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PROSITE entry PS51133


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PURL: https://purl.expasy.org/prosite/signature/PS51133

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General information about the entry

Entry name [info] ZF_TFIIS_2
Accession [info] PS51133
Entry type [info] MATRIX
Date [info] 01-JUN-2005 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00383
Associated ProRule [info] PRU00472

Name and characterization of the entry

Description [info] Zinc finger TFIIS-type profile.
Matrix / Profile [info] 
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=41;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=37;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.4266217; R2=0.0051143; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=4801.4287109; R2=1.2132797; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1384; H_SCORE=6481; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=992; H_SCORE=6005; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-23; D=-20; I=-20; B1=-200; E1=-200; MI=-105; MD=-105; IM=-105; DM=-105;

...
 
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='T';  M= -17, -49,  11,   4, -34,   0, -14,  14,  -6, -25, -36, -22, -30, -19,   5,  33,  36,   3, -54,   6;
/M: SY='D';  M=  -2, -52,  51,  20, -31, -11, -33, -44,  13, -21,  -8,  31, -45,  25,  -2,   0,  -3, -41, -12,  -6;
/M: SY='W';  M=   4, -52, -42,  22,  17, -52,  33,  28,  13,  -6, -30, -28, -48, -35,  -1, -31,  -3,  10,  53,   6;
/M: SY='K';  M= -26, -54, -32,  29, -52, -41, -38,  -9,  46, -35, -39,  11,  35,  26,   8, -15,  17,  -3, -56, -45;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/I:         I=-6; MD=-32;
/M: SY='P';  M= -33, -63, -34,   3, -43,   6, -43, -51,   2, -48, -46, -42,  95,  -1,   2, -16, -23, -34, -54, -11; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='K';  M=   3, -52,   4,  12, -35, -22, -34, -47,  61, -42, -42,  31, -44,  11,  25,  -6, -30, -20, -54, -27;
/I:         I=-5; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='G';  M= -21, -54,   1, -32, -57,  65,  44, -62,  31, -58, -47,   6, -27,   2, -11,   3, -22, -57, -56, -45;
/M: SY='H';  M= -30, -32, -28, -16,  -4,   4,  87, -55,  16, -51, -41,  54, -47,  16, -30,  31, -28, -54, -61, -24;
/M: SY='N';  M= -29, -54,  29,  20, -53, -13,  34, -41,  27, -41,  -7,  40,   7, -12,  36,  -6,  -9, -44, -60, -30;
/M: SY='E';  M= -38, -54,  10,  58, -28,   1, -20, -54,  37, -52, -22,  38, -41,  -7,  16, -20,  -4, -33, -58, -45;
/M: SY='A';  M=  57,  40, -47, -44, -43, -18, -47, -16, -43, -12,  39, -19, -47, -41, -47, -20,  30,  16, -57, -28;
/M: SY='Y';  M=  -6, -49, -48, -34,  16, -51,  24,   1, -41, -11,   1, -42, -52, -11, -12,   5,  19,  41,  23,  53;
/I:         I=-6; MD=-29;
/M: SY='F';  M= -43, -56, -56, -42,  79, -55, -35, -34, -48, -29, -33, -52,  24, -50, -34, -21, -28, -30,  65,  78; D=-6;
/I:         I=-6; MI=-29; MD=-29; IM=-29; DM=-29;
/M: SY='F';  M= -28, -51, -53, -39,  62, -54,  22,  -7, -21,   1,  37, -22, -55, -35, -11, -24,  10,  -1,  62,  36; D=-6;
/I:         I=-6; DM=-29;
/M: SY='Q';  M= -36, -54, -34,  18, -50, -47,  -9,  -3, -26, -11,  38, -13, -44,  89, -29,  -4,  30, -32, -54, -38;
/M: SY='M';  M=   5, -49, -31, -41, -23, -50, -42,  19,   4,  37,  48, -43, -12,   4,   2,  11, -21,  -2, -52, -36;
/I:         I=-6; MD=-32;
/M: SY='Q';  M= -26, -62, -34, -15, -65, -46,  23, -53, -19, -48, -10, -29,  -1, 113,  -2, -28, -40, -55, -52, -38; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='T';  M= -27, -45, -39,   0, -41, -16, -44,  24, -37,  -1,   9, -32, -42,  16, -43,  -7,  78, -19, -59, -41;
/M: SY='R';  M= -16, -59, -41, -29, -54, -16, -32, -59,  25, -43, -42, -33, -51, -20,  98, -37, -42, -52, -53, -41;
/I:         I=-5; MD=-27;
/M: SY='S';  M=  19, -19, -22, -14, -52, -16, -39, -17,  -9, -50, -44, -29, -45, -28,  27,  73, -23, -26, -59, -45; D=-5;
/I:         I=-5; MI=-27; MD=-27; IM=-27; DM=-27;
/M: SY='A';  M=  71,  -2, -43, -16, -54,  18, -46, -33, -18, -39, -41, -37, -45, -36, -32,  18, -23, -28, -55, -49; D=-5;
/I:         I=-5; DM=-27;
/M: SY='D';  M= -45, -59, 101,  25, -59, -44, -31, -62, -32, -60, -58, -17, -44, -30, -41, -20, -23, -59, -71,   0; D=-5;
/I:         I=-5; DM=-27;
/M: SY='E';  M= -37, -56,  -2,  93, -58, -51, -32, -55, -10, -52, -48,   9, -35, -15, -30, -32,  12, -27, -60, -50;
/M: SY='P';  M=   7, -57, -39,   1, -59,  39, -44, -53, -39, -57, -18, -11,  87, -38, -48,  13, -20, -52, -56, -55;
/M: SY='M';  M= -19, -50, -44,   9, -40, -47, -35, -18, -37,   0,  98, -40,  37,  31, -39,  13,  -1, -31, -54, -37;
/M: SY='T';  M= -11, -42, -39, -39, -43, -45, -45,  -4, -35, -11, -34, -29, -41, -38,   0,  20,  87, -12, -62, -42;
/M: SY='V';  M= -37, -48, -53, -47, -31, -59, -50,  35, -15,  34, -19, -46, -52, -43,  22, -30,  31,  43, -56, -37;
/M: SY='F';  M= -38, -51, -59, -40,  96, -59, -41,  11, -28, -16,  -1, -51, -60, -53,   5, -49, -43, -17, -23,  39;
/M: SY='Y';  M= -15,  14, -52, -52,  51, -55,  22, -21, -46, -24, -28, -49, -60, -44, -44, -43, -41,  11, -17, 101;
/M: SY='V';  M= -14, -11, -33,  -2, -14, -52, -44,   4,  30, -10, -15, -24, -47, -22,  12, -16,  36,  40, -55,  -9;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/I:         I=-5; MD=-27;
/M: SY='C';  M=  -5,  56, -26, -19, -43, -49, -28, -13,  14,   2,   3,  -8,   1, -19,  -9,  -8,  43,   8, -60, -23; D=-5;
/I:         I=-5; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='N';  M= -14, -52,  34,  24, -54, -20,  33, -55,  34, -52, -24,  47, -44,  -3,   8,  22, -18, -42, -61, -24;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/I:         I=-6; MD=-32;
/M: SY='G';  M= -14, -54, -30, -16, -39,  65, -25, -58,  31, -45, -27,  11, -46,  21, -13,  -1, -33, -54, -51,  -9; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='H';  M= -44, -55, -22,  -2,  25, -47,  99, -51,  35, -44, -36,  26, -48,  -7, -26, -19, -39, -52, -46,  44;
/M: SY='R';  M= -24, -55, -29, -15, -34, -49,  22, -14,  28, -20, -36,   8, -48,  32,  62, -24,  10, -14,  40, -14;
/M: SY='W';  M= -50, -65, -50,  -2,  56, -54, -57, -41, -46, -37, -12, -60, -55, -31, -36, -52, -22, -32, 148,  17;
/M: SY='R';  M= -24, -52, -36,  -8, -51, -48, -36, -15,  47, -47, -40,  -9, -45, -14,  64,   6,  38, -22, -56, -42;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 66 in 66 different sequences
Number of true positive hits 66 in 66 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] N_Hulo
Feature key [info] ZN_FING
Feature description [info] TFIIS-type
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 66 sequences 

081R_FRG3G  (Q6GZP4), RDO2_ARATH  (Q9ZVH8), RP30_MONPV  (A0A7H0DN39), 

RP30_VACCA  (O57187), RP30_VACCC  (P21082), RP30_VACCW  (P21603), 
RP30_VAR67  (P33796), RPA12_BOVIN (Q1RMP0), RPA12_HUMAN (Q9P1U0), 
RPA12_MACMU (Q5TM50), RPA12_MOUSE (Q791N7), RPA12_PANTR (Q1XHV8), 
RPA12_RAT   (Q6MFY5), RPA12_SCHPO (O94703), RPA12_YEAST (P32529), 
RPB9A_ARATH (Q6NLH0), RPB9B_ARATH (Q8L5V0), RPB9_BOVIN  (Q32P73), 
RPB9_CAEEL  (Q965S0), RPB9_CANGA  (Q6FS48), RPB9_DROME  (P36958), 
RPB9_ENCCU  (Q8SQU1), RPB9_EREGS  (Q755B3), RPB9_HUMAN  (P36954), 
RPB9_MOUSE  (P60898), RPB9_PIG(P60899), RPB9_SCHPO  (O74635), 
RPB9_YEAST  (P27999), RPC10_BOVIN (Q2M2S7), RPC10_HUMAN (Q9Y2Y1), 
RPC10_MOUSE (Q9CQZ7), RPC10_SCHPO (O13896), RPC10_YEAST (Q04307), 
RPO5_FOWPN  (Q9J5C0), TCEA1_BOVIN (Q29RL9), TCEA1_DICDI (Q54YG9), 
TCEA1_HUMAN (P23193), TCEA1_MOUSE (P10711), TCEA1_RAT   (Q4KLL0), 
TCEA2_BOVIN (Q148K0), TCEA2_HUMAN (Q15560), TCEA2_MOUSE (Q9QVN7), 
TCEA2_RAT   (Q63799), TCEA3_BOVIN (Q2KI09), TCEA3_HUMAN (O75764), 
TCEA3_MOUSE (P23881), TFIIS_ASFB7 (P27948), TFIIS_ASFK5 (P0C8F5), 
TFIIS_ASFM2 (P0C8F6), TFIIS_ASFP4 (P0C8F7), TFIIS_ASFWA (P0C8F8), 
TFS1_SACS2  (Q980K2), TFS2_CAEEL  (P52652), TFS2_DROME  (P20232), 
TFS2_MIMIV  (Q5UQS8), TFS2_SCHPO  (P49373), TFS2_YEAST  (P07273), 
TFS_ARCFU   (O29033), TFS_METJA   (Q58548), TFS_METTH   (O27369), 
TFS_METTL   (Q9P9I8), TFS_SULAC   (Q07271), TFS_THECE   (Q56254), 
TFS_THEKO   (Q5JF34), VF349_IIV3  (Q197A5), VF349_IIV6  (Q91FH5)
» more

PDB
[Detailed view]		 424 PDB

pdb_00001i3q; pdb_00001i50; pdb_00001i6h; pdb_00001k83; pdb_00001nik; pdb_00001nt9; pdb_00001pqv; pdb_00001qyp; pdb_00001r5u; pdb_00001r9s; pdb_00001r9t; pdb_00001sfo; pdb_00001tfi; pdb_00001twa; pdb_00001twc; pdb_00001twf; pdb_00001twg; pdb_00001twh; pdb_00001wcm; pdb_00001y1v; pdb_00001y1w; pdb_00001y1y; pdb_00001y77; pdb_00002b63; pdb_00002b8k; pdb_00002e2h; pdb_00002e2i; pdb_00002e2j; pdb_00002ja5; pdb_00002ja6; pdb_00002ja7; pdb_00002ja8; pdb_00002nvq; pdb_00002nvt; pdb_00002nvx; pdb_00002nvy; pdb_00002nvz; pdb_00002r7z; pdb_00002r92; pdb_00002r93; pdb_00002vum; pdb_00002yu9; pdb_00003cqz; pdb_00003fki; pdb_00003gtg; pdb_00003gtj; pdb_00003gtk; pdb_00003gtl; pdb_00003gtm; pdb_00003gto; pdb_00003gtp; pdb_00003gtq; pdb_00003h0g; pdb_00003h3v; pdb_00003hou; pdb_00003hov; pdb_00003how; pdb_00003hox; pdb_00003hoy; pdb_00003hoz; pdb_00003i4m; pdb_00003i4n; pdb_00003j0k; pdb_00003j1n; pdb_00003k1f; pdb_00003k7a; pdb_00003m3y; pdb_00003m4o; pdb_00003po2; pdb_00003po3; pdb_00003qt1; pdb_00003rzd; pdb_00003rzo; pdb_00003s14; pdb_00003s15; pdb_00003s16; pdb_00003s17; pdb_00003s1m; pdb_00003s1n; pdb_00003s1q; pdb_00003s1r; pdb_00003s2d; pdb_00003s2h; pdb_00004a3b; pdb_00004a3c; pdb_00004a3d; pdb_00004a3e; pdb_00004a3f; pdb_00004a3g; pdb_00004a3i; pdb_00004a3j; pdb_00004a3k; pdb_00004a3l; pdb_00004a3m; pdb_00004a93; pdb_00004bbr; pdb_00004bbs; pdb_00004bxx; pdb_00004bxz; pdb_00004by1; pdb_00004by7; pdb_00004c2m; pdb_00004c3h; pdb_00004c3i; pdb_00004c3j; pdb_00004v1m; pdb_00004v1n; pdb_00004v1o; pdb_00004x67; pdb_00004x6a; pdb_00004y52; pdb_00004y7n; pdb_00004ym7; pdb_00005c3e; pdb_00005c44; pdb_00005c4a; pdb_00005c4j; pdb_00005c4x; pdb_00005fj8; pdb_00005fj9; pdb_00005fja; pdb_00005flm; pdb_00005fmf; pdb_00005fyw; pdb_00005fz5; pdb_00005g5l; pdb_00005ip7; pdb_00005ip9; pdb_00005iy6; pdb_00005iy7; pdb_00005iy8; pdb_00005iy9; pdb_00005iya; pdb_00005iyb; pdb_00005iyc; pdb_00005iyd; pdb_00005lmx; pdb_00005m3f; pdb_00005m3m; pdb_00005m5w; pdb_00005m5x; pdb_00005m5y; pdb_00005m64; pdb_00005n5y; pdb_00005n5z; pdb_00005n60; pdb_00005n61; pdb_00005oa1; pdb_00005oik; pdb_00005oqj; pdb_00005oqm; pdb_00005ot2; pdb_00005sva; pdb_00005u0s; pdb_00005u5q; pdb_00005vvr; pdb_00005vvs; pdb_00005w4u; pdb_00005w51; pdb_00005w5y; pdb_00005w64; pdb_00005w65; pdb_00005w66; pdb_00006blo; pdb_00006blp; pdb_00006bm2; pdb_00006bm4; pdb_00006bqf; pdb_00006cnb; pdb_00006cnc; pdb_00006cnd; pdb_00006cnf; pdb_00006drd; pdb_00006eu0; pdb_00006eu1; pdb_00006eu2; pdb_00006eu3; pdb_00006exv; pdb_00006f40; pdb_00006f41; pdb_00006f42; pdb_00006f44; pdb_00006gmh; pdb_00006gml; pdb_00006gyk; pdb_00006gyl; pdb_00006gym; pdb_00006h67; pdb_00006h68; pdb_00006hko; pdb_00006hlq; pdb_00006hlr; pdb_00006hls; pdb_00006i84; pdb_00006o6c; pdb_00006o9l; pdb_00006rie; pdb_00006rqh; pdb_00006rql; pdb_00006rqt; pdb_00006rrd; pdb_00006rui; pdb_00006ruo; pdb_00006rwe; pdb_00006ted; pdb_00006tps; pdb_00006tut; pdb_00006upx; pdb_00006upy; pdb_00006upz; pdb_00006uq0; pdb_00006uq1; pdb_00006uq2; pdb_00006uq3; pdb_00006xre; pdb_00007a6h; pdb_00007ae1; pdb_00007ae3; pdb_00007aea; pdb_00007aoc; pdb_00007aod; pdb_00007aoe; pdb_00007ast; pdb_00007b0y; pdb_00007b7u; pdb_00007d58; pdb_00007d59; pdb_00007dn3; pdb_00007du2; pdb_00007edx; pdb_00007eg7; pdb_00007eg8; pdb_00007eg9; pdb_00007ega; pdb_00007egb; pdb_00007egc; pdb_00007ena; pdb_00007enc; pdb_00007eu0; pdb_00007eu1; pdb_00007f4g; pdb_00007fji; pdb_00007fjj; pdb_00007ked; pdb_00007kee; pdb_00007kef; pdb_00007lbm; pdb_00007mei; pdb_00007mk9; pdb_00007mka; pdb_00007ml0; pdb_00007ml1; pdb_00007ml2; pdb_00007ml4; pdb_00007nkx; pdb_00007nky; pdb_00007nvr; pdb_00007nvs; pdb_00007nvt; pdb_00007nvu; pdb_00007nvy; pdb_00007nvz; pdb_00007nw0; pdb_00007o4i; pdb_00007o4j; pdb_00007o72; pdb_00007o73; pdb_00007o75; pdb_00007ob9; pdb_00007oba; pdb_00007obb; pdb_00007okx; pdb_00007oky; pdb_00007ol0; pdb_00007oo3; pdb_00007oob; pdb_00007oop; pdb_00007opc; pdb_00007opd; pdb_00007ozn; pdb_00007ozo; pdb_00007ozp; pdb_00007pks; pdb_00007rim; pdb_00007rip; pdb_00007riq; pdb_00007riw; pdb_00007rix; pdb_00007riy; pdb_00007ui9; pdb_00007uif; pdb_00007uio; pdb_00007unc; pdb_00007und; pdb_00007vba; pdb_00007vbb; pdb_00007vbc; pdb_00007ycx; pdb_00007z0h; pdb_00007z1l; pdb_00007z1m; pdb_00007z1o; pdb_00007z2z; pdb_00007z30; pdb_00007z31; pdb_00007zs9; pdb_00007zsa; pdb_00007zsb; pdb_00007zwd; pdb_00007zx7; pdb_00007zx8; pdb_00008a3y; pdb_00008a40; pdb_00008a43; pdb_00008b3d; pdb_00008b3f; pdb_00008bvw; pdb_00008bws; pdb_00008byq; pdb_00008bz1; pdb_00008c8h; pdb_00008cen; pdb_00008ceo; pdb_00008gxq; pdb_00008gxs; pdb_00008hyj; pdb_00008ity; pdb_00008iue; pdb_00008iuh; pdb_00008jch; pdb_00008k5p; pdb_00008oeu; pdb_00008oev; pdb_00008oew; pdb_00008of0; pdb_00008p0j; pdb_00008p0k; pdb_00008p0n; pdb_00008p4a; pdb_00008p4b; pdb_00008p4c; pdb_00008p4d; pdb_00008p4e; pdb_00008p4f; pdb_00008qep; pdb_00008qeq; pdb_00008qsz; pdb_00008ram; pdb_00008rap; pdb_00008rbx; pdb_00008rqk; pdb_00008s51; pdb_00008s52; pdb_00008s54; pdb_00008s55; pdb_00008s5n; pdb_00008tug; pdb_00008tvp; pdb_00008tvq; pdb_00008tvs; pdb_00008tvv; pdb_00008tvw; pdb_00008tvx; pdb_00008tvy; pdb_00008uha; pdb_00008uhd; pdb_00008uhg; pdb_00008ui0; pdb_00008uis; pdb_00008ukq; pdb_00008ukr; pdb_00008uks; pdb_00008ukt; pdb_00008uku; pdb_00008umh; pdb_00008umi; pdb_00008uoq; pdb_00008uot; pdb_00008w8e; pdb_00008w8f; pdb_00008wak; pdb_00008wal; pdb_00008wan; pdb_00008wao; pdb_00008wap; pdb_00008waq; pdb_00008war; pdb_00008was; pdb_00008wat; pdb_00008wau; pdb_00008wav; pdb_00008waw; pdb_00008wax; pdb_00008way; pdb_00008waz; pdb_00008wb0; pdb_00008xmb; pdb_00008xmc; pdb_00008xmd; pdb_00008xme; pdb_00009bvt; pdb_00009bw0; pdb_00009bz0; pdb_00009egx; pdb_00009egy; pdb_00009egz; pdb_00009eh0; pdb_00009eh1; pdb_00009eh2; pdb_00009ehz; pdb_00009ei1; pdb_00009ei3; pdb_00009ei4; pdb_00009er2; pdb_00009fd2; pdb_00009fso; pdb_00009fsp; pdb_00009fsq; pdb_00009fsr; pdb_00009fss; pdb_00009j0n; pdb_00009j0o; pdb_00009j0p; pdb_00009mu9
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