PROSITE logo

PROSITE entry PS51670


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] SHKT
Accession [info] PS51670
Entry type [info] MATRIX
Date [info] 01-MAR-2013 CREATED;
01-MAR-2013 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC51670
Associated ProRule [info] PRU01005

Name and characterization of the entry

Description [info] ShKT domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=35;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=35;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.4714091; R2=0.0058477; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=689; N_SCORE=7.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=518; N_SCORE=6.5; MODE=1; TEXT='RR';
/DEFAULT: M0=-50; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='C';  M= -91, 158,-111,-111,-101,-107,-111,-108,-107, -99, -99, -97,-122,-115,-113, -94, -91, -96,-131,-112;
/M: SY='K';  M= -14, -26,   0,  36, -45, -72, -34, -24,  36,   8, -32, -40, -17,   7,  24,   2,  35, -45,-106, -20;
/I:         I=-28; MD=-71;
/M: SY='H';  M=-117,-129,  20, -35, -67,-122,  80, -29, -59, -96,-108,  -2,-123, -25, -23, -50,-112, -23,-120,  51; D=-28;
/I:         I=-28; MD=-71;
/M: SY='E';  M=-111,-127, -91,  68,-123,-120, -47,-125, -23,-125,-119,  30, -61, -60,-105, -18, -19, -45,-128,   4; D=-28;
/I:         I=-28; MI=-71; IM=-71; DM=-71;
/M: SY='D';  M= -54,-105, 104, -70, -27, -90, -80, -57, -83, -72,-105,  84,-100, -84, -92, -82, -84,-107,-126, -98;
/M: SY='K';  M= -25,-106,  16,   9, -99,-101,  -6, -52,  57,   8, -29, -52,  20,  19,  28, -25,   7, -11,  -7, -48;
/I:         I=-26; MD=-65;
/M: SY='F';  M=  -1,-105, -57,-101,  78, -51,  33, -11, -24, -21, -85,   9,-110, -97, -18, -15, -35, -71, -84,  69; D=-26;
/I:         I=-26; MD=-65;
/M: SY='T';  M= -30,-100, -29, -53,  -4, -66, -16,  -2,  -8, -72, -18,  12, -17, -91, -95,  44,  76, -14,-113, -48; D=-26;
/I:         I=-26; MI=-65; MD=-65; IM=-65; DM=-65;
/M: SY='N';  M= -47,  14,  26, -15, -62, -90, -10, -10, -38, -69, -34,  98,-103, -40, -30,   8, -26, -31,  34, -29; D=-26;
/I:         I=-26; DM=-65;
/M: SY='C';  M= -91, 158,-111,-111,-101,-107,-111,-108,-107, -99, -99, -97,-122,-115,-113, -94, -91, -96,-131,-112;
/M: SY='P';  M=   1,-109,  29,  -2,-111,   4, -94,-106,  34, -81,-102,  32,  49, -35, -29,  -8,  14, -44,  17,-103;
/M: SY='D';  M=   2,-106,  47, -45, -18, -52,  29, -19, -29, -43, -11, -11, -36,  -6,  -8,  43,   5, -25, -16,   3;
/M: SY='W';  M= -65,-110,-114, -62,   0,-112,-104, -27, -32,  58,  22,  -9,-113, -50,-103, -66, -61, -36, 119,  14;
/M: SY='A';  M=  46,-102, -99, -24,-101, -99,-101, -10,  33, -38, -89, -93,-102, -16,  13,  -6,  19,  37,-112, -99;
/I:         I=-15; MD=-39;
/M: SY='K';  M=  -9,-112, -32, -25, -59, -28, -12,-108,  50, -41,-100,  -2, -52,  41,  21,  19, -12, -48,-114, -42; D=-15;
/I:         I=-15; MD=-39;
/M: SY='Q';  M= -55,-113, -65, -11, -20, -52, -38, -32,   5, -17, -20,  14,-107,  75,  20,   5,   3, -64,-111, -24; D=-15;
/I:         I=-15; MD=-39;
/M: SY='G';  M= -37,-120, -23,-110, -64,  48, -65, -75, -56, -40,-111,  23,-117, -14, -33,  13, -53, -14,-125, -60; D=-15;
/I:         I=-15; MD=-39;
/M: SY='M';  M= -78,-121, -57,   1,  13,  19, -13,-111,  -5,  -9,  20,   4,-118, -47,-108,  10, -41,-112, -15, -29; D=-15;
/I:         I=-15; MI=0; MD=-39; IM=0; DM=-39;
/M: SY='C';  M= -99, 150,-119,-119,-109,-114,-119,-116,-115,-107,-107,-105,-130,-122,-121,-101, -99,-103,-139,-120;
/M: SY='Q';  M= -97,-115, -18,  12, -58, -15,  20, -69,  26, -80, -57,  36,-104,  74,  21, -18, -13,-111,-116,-100;
/I:         I=-20; MI=0; MD=-50; IM=0; DM=-50;
/M: SY='H';  M= -69,-114,  48, -47, -52,-108,  51,-102, -10, -77,  38, -38,  13, -52, -45,  11,  26,  -6,-125, -29; D=-20;
/I:         I=-20; DM=-50;
/M: SY='E';  M= -88,-118,  14,  41, -63, -49, -97,-115,  37, -82,-108,  21,  22,  17, -19,  12, -68, -45,-121,-109; D=-20;
/I:         I=-20; DM=-50;
/M: SY='W';  M= -72,-117,-107,-100,  18, -50,  30, -97,  -7,   2, -91, -46,-113,  39, -31, -44, -14, -68,  98,  72;
/I:         I=-22; MI=0; MD=-57; IM=0; DM=-57;
/M: SY='M';  M= -66,-109, -75,-109, -42,-116, -99,  26, -40,   5, 109,-108, -52, -99,  -4,-106, -47,  15,-109,   1;
/M: SY='K';  M=  -6,-111, -47, -54, -37,-105, -34, -35,  59, -33, -12,   5, -57,  28,  26, -16,  12, -73,-111, -19;
/M: SY='S';  M=   6, -32, -36,  29, -55,-100, -33, -62,  13, -47, -34,  -5,-102,   0,  -8,  47,  26, -37,-117,-103;
/M: SY='N';  M= -79,-110,  -1, -65,  22, -55, -16, -49,  18,  -9, -97,  78,-110,   1, -20,  -3, -92,-104,  -1,  11;
/M: SY='C';  M= -99, 150,-119,-119,-109,-114,-119,-116,-115,-107,-107,-105,-130,-122,-121,-101, -99,-103,-139,-120;
/M: SY='P';  M=  26,-116,-101, -60,-118, -38,-101,-112,  33, -66, -40, -98,  71,  22,  30, -12, -96,-108,-115,-109;
/M: SY='A';  M=  61,-107,-101, -56, -36, -99,-103, -40,  58, -51, -99, -55,-106, -90,   4, -13, -68, -63,-113,-104;
/M: SY='T';  M= -36,-102, -97, -98, -56, -98,-103, -58, -97,-106,-102, -86,-101, -95,-103,  68,  86, -95,-123,-104;
/M: SY='C';  M=-100, 149,-120,-120,-110,-116,-120,-117,-116,-108,-108,-106,-131,-124,-122,-103,-100,-105,-140,-121;
/I:         I=-24; MD=-61;
/M: SY='G';  M=-115,-134, -21, -63, -17,  49, -40,-140, -19,-137,-128,  32,-128, -28, -26,-109,-119,-137,-134,-124; D=-24;
/I:         I=-24; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='F';  M= -70,-111, -61,-104,  68, -65, -37, -58,  20,  20,  -5, -57,-115,  -1, -23, -15,   7, -62, -13, -34;
/M: SY='C';  M=-102, 147,-122,-122,-112,-118,-122,-119,-118,-110,-110,-108,-133,-126,-124,-105,-102,-107,-142,-123;
/I:         E1=0; IE=-255; DE=-255;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.


Total number of hits 136 in 120 different sequences
Number of true positive hits 136 in 120 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 10
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 93.15 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 4
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] ShKT
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
120 sequences

1AK_HETMG   (O16846), AURE_AURAU  (Q0MWV8), CRIS1_HUMAN (P54107), 
CRIS1_MACMU (Q9XSD3), CRIS1_MOUSE (Q03401), CRIS1_RAT   (P12020), 
CRIS2_CAVPO (Q60477), CRIS2_HUMAN (P16562), CRIS2_MOUSE (P16563), 
CRIS3_HORSE (O19010), CRIS3_HUMAN (P54108), CRIS3_MOUSE (Q03402), 
CRIS_PROFL  (P0CB15), CRVP1_DISTY (Q2XXQ6), CRVP1_HYDHA (Q8UW25), 
CRVP1_NAJAT (Q7T1K6), CRVP1_NAJKA (P84805), CRVP1_PSEPL (Q2XXQ3), 
CRVP2_DISTY (Q2XXQ5), CRVP2_HYDHA (Q8UW11), CRVP2_NAJAT (Q7ZZN8), 
CRVP2_NAJKA (P84808), CRVP2_PSEPL (Q2XXQ2), CRVP3_DISTY (Q2XXQ4), 
CRVP5_VARAC (Q2XXR0), CRVPA_VARVA (Q2XXP2), CRVPB_VARVA (Q2XXP1), 
CRVP_AGKPI  (Q7ZTA0), CRVP_AUSSU  (A8S6B6), CRVP_CAURH  (A7X4T8), 
CRVP_CERRY  (D8VNS1), CRVP_CROAD  (F8S0Y4), CRVP_CROAT  (Q7ZT99), 
CRVP_DEMVE  (A6MFK9), CRVP_DRYCN  (F8J2D4), CRVP_ECHCO  (P0DMT4), 
CRVP_ERYPO  (Q2XXQ0), CRVP_GLOBL  (Q8JI40), CRVP_HELHO  (Q91055), 
CRVP_HOPST  (Q3SB03), CRVP_LATSE  (Q8JI38), CRVP_LEIMD  (Q2XXQ1), 
CRVP_NOTSC  (Q3SB04), CRVP_OPHHA  (Q7ZT98), CRVP_OXYMI  (Q3SB06), 
CRVP_OXYSC  (Q3SB07), CRVP_PHIOL  (Q09GJ9), CRVP_PROFL  (Q8JI39), 
CRVP_PROJR  (Q7ZZN9), CRVP_PROMU  (P79845), CRVP_PSEAU  (Q8AVA4), 
CRVP_PSEPO  (Q8AVA3), CRVP_PSETE  (Q3SB05), CRVP_RHATT  (Q8JGT9), 
CRVP_SISCA  (B0VXV6), CRVP_TELDH  (Q2XXP5), CRVP_TRIBI  (Q2XXP4), 
CRVP_TRIST  (P60623), CRVP_VIPBE  (B7FDI1), CRVP_VIPNI  (B7FDI0), 
CUE3_CONIM  (P0DUB0), K1A_ANEER   (Q0EAE5), K1A_CRYAD   (E2S064), 
K1A_HETHE   (E2S065), K1A_STIGI   (E2S061), K1A_STIHA   (E2S062), 
K1A_STIHL   (P29187), K1A_STIME   (E2S063), K1A_THAAS   (E2S066), 
K1B1_BUNCI  (C0HJC2), K1B1_OULSP  (A0A330KW27), K1B2_BUNCI  (C0HJC3), 
K1B2_OULSP  (A0A330KUG5), K1B9A_ANEVI (P0DN00), K1B9C_ANEVI (P0DN02), 
K1B9D_ANEVI (P0DN03), K1BAA_ANEVI (P0DN04), K1BBA_ANEVI (P0DN05), 
K1B_ACTEQ   (P81897), K1B_ANESU   (Q9TWG1), K1B_BUNGR   (P29186), 
K1B_METSE   (P11495), MAB7_CAEEL  (Q95Q39), MFAP2_BOVIN (P27424), 
MFAP2_HUMAN (P55001), MFAP2_MOUSE (P55002), MLT7_CAEEL  (Q23490), 
MMP23_BOVIN (Q2TBM7), MMP23_HUMAN (O75900), MMP23_MOUSE (O88676), 
MMP23_RAT   (O88272), NAS10_CAEEL (Q21388), NAS11_CAEEL (Q21432), 
NAS12_CAEEL (Q9XTD6), NAS13_CAEEL (Q20191), NAS14_CAEEL (Q19269), 
NAS15_CAEEL (P55115), NAS31_CAEEL (Q7JLI1), NAS32_CAEEL (O16977), 
NAS6_CAEEL  (Q9U3S9), NAS7_CAEEL  (P55113), NAS8_CAEEL  (Q18439), 
NAS8_STECR  (D2KBH9), NAS9_CAEEL  (P91137), NEP4_NEMVE  (A7RNZ0), 
NEP8_NEMVE  (A7SXG9), P4H12_ARATH (Q8GXT7), P4H2_ARATH  (F4JAU3), 
P4H4_ARATH  (Q8LAN3), P4H7_ARATH  (Q8L970), SKPO1_CAEEL (Q20616), 
SRGT1_CHLRE (H3JU05), SURO1_CAEEL (Q9XU75), TES26_TOXCA (P54190), 
TYR1_CAEEL  (P34269), TYR3_CAEEL  (Q19673), YOFA_CAEEL  (Q09337), 
YOW6_CAEEL  (P30652), YP95_CAEEL  (Q09244), YS51_CAEEL  (Q09662)
» more

UniProtKB/Swiss-Prot
False negative sequences
10 sequences

CL8L_NEMVE  (P0DQR8), K1B9B_ANEVI (P0DN01), K1HH_ANESU  (P0DPF1), 
NEP3L_NEMVE (A7RJ13), NEP3_NEMVE  (A7RJ12), P4H6_ARATH  (F4J0A8), 
SHKL1_NEMVE (P0DQR6), SHKL2_NEMVE (A7SRR3), SHKL4_NEMVE (A7ST80), 
TX8E_ANEVI  (P0DMZ7)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
2 sequences

CRVP_BOTCO  (P0DMG5), CRVP_BOTFO  (P0DMG6)

		
PDB
[Detailed view]
29 PDB

1BEI; 1BGK; 1RC9; 1ROO; 1WVR; 1XTA; 1XX5; 2A05; 2CQ7; 2DDA; 2DDB; 2EPF; 2GIZ; 2K72; 2K9E; 2LG4; 3MZ8; 4LFQ; 4LFS; 4Z7P; 5I5A; 5I5B; 5I5C; 5WCV; 6BUC; 6CKD; 6CKF; 6IMF; 7OD2
» more