General rule information
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Accession |
PRU01153 |
Dates |
7-SEP-2016 (Created) 22-NOV-2019 (Last updated, Version 6) |
Predictors |
PROSITE; PS51810; ZF_CCHC_FOG
|
Name |
Zinc finger CCHC FOG-type |
Function |
Transcriptional cofactors of the Friend of GATA (FOG) family contain either eight or nine ZnFs that are related to the classical CCHH ZnFs (which have a conserved C-X(2,5)-C-X(12)-H-X(2,5)-H sequence). Several of the fingers in each FOG protein, however, have an altered consensus sequence in which the final zinc binding histidine is replaced with a cysteine. Interestingly, it is only these variant CCHC ZbFs that mediate interactions with GATA N-terminal zinc fingers (NFs). |
Propagated annotation
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Similarity |
Belongs to the FOG (Friend of GATA) family. |
GO:0006351; Biological process: transcription, DNA-templated.
case <Feature:PS51810:9=[CH]> and <Feature:PS51810:12=[CH]> and <Feature:PS51810:25=[CH]> and <Feature:PS51810:30=[CH]>
GO:0046872; Molecular function: metal ion binding.
end case
case <Feature:PS51810:9=C> and <Feature:PS51810:12=C> and <Feature:PS51810:25=H> and <Feature:PS51810:30=C>
From: PS51810 |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ZN_FING
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from
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to
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CCHC FOG-type #
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else case <Feature:PS51810:9=[CH]> and <Feature:PS51810:12=[CH]> and <Feature:PS51810:25=[CH]> and <Feature:PS51810:30=[CH]>
ZN_FING
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from
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to
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CCHC FOG-type #; atypical
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else
ZN_FING
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from
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to
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CCHC FOG-type #; degenerate
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end case
Additional information
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Size range |
24-44 amino acids |
Related rules |
None |
Repeats |
2-5 |
Topology |
Undefined |
Example |
Q9VPQ6 (USH_DROME) |
Scope |
Eukaryota; Metazoa |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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