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|
| annotation rule: PRU01153 |
General rule information
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| Accession | PRU01153 |
| Dates | 7-SEP-2016 (Created) 22-NOV-2019 (Last updated, Version 6) |
| Data class | Domain |
| Predictors | PROSITE; PS51810; ZF_CCHC_FOG |
| Name | Zinc finger CCHC FOG-type |
| Function | Transcriptional cofactors of the Friend of GATA (FOG) family contain either eight or nine ZnFs that are related to the classical CCHH ZnFs (which have a conserved C-X(2,5)-C-X(12)-H-X(2,5)-H sequence). Several of the fingers in each FOG protein, however, have an altered consensus sequence in which the final zinc binding histidine is replaced with a cysteine. Interestingly, it is only these variant CCHC ZbFs that mediate interactions with GATA N-terminal zinc fingers (NFs). |
Propagated annotation
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Comments
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| Similarity | Belongs to the FOG (Friend of GATA) family. |
Gene Ontology
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GO:0006351; Biological process: transcription, DNA-templated.
case <Feature:PS51810:9=[CH]> and <Feature:PS51810:12=[CH]> and <Feature:PS51810:25=[CH]> and <Feature:PS51810:30=[CH]>
GO:0046872; Molecular function: metal ion binding.
Keywords
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end case
Features
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case <Feature:PS51810:9=C> and <Feature:PS51810:12=C> and <Feature:PS51810:25=H> and <Feature:PS51810:30=C>
| From: PS51810 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ZN_FING | from | to | CCHC FOG-type # | |||||||||
else case <Feature:PS51810:9=[CH]> and <Feature:PS51810:12=[CH]> and <Feature:PS51810:25=[CH]> and <Feature:PS51810:30=[CH]>
else
end case
Additional information
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| Size range | 24-44 amino acids |
| Related rules | None |
| Repeats | 2-5 |
| Topology | Undefined |
| Example | Q9VPQ6 (USH_DROME) |
| Scope | Eukaryota; Metazoa |
| Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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