We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS51810

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PURL: https://purl.expasy.org/prosite/signature/PS51810

Direct ScanProsite submission

General information about the entry

Entry name [info]	ZF_CCHC_FOG
Accession [info]	PS51810
Entry type [info]	MATRIX
Date [info]	01-SEP-2016 CREATED; 01-SEP-2016 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51810
Associated ProRule [info]	PRU01153

Name and characterization of the entry

Description [info]

Zinc finger CCHC FOG-type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=34;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=31;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.6549518; R2=0.0111699; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1553; N_SCORE=20.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=345; N_SCORE=6.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-68; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='P';  M=   2,-154,  -3, -18,  -2, -32, -61,  -1,  13,  -4, -24, -26,  42,   4, -47,  16,   4,   4,-156, -48;
/M: SY='P';  M=  -7,-155, -21, -14, -72, -11, -44, -39, -50, -30, -34,  -8,  60,   8,  13,  15,   6,  27,-161, -92;
/M: SY='P';  M=  15,-155,  18, -24, -61, -38, -35, -71,  30,  12, -52,  15,  42,   7, -11,   0, -18, -50,-158, -51;
/M: SY='P';  M=  13,-101, -37, -32,-148, -14,   4, -58,  -7, -10,   0, -40,  62,  43, -72,   7,   5, -11,-156,   0;
/M: SY='D';  M= -26, -96,  57, -68, -41,  24, -46, -54,   8, -34, -13,  29,  11,   6, -91,  16,  -8, -19,-160, -26;
/M: SY='Y';  M= -25, -81,  26, -36,-142,  12,  17, -11,  10, -59, -68, -27,   9,  44,   4, -31, -58,  12,-150,  50;
/M: SY='H';  M= -11, -88,-143,-139,  40,-150,  79, -83,  33, -14, -28, -21,-151,-134,  32,  10,  20, -87,-147,  33;
/M: SY='Y';  M= -47,-156, -77,  26,   8, -62,   5,  12,  15, -39,  11,-142,  14, -84, -27, -53,  20, -53,-136,  85;
/M: SY='C';  M=-141, 157,-161,-161,-152,-157,-161,-158, -76,-149,-149,-147,-171,-164,-162,-144, -78,-146,-181,-162;
/M: SY='K';  M=  12, -20, -25,  28,  12, -76, -58, -89,  40, -40,  -3, -56,   7,  21,  18,  -9,  19, -17,-155, -85;
/M: SY='E';  M=  42,-151,  27,  48, -74, -72,  -7,-143,-109, -24, -25, -29,  26, -40,-143,  21,   8,  -5,-161, -60;
/M: SY='C';  M=-141, 158,-161,-161,-151,-157,-161,-157,-157, -89,-148,-147,-172,-164,-163,-144,-141,-145,-181,-161;
/M: SY='D';  M=-139, -89,  69, -24, -67,  53, -18,-163,  28,-162,-153,  66,-148, -91, -11, -40,-137,-160,-164,-150;
/M: SY='I';  M=-145,-158,-167,-165,-130,-171,-167, 111,-160, -92,-117,-158,-156,-157,-163,-154,-139,   5,-156,-138;
/M: SY='W';  M= -56, -44,-142, -57,-151, -67, -27,-102,  26,-150,-144, -58, -96,  34,  50,  52,  35,   7,  60, -83;
/M: SY='F';  M=-157,-155,-168,-164, 122,-164,-145,-132,-159,-124,-133,-158,-168,-167,-156,-155,-149,-137,-121,  46;
/M: SY='N';  M= -56,  30,-133, -49,-111, -95,  -3,-130, -62,-121, -21,  77,-151, -51,  15,  65,  21,-150,-163,   5;
/M: SY='S';  M=-135,-152,-136, -87, -46,-121, -77,-155,  40,-121, -83,  48,-150, -84,  14,  80, -54,-151,-153,  41;
/M: SY='H';  M= -12,-154,-151,   5, -36,-158,  52,  12, -79,  41,  31, -57,   3, -36,-108, -66, -42,  23,-154,  20;
/M: SY='E';  M= -62,-156,  37,  62,-160,-145, -87,-157,  24,-158,-152,  41,-146, -86,   8,  46, -59, -33,-166,-151;
/M: SY='N';  M= -46,-147, -49,-141,-154, -95,-136,-147,-135, -65,-146,  99,-149,-137,-143,   2,  77, -51,-173,-151;
/M: SY='Y';  M=-153,-157,-161,-159,  67,-164,-135,-127,-155,  52,-123,-159,-167,-152,-152,-154,-147,-133,-124, 100;
/M: SY='Q';  M= -89,-157, -67,  -4, -87,-140, -94,  29, -17,  39, -12, -21,-155,  50,  25, -48,  -6, -14,-152,  20;
/M: SY='A';  M=  88, -66,-152,-145,-152, -61,-154, -37, -86,-141,-138,-146,-150,-145,-151,-127,   1,  37,-161,-151;
/M: SY='H';  M=-151,-163,-135,-136,-150,-153, 153,-168,-140,-151,-136, -31,-152,-129,-134,-141,-149,-168,-185,-119;
/M: SY='K';  M= -86,-160,-140,-126,-157, -79,-140, -83,  97, -14,-142,-134,-148,  59, -11,-139,-141, -54, -63,-146;
/M: SY='Q';  M= -11,-155, -97, -42,-120,-150,-138,-146,  59, -35,  60, -27,-148,  67,  28, -55,  37,-144,-157,-144;
/M: SY='Y';  M= -80,-159,-111,-151,  69,-157,  80,-139,-147, -26,-132,  -8,-162, -99, -77, -67,-146,-101,-125, 104;
/M: SY='Y';  M= -97,-109,-152,-154, -13,-158, -56,-139,-147,-135,-132,-152, -59, -91,-144, -38,-146,-143,-111, 136;
/M: SY='C';  M=-142, 156,-162,-162,-153,-158,-162,-160,-158,-151,-151,-148,-173,-166,-165, -70, -95,-147,-183,-163;
/M: SY='S';  M=  29, -72,-141,-105,-120, -68,-143, -90, -25, -76,-147, -18,  59,  12, -37,  76,  -9,-110,-161,-151;
/M: SY='S';  M=  32,-150,-140,-100,-156,  21,  40,-106,  33,-155,-147, -11,-110, -46, -93,  65,   8, -54,-162,-147;
/M: SY='R';  M= -34,-160,-142, -64,-156, -25,  46,-109,   0, -97,-111, -55, -64, -43,  99, -25,  14,-154,-160, -95;
/M: SY='H';  M=  10, -84, -78, -13, -63, -44,  73, -56, -20, -53, -35,  11,  41,  55,  16, -11,   1, -79, -15, -98;
/I:         E1=0; IE=-255; DE=-255;

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Post-processing [info]

COMPETES_HIT_WITH

PS50157; PS51811

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	32 in 7 different sequences
Number of true positive hits	32 in 7 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	5
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	ZN_FING
Feature description [info]	CCHC FOG-type
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

7 sequences

FOG1_DANRE  (P60622), FOG1_HUMAN  (Q8IX07), FOG1_MOUSE  (O35615),

FOG1_XENLA  (Q9I9K0), FOG2_HUMAN  (Q8WW38), FOG2_MOUSE  (Q8CCH7), 
USH_DROME   (Q9VPQ6)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

5 PDB

pdb_00001fu9; pdb_00001fv5; pdb_00001jn7; pdb_00001y0j; pdb_00002l6z