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PROSITE entry PS51670


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General information about the entry

Entry name [info] SHKT
Accession [info] PS51670
Entry type [info] MATRIX
Date [info] 01-MAR-2013 CREATED;
01-MAR-2013 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC51670
Associated ProRule [info] PRU01005

Name and characterization of the entry

Description [info] ShKT domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=35;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=35;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.4714091; R2=0.0058477; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=689; N_SCORE=7.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=518; N_SCORE=6.5; MODE=1; TEXT='RR';
/DEFAULT: M0=-50; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='C';  M= -91, 158,-111,-111,-101,-107,-111,-108,-107, -99, -99, -97,-122,-115,-113, -94, -91, -96,-131,-112;
/M: SY='K';  M= -14, -26,   0,  36, -45, -72, -34, -24,  36,   8, -32, -40, -17,   7,  24,   2,  35, -45,-106, -20;
/I:         I=-28; MD=-71;
/M: SY='H';  M=-117,-129,  20, -35, -67,-122,  80, -29, -59, -96,-108,  -2,-123, -25, -23, -50,-112, -23,-120,  51; D=-28;
/I:         I=-28; MD=-71;
/M: SY='E';  M=-111,-127, -91,  68,-123,-120, -47,-125, -23,-125,-119,  30, -61, -60,-105, -18, -19, -45,-128,   4; D=-28;
/I:         I=-28; MI=-71; IM=-71; DM=-71;
/M: SY='D';  M= -54,-105, 104, -70, -27, -90, -80, -57, -83, -72,-105,  84,-100, -84, -92, -82, -84,-107,-126, -98;
/M: SY='K';  M= -25,-106,  16,   9, -99,-101,  -6, -52,  57,   8, -29, -52,  20,  19,  28, -25,   7, -11,  -7, -48;
/I:         I=-26; MD=-65;
/M: SY='F';  M=  -1,-105, -57,-101,  78, -51,  33, -11, -24, -21, -85,   9,-110, -97, -18, -15, -35, -71, -84,  69; D=-26;
/I:         I=-26; MD=-65;
/M: SY='T';  M= -30,-100, -29, -53,  -4, -66, -16,  -2,  -8, -72, -18,  12, -17, -91, -95,  44,  76, -14,-113, -48; D=-26;
/I:         I=-26; MI=-65; MD=-65; IM=-65; DM=-65;
/M: SY='N';  M= -47,  14,  26, -15, -62, -90, -10, -10, -38, -69, -34,  98,-103, -40, -30,   8, -26, -31,  34, -29; D=-26;
/I:         I=-26; DM=-65;
/M: SY='C';  M= -91, 158,-111,-111,-101,-107,-111,-108,-107, -99, -99, -97,-122,-115,-113, -94, -91, -96,-131,-112;
/M: SY='P';  M=   1,-109,  29,  -2,-111,   4, -94,-106,  34, -81,-102,  32,  49, -35, -29,  -8,  14, -44,  17,-103;
/M: SY='D';  M=   2,-106,  47, -45, -18, -52,  29, -19, -29, -43, -11, -11, -36,  -6,  -8,  43,   5, -25, -16,   3;
/M: SY='W';  M= -65,-110,-114, -62,   0,-112,-104, -27, -32,  58,  22,  -9,-113, -50,-103, -66, -61, -36, 119,  14;
/M: SY='A';  M=  46,-102, -99, -24,-101, -99,-101, -10,  33, -38, -89, -93,-102, -16,  13,  -6,  19,  37,-112, -99;
/I:         I=-15; MD=-39;
/M: SY='K';  M=  -9,-112, -32, -25, -59, -28, -12,-108,  50, -41,-100,  -2, -52,  41,  21,  19, -12, -48,-114, -42; D=-15;
/I:         I=-15; MD=-39;
/M: SY='Q';  M= -55,-113, -65, -11, -20, -52, -38, -32,   5, -17, -20,  14,-107,  75,  20,   5,   3, -64,-111, -24; D=-15;
/I:         I=-15; MD=-39;
/M: SY='G';  M= -37,-120, -23,-110, -64,  48, -65, -75, -56, -40,-111,  23,-117, -14, -33,  13, -53, -14,-125, -60; D=-15;
/I:         I=-15; MD=-39;
/M: SY='M';  M= -78,-121, -57,   1,  13,  19, -13,-111,  -5,  -9,  20,   4,-118, -47,-108,  10, -41,-112, -15, -29; D=-15;
/I:         I=-15; MI=0; MD=-39; IM=0; DM=-39;
/M: SY='C';  M= -99, 150,-119,-119,-109,-114,-119,-116,-115,-107,-107,-105,-130,-122,-121,-101, -99,-103,-139,-120;
/M: SY='Q';  M= -97,-115, -18,  12, -58, -15,  20, -69,  26, -80, -57,  36,-104,  74,  21, -18, -13,-111,-116,-100;
/I:         I=-20; MI=0; MD=-50; IM=0; DM=-50;
/M: SY='H';  M= -69,-114,  48, -47, -52,-108,  51,-102, -10, -77,  38, -38,  13, -52, -45,  11,  26,  -6,-125, -29; D=-20;
/I:         I=-20; DM=-50;
/M: SY='E';  M= -88,-118,  14,  41, -63, -49, -97,-115,  37, -82,-108,  21,  22,  17, -19,  12, -68, -45,-121,-109; D=-20;
/I:         I=-20; DM=-50;
/M: SY='W';  M= -72,-117,-107,-100,  18, -50,  30, -97,  -7,   2, -91, -46,-113,  39, -31, -44, -14, -68,  98,  72;
/I:         I=-22; MI=0; MD=-57; IM=0; DM=-57;
/M: SY='M';  M= -66,-109, -75,-109, -42,-116, -99,  26, -40,   5, 109,-108, -52, -99,  -4,-106, -47,  15,-109,   1;
/M: SY='K';  M=  -6,-111, -47, -54, -37,-105, -34, -35,  59, -33, -12,   5, -57,  28,  26, -16,  12, -73,-111, -19;
/M: SY='S';  M=   6, -32, -36,  29, -55,-100, -33, -62,  13, -47, -34,  -5,-102,   0,  -8,  47,  26, -37,-117,-103;
/M: SY='N';  M= -79,-110,  -1, -65,  22, -55, -16, -49,  18,  -9, -97,  78,-110,   1, -20,  -3, -92,-104,  -1,  11;
/M: SY='C';  M= -99, 150,-119,-119,-109,-114,-119,-116,-115,-107,-107,-105,-130,-122,-121,-101, -99,-103,-139,-120;
/M: SY='P';  M=  26,-116,-101, -60,-118, -38,-101,-112,  33, -66, -40, -98,  71,  22,  30, -12, -96,-108,-115,-109;
/M: SY='A';  M=  61,-107,-101, -56, -36, -99,-103, -40,  58, -51, -99, -55,-106, -90,   4, -13, -68, -63,-113,-104;
/M: SY='T';  M= -36,-102, -97, -98, -56, -98,-103, -58, -97,-106,-102, -86,-101, -95,-103,  68,  86, -95,-123,-104;
/M: SY='C';  M=-100, 149,-120,-120,-110,-116,-120,-117,-116,-108,-108,-106,-131,-124,-122,-103,-100,-105,-140,-121;
/I:         I=-24; MD=-61;
/M: SY='G';  M=-115,-134, -21, -63, -17,  49, -40,-140, -19,-137,-128,  32,-128, -28, -26,-109,-119,-137,-134,-124; D=-24;
/I:         I=-24; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='F';  M= -70,-111, -61,-104,  68, -65, -37, -58,  20,  20,  -5, -57,-115,  -1, -23, -15,   7, -62, -13, -34;
/M: SY='C';  M=-102, 147,-122,-122,-112,-118,-122,-119,-118,-110,-110,-108,-133,-126,-124,-105,-102,-107,-142,-123;
/I:         E1=0; IE=-255; DE=-255;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 136 in 120 different sequences
Number of true positive hits 136 in 120 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 10
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 93.15 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 4
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] ShKT
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
120 sequences

1AK_HETMG   (O16846), AURE_AURAU  (Q0MWV8), CRIS1_HUMAN (P54107), 
CRIS1_MACMU (Q9XSD3), CRIS1_MOUSE (Q03401), CRIS1_RAT   (P12020), 
CRIS2_CAVPO (Q60477), CRIS2_HUMAN (P16562), CRIS2_MOUSE (P16563), 
CRIS3_HORSE (O19010), CRIS3_HUMAN (P54108), CRIS3_MOUSE (Q03402), 
CRIS_PROFL  (P0CB15), CRVP1_DISTY (Q2XXQ6), CRVP1_HYDHA (Q8UW25), 
CRVP1_NAJAT (Q7T1K6), CRVP1_NAJKA (P84805), CRVP1_PSEPL (Q2XXQ3), 
CRVP2_DISTY (Q2XXQ5), CRVP2_HYDHA (Q8UW11), CRVP2_NAJAT (Q7ZZN8), 
CRVP2_NAJKA (P84808), CRVP2_PSEPL (Q2XXQ2), CRVP3_DISTY (Q2XXQ4), 
CRVP5_VARAC (Q2XXR0), CRVPA_VARVA (Q2XXP2), CRVPB_VARVA (Q2XXP1), 
CRVP_AGKPI  (Q7ZTA0), CRVP_AUSSU  (A8S6B6), CRVP_CAURH  (A7X4T8), 
CRVP_CERRY  (D8VNS1), CRVP_CROAD  (F8S0Y4), CRVP_CROAT  (Q7ZT99), 
CRVP_DEMVE  (A6MFK9), CRVP_DRYCN  (F8J2D4), CRVP_ECHCO  (P0DMT4), 
CRVP_ERYPO  (Q2XXQ0), CRVP_GLOBL  (Q8JI40), CRVP_HELHO  (Q91055), 
CRVP_HOPST  (Q3SB03), CRVP_LATSE  (Q8JI38), CRVP_LEIMD  (Q2XXQ1), 
CRVP_NOTSC  (Q3SB04), CRVP_OPHHA  (Q7ZT98), CRVP_OXYMI  (Q3SB06), 
CRVP_OXYSC  (Q3SB07), CRVP_PHIOL  (Q09GJ9), CRVP_PROFL  (Q8JI39), 
CRVP_PROJR  (Q7ZZN9), CRVP_PROMU  (P79845), CRVP_PSEAU  (Q8AVA4), 
CRVP_PSEPO  (Q8AVA3), CRVP_PSETE  (Q3SB05), CRVP_RHATT  (Q8JGT9), 
CRVP_SISCA  (B0VXV6), CRVP_TELDH  (Q2XXP5), CRVP_TRIBI  (Q2XXP4), 
CRVP_TRIST  (P60623), CRVP_VIPBE  (B7FDI1), CRVP_VIPBN  (B7FDI0), 
CUE3_CONIM  (P0DUB0), K1A_ANEER   (Q0EAE5), K1A_CRYAD   (E2S064), 
K1A_HETHE   (E2S065), K1A_STIGI   (E2S061), K1A_STIHA   (E2S062), 
K1A_STIHL   (P29187), K1A_STIME   (E2S063), K1A_THAAS   (E2S066), 
K1B1_BUNCI  (C0HJC2), K1B1_OULSP  (A0A330KW27), K1B2_BUNCI  (C0HJC3), 
K1B2_OULSP  (A0A330KUG5), K1B9A_ANEVI (P0DN00), K1B9C_ANEVI (P0DN02), 
K1B9D_ANEVI (P0DN03), K1BAA_ANEVI (P0DN04), K1BBA_ANEVI (P0DN05), 
K1B_ACTEQ   (P81897), K1B_ANESU   (Q9TWG1), K1B_BUNGR   (P29186), 
K1B_METSE   (P11495), MAB7_CAEEL  (Q95Q39), MFAP2_BOVIN (P27424), 
MFAP2_HUMAN (P55001), MFAP2_MOUSE (P55002), MLT7_CAEEL  (Q23490), 
MMP23_BOVIN (Q2TBM7), MMP23_HUMAN (O75900), MMP23_MOUSE (O88676), 
MMP23_RAT   (O88272), NAS10_CAEEL (Q21388), NAS11_CAEEL (Q21432), 
NAS12_CAEEL (Q9XTD6), NAS13_CAEEL (Q20191), NAS14_CAEEL (Q19269), 
NAS15_CAEEL (P55115), NAS31_CAEEL (Q7JLI1), NAS32_CAEEL (O16977), 
NAS6_CAEEL  (Q9U3S9), NAS7_CAEEL  (P55113), NAS8_CAEEL  (Q18439), 
NAS8_STECR  (D2KBH9), NAS9_CAEEL  (P91137), NEP4_NEMVE  (A7RNZ0), 
NEP8_NEMVE  (A7SXG9), P4H12_ARATH (Q8GXT7), P4H2_ARATH  (F4JAU3), 
P4H4_ARATH  (Q8LAN3), P4H7_ARATH  (Q8L970), SKPO1_CAEEL (Q20616), 
SRGT1_CHLRE (H3JU05), SURO1_CAEEL (Q9XU75), TES26_TOXCA (P54190), 
TYR1_CAEEL  (P34269), TYR3_CAEEL  (Q19673), YOFA_CAEEL  (Q09337), 
YOW6_CAEEL  (P30652), YP95_CAEEL  (Q09244), YS51_CAEEL  (Q09662)
» more

UniProtKB/Swiss-Prot
False negative sequences
10 sequences

CL8L_NEMVE  (P0DQR8), K1B9B_ANEVI (P0DN01), K1HH_ANESU  (P0DPF1), 
NEP3L_NEMVE (A7RJ13), NEP3_NEMVE  (A7RJ12), P4H6_ARATH  (F4J0A8), 
SHKL1_NEMVE (P0DQR6), SHKL2_NEMVE (A7SRR3), SHKL4_NEMVE (A7ST80), 
TX8E_ANEVI  (P0DMZ7)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
2 sequences

CRVP_BOTCO  (P0DMG5), CRVP_BOTFO  (P0DMG6)

		
PDB
[Detailed view]
29 PDB

1BEI; 1BGK; 1RC9; 1ROO; 1WVR; 1XTA; 1XX5; 2A05; 2CQ7; 2DDA; 2DDB; 2EPF; 2GIZ; 2K72; 2K9E; 2LG4; 3MZ8; 4LFQ; 4LFS; 4Z7P; 5I5A; 5I5B; 5I5C; 5WCV; 6BUC; 6CKD; 6CKF; 6IMF; 7OD2
» more