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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00379


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00379
General rule information [?]

Accession PRU00379
Dates 05-JAN-2005 (Created)
21-NOV-2019 (Last updated, Version 14)
Data class Domain;
Predictors
case c? <OC:Eukaryota>
PROSITE; PS51055; ITAM_1
end case
case c? <OC:Viruses>
PROSITE; PS51056; ITAM_2
end case
Name ITAM motif
Function The ITAM is an immunoreceptor tyrosine-based activation motif. Phosphorylation of the two ITAM tyrosines is a critical event in signal transduction. This phosphorylation was found to reflect activation of the src family kinase Lyn and Syk.
Scope(s) Eukaryota
Viruses
Example(s) P04234; P28728;

Propagated annotation [?]

Cross-references [?]

PROSITE PS51055; ITAM_1; 1;
PROSITE PS51056; ITAM_2; 1;

Features [?]

From: PS51055
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="ITAM #"
MOD_RES 12 12 /note="Phosphotyrosine" Y
MOD_RES 23 23 /note="Phosphotyrosine" Y
From: PS51056
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="ITAM #"
MOD_RES 5 5 /note="Phosphotyrosine" Y
MOD_RES 18 18 /note="Phosphotyrosine" Y

Additional information [?]

Size range 24-26 amino acids
Related rules none
Fusion None
Repeats 1-3
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]