ProRule PRU01387

General rule information [?]

Accession PRU01387
Dates 15-FEB-2024 (Created)
-- (Last updated, Version 1)
Data class Domain;
Predictors PROSITE; PS50049; THD_2
Name TNF domain
Function TNF ligands share a common structural motif, the TNF homology domain (THD), which binds to cysteine-rich domains (CRDs) of TNF receptors. The THD is a 150 amino acid long sequence containing a conserved framework of aromatic and hydrophobic residues.
Scope(s) Eukaryota
Example(s) Q3ZDR4 (CD70_PIG);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the tumor necrosis factor family.

Keywords [?]

Gene Ontology [?]

GO:0005164; Molecular function:tumor necrosis factor receptor binding
GO:0005125; Molecular function:cytokine activity
GO:0005615; Cellular component:extracellular space

Cross-references [?]

PROSITE PS00251; THD_1; 1;

Features [?]

From: PS50049
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="THD #"
DISULFID 12 32 disulf C-x*-C
DISULFID 12 136 disulf C-x*-C
DISULFID 62 96 disulf C-x*-C
DISULFID 75 126 disulf C-x*-C
DISULFID 96 111 disulf C-x*-C

Additional information [?]

Size range 131-167 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]