PROSITE entry PS51055
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General information about the entry
| Entry name [info] | ITAM_1 |
| Accession [info] | PS51055 |
| Entry type [info] | MATRIX |
| Date [info] |
01-JAN-2005 CREATED;
01-OCT-2013 DATA UPDATE; 03-MAY-2023 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51055 |
| Associated ProRule [info] | PRU00379 |
Name and characterization of the entry
| Description [info] | ITAM motif mammalian type profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=29; /DISJOINT: DEFINITION=PROTECT; N1=3; N2=27; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.9674824; R2=0.0197046; TEXT='NScore'; /CUT_OFF: LEVEL=0; SCORE=337; N_SCORE=8.6; MODE=1; TEXT='R'; /CUT_OFF: LEVEL=-1; SCORE=195; N_SCORE=5.8000; MODE=1; TEXT='R?'; /DEFAULT: M0=-7; D=-20; I=-20; B1=*; E1=*; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='D'; M= -4, 18,-25, 24, 15,-30,-12, -5,-26, 2,-23,-19, 8, -5, 6, -5, 4, -3,-21,-32,-18, 10; /M: SY='R'; M= -6, -8,-26, -8, 0,-22,-17, -9,-15, 8,-17, -7, -5, -4, 6, 14, -2, -4,-12,-24,-13, 1; /M: SY='R'; M= -1, -8,-27, -8, 3,-27,-15, -8,-21, 11,-21,-10, -6, 5, 11, 12, -3, -7,-18,-23,-16, 5; /M: SY='R'; M= -3, 0,-24, 0, 2,-21,-14, -7,-19, 4,-21,-14, 1, 1, 0, 5, 2, -1,-16,-26,-12, -1; /M: SY='R'; M=-11, -9,-29, -7, 0,-18,-11, -9,-16, -1, -9, -7, -8, 0, 0, 2,-10,-10,-18,-22,-11, -2; /M: SY='M'; M=-10, -7,-24, -9, -2,-11,-22, 0, -2, -6, -2, 2, -4,-15, -1, -7,-10, -8, -5,-23, -3, -3; /M: SY='P'; M= -7, -6,-32, -1, 8,-28, -5,-12,-25, 1,-25,-17, -5, 26, -1, -6, -5,-11,-26,-27,-23, 2; /M: SY='N'; M= -9, 16,-25, 12, 11,-27,-10, 14,-23, 0,-26,-14, 22, -6, 14, -2, 6, -5,-27,-33,-14, 11; /M: SY='D'; M=-14, 25,-30, 35, 26,-33,-14, -2,-31, 1,-26,-24, 12, 7, 4, -7, 0, -7,-29,-35,-21, 15; /M: SY='Q'; M= -7, 7,-27, 9, 2,-31, 8, 5,-28, -5,-24,-13, 7,-12, 10, -7, 1,-11,-26,-27,-16, 5; /I: I=-6; MD=-32; /M: SY='L'; M= -5,-23,-14,-24,-19, 3,-25,-20, 19,-21, 25, 12,-22,-23,-19,-17,-15, 0, 19,-21, -3,-19; D=-6; /I: I=-6; MI=-32; IM=-32; DM=-32; /M: SY='Y'; M=-20,-20,-30,-20,-20, 30,-30, 20, 0,-10, 0, 0,-20,-30,-10,-10,-20,-10,-10, 30, 80,-20; /M: SY='E'; M= -9, 13,-25, 10, 23,-28,-15, 3,-22, 5,-21,-13, 15, -9, 23, 2, 5, 1,-26,-29,-16, 23; /M: SY='P'; M= 0,-10,-31, -6, 3,-29, 14,-16,-28,-10,-26,-19, -8, 24, -8,-16, -3,-12,-27,-25,-27, -4; /M: SY='L'; M=-10,-30,-21,-31,-21, 9,-31,-21, 24,-30, 46, 20,-29,-29,-20,-21,-29,-10, 13,-20, 0,-21; /M: SY='R'; M=-10, 7,-25, 4, 6,-25, -8, 1,-26, 12,-25,-14, 16,-15, 13, 21, 4, -5,-24,-28,-15, 8; /M: SY='K'; M= -9, -1,-24, -1, 0,-18,-22,-10,-11, 6, -8, -5, -5,-15, -2, 2, -5, 1, -6,-26, -9, -2; /M: SY='R'; M=-10, 7,-29, 12, 3,-28, 7, -7,-34, 7,-25,-18, 5,-16, -1, 17, -3,-12,-24,-26,-19, -1; /M: SY='Q'; M=-10, 12,-26, 11, 15,-28,-15, 0,-25, 13,-24,-13, 13,-11, 17, 12, 3, -2,-24,-29,-15, 16; /M: SY='R'; M=-13, -1,-17, -1, 2,-21,-21, -4,-16, 6,-13, -1, -3,-16, 9, 12, -6, -4,-14,-25, -9, 4; /M: SY='E'; M= 7, 13,-22, 18, 20,-28, -7, -8,-26, -2,-21,-20, 3, -7, 3,-10, 7, -4,-19,-30,-20, 11; /M: SY='T'; M= -4, -5,-19, -6, 8,-17,-21,-10, -8, -4, -6, -2, -7,-12, 6, -7, 2, 10, -5,-27,-11, 7; /M: SY='Y'; M=-10,-19,-27,-20,-19, 23,-26, 14, -1,-10, -1, -1,-19,-27,-10,-11,-16, -9, -9, 23, 66,-19; /M: SY='E'; M= 0, 7,-22, 12, 17,-19,-12, -2,-22, -3,-21,-18, 2,-10, 3, -8, 10, 0,-18,-25, -6, 9; /M: SY='S'; M= -3, 1,-15, 2, -6,-22, -2, -2,-21, -8,-19,-13, 1,-17, -6, -6, 5, 1,-11,-31,-14, -7; /M: SY='L'; M=-10,-24,-24,-25,-11, 2,-31,-19, 20,-24, 33, 14,-23,-23,-14,-19,-23,-10, 9,-21, -3,-14; /M: SY='N'; M= -7, 3,-24, 1, 2,-21,-11, 0,-13, -1,-17, -9, 6,-14, 0, -5, 0, -3,-12,-29,-11, 0; /M: SY='G'; M= -7, -4,-26, -6, -4,-23, 3, 3,-24, 1,-21, -7, 1, -9, 0, 2, -2, -7,-19,-25,-13, -3; /M: SY='R'; M=-10, -2,-25, -5, 5,-16,-12, -4,-18, 7,-13, -4, 2,-16, 6, 14, -4, -6,-17,-23,-11, 4; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 53 in 43 different sequences |
| Number of true positive hits | 53 in 43 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 28 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 65.43 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | window20 |
| Author [info] | V_Lesaux |
| Taxonomic range [info] | Eukaryotes, Eukaryotic viruses |
| Maximum number of repetitions [info] | 3 |
| Feature key [info] | DOMAIN |
| Feature description [info] | ITAM |
| Version [info] | 3 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
43 sequences
CD3D_BOVIN (Q28072 ), CD3D_HUMAN (P04234 ), CD3D_MACFA (Q95LI8 ), CD3D_MOUSE (P04235 ), CD3D_PIG (Q764N2 ), CD3D_RAT (P19377 ), CD3D_SHEEP (P18438 ), CD3E_BOVIN (Q28073 ), CD3E_CANLF (P27597 ), CD3E_CHICK (Q98910 ), CD3E_FELCA (Q5R1Q1 ), CD3E_HUMAN (P07766 ), CD3E_MACFA (Q95LI5 ), CD3E_MOUSE (P22646 ), CD3E_PIG (Q7YRN2 ), CD3E_RABIT (Q9TUF9 ), CD3E_SHEEP (P29328 ), CD3G_BOVIN (Q28074 ), CD3G_HUMAN (P09693 ), CD3G_MACFA (Q95LI7 ), CD3G_MOUSE (P11942 ), CD3G_PIG (Q5PXD3 ), CD3G_RAT (Q64159 ), CD3G_SHEEP (P18439 ), CD3Z_HUMAN (P20963 ), CD3Z_MOUSE (P24161 ), CD3Z_PIG (Q9XSJ9 ), CD3Z_RABIT (Q9TUF8 ), CD3Z_SHEEP (P29329 ), CD79A_BOVIN (P40293 ), CD79A_CANLF (P0CAN6 ), CD79A_HUMAN (P11912 ), CD79A_MOUSE (P11911 ), CD79B_HUMAN (P40259 ), CD79B_MOUSE (P15530 ), FCERG_BOVIN (Q9BDR7 ), FCERG_CAVPO (Q07249 ), FCERG_HUMAN (P30273 ), FCERG_MACFA (Q8SPW1 ), FCERG_MOUSE (P20491 ), FCERG_PIG (Q9XSZ6 ), FCERG_RAT (P20411 ), NFAM1_HUMAN (Q8NET5 )» more
|
| UniProtKB/Swiss-Prot False negative sequences |
28 sequences
GP_HANTB (P28728 ), GP_HANTH (P16493 ), GP_HANTL (P16853 ), GP_HANTV (P08668 ), GP_NYV (Q83887 ), GP_PHV (P27315 ), GP_PUUMG (P21400 ), GP_PUUMK (P41265 ), GP_PUUMP (P41266 ), GP_PUUMS (P27312 ), GP_SEOU8 (P33455 ), GP_SEOUR (P28729 ), GP_SEOUS (P17880 ), NFAM1_MOUSE (Q8R4V1 ), STAM1_CAEEL (O01498 ), STAM1_HUMAN (Q92783 ), STAM1_MOUSE (P70297 ), STAM2_CHICK (O93436 ), STAM2_HUMAN (O75886 ), STAM2_MOUSE (O88811 ), STAM2_RAT (Q5XHY7 ), TYOBP_BOVIN (Q95J79 ), TYOBP_HUMAN (O43914 ), TYOBP_MACMU (Q8WNQ8 ), TYOBP_MOUSE (O54885 ), TYOBP_PANTR (A4F4L0 ), TYOBP_PIG (Q9TU45 ), TYOBP_RAT (Q6X9T7 )» more |
| PDB [Detailed view] |
18 PDB
1A81; 1CV9; 1TCE; 2K4F; 2OQ1; 3IK5; 3IOZ; 4XZ1; 6JXR; 7FJD; 7FJE; 7FJF; 7Q5T; 7Q5U; 7Q5W; 7XQ8; 8E4C; 8EMA » more |