6, -71,  50, -10, -71, -61,  23, -68, -36,   7, -61,  27, -24,  27,  -3,  52,  -2, -66, -84, -64;
/I:         I=-28; MD=-70;
/M: SY='H';  M=  11, -77, -69, -63, -54, -75,  66, -24, -60,  26,  27, -29, -77,  36,  12, -61,   3, -59, -68,  55; D=-28;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='L';  M= -63, -71, -26, -75, -48, -86, -75,  28, -35,  64,  -7, -79, -81, -72, -75, -73, -59,  53, -78, -58; D=-28;
/I:         I=-28; DM=-70;
/M: SY='D';  M= -31,  35,  77, -23, -76, -64, -14, -39,  -4, -37,  -4,  31,   4, -54,   3,  24,   0, -41, -90, -68;
/I:         I=-24; MD=-60;
/M: SY='F';  M= -30, -76, -22,  -1,  54, -75,  42, -49, -26,  12,  20, -64,   5,  17, -32, -10,   5, -40, -62,  46; D=-24;
/I:         I=-24; MD=-60;
/M: SY='R';  M=  27, -78,  27,  -7, -84,   8,  11, -83, -55, -82, -74,  -8, -74, -10,  42,  30,  -8, -76, -88, -73; D=-24;
/I:         I=-24; MD=-60;
/M: SY='P';  M= -72, -90,   9,  41, -91, -25, -11, -61,   3, -87, -79,  17,  45,   8,   9, -65,   2, -62, -93, -81; D=-24;
/I:         I=-24; MI=0; MD=-60; IM=0; DM=-60;
/M: SY='G';  M= -59, -77,  42,  -1,   3,  58,  32, -78, -64, -19, -69,  19, -71, -61, -70,  19, -15, -76, -82, -66; D=-24;
/I:         I=-24; DM=-60;
/M: SY='Q';  M=   6, -74, -27,  -4,  17, -24,   1, -69,  40, -36, -61,  23, -68,  59,   6,   2,  13, -36, -75, -59; D=-24;
/I:         I=-24; DM=-60;
/M: SY='T';  M= -51, -63, -63, -64, -63, -69, -70,  -9, -61, -39, -55, -53, -64, -63, -68,  29,  93,  41, -86, -64;
/M: SY='F';  M= -67, -73, -71, -74,  92, -73, -53, -54, -68, -49, -53,  23, -81, -70, -68,  16, -60, -25, -42,  85;
/M: SY='F';  M= -37, -73, -17, -77, 109, -37, -69, -15, -76,  -7, -51, -74,  -1, -82, -75, -71, -66, -54,  48, -26;
/M: SY='G';  M= -50, -76, -65, -76, -80, 101, -71, -86, -70, -31, -72, -51, -69, -67, -77, -50, -68, -81, -74, -76;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='A';  M=  55, -67, -28, -32,  -8, -69, -71,  28, -70,  43, -11, -71, -74, -66, -72, -59, -57,  25, -74, -59;
/M: SY='F';  M= -67, -73, -78, -75,  77, -82, -68,  57, -31,  12, -43,  -2, -79,   6, -71, -69, -61,  17, -58,  15;
/M: SY='K';  M=  34, -71, -69, -58, -60, -61, -64, -27,  55,  28,  52, -63, -71,  -5,   4, -59, -58,   7,  30, -59;
/M: SY='L';  M= -32, -68, -84, -77, -46, -84, -74,  21, -76,  66,   4, -80, -81, -73, -76, -72, -58,  58, -76, -56;
/I:         E1=0; IE=-380; DE=-380;

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Post-processing [info]

COMPETES_HIT_WITH

PS50871

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	109 in 109 different sequences
Number of true positive hits	109 in 109 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	THD
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

109 sequences

CD40L_AOTTR (Q9BDM3), CD40L_BOVIN (P51749), CD40L_CALJA (Q9BDN3),

CD40L_CANLF (O97626), CD40L_CERAT (P63305), CD40L_CHICK (Q9I8D8), 
CD40L_FELCA (O97605), CD40L_HUMAN (P29965), CD40L_MACMU (P63304), 
CD40L_MACNE (Q9BDM7), CD40L_MOUSE (P27548), CD40L_PIG   (Q95MQ5), 
CD40L_RAT   (Q9Z2V2), CD70_HUMAN  (P32970), CD70_MOUSE  (O55237), 
CD70_PIG(Q3ZDR4), EDA_BOVIN   (Q9BEG5), EDA_HUMAN   (Q92838), 
EDA_MOUSE   (O54693), EIGER_DROME (Q8MUJ1), TN13B_HUMAN (Q9Y275), 
TN13B_MOUSE (Q9WU72), TNF10_HUMAN (P50591), TNF10_MOUSE (P50592), 
TNF11_HUMAN (O14788), TNF11_MOUSE (O35235), TNF11_RAT   (Q9ESE2), 
TNF12_HUMAN (O43508), TNF12_MOUSE (O54907), TNF13_HUMAN (O75888), 
TNF13_MOUSE (Q9D777), TNF14_HUMAN (O43557), TNF14_MOUSE (Q9QYH9), 
TNF15_HUMAN (O95150), TNF15_MOUSE (Q5UBV8), TNF15_RAT   (Q8K3Y7), 
TNF18_HUMAN (Q9UNG2), TNF18_MOUSE (Q7TS55), TNFA_BOSIN  (P59684), 
TNFA_BOSTR  (Q1G1A2), TNFA_BOVIN  (Q06599), TNFA_BUBBU  (P59693), 
TNFA_BUBCA  (Q2MH05), TNFA_CALJA  (Q19LH4), TNFA_CAMBA  (Q75N23), 
TNFA_CANLF  (P51742), TNFA_CAPHI  (P13296), TNFA_CAVPO  (P51435), 
TNFA_CEREL  (P51743), TNFA_DASNO  (Q1WM27), TNFA_DELLE  (Q8WNR1), 
TNFA_FELCA  (P19101), TNFA_HORSE  (P29553), TNFA_HUMAN  (P01375), 
TNFA_LAMGL  (P59694), TNFA_MACFA  (P79337), TNFA_MACMU  (P48094), 
TNFA_MARMO  (O35734), TNFA_MOUSE  (P06804), TNFA_NOTEU  (O77764), 
TNFA_PANTR  (Q8HZD9), TNFA_PAPAN  (P59695), TNFA_PAPHU  (O77510), 
TNFA_PAPSP  (P33620), TNFA_PERLE  (P36939), TNFA_PIG(P23563), 
TNFA_RABIT  (P04924), TNFA_RAT(P16599), TNFA_SAISC  (Q8MKG8), 
TNFA_SHEEP  (P23383), TNFA_SPAAU  (Q8JFG3), TNFA_TRIVU  (P79374), 
TNFA_TUPTA  (Q539C2), TNFA_TURTR  (Q9BEA1), TNFB_BOVIN  (Q06600), 
TNFB_CANLF  (Q5WR07), TNFB_HUMAN  (P01374), TNFB_MACMU  (Q5TM20), 
TNFB_MARMO  (Q9JM09), TNFB_MOUSE  (P09225), TNFB_NOTEU  (Q9XT48), 
TNFB_PANTR  (P61125), TNFB_PIG(P26445), TNFB_RABIT  (P10154), 
TNFB_RAT(Q06332), TNFC_HUMAN  (Q06643), TNFC_MACMU  (Q5TM22), 
TNFC_MARMO  (Q9JM10), TNFC_MOUSE  (P41155), TNFC_NOTEU  (Q9XT47), 
TNFC_PANTR  (Q862Z7), TNFC_PIG(Q9TSV8), TNFL4_HUMAN (P23510), 
TNFL4_MOUSE (P43488), TNFL4_RABIT (O02765), TNFL4_RAT   (Q9Z2P3), 
TNFL6_CERAT (Q9BDN1), TNFL6_FELCA (Q861W5), TNFL6_HUMAN (P48023), 
TNFL6_MACFA (P63308), TNFL6_MACMU (P63307), TNFL6_MACNE (P63306), 
TNFL6_MOUSE (P41047), TNFL6_PIG   (Q9BEA8), TNFL6_RAT   (P36940), 
TNFL8_HUMAN (P32971), TNFL8_MOUSE (P32972), TNFL9_HUMAN (P41273), 
TNFL9_MOUSE (P41274)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

136 PDB

1A8M; 1ALY; 1D0G; 1D2Q; 1D4V; 1DG6; 1DU3; 1I9R; 1IQA; 1JH5; 1JTZ; 1KD7; 1KXG; 1OQD; 1OQE; 1OSG; 1RJ7; 1RJ8; 1S55; 1TNF; 1TNR; 1U5X; 1U5Y; 1U5Z; 1XU1; 1XU2; 2AZ5; 2E7A; 2HEV; 2HEW; 2HEY; 2O0O; 2Q1M; 2Q8O; 2QDN; 2QE3; 2R30; 2R32; 2RE9; 2RJK; 2RJL; 2TNF; 2TUN; 2X29; 2ZJC; 2ZPX; 3ALQ; 3B93; 3B94; 3B9I; 3FC0; 3IT8; 3K48; 3K51; 3L9J; 3LKJ; 3ME2; 3MI8; 3QBQ; 3QD6; 3URF; 3V56; 3WD5; 4E4D; 4EN0; 4G3Y; 4GIQ; 4HT1; 4J6G; 4KG8; 4KGG; 4KGQ; 4MSV; 4MXV; 4MXW; 4N90; 4RSU; 4TSV; 4TWT; 4V46; 4ZCH; 5BNQ; 5CIR; 5L19; 5L36; 5M2I; 5M2J; 5M2M; 5MU8; 5TSW; 5UUI; 5WUX; 5Y9J; 5YOY; 6A3V; 6BRB; 6BWV; 6CPR; 6CU0; 6D3N; 6FIB; 6FXN; 6MGE; 6MGP; 6MKB; 6MKZ; 6OOY; 6OOZ; 6OP0; 6RMJ; 6W9G; 6X81; 6X82; 6X83; 6X85; 6X86; 6ZT0; 7E57; 7JRA; 7KHD; 7KHX; 7KP7; 7KP8; 7KP9; 7KPA; 7KPB; 7KX0; 7LAW; 7MSG; 7SGM; 7TA3; 7TA6; 7X9G; 8KB6; 8SLR; 8Z8M
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