PROSITE entry PS51344
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General information about the entry
| Entry name [info] | HTH_TFE_IIE |
| Accession [info] | PS51344 |
| Entry type [info] | MATRIX |
| Date [info] |
01-DEC-2007 CREATED;
10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51344 |
| Associated ProRule [info] | PRU00676 |
Name and characterization of the entry
| Description [info] | TFE/IIEalpha-type HTH domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=89; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=84; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.7896526; R2=0.0077522; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=13692.6064453; R2=1.8483009; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=737; H_SCORE=15055; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=479; H_SCORE=14578; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-92; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-255; BD=-255; /M: SY='M'; M= 27, -14, 14, -24, 27, -91,-215, -8, -52, 18, 44, 30, -64,-215, -94,-212, -62, 4,-223, 12; /M: SY='N'; M= -93,-228, 35, 1,-227,-218, -48, -6, 62, -62,-216, 63, -30, 1, -12, -17,-207, -25,-235,-219; /M: SY='P'; M= -94,-229, 35, 26, -42,-219,-209,-227, 23,-226, -3, -1, 42, 19, 42, 14, 19,-224,-232,-219; /M: SY='L'; M= 16,-220,-227, -14, -43,-229,-221, -10, -29, 74, -46,-227, -53,-217,-221, -63,-211, 13,-225,-208; /M: SY='V'; M= 4,-221,-231,-225, -31,-231, -57, 48, -32, 32, -30,-225,-228,-222,-223,-217, -39, 64,-225, 2; /M: SY='R'; M= -96,-230,-212, -25, -34,-225, -27, -44, 57, 2,-207, -37,-222, 48, 76, -83,-212, -54,-222, -12; /M: SY='C'; M= -10, 45, -7, 14, 22, -30,-210, -23, 2, -10, 38, -44,-222, 28, -32, -2, -11, -74,-217, 43; /M: SY='V'; M= -25, 10,-229, -53, -29,-231,-219, 27,-223, 5, -8,-226, -30,-222,-224,-217,-207, 74,-216, 64; /M: SY='V'; M= 40,-218,-228,-222, -42,-108,-225, 23, -70, 15, 33,-221,-225,-219,-223, -82, 7, 66,-229,-211; /M: SY='R'; M=-216,-230,-213, -7, -28, -60, 22,-100, 0, -20,-208,-209,-224, -3, 95, -55, -65, -17,-219, 37; /M: SY='K'; M= 19,-223, 16, 7,-224, 36,-212, -28, 37, -25, 28, -8,-218, -29, -6, 11, -22,-214,-229,-218; /M: SY='F'; M= -86,-221,-234,-228, 102,-231,-219, 19, -44, 24, 33,-225,-231,-226, -62, -23,-213, -25,-203,-183; /I: I=-28; MI=0; MD=-71; IM=0; DM=-71; /M: SY='Y'; M= -59,-227,-224,-225, 29, -24, -17, 7,-219, -27, -16, -47,-230,-216,-218,-216, -73, 17,-192, 115; /M: SY='D'; M=-206, -10, 74, 36,-233, 70,-212,-235,-209, -91,-226,-197, -28,-206,-217, 9, -72,-229,-234,-224; /M: SY='D'; M= -75,-224, 66, 42,-224, -48,-209, 7, 9, -38,-215, 11, -13,-202, -66, 24, 29, -60,-235,-218; /M: SY='E'; M= -66,-230, 35, 81,-225,-221, -21, -36, 15,-222,-217, -70, 37, -23, -12, -17, -82, -21,-228, 0; /I: I=-17; MI=0; MD=-44; IM=0; DM=-44; /M: SY='H'; M= 50,-222, -34, 1, -72, 34, 79,-214, -48,-215, -17, -56,-220, -32,-213, -72,-209, 12,-221, 47; /M: SY='I'; M= 11,-221,-226, -43, 2,-228,-224, 60, -12, -13, 23,-221,-224,-216, 4, -49, -74, 58,-225,-207; /M: SY='L'; M= -36,-223, -16, 12,-208, -84, -24, 15, 22, 40, 31, -40, -6, -75, 17,-214,-208, 36,-227,-210; /M: SY='V'; M= -26,-219,-232,-227, -49,-232,-231, 67,-224, -15, 5,-225,-226,-224,-226,-216, -27, 82, -17,-208; /M: SY='L'; M= -9,-219,-233,-226, 24, -64,-222, 40,-225, 57, 54,-227,-228,-221,-224,-219,-209, 44,-221,-202; /M: SY='D'; M= -67,-229, 98, 48,-228, -78, -24,-230, 6, -82, -49, -11,-215, -49, 1, -35,-207,-227,-236, -8; /M: SY='A'; M= 68, 4,-217, -21, -45, -35, 9, 1, -32, -2, 37, -43,-220, -74, -34, -31, -33, 0,-225, -50; /M: SY='L'; M=-216,-220,-234,-227, 24, -85,-219, 26, -82, 83, 24,-230, -42,-221,-224,-225,-212, -30,-218,-200; /I: I=-15; MD=-38; /M: SY='T'; M= -56, -15,-229, -39, -27,-234,-223, 39,-225, 35, 34,-224, -26,-222,-227,-217, 45, 11,-225, 27; D=-15; /I: I=-15; MI=0; MD=-38; IM=0; DM=-38; /M: SY='R'; M= -74,-227, -77, -4, 9, -65,-208, 2, 28, -65, -42, -6, 39, -11, 79, -44, -1, -58,-222, -32; /M: SY='H'; M= -23,-226, 23, 27, -49, -12, 84,-226, 32,-104, -55, 42,-217, -5, 24, -85, -39,-223,-225, 29; /M: SY='Q'; M= -57, -7,-204, 27,-227, 40,-209, -82, 1, -74,-215, -9, 24, 57, -23, 43, 14, -56,-228,-218; /M: SY='W'; M= -12, 72, 1, 67,-214, -71,-218, -17, -78, -42,-211, -81, -7,-204, -26, -55,-210, 27, 99,-210; /M: SY='V'; M= -21,-218,-229, -70, -23,-230, -18, 32,-221, 39, 60,-224,-226,-219, -76,-216, -50, 68,-224, -9; /M: SY='T'; M= -40,-218, -46,-204,-218,-215, 0, -69, 29, -66,-211, -40, -13,-201, 48, 42, 79, -52,-229, -34; /M: SY='D'; M= -60,-229, 100, 82,-233,-218,-203,-231,-198, -67,-225,-193, -88,-194,-208,-205, -48,-226,-240,-220; /M: SY='E'; M= -74,-228, 70, 96,-230,-221,-204, -56, -1, -74,-221,-199,-209,-190, -48,-205, -5,-222,-234,-220; /M: SY='D'; M= -82,-229, 97, 63,-232,-217, 19,-228, -67,-226,-222, -39,-213, 26, -17, -55, -57, -37,-240,-217; /M: SY='L'; M=-214,-220,-233,-227,-193,-235,-221, 65,-226, 77, 39,-229,-228,-220,-225,-224, -54, -31,-222,-204; /M: SY='A'; M= 83, 18,-215, -25,-220, 4, -35, -55, -16, -30, -9,-209,-217,-208,-214, 1, -37, -18,-226,-218; /M: SY='E'; M= -25,-225, -20, 66, -53,-219, 23, -24, 41, -13,-209, 4,-214, 23, 5, -8, -23,-214,-223, 13; /M: SY='L'; M= -32,-222, 17, 34, -62,-222,-210, -19, 27, 54, -51, -32,-220, -1, 18, 5, -72, -95,-225,-210; /M: SY='L'; M= -66,-217,-226,-221,-197,-228,-218, 7,-220, 75, 44,-220,-224,-216,-221, -22, 51, -11,-225,-205; /M: SY='G'; M=-205,-225, -15, -17,-229, 69, -10,-231, 57,-229, -21, 44,-216, 4, -2, -12,-208,-227,-227,-219; /M: SY='M'; M=-212,-220,-231,-225, 43,-232,-217, 62, -55, 35, 76,-223,-226,-219, -62,-219, -27, 25,-214, 11; /M: SY='N'; M=-209,-224, 42, 7,-226, -82, 29,-224, 53, -44, -40, 59, 15, 39, -16, 27,-202,-223,-231,-214; /M: SY='L'; M= -20,-222, -46, -18, -27,-221,-211, 12, 26, 32,-199, -58, 19, 28, 32, -4, 18, -14,-223, -44; /M: SY='N'; M= -34,-221,-196,-198,-226,-209,-201, -69, 83,-226,-215, 94, -23, -25, -10, -62, -9,-221,-230,-217; /M: SY='Q'; M= -64,-225, 39, 62, -59,-219, -17, -9, -6, -97, 19, -38,-213, 71, -18, -39, 19, -16,-227, -39; /M: SY='V'; M= -74, -20,-230,-225,-197,-232,-225, 32,-224, 61,-185,-226,-227,-222,-224,-217, -4, 73,-227,-206; /M: SY='R'; M=-215, 13, -40,-202,-225, -26, 20,-232,-177,-225,-214, -43,-224,-192, 118,-209,-215,-226,-227,-212; /M: SY='K'; M= -29,-226, -40, -21, -49,-218, 0,-224, 77, -46,-212, -74, -24, 27, 64, 12, -49,-221,-224,-212; /M: SY='I'; M= 13, -8,-224,-220,-201,-226, -13, 69, -36, 33,-191,-217,-223, -59, -36, -94, 34, 4,-223, 5; /M: SY='L'; M= -71, 63,-233,-227,-194,-233,-221, 30,-226, 84, -16,-228,-232,-221,-226,-222, -52, -60,-224,-206; /M: SY='Y'; M= 11,-223,-210, -26, 25, 9, 3, -60,-204,-211, -26, 33,-222, 23, 24, -20, -1, -74,-205, 85; /M: SY='K'; M= -22,-222, -16,-205, 20, -82, -30, 7, 55, -17, -55, -17,-219, -7, 29, -18, 39, -57,-217, 28; /M: SY='L'; M=-217,-219,-234,-226, 19,-235,-217,-182,-227, 95, -3,-232,-233,-221,-224,-226,-213,-190,-217,-199; /M: SY='Y'; M= -35,-227,-204, 50, -35, -71, 36,-215, 40, -51, 15, -26,-218, -32, 40, -49,-210, -30,-210, 76; /M: SY='E'; M= -42, -32, 50, 85,-230, -12,-205,-230, 20, -73,-220, -9,-211, -36, 17, -39, -60,-224,-231,-220; /M: SY='D'; M= 10,-226, 79, 25,-226,-214, 48, -77, -9, -72, 20, 37,-216, 46, -41,-203,-207, -76,-235, -54; /M: SY='R'; M= -74,-227, -48,-202,-225, 43, -42,-227, 64, -74, 20, 3,-218, -26, 75, -37,-210,-223,-225,-215; /M: SY='L'; M=-217,-220,-235,-228, 68,-234,-219, 36,-227, 71, 46,-229,-231,-223,-225,-225,-212, -49,-212,-192; /M: SY='V'; M= 41, -15,-229,-223,-204,-224,-228, 58,-222, 18,-191,-223,-225,-220,-225, -65,-204, 68,-228,-210; /M: SY='K'; M= 0,-220, 9, -13,-220, -7,-211, -14, 41, -98, 23, -24,-216, -20, 22, 26, 37, 7,-229,-215; /M: SY='Y'; M=-211, 44, -64, -20, -11, -77,-203, -23, -54,-207,-204, -37,-226, -46, 54, 9, -51, 31,-205, 92; /M: SY='H'; M= -55, 13, 6, -57, -39,-221, 79, -22, 26,-216,-209, -22,-221, -38, 78, -35, -63, -15,-225, 20; /M: SY='R'; M=-210,-224, -55, -12, -69,-220, 52, -48, 32, -44, 23, -39,-218, 19, 69, 8, 40, -43,-227, -34; /M: SY='R'; M= -96,-226,-205, 36,-221, -42, -30, 1, 29, -80,-208, -7,-217, 52, 65, -46, 3, 15, -28,-213; /M: SY='R'; M= -75,-226,-211, -52, -57,-222,-207,-215, 64, -48, -5,-205, 8, -3, 78, -40, 17, -8,-223, -23; /M: SY='E'; M= -39,-226, 73, 81,-230,-216, 5,-225, -47,-225,-220, 37,-212, -32, -62, -51, -17, -20,-237,-219; /M: SY='E'; M= -69,-224, 11, 47, -43, -72,-209, -31, 45, -33, 9, 3, 38, -50,-202, 1, 32, -28,-226, -14; /M: SY='D'; M= 20,-223, 51, 48,-228, -20,-206, -60, -33,-224,-217, 37, -24, 24, 23, -22, 21,-218,-232,-219; /I: I=-13; MD=-32; /M: SY='E'; M= -9,-251, -11, 31,-249, -10, -21, -56, -3, -74,-239, -35, 22, -59, -63, -84, -79, -90,-252, -60; D=-13; /I: I=-13; MD=-32; /M: SY='W'; M= -64,-253, 35,-230,-248, 24,-236, -52, -47, -51,-243, 31,-247, -33, -8,-230,-237,-248, 44,-241; D=-13; /I: I=-13; MD=-32; /M: SY='Q'; M= -4,-246, -40,-229, -40, 11,-232,-245, -46,-244, 6, 18, -15, 34, -23, -9, -22,-242,-251,-239; D=-13; /I: I=-13; MI=0; MD=-32; IM=0; DM=-32; /M: SY='H'; M= -70,-247, -46,-234, -70,-248, 46, -7, -80, -65,-226, -10,-247, 16, -23,-231, 13, 21,-253, -12; D=-13; /I: I=-13; DM=-32; /M: SY='T'; M=-231,-245,-224, -1,-247,-238, -22,-245, 19, -78, -47, 34,-239, -51, -1, 3, 37,-240,-257,-240; D=-13; /I: I=-13; DM=-32; /M: SY='H'; M=-210,-224,-213,-209, -33,-221, 63, -24, 13,-218,-212,-204, -43,-204, 54, 43, 56, -20,-229, 8; D=-13; /I: I=-13; DM=-32; /M: SY='N'; M=-204, -50,-204, -2,-218, 53,-208, -23, -27,-220, -53, 56,-217, 13, -62, 31, 35, -29,-225, 19; D=-13; /I: I=-13; DM=-32; /M: SY='W'; M= -73,-231,-223,-217, -43,-222, 44,-210, -34, -41,-205,-218,-226,-208, 20, -10, -44, -20, 134, 98; /M: SY='Y'; M=-215, 59, -46,-220, 35,-226,-202, 2,-217, 20, -38, -21, 1,-216,-217,-212, 18, -64,-197, 104; /M: SY='Y'; M=-208, 48,-212, 11, 31,-222, 11, -20, -18, -81,-202,-209,-220,-209, -56, 5, 55, 23,-207, 82; /M: SY='Y'; M=-215,-226,-223,-222, -51,-229, 27, 67,-218, 13,-191,-219,-226, -46,-217, -55, -17, -58, 38, 105; /M: SY='Y'; M= -91,-222, 61,-202, -51,-215, 47,-211, -16, 16,-205, 57, -23,-204, -61, -23, 11,-213,-214, 77; /M: SY='W'; M= -69, 13,-232,-225, 8,-223,-212, -83,-218, -57,-208,-228,-229,-216,-218, -37, -79, -57, 153, 99; /M: SY='R'; M= 10, 37, -46, -37,-213, -54, 48, -43, 39, -76,-209,-203, -1, -28, 69, -46, 19,-214,-220, 37; /M: SY='Q'; M= -25,-222,-217, -25, 15,-224, 13, 46, -36, 29, -44,-213, 14, 56, -14, -35, 1, 14,-221,-203; /M: SY='N'; M= 16, -17, 53, -10, 13,-213, -74, -8, -27, -33,-207, 58,-218, -48, -14, -36, 23, 16,-228, -40; /M: SY='Y'; M=-211, -22, 5, -70, -24,-225,-209, 50,-213, 13, -44, -35, 15, -25, -7, -16, -34, 24, -15, 76; /M: SY='D'; M= -39,-225, 93, 48, -77, -88, -12,-227, -2, -99, -10, 47,-213, -49, -10, -33, -34,-223,-237,-216; /M: SY='V'; M= 24,-218, 0, 10,-216, -72, -4, -11, 31, -70,-204, 33, -71, 14, -33, -13, -11, 53,-230,-213; /M: SY='I'; M= -54, -15,-228,-226, -1,-230,-226, 85,-223, 7, -19, -6,-224,-221,-225, -55, -38, 55,-224,-204; /M: SY='K'; M= -25, 33, -15, 10,-220,-217, -51, -16, 70, -37,-210, 35, 34, -63, 41, -60, -73, -85,-225, -32; /I: E1=0; IE=-255; DE=-255;» more |
Numerical results [info]
| Total number of hits | 60 in 60 different sequences |
| Number of true positive hits | 60 in 60 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Archaea, Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | HTH TFE/IIEalpha-type |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
60 sequences
EFUD_HORCR (A0A2Z4HPY1), T2EA_BOVIN (A6QLI8), T2EA_DICDI (Q557M8), T2EA_HUMAN (P29083), T2EA_MOUSE (Q9D0D5), T2EA_PONAB (Q5R8H5), T2EA_SCHPO (Q9P3W1), T2EA_YEAST (P36100), TFE_AERPE (Q9YAD5), TFE_ARCFU (O29501), TFE_CALMQ (A8M8Z5), TFE_CENSY (A0RYF4), TFE_HALMA (Q5V3R0), TFE_HALSA (Q9HRC7), TFE_HALWD (Q18HD8), TFE_HYPBU (A2BLW2), TFE_IGNH4 (A8ABJ9), TFE_META3 (A6UW55), TFE_METAC (Q8TJB7), TFE_METAR (Q0W8N8), TFE_METB6 (A7I7T6), TFE_METBF (Q46G12), TFE_METBU (Q12YV9), TFE_METHJ (Q2FT22), TFE_METJA (Q58187), TFE_METKA (Q8TY11), TFE_METLZ (A2SQM6), TFE_METM5 (A4G0F7), TFE_METM7 (A6VI24), TFE_METMA (Q8PZ06), TFE_METMJ (A3CVQ3), TFE_METMP (Q6M181), TFE_METS3 (A5UKV8), TFE_METS5 (A4YJ15), TFE_METST (Q2NEV4), TFE_METTH (O27705), TFE_METTP (A0B9P3), TFE_METVS (A6UR14), TFE_NANEQ (Q74MZ3), TFE_NATPD (Q3IP08), TFE_PYRAB (Q9UYS6), TFE_PYRAE (Q8ZYH0), TFE_PYRAR (A4WGY5), TFE_PYRCJ (A3MY45), TFE_PYRFU (Q8U3H5), TFE_PYRHO (O58353), TFE_PYRIL (A1RTG5), TFE_PYRNV (B1YA16), TFE_SACS2 (Q980M5), TFE_STAMF (A3DN07), TFE_SULAC (Q4JAZ3), TFE_SULIA (C3MZJ0), TFE_SULIK (C4KIS0), TFE_SULIL (C3MRF5), TFE_SULIM (C3MY51), TFE_SULIN (C3NFW2), TFE_SULIY (C3N7L2), TFE_SULTO (Q975T8), TFE_THEKO (Q5JDD5), TFE_THEPD (A1RY32)» more
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| PDB [Detailed view] |
73 PDB
1Q1H; 5FMF; 5FYW; 5FZ5; 5GPY; 5IY6; 5IY7; 5IY8; 5IY9; 5IYA; 5IYB; 5IYC; 5IYD; 5OQJ; 5OQM; 5SVA; 6GYL; 6GYM; 6KF4; 6KF9; 6O9L; 6PLN; 6XJF; 7EG9; 7EGA; 7EGB; 7EGC; 7ENA; 7ENC; 7LBM; 7ML0; 7ML1; 7ML2; 7ML4; 7NVR; 7NVS; 7NVT; 7NVU; 7NVV; 7NVW; 7NVX; 7NVY; 7NVZ; 7NW0; 7O4I; 7O4J; 7O4K; 7O4L; 7O72; 7O73; 7O75; 7ZS9; 7ZSA; 7ZSB; 8BVW; 8BYQ; 8CEN; 8CEO; 8GXQ; 8GXS; 8S51; 8S52; 8S54; 8S55; 8S5N; 8WAK; 8WAL; 8WAN; 8WAO; 8WAP; 8WAQ; 8WAR; 8WAS » more |