ProRule PRU01153

General rule information [?]

Accession PRU01153
Dates 7-SEP-2016 (Created)
19-NOV-2022 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS51810; ZF_CCHC_FOG
Name Zinc finger CCHC FOG-type
Function Transcriptional cofactors of the Friend of GATA (FOG) family contain either eight or nine ZnFs that are related to the classical CCHH ZnFs (which have a conserved C-X(2,5)-C-X(12)-H-X(2,5)-H sequence). Several of the fingers in each FOG protein, however, have an altered consensus sequence in which the final zinc binding histidine is replaced with a cysteine. Interestingly, it is only these variant CCHC ZbFs that mediate interactions with GATA N-terminal zinc fingers (NFs).
Scope(s) Eukaryota
Example(s) Q9VPQ6 (USH_DROME);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the FOG (Friend of GATA) family.

Keywords [?]

Gene Ontology [?]

GO:0006351; Biological process:DNA-templated transcription
case <Feature:PS51810:9=[CH]> and <Feature:PS51810:12=[CH]> and <Feature:PS51810:25=[CH]> and <Feature:PS51810:30=[CH]>
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51810
Key From To Description Tag Condition FTGroup
case <Feature:PS51810:9=C> and <Feature:PS51810:12=C> and <Feature:PS51810:25=H> and <Feature:PS51810:30=C>
ZN_FING from to /note="CCHC FOG-type #"
else case <Feature:PS51810:9=[CH]> and <Feature:PS51810:12=[CH]> and <Feature:PS51810:25=[CH]> and <Feature:PS51810:30=[CH]>
ZN_FING from to /note="CCHC FOG-type #; atypical"
ZN_FING from to /note="CCHC FOG-type #; degenerate"
end case
BINDING 9 9 /ligand="Zn(2+)"
[CH] 1
BINDING 12 12 /ligand="Zn(2+)"
[CH] 1
BINDING 25 25 /ligand="Zn(2+)"
[CH] 1
BINDING 30 30 /ligand="Zn(2+)"
[CH] 1

Additional information [?]

Size range 24-44 amino acids
Related rules None
Fusion None
Repeats 2-5
Topology Undefined


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UniProtKB rule member sequences [?]