ProRule PRU00379
General rule information
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| Accession | PRU00379 |
| Dates | 5-JAN-2005 (Created)
21-NOV-2019 (Last updated, Version 13) |
| Data class | Domain; |
| Predictors |
case c? <OC:Eukaryota>
PROSITE; PS51055; ITAM_1 end case
case c? <OC:Viruses>
PROSITE; PS51056; ITAM_2 end case
|
Name | ITAM motif |
| Function | The ITAM is an immunoreceptor tyrosine-based activation motif. Phosphorylation of the two ITAM tyrosines is a critical event in signal transduction. This phosphorylation was found to reflect activation of the src family kinase Lyn and Syk. |
| Scope(s) |
Eukaryota Viruses |
| Example(s) | P04234 (CD3D_HUMAN); P28728 (GP_HANTB); |
Propagated annotation
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Cross-references
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Features
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| From: PS51055 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="ITAM #" | |||||||||
| MOD_RES | 12 | 12 | /note="Phosphotyrosine" | Y | ||||||||
| MOD_RES | 23 | 23 | /note="Phosphotyrosine" | Y | ||||||||
| From: PS51056 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="ITAM #" | |||||||||
| MOD_RES | 5 | 5 | /note="Phosphotyrosine" | Y | ||||||||
| MOD_RES | 18 | 18 | /note="Phosphotyrosine" | Y | ||||||||
Additional information
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| Size range | 24-26 amino acids |
| Related rules |
none |
| Fusion | None |
| Repeats | 1-3 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [58] Viruses [13] All [ 71 ]
- Retrieve set of proteins with 3D structure for this domain