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annotation rule: PRU00379

General rule information [?]

Accession PRU00379
Dates 5-JAN-2005 (Created)
21-NOV-2019 (Last updated, Version 13)
Data class Domain
case <OC:Eukaryota>
Predictors PROSITE; PS51055; ITAM_1
end case

case <OC:Viruses>
Predictors PROSITE; PS51056; ITAM_2
end case

Name ITAM motif
Function The ITAM is an immunoreceptor tyrosine-based activation motif. Phosphorylation of the two ITAM tyrosines is a critical event in signal transduction. This phosphorylation was found to reflect activation of the src family kinase Lyn and Syk.

Propagated annotation [?]

Cross-references [?]

case <OC:Eukaryota>
PROSITE PS51055; ITAM_1; 1;
end case

case <OC:Viruses>
PROSITE PS51056; ITAM_2; 1;
end case

Features [?]

From: PS51055
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       ITAM #        
MOD_RES     12     12       Phosphotyrosine     Y  
MOD_RES     23     23       Phosphotyrosine     Y  
From: PS51056
DOMAIN     from     to       ITAM #        
MOD_RES     5     5       Phosphotyrosine     Y  
MOD_RES     18     18       Phosphotyrosine     Y  

Additional information [?]

Size range 24-26 amino acids
Related rules none
Repeats 1-3
Topology Undefined
Examples P04234 (CD3D_HUMAN); P28728 (GP_HANTB): [Recover all]


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]