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PROSITE entry PS50977


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PURL: https://purl.expasy.org/prosite/signature/PS50977

Direct ScanProsite submission
General information about the entry

Entry name [info] HTH_TETR_2
Accession [info] PS50977
Entry type [info] MATRIX
Date [info] 01-APR-2004 CREATED;
26-FEB-2020 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00830
Associated ProRule [info] PRU00335

Name and characterization of the entry

Description [info] TetR-type HTH domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=61;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=56;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.6312854; R2=0.0271566; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2490.1689453; R2=3.6023810; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=382; H_SCORE=3866; N_SCORE=13.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=143; H_SCORE=3005; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 386 in 384 different sequences
Number of true positive hits 385 in 383 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 2
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.74 %
Recall (true positives / (true positives + false negatives)) 99.48 %

Comments [info]

Taxonomic range [info] Prokaryotes (Bacteria)
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] PS_Langendijk_Genevaux
Feature key [info] DOMAIN
Feature description [info] HTH tetR-type
Version [info] 6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
383 sequences

ABRTH_SACEN (A4FLS1), ABRT_STRLN  (P0DXG2), ACNR_CORDI  (Q6NH62), 
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UniProtKB/Swiss-Prot
False negative sequences
2 sequences

Y196_MYCTO  (P9WME0), Y196_MYCTU  (P9WME1)

		
UniProtKB/Swiss-Prot
False positive sequences
1 sequence

PTXS_PSEDL  (A0A167V873)

		
PDB
[Detailed view]
266 PDB

1A6I; 1BJZ; 1JT0; 1JT6; 1JTX; 1JTY; 1JUM; 1JUP; 1JUS; 1ORK; 1QPI; 1QVT;
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