ProRule PRU01387
General rule information
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| Accession | PRU01387 |
| Dates | 15-FEB-2024 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50049; THD_2 |
Name | TNF domain |
| Function | TNF ligands share a common structural motif, the TNF homology domain (THD), which binds to cysteine-rich domains (CRDs) of TNF receptors. The THD is a 150 amino acid long sequence containing a conserved framework of aromatic and hydrophobic residues. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q3ZDR4 (CD70_PIG); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the tumor necrosis factor family. |
Keywords
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Gene Ontology
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| GO:0005164; Molecular function:tumor necrosis factor receptor binding |
| GO:0005125; Molecular function:cytokine activity |
| GO:0005615; Cellular component:extracellular space |
Cross-references
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| PROSITE | PS00251; THD_1; 1; |
Features
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| From: PS50049 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="THD #" | |||||||||
| DISULFID | 12 | 32 | disulf | C-x*-C | ||||||||
| DISULFID | 12 | 136 | disulf | C-x*-C | ||||||||
| DISULFID | 62 | 96 | disulf | C-x*-C | ||||||||
| DISULFID | 75 | 126 | disulf | C-x*-C | ||||||||
| DISULFID | 96 | 111 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 131-167 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [109] All [ 109 ]
- Retrieve set of proteins with 3D structure for this domain