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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01387


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PURL: https://purl.expasy.org/prosite/rule/PRU01387
General rule information [?]

Accession PRU01387
Dates 15-FEB-2024 (Created)
15-FEB-2024 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS50049; THD_2
Name TNF domain
Function TNF ligands share a common structural motif, the TNF homology domain (THD), which binds to cysteine-rich domains (CRDs) of TNF receptors. The THD is a 150 amino acid long sequence containing a conserved framework of aromatic and hydrophobic residues.
Scope(s) Eukaryota
Metazoa
Example(s) Q3ZDR4;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the tumor necrosis factor family.

Keywords [?]

Cytokine

Gene Ontology [?]

GO:0005164; Molecular function:tumor necrosis factor receptor binding
GO:0005125; Molecular function:cytokine activity
GO:0005615; Cellular component:extracellular space

Cross-references [?]

PROSITE PS00251; THD_1; 1;

Features [?]

From: PS50049
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="THD #"
DISULFID 12 32 disulf C-x*-C
DISULFID 12 136 disulf C-x*-C
DISULFID 62 96 disulf C-x*-C
DISULFID 75 126 disulf C-x*-C
DISULFID 96 111 disulf C-x*-C

Additional information [?]

Size range 131-167 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]