We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS50940

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PURL: https://purl.expasy.org/prosite/signature/PS50940

Direct ScanProsite submission

General information about the entry

Entry name [info]	CHIT_BIND_II
Accession [info]	PS50940
Entry type [info]	MATRIX
Date [info]	01-NOV-2003 CREATED; 01-JUL-2016 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50940
Associated ProRule [info]	PRU00144

Name and characterization of the entry

Description [info]

Chitin-binding type-2 domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=57;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=57;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.5475686; R2=0.0126845; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=462; N_SCORE=8.4; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=257; N_SCORE=5.8; MODE=1; TEXT='RR';
/DEFAULT: M0=-9; D=-40; I=-40; B1=-150; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A    B    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y    Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='S';  M=  -2,  -1,-100,  -1,  -1, -17, -10,  -9, -15,  -6, -15, -11,  -1,  -6,  -5,  -8,   3,   0, -11, -27, -13,  -4;
/M: SY='N';  M=  -8,   0,-100,  -2,  -3,  -9,  -9,  -9, -15,  -8, -14, -11,   3,  -9,  -8,  -9,  -2,  -3, -15, -24, -10,  -6;
/M:         M=  -5,  -7,-100,  -8,  -4, -13, -19, -12,  -5,  -7,  -7,  -5,  -7, -10,  -6,  -8,  -3,  -1,  -3, -25,  -8,  -6;
/M: SY='C';  M=  -9, -20, 117, -30, -29, -20, -30, -30, -30, -30, -20, -20, -20, -39, -29, -30,  -9,  -9, -10, -50, -30, -29;
/M: SY='P';  M=  -2,  -4,-100,  -4,   2, -22, -12, -11, -17,  -1, -18, -11,  -3,   5,   0,  -4,   2,   0, -15, -27, -16,   0;
/M: SY='N';  M=  -5,   3,-100,   3,   2, -20,  -2,  -6, -19,  -6, -18, -13,   5,  -9,  -3,  -7,   2,  -4, -17, -28, -15,  -1;
/M:         M=  -6,  -4,-100,  -4,  -1, -18,  -7,  -8, -16,  -1, -13,  -7,  -3, -14,  -1,  -1,  -4,  -6, -13, -22, -11,  -2;
/M:         M=  -4,  -1,-100,  -1,  -1, -17,  -6,  -9, -17,  -5, -17, -12,   0,  -8,  -4,  -7,   0,  -4, -14, -25, -13,  -3;
/I:         I=-10,-10,-100,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='G';  M=  -5,  -1,-100,  -3, -10, -18,  18, -10, -22, -10, -19, -13,   4, -17, -10,  -9,  -1,  -9, -18, -21, -15, -10; D=-10;
/I:         I=-10,-10,-100,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10; DM=-27;
/M:         M=  -6,  -8,-100, -11,  -8,  -5, -10,  -8, -11,  -8,  -9,  -6,  -5, -16,  -8,  -8,  -3,  -2,  -9, -17,  -2,  -8;
/I:         I=-9,-9,-90,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9; MD=-23;
/M: SY='Y';  M= -10, -14,-100, -17, -14,  13, -19,  -5,   2, -12,   4,   2, -10, -19, -12,  -9, -10,  -4,   0,  -4,  14, -13; D=-9;
/I:         I=-9,-9,-90,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='F';  M=  -4, -16,-100, -19, -14,   9, -18, -10,   6, -13,   6,   4, -14, -16, -14, -12, -11,  -5,   5,  -7,   6, -14; D=-9;
/I:         I=-9,-9,-90,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9; DM=-23;
/M: SY='P';  M=   2, -10,-100,  -8,  -3, -18,  -8, -14, -14,  -7, -16, -11,  -9,  23,  -6, -11,  -2,  -4, -14, -21, -17,  -7; D=-9;
/I:         I=-9,-9,-90,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9,-9; DM=-23;
/M: SY='D';  M=  -9,  10,-100,  13,   0, -17, -14,  13, -20,  -6, -18, -13,   7, -13,  -3,  -8,   0,  -5, -17, -26,   0,  -3;
/M: SY='P';  M=  -4,  -8,-100,  -5,   1, -21, -13,  -9, -17,  -7, -20, -13,  -7,  23,  -4, -11,  -2,  -6, -19, -27, -17,  -4;
/M: SY='N';  M=  -5,   1,-100,  -1,   1, -15,  -7,  -7, -18,  -3, -15, -11,   2, -13,  -3,  -4,   1,   0, -15, -23,  -9,  -2;
/M: SY='D';  M=  -9,  23,-100,  24,   5, -25,  -5,  -1, -25,  -3, -24, -19,  19, -14,  -1,  -5,   6,  -1, -21, -34, -16,   1;
/M: SY='C';  M=  -8, -19, 105, -28, -28, -20, -28, -28, -27, -28, -19, -18, -19, -36, -27, -28,  -8,  -8,  -9, -48, -28, -28;
/M: SY='S';  M=  -1,   5,-100,   3,   2, -22,  -7,  -2, -21,   0, -22, -13,   9, -13,   6,   1,  10,   4, -17, -29, -14,   3;
/M: SY='K';  M=  -5,  -3,-100,  -4,   0, -20,  -9,  -7, -19,   7, -18,  -9,   0, -12,   2,   5,   0,  -4, -15, -23, -11,   0;
/I:         I=-12,-12,-120,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='Y';  M= -19, -24,-100, -28, -23,  44, -29,   3,  -1, -17,   2,  -1, -21, -30, -21, -14, -30, -11,  -7,  27,  57, -23;
/M: SY='Y';  M= -14, -21,-100, -24, -21,  18, -27,   3,   5, -18,   6,   4, -18, -27, -15, -15, -17, -29,   0,   3,  33, -20;
/M: SY='Y';  M=  -9, -13,-100, -16,  -7,  -5, -23,  -6,  -1,  -5,  -2,   1, -11, -20,  -2,  -2,  -8,  -4,  -1, -15,   4,  -6;
/M: SY='C';  M= -10, -20, 120, -30, -30, -20, -30, -30, -30, -30, -20, -20, -20, -40, -30, -30, -10, -10, -10, -50, -30, -30;
/M:         M=  -3,  -8,-100,  -9,  -6, -12, -17, -11,  -4,  -8,  -6,  -4,  -7, -17,  -5,  -8,  -2,  -1,  -1, -23,  -8,  -6;
/M: SY='N';  M=  -6,  10,-100,   9,   2, -20,  -3,  -2, -23,  -2, -22, -16,  11, -13,  -2,  -5,   3,  -5, -21, -25, -12,  -1;
/M: SY='G';  M=  -3,  -1,-100,  -2,  -8, -25,  28, -12, -28, -10, -23, -16,   5, -15,  -9, -12,   1, -11, -23, -25, -22,  -9;
/I:         I=-10,-10,-100,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10; MD=-25;
/M:         M=  -7,  -3,-100,  -4,  -1, -18,  -8,  -6, -15,  -2, -15,  -8,  -1, -16,  -1,  -1,  -3,  -6, -12, -24, -11,  -2; D=-10;
/I:         I=-10,-10,-100,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='P';  M=   1, -15,-100, -16,  -9, -11, -14, -17,  -7, -11,  -7,  -6, -13,   2, -10, -13,  -5,  -4,  -7, -16, -11, -11;
/M: SY='Y';  M=  -7, -15,-100, -17, -10,  -5, -22,  -8,   0,  -8,  -2,   0, -12, -20,  -7,  -6,  -8,  -3,   1, -15,   2, -10;
/M:         M=  -5, -12,-100, -13,  -4, -10, -21, -10,  -3,  -8,  -2,  -1, -11, -12,  -6,  -7,  -8,  -5,  -3, -20,  -6,  -6;
/M:         M=  -8, -11,-100, -14,  -8,  -4, -10,  -6,  -9,  -7,  -5,   0,  -7, -19,  -4,  -4,  -8,  -7,  -9, -16,  -2,  -7;
/M: SY='S';  M=  -6,   1,-100,  -1,   1, -17, -15,  -6, -16,  -1, -16, -10,   4, -13,   3,  -1,   5,   5, -13, -26,  -9,   1;
/M: SY='C';  M= -10, -20, 117, -30, -29, -20, -29, -30, -30, -30, -20, -20, -20, -39, -29, -30, -10, -10, -10, -50, -30, -29;
/M: SY='P';  M=  -3, -11,-100,  -6,  -1, -25,  -9, -15, -20,  -8, -23, -16, -10,  37,  -6, -14,  -2,  -6, -22, -28, -22,  -6;
/M: SY='E';  M=  -2,   2,-100,   2,   4, -21,  -8, -10, -19,  -2, -19, -14,   3,  -4,  -2,  -6,   2,  -2, -16, -27, -16,   1;
/M: SY='G';  M=  -4,   2,-100,   1,  -9, -25,  37, -12, -32, -12, -27, -19,   8, -17, -11, -13,   2, -12, -27, -24, -22, -10;
/M: SY='L';  M=  -8, -10,-100, -12,  -5,  -3, -22,  -6,  -4, -10,   6,   2, -10, -19,  -4,  -7,  -7,   3,  -6, -20,   1,  -5;
/M: SY='Y';  M=  -5, -17,-100, -20, -16,   6, -22,  -1,   2, -15,   2,   2, -14, -23, -12, -13, -11,  -6,   3, -10,  14, -15;
/M: SY='F';  M= -19, -28,-100, -35, -27,  60, -29, -13,  -2, -24,   5,  -2, -22, -30, -31, -18, -22, -12,  -5,  27,  39, -26;
/M: SY='D';  M= -11,  33,-100,  34,   8, -27,  -6,   4, -27,  -2, -28, -22,  30, -14,   0,  -6,   8,  -2, -25, -37, -18,   4;
/I:         I=-11,-11,-110,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='E';  M=  -2,  -6,-100,  -5,   4, -20, -16, -11, -14,  -2, -16, -10,  -6,   4,   0,  -5,  -1,  -3, -12, -25, -14,   1;
/I:         I=-12,-12,-120,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12,-12; MD=-32;
/M: SY='E';  M=  -2,   1,-100,  -1,   4, -19, -15,  -7, -13,   0, -14, -10,   1, -12,   1,  -2,   3,   1, -10, -26, -12,   2; D=-12;
/I:         I=-11,-11,-110,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='T';  M=  -4,  -8,   0, -11,  -6, -11, -19, -10,  -6,  -7,  -3,  -3,  -5, -17,  -3,  -4,   1,   7,  -4, -25,  -7,  -5;
/M: SY='Q';  M=  -6,  -2,-100,  10,   1, -23,   3,  -5, -23,   1, -18, -10,  10, -15,   5,   2,  -2,  -9, -21, -24, -15,   3;
/M:         M=  -4,  -8,   0, -12,  -6, -12, -16,  -9,  -7,  -3,  -9,  -2,  -5, -16,  -2,  -2,  -1,   0,  -5, -22,  -6,  -5;
/M: SY='C';  M= -10, -20, 119, -30, -30, -20, -29, -30, -30, -30, -20, -20, -20, -40, -30, -30, -10, -10, -10, -50, -30, -30;
/M: SY='D';  M=  -8,   4,-100,  20,  -2, -18, -15, -11,  -9,  -7,  -9,  -7,  10, -17,  -7,  -9,  -3,  -2,  -3, -29, -13,  -5;
/M: SY='W';  M=  -8, -13,-100, -13,  -9,  -4, -19,  -8, -11, -11, -10,  -8, -13,  -5,  -9, -11, -10,  -7, -12,  20,   5, -10;
/M: SY='P';  M=  -3,  -4,-100,  -2,  -1, -20, -12, -10, -19,  -3, -20, -13,  -4,   9,  -3,  -6,  -1,  -3, -17, -22, -14,  -3;
/M: SY='E';  M=  -4,   2,-100,   3,   4, -18, -12,  -5, -17,  -3, -16, -11,   1, -12,   0,  -5,   2,  -2, -13, -23, -11,   1;
/M: SY='N';  M=  -6,   5,-100,   3,   4, -18, -11,  -4, -17,  -2, -16, -11,   6,  -8,   2,  -5,   1,  -2, -17, -27, -11,   2;
/I:         I=-10,-10,-100,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10; MD=-25;
/M: SY='V';  M=   4, -11,-100, -13, -12,  -9, -13, -15,   1, -12,  -5,  -3, -10, -13, -13, -13,   0,   1,   8, -23, -10, -13; D=-10;
/I:         I=-10,-10,-100,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='D';  M=  -4,   3,-100,   4,   4, -21,  -8,  -5, -16,   0, -16, -10,   3, -10,   2,  -2,   1,  -4, -13, -25, -13,   3; D=-10;
/I:         I=-10,-10,-100,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10,-10; DM=-25;
/M: SY='C';  M=  -8, -18, 106, -28, -27, -19, -28, -28, -28, -27, -19, -19, -18, -37, -27, -27,  -8,  -8, -10, -47, -28, -28;
/M: SY='S';  M=  -4,  -3,-100,  -3,  -2, -16, -11,  -9, -15,  -5, -14, -10,  -2,  -9,  -3,  -5,   2,   1, -12, -25, -10,  -4; D=-5;
/M:         M=  -5,   0,-100,   0,  -1, -18,  -8,  -9, -17,  -5, -15, -11,   0,  -9,  -4,  -7,   0,  -4, -14, -24, -13,  -3; D=-5;
/I:         E1=0; IE=-105; DE=-105;

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Post-processing [info]

COMPETES_HIT_WITH

PS51807

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	82 in 38 different sequences
Number of true positive hits	82 in 38 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	2
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	97.62 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	12
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	N_Hulo
Feature key [info]	DOMAIN
Feature description [info]	Chitin-binding type-2
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

38 sequences

AC150_NPVAC (P41707), AC83_NPVAC  (Q06670), ALL12_BLOTA (Q17282),

AVR4_PASFU  (Q00363), CBD1_CAEEL  (O45599), CDA1_BOMMO  (H9J9M0), 
CHI10_DROME (Q9W5U2), CHIA_BOVIN  (Q95M17), CHIA_HUMAN  (Q9BZP6), 
CHIA_MOUSE  (Q91XA9), CHIA_RAT(Q6RY07), CHIT1_HUMAN (Q13231), 
CHIT1_MOUSE (Q9D7Q1), CHIT_BRUMA  (P29030), CHIT_CAEEL  (Q11174), 
CHIT_MANSE  (P36362), CHL18_DERPT (Q4JK71), CPG1_CAEBR  (A8WVU7), 
CPG1_CAEEL  (Q17802), CPG2_CAEBR  (A8XWX5), CPG2_CAEEL  (P41996), 
DEP23_DERPT (L7N6F8), OBSTE_DROME (Q9VMM6), PE1_ANOGA   (O76217), 
PE44_LUCCU  (Q25255), PE48A_LUCCU (P91745), PE48_CHRBE  (O17450), 
PE55_LUCCU  (Q95UE8), PIF_PINFU   (C7G0B5), PIF_PINMG   (H2A0N4), 
TX11A_CORWE (P0DPW5), TX11A_ETHRU (P0DPW4), TX11A_THELO (P0DPW3), 
VP91_NPVBM  (O92446), VP91_NPVCF  (Q7TLR9), VP91_NPVEP  (Q91GH8), 
VP91_NPVOP  (O10336), Y091_NPVOP  (O10341)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

2 sequences

CHL18_DERFA (Q86R84), CHTB1_CAEEL (P34504)

PDB
[Detailed view]

7 PDB

pdb_00001waw; pdb_00001wb0; pdb_00002mfk; pdb_00004zce; pdb_00005hbf; pdb_00006bn0; pdb_00006so0