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PRU01153


General rule information [?]

Accession PRU01153
Dates 7-SEP-2016 (Created)
19-NOV-2022 (Last updated, Version 10)
Data class Domain
Predictors PROSITE; PS51810; ZF_CCHC_FOG
Name Zinc finger CCHC FOG-type
Function Transcriptional cofactors of the Friend of GATA (FOG) family contain either eight or nine ZnFs that are related to the classical CCHH ZnFs (which have a conserved C-X(2,5)-C-X(12)-H-X(2,5)-H sequence). Several of the fingers in each FOG protein, however, have an altered consensus sequence in which the final zinc binding histidine is replaced with a cysteine. Interestingly, it is only these variant CCHC ZbFs that mediate interactions with GATA N-terminal zinc fingers (NFs).

Propagated annotation [?]


Comments [?]

Similarity Belongs to the FOG (Friend of GATA) family.

Gene Ontology [?]

GO:0006351; Biological process: DNA-templated transcription.
case <Feature:PS51810:9=[CH]> and <Feature:PS51810:12=[CH]> and <Feature:PS51810:25=[CH]> and <Feature:PS51810:30=[CH]>
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

Metal-binding
Zinc
end case

Transcription
Transcription regulation
Zinc-finger

Features [?]

case <Feature:PS51810:9=C> and <Feature:PS51810:12=C> and <Feature:PS51810:25=H> and <Feature:PS51810:30=C>
From: PS51810
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     from     to       CCHC FOG-type #        
else case <Feature:PS51810:9=[CH]> and <Feature:PS51810:12=[CH]> and <Feature:PS51810:25=[CH]> and <Feature:PS51810:30=[CH]>
ZN_FING     from     to       CCHC FOG-type #; atypical        
else
ZN_FING     from     to       CCHC FOG-type #; degenerate        
end case

BINDING     9     9       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     12     12       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     25     25       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     30     30       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1

Additional information [?]

Size range 24-44 amino acids
Related rules None
Repeats 2-5
Topology Undefined
Example Q9VPQ6 (USH_DROME)
Scope
Eukaryota; Metazoa
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]