ProRule PRU01153

Accession	PRU01153
Dates	7-SEP-2016 (Created) 19-NOV-2022 (Last updated, Version 10)
Data class	Domain;
Predictors	PROSITE; PS51810; ZF_CCHC_FOG
Name	Zinc finger CCHC FOG-type
Function	Transcriptional cofactors of the Friend of GATA (FOG) family contain either eight or nine ZnFs that are related to the classical CCHH ZnFs (which have a conserved C-X(2,5)-C-X(12)-H-X(2,5)-H sequence). Several of the fingers in each FOG protein, however, have an altered consensus sequence in which the final zinc binding histidine is replaced with a cysteine. Interestingly, it is only these variant CCHC ZbFs that mediate interactions with GATA N-terminal zinc fingers (NFs).
Scope(s)	Eukaryota Metazoa
Example(s)	Q9VPQ6 (USH_DROME);

From: PS51810
Key	From	To	Description	Tag	Condition	FTGroup
case <Feature:PS51810:9=C> and <Feature:PS51810:12=C> and <Feature:PS51810:25=H> and <Feature:PS51810:30=C>
ZN_FING	from	to	/note="CCHC FOG-type #"
else case <Feature:PS51810:9=[CH]> and <Feature:PS51810:12=[CH]> and <Feature:PS51810:25=[CH]> and <Feature:PS51810:30=[CH]>
ZN_FING	from	to	/note="CCHC FOG-type #; atypical"
else
ZN_FING	from	to	/note="CCHC FOG-type #; degenerate"
end case
BINDING	9	9	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	12	12	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	25	25	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	30	30	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1