PROSITE entry PS50940

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General information about the entry

Entry name [info]	CHIT_BIND_II
Accession [info]	PS50940
Entry type [info]	MATRIX
Date [info]	01-NOV-2003 CREATED; 01-JUL-2016 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50940
Associated ProRule [info]	PRU00144

Name and characterization of the entry

Description [info]

Chitin-binding type-2 domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=57;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=57;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.5475686; R2=0.0126845; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=462; N_SCORE=8.4; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=257; N_SCORE=5.8; MODE=1; TEXT='RR';
/DEFAULT: M0=-9; D=-40; I=-40; B1=-150; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A    B    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y    Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='S';  M=  -2,  -1,-100,  -1,  -1, -17, -10,  -9, -15,  -6, -15, -11,  -1,  -6,  -5,  -8,   3,   0, -11, -27, -13,  -4;
/M: SY='N';  M=  -8,   0,-100,  -2,  -3,  -9,  -9,  -9, -15,  -8, -14, -11,   3,  -9,  -8,  -9,  -2,  -3, -15, -24, -10,  -6;
/M:         M=  -5,  -7,-100,  -8,  -4, -13, -19, -12,  -5,  -7,  -7,  -5,  -7, -10,  -6,  -8,  -3,  -1,  -3, -25,  -8,  -6;
/M: SY='C';  M=  -9, -20, 117, -30, -29, -20, -30, -30, -30, -30, -20, -20, -20, -39, -29, -30,  -9,  -9, -10, -50, -30, -29;
/M: SY='P';  M=  -2,  -4,-100,  -4,   2, -22, -12, -11, -17,  -1, -18, -11,  -3,   5,   0,  -4,   2,   0, -15, -27, -16,   0;
/M: SY='N';  M=  -5,   3,-100,   3,   2, -20,  -2,  -6, -19,  -6, -18, -13,   5,  -9,  -3,  -7,   2,  -4, -17, -28, -15,  -1;
/M:         M=  -6,  -4,-100,  -4,  -1, -18,  -7,  -8, -16,  -1, -13,  -7,  -3, -14,  -1,  -1,  -4,  -6, -13, -22, -11,  -2;
/M:         M=  -4,  -1,-100,  -1,  -1, -17,  -6,  -9, -17,  -5, -17, -12,   0,  -8,  -4,  -7,   0,  -4, -14, -25, -13,  -3;
/I:         I=-10,-10,-100,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='G';  M=  -5,  -1,-100,  -3, -10, -18,  18, -10, -22, -10, -19, -13,   4, -17, -10,  -9,  -1,  -9, -18, -21, -15, -10; D=-10;
/I:         I=-10,-10,-100,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10; DM=-27;
/M:         M=  -6,  -8,-100, -11,  -8,  -5, -10,  -8, -11,  -8,  -9,  -6,  -5, -16,  -8,  -8,  -3,  -2,  -9, -17,  -2,  -8;
/I:         I=-9,-9,-90,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9; MD=-23;
/M: SY='Y';  M= -10, -14,-100, -17, -14,  13, -19,  -5,   2, -12,   4,   2, -10, -19, -12,  -9, -10,  -4,   0,  -4,  14, -13; D=-9;
/I:         I=-9,-9,-90,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='F';  M=  -4, -16,-100, -19, -14,   9, -18, -10,   6, -13,   6,   4, -14, -16, -14, -12, -11,  -5,   5,  -7,   6, -14; D=-9;
/I:         I=-9,-9,-90,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9; DM=-23;
/M: SY='P';  M=   2, -10,-100,  -8,  -3, -18,  -8, -14, -14,  -7, -16, -11,  -9,  23,  -6, -11,  -2,  -4, -14, -21, -17,  -7; D=-9;
/I:         I=-9,-9,-90,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9; DM=-23;
/M: SY='D';  M=  -9,  10,-100,  13,   0, -17, -14,  13, -20,  -6, -18, -13,   7, -13,  -3,  -8,   0,  -5, -17, -26,   0,  -3;
/M: SY='P';  M=  -4,  -8,-100,  -5,   1, -21, -13,  -9, -17,  -7, -20, -13,  -7,  23,  -4, -11,  -2,  -6, -19, -27, -17,  -4;
/M: SY='N';  M=  -5,   1,-100,  -1,   1, -15,  -7,  -7, -18,  -3, -15, -11,   2, -13,  -3,  -4,   1,   0, -15, -23,  -9,  -2;
/M: SY='D';  M=  -9,  23,-100,  24,   5, -25,  -5,  -1, -25,  -3, -24, -19,  19, -14,  -1,  -5,   6,  -1, -21, -34, -16,   1;
/M: SY='C';  M=  -8, -19, 105, -28, -28, -20, -28, -28, -27, -28, -19, -18, -19, -36, -27, -28,  -8,  -8,  -9, -48, -28, -28;
/M: SY='S';  M=  -1,   5,-100,   3,   2, -22,  -7,  -2, -21,   0, -22, -13,   9, -13,   6,   1,  10,   4, -17, -29, -14,   3;
/M: SY='K';  M=  -5,  -3,-100,  -4,   0, -20,  -9,  -7, -19,   7, -18,  -9,   0, -12,   2,   5,   0,  -4, -15, -23, -11,   0;
/I:         I=-12,-12,-120,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='Y';  M= -19, -24,-100, -28, -23,  44, -29,   3,  -1, -17,   2,  -1, -21, -30, -21, -14, -30, -11,  -7,  27,  57, -23;
/M: SY='Y';  M= -14, -21,-100, -24, -21,  18, -27,   3,   5, -18,   6,   4, -18, -27, -15, -15, -17, -29,   0,   3,  33, -20;
/M: SY='Y';  M=  -9, -13,-100, -16,  -7,  -5, -23,  -6,  -1,  -5,  -2,   1, -11, -20,  -2,  -2,  -8,  -4,  -1, -15,   4,  -6;
/M: SY='C';  M= -10, -20, 120, -30, -30, -20, -30, -30, -30, -30, -20, -20, -20, -40, -30, -30, -10, -10, -10, -50, -30, -30;
/M:         M=  -3,  -8,-100,  -9,  -6, -12, -17, -11,  -4,  -8,  -6,  -4,  -7, -17,  -5,  -8,  -2,  -1,  -1, -23,  -8,  -6;
/M: SY='N';  M=  -6,  10,-100,   9,   2, -20,  -3,  -2, -23,  -2, -22, -16,  11, -13,  -2,  -5,   3,  -5, -21, -25, -12,  -1;
/M: SY='G';  M=  -3,  -1,-100,  -2,  -8, -25,  28, -12, -28, -10, -23, -16,   5, -15,  -9, -12,   1, -11, -23, -25, -22,  -9;
/I:         I=-10,-10,-100,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10; MD=-25;
/M:         M=  -7,  -3,-100,  -4,  -1, -18,  -8,  -6, -15,  -2, -15,  -8,  -1, -16,  -1,  -1,  -3,  -6, -12, -24, -11,  -2; D=-10;
/I:         I=-10,-10,-100,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='P';  M=   1, -15,-100, -16,  -9, -11, -14, -17,  -7, -11,  -7,  -6, -13,   2, -10, -13,  -5,  -4,  -7, -16, -11, -11;
/M: SY='Y';  M=  -7, -15,-100, -17, -10,  -5, -22,  -8,   0,  -8,  -2,   0, -12, -20,  -7,  -6,  -8,  -3,   1, -15,   2, -10;
/M:         M=  -5, -12,-100, -13,  -4, -10, -21, -10,  -3,  -8,  -2,  -1, -11, -12,  -6,  -7,  -8,  -5,  -3, -20,  -6,  -6;
/M:         M=  -8, -11,-100, -14,  -8,  -4, -10,  -6,  -9,  -7,  -5,   0,  -7, -19,  -4,  -4,  -8,  -7,  -9, -16,  -2,  -7;
/M: SY='S';  M=  -6,   1,-100,  -1,   1, -17, -15,  -6, -16,  -1, -16, -10,   4, -13,   3,  -1,   5,   5, -13, -26,  -9,   1;
/M: SY='C';  M= -10, -20, 117, -30, -29, -20, -29, -30, -30, -30, -20, -20, -20, -39, -29, -30, -10, -10, -10, -50, -30, -29;
/M: SY='P';  M=  -3, -11,-100,  -6,  -1, -25,  -9, -15, -20,  -8, -23, -16, -10,  37,  -6, -14,  -2,  -6, -22, -28, -22,  -6;
/M: SY='E';  M=  -2,   2,-100,   2,   4, -21,  -8, -10, -19,  -2, -19, -14,   3,  -4,  -2,  -6,   2,  -2, -16, -27, -16,   1;
/M: SY='G';  M=  -4,   2,-100,   1,  -9, -25,  37, -12, -32, -12, -27, -19,   8, -17, -11, -13,   2, -12, -27, -24, -22, -10;
/M: SY='L';  M=  -8, -10,-100, -12,  -5,  -3, -22,  -6,  -4, -10,   6,   2, -10, -19,  -4,  -7,  -7,   3,  -6, -20,   1,  -5;
/M: SY='Y';  M=  -5, -17,-100, -20, -16,   6, -22,  -1,   2, -15,   2,   2, -14, -23, -12, -13, -11,  -6,   3, -10,  14, -15;
/M: SY='F';  M= -19, -28,-100, -35, -27,  60, -29, -13,  -2, -24,   5,  -2, -22, -30, -31, -18, -22, -12,  -5,  27,  39, -26;
/M: SY='D';  M= -11,  33,-100,  34,   8, -27,  -6,   4, -27,  -2, -28, -22,  30, -14,   0,  -6,   8,  -2, -25, -37, -18,   4;
/I:         I=-11,-11,-110,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='E';  M=  -2,  -6,-100,  -5,   4, -20, -16, -11, -14,  -2, -16, -10,  -6,   4,   0,  -5,  -1,  -3, -12, -25, -14,   1;
/I:         I=-12,-12,-120,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12; MD=-32;
/M: SY='E';  M=  -2,   1,-100,  -1,   4, -19, -15,  -7, -13,   0, -14, -10,   1, -12,   1,  -2,   3,   1, -10, -26, -12,   2; D=-12;
/I:         I=-11,-11,-110,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='T';  M=  -4,  -8,   0, -11,  -6, -11, -19, -10,  -6,  -7,  -3,  -3,  -5, -17,  -3,  -4,   1,   7,  -4, -25,  -7,  -5;
/M: SY='Q';  M=  -6,  -2,-100,  10,   1, -23,   3,  -5, -23,   1, -18, -10,  10, -15,   5,   2,  -2,  -9, -21, -24, -15,   3;
/M:         M=  -4,  -8,   0, -12,  -6, -12, -16,  -9,  -7,  -3,  -9,  -2,  -5, -16,  -2,  -2,  -1,   0,  -5, -22,  -6,  -5;
/M: SY='C';  M= -10, -20, 119, -30, -30, -20, -29, -30, -30, -30, -20, -20, -20, -40, -30, -30, -10, -10, -10, -50, -30, -30;
/M: SY='D';  M=  -8,   4,-100,  20,  -2, -18, -15, -11,  -9,  -7,  -9,  -7,  10, -17,  -7,  -9,  -3,  -2,  -3, -29, -13,  -5;
/M: SY='W';  M=  -8, -13,-100, -13,  -9,  -4, -19,  -8, -11, -11, -10,  -8, -13,  -5,  -9, -11, -10,  -7, -12,  20,   5, -10;
/M: SY='P';  M=  -3,  -4,-100,  -2,  -1, -20, -12, -10, -19,  -3, -20, -13,  -4,   9,  -3,  -6,  -1,  -3, -17, -22, -14,  -3;
/M: SY='E';  M=  -4,   2,-100,   3,   4, -18, -12,  -5, -17,  -3, -16, -11,   1, -12,   0,  -5,   2,  -2, -13, -23, -11,   1;
/M: SY='N';  M=  -6,   5,-100,   3,   4, -18, -11,  -4, -17,  -2, -16, -11,   6,  -8,   2,  -5,   1,  -2, -17, -27, -11,   2;
/I:         I=-10,-10,-100,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10; MD=-25;
/M: SY='V';  M=   4, -11,-100, -13, -12,  -9, -13, -15,   1, -12,  -5,  -3, -10, -13, -13, -13,   0,   1,   8, -23, -10, -13; D=-10;
/I:         I=-10,-10,-100,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='D';  M=  -4,   3,-100,   4,   4, -21,  -8,  -5, -16,   0, -16, -10,   3, -10,   2,  -2,   1,  -4, -13, -25, -13,   3; D=-10;
/I:         I=-10,-10,-100,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10; DM=-25;
/M: SY='C';  M=  -8, -18, 106, -28, -27, -19, -28, -28, -28, -27, -19, -19, -18, -37, -27, -27,  -8,  -8, -10, -47, -28, -28;
/M: SY='S';  M=  -4,  -3,-100,  -3,  -2, -16, -11,  -9, -15,  -5, -14, -10,  -2,  -9,  -3,  -5,   2,   1, -12, -25, -10,  -4; D=-5;
/M:         M=  -5,   0,-100,   0,  -1, -18,  -8,  -9, -17,  -5, -15, -11,   0,  -9,  -4,  -7,   0,  -4, -14, -24, -13,  -3; D=-5;
/I:         E1=0; IE=-105; DE=-105;

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Post-processing [info]

COMPETES_HIT_WITH

PS51807

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.

Total number of hits	82 in 38 different sequences
Number of true positive hits	82 in 38 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	2
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	97.62 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	12
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	N_Hulo
Feature key [info]	DOMAIN
Feature description [info]	Chitin-binding type-2
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

38 sequences

AC150_NPVAC (P41707), AC83_NPVAC  (Q06670), ALL12_BLOTA (Q17282),

AVR4_PASFU  (Q00363), CBD1_CAEEL  (O45599), CDA1_BOMMO  (H9J9M0), 
CHI10_DROME (Q9W5U2), CHIA_BOVIN  (Q95M17), CHIA_HUMAN  (Q9BZP6), 
CHIA_MOUSE  (Q91XA9), CHIA_RAT(Q6RY07), CHIT1_HUMAN (Q13231), 
CHIT1_MOUSE (Q9D7Q1), CHIT_BRUMA  (P29030), CHIT_CAEEL  (Q11174), 
CHIT_MANSE  (P36362), CHL18_DERPT (Q4JK71), CPG1_CAEBR  (A8WVU7), 
CPG1_CAEEL  (Q17802), CPG2_CAEBR  (A8XWX5), CPG2_CAEEL  (P41996), 
DEP23_DERPT (L7N6F8), OBSTE_DROME (Q9VMM6), PE1_ANOGA   (O76217), 
PE44_LUCCU  (Q25255), PE48A_LUCCU (P91745), PE48_CHRBE  (O17450), 
PE55_LUCCU  (Q95UE8), PIF_PINFU   (C7G0B5), PIF_PINMG   (H2A0N4), 
TX11A_CORWE (P0DPW5), TX11A_ETHRU (P0DPW4), TX11A_THELO (P0DPW3), 
VP91_NPVBM  (O92446), VP91_NPVCF  (Q7TLR9), VP91_NPVEP  (Q91GH8), 
VP91_NPVOP  (O10336), Y091_NPVOP  (O10341)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

2 sequences

CHL18_DERFA (Q86R84), YMV2_CAEEL  (P34504)

PDB
[Detailed view]

7 PDB

1WAW; 1WB0; 2MFK; 4ZCE; 5HBF; 6BN0; 6SO0