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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00472


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00472
General rule information [?]

Accession PRU00472
Dates 10-AUG-2005 (Created)
19-NOV-2022 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS51133; ZF_TFIIS_2
Name Zinc finger TFIIS-type
Function involved in RNA cleavages when pol II is blocked by backtracking
Scope(s) Eukaryota
Viruses
Archaea
Example(s) P07273;

Propagated annotation [?]

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger

Gene Ontology [?]

case <Feature:PS51133:5=[CH]> and <Feature:PS51133:8=[CH]> and <Feature:PS51133:33=[CH]> and <Feature:PS51133:36=[CH]>
GO:0046872; Molecular function:metal ion binding
GO:0008270; Molecular function:zinc ion binding

Cross-references [?]

PROSITE PS00466; ZF_TFIIS_1; 1;

Features [?]

From: PS51133
Key From To Description Tag Condition FTGroup
case <Feature:PS51133:5=C> and <Feature:PS51133:8=C> and <Feature:PS51133:33=C> and <Feature:PS51133:36=C>
ZN_FING from to /note="TFIIS-type #"
else case <Feature:PS51133:5=[CH]> and <Feature:PS51133:8=[CH]> and <Feature:PS51133:33=[CH]> and <Feature:PS51133:36=[CH]>
ZN_FING from to /note="TFIIS-type #; atypical"
else
ZN_FING from to /note="TFIIS-type #; degenerate"
end case
BINDING 5 5 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 8 8 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 33 33 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 36 36 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 39-42 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]