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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01153


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01153
General rule information [?]

Accession PRU01153
Dates 07-SEP-2016 (Created)
19-NOV-2022 (Last updated, Version 11)
Data class Domain;
Predictors PROSITE; PS51810; ZF_CCHC_FOG
Name Zinc finger CCHC FOG-type
Function Transcriptional cofactors of the Friend of GATA (FOG) family contain either eight or nine ZnFs that are related to the classical CCHH ZnFs (which have a conserved C-X(2,5)-C-X(12)-H-X(2,5)-H sequence). Several of the fingers in each FOG protein, however, have an altered consensus sequence in which the final zinc binding histidine is replaced with a cysteine. Interestingly, it is only these variant CCHC ZbFs that mediate interactions with GATA N-terminal zinc fingers (NFs).
Scope(s) Eukaryota
Metazoa
Example(s) Q9VPQ6;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the FOG (Friend of GATA) family.

Keywords [?]

Metal-binding
Zinc
end case
Transcription
Transcription regulation
Zinc-finger

Gene Ontology [?]

GO:0006351; Biological process:DNA-templated transcription
case <Feature:PS51810:9=[CH]> and <Feature:PS51810:12=[CH]> and <Feature:PS51810:25=[CH]> and <Feature:PS51810:30=[CH]>
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51810
Key From To Description Tag Condition FTGroup
case <Feature:PS51810:9=C> and <Feature:PS51810:12=C> and <Feature:PS51810:25=H> and <Feature:PS51810:30=C>
ZN_FING from to /note="CCHC FOG-type #"
else case <Feature:PS51810:9=[CH]> and <Feature:PS51810:12=[CH]> and <Feature:PS51810:25=[CH]> and <Feature:PS51810:30=[CH]>
ZN_FING from to /note="CCHC FOG-type #; atypical"
else
ZN_FING from to /note="CCHC FOG-type #; degenerate"
end case
BINDING 9 9 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 12 12 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 25 25 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 30 30 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 24-44 amino acids
Related rules None
Fusion None
Repeats 2-5
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]