We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00335
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00335
General rule information
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| Accession | PRU00335 |
| Dates | 07-APR-2004 (Created)
21-NOV-2019 (Last updated, Version 12) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50977; HTH_TETR_2 |
Name | TetR-type HTH domain |
| Function | The tetR-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 60 residues present in the tetR family of prokaryotic transcription regulators. |
| Scope(s) |
Bacteria Archaea |
| Example(s) | P0ACT4; |
Propagated annotation
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Keywords
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Gene Ontology
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| GO:0003677; Molecular function:DNA binding |
Cross-references
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| PROSITE | PS01081; HTH_TETR_1; 1; |
Features
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| From: PS50977 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="HTH tetR-type #" | |||||||||
| DNA_BIND | 24 | 43 | /note="H-T-H motif" | |||||||||
Additional information
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| Size range | 54-67 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-2 |
| Topology | Cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [385] All [ 385 ]
- Retrieve set of proteins with 3D structure for this domain