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ProRule PRU00379


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PURL: https://purl.expasy.org/prosite/rule/PRU00379
General rule information [?]

Accession PRU00379
Dates 05-JAN-2005 (Created)
21-NOV-2019 (Last updated, Version 14)
Data class Domain;
Predictors
case c? <OC:Eukaryota>
PROSITE; PS51055; ITAM_1
end case
case c? <OC:Viruses>
PROSITE; PS51056; ITAM_2
end case
Name ITAM motif
Function The ITAM is an immunoreceptor tyrosine-based activation motif. Phosphorylation of the two ITAM tyrosines is a critical event in signal transduction. This phosphorylation was found to reflect activation of the src family kinase Lyn and Syk.
Scope(s) Eukaryota
Viruses
Example(s) P04234; P28728;

Propagated annotation [?]

Cross-references [?]

PROSITE PS51055; ITAM_1; 1;
PROSITE PS51056; ITAM_2; 1;

Features [?]

From: PS51055
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="ITAM #"
MOD_RES 12 12 /note="Phosphotyrosine" Y
MOD_RES 23 23 /note="Phosphotyrosine" Y
From: PS51056
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="ITAM #"
MOD_RES 5 5 /note="Phosphotyrosine" Y
MOD_RES 18 18 /note="Phosphotyrosine" Y

Additional information [?]

Size range 24-26 amino acids
Related rules none
Fusion None
Repeats 1-3
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]