PROSITE entry PS51862

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51862
Entry name [info]	BSPN_CSAB
Accession [info]	PS51862
Entry type [info]	MATRIX
Date [info]	20-JUN-2018 CREATED; 07-APR-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51862
Associated ProRule [info]	PRU01209

Name and characterization of the entry

Description [info]

BetaSPN-type cysteine-stabilized alpha/beta (CS-alpha/beta) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=37;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=34;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.5954342; R2=0.0068160; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1355.9521484; R2=3.6597052; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=867; H_SCORE=4529; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=573; H_SCORE=3453; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-10; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='E';  M=-11,  9,-30, 15, 42,-33,-19,  6,-27,  9,-21,-13,  2, -5, 32,  3,  0,-10,-30,-27,-16, 37;
/M: SY='Y';  M=-15,-16,-24,-19,-15, 24,-25,  3, -2,-14,  1, -1,-13,-25,-10,-11,-12, -5, -8,  7, 40,-14;
/M: SY='G';  M= 11,-14,-22,-18,-16,-14, 21,-18,-17,-17, -9, -5, -9,-17,-14,-18, -3,-11,-12,-19,-17,-15;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='P';  M= -4,-20,-31,-17, -8,-19,-20,-18, -7,-12,-14, -2,-20, 49,-10,-19,-11, -9,-13,-26,-21,-12;
/M: SY='F';  M=  2,-25,-16,-31,-25, 20,-22,-23, 12,-22,  9,  6,-21,-25,-26,-20,-12, -5, 17,-14,  1,-24;
/I:         I=-12; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='I';  M= -8,-24,-23,-30,-24,  1,-31,-19, 25,-19,  9, 13,-20,-20,-17,-18,-14, -3, 20,-14,  5,-23;
/M: SY='E';  M= -5,  2,-24,  5, 18,-23,-12, -7,-19,  2,-17,-13,  1, -9,  6, -1,  3, -3,-15,-29,-17, 12;
/M: SY='K';  M= -5,  0,-27,  0, -1,-29, 14,-12,-32, 15,-30,-15,  4,-14, -1,  5,  1,-10,-23,-24,-19, -1;
/M: SY='W';  M=-16,-22,-32,-25,-21, 17,-21,-12, -8,-16, -4, -3,-20,-26,-15,-14,-23,-16,-14, 49, 25,-16;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E';  M=-10, 16,-28, 20, 36,-29,-14,  0,-28, 10,-23,-18, 10, -6, 15,  1,  2, -8,-28,-31,-18, 25;
/M: SY='D';  M=-13, 22,-28, 30, 13,-30,-14, -2,-30,  8,-24,-17,  9,-11, 10,  2, -2, -7,-25,-26,-13, 12;
/M: SY='H';  M=-14, -1,-28,  0,  0,-21,-16, 54,-27, -9,-23, -8,  5, -1,  3, -5, -3,-11,-26,-31,  3, -2;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='Q';  M= -3, -2,-26, -3, 10,-28, -4, -4,-21,  5,-17, -5, -2,-12, 17,  1, -2, -9,-21,-22,-15, 14;
/I:         I=-15; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='A';  M= 13, -9,-17,-15, -6,-16,-12,-15, -8, -7, -8, -7, -6,-13, -4, -5,  7,  6, -3,-25,-14, -6;
/M: SY='K';  M= -7, -3,-25, -2, 11,-22,-14,-10,-20, 16,-15, -7, -4,-12,  4,  7, -4, -6,-15,-25,-13,  7;
/M: SY='K';  M= -8,  7,-27,  5,  4,-28, -2, -3,-29, 21,-28,-14, 11,-14,  5, 13, -2, -9,-24,-25,-15,  5;
/M: SY='K';  M=  8, -3,-22, -6,  6,-24,-12, -3,-17,  9,-16, -4, -3,-11,  9,  1,  0, -6,-14,-23,-12,  7;
/M: SY='E';  M= -8, -6,-26, -6,  4,-18,-24,-15, -2,  4, -8, -3, -7,-13, -2, -4, -7, -7, -1,-25,-10, -1;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='K';  M=-12, -6,-27, -7,  0, -5,-23, -1,-13, 11,-14, -6, -4,-18,  0,  5,-10, -9,-12,-11, 10, -1;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='H';  M=-16, 11,-29, 17, 20,-26,-18, 52,-31, -3,-22,-11,  9,-13, 11, -2, -4,-14,-29,-32,  1, 12;
/M: SY='G';  M=  4, -2,-24, -4,-13,-22, 32,-15,-27,-16,-18,-15,  2,-18,-15,-17,  0,-12,-20,-23,-22,-14;
/M: SY='T';  M= -6,-11,-14,-20,-16, 12,-23,-18, -2,-16,  3,  1, -9,-17,-16,-13,  3, 25,  2,-20,  0,-15;
/M: SY='K';  M=-11,  7,-30, 11, 25,-30,-19, -6,-30, 34,-27,-14,  3, -7, 12, 18, -6,-10,-24,-25,-14, 19;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='K';  M= -7, -1,-27, -2,  7,-26,-19,-11,-23, 35,-25, -9,  0,-11,  7, 20, -5, -6,-15,-23,-11,  7;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='G';  M= -3, -8,-23, -8, -9,-16,  9,-15,-13,-16, -4, -5, -6,-19,-12,-15, -4, -8,-10,-26,-17,-11;
/M: SY='T';  M= -6,-11,-22,-15, -9,-15,-24,-19,  1,  3, -9, -1, -9, -9, -7, -3, -4,  5,  5,-25,-10, -9;
/M: SY='P';  M= -8,-17,-29,-13, -3,-16,-22,-17, -7,-11, -1, -4,-18, 26, -9,-15,-13, -9,-13,-26,-17, -8;
/M: SY='P';  M= -9,-18,-27,-17,-10,-12,-15,-16, -3,-15,  3,  1,-15, 11,-12,-13,-13, -9, -9,-25,-15,-13;
/M: SY='E';  M= -2,  6,-23,  9, 18,-27,  2, -7,-28,  2,-26,-19,  7, -9,  5, -4, 11, -2,-23,-31,-20, 11;
/M: SY='Y';  M=-18,-19,-28,-20,-18, 29,-28, 12, -3, -7, -3, -2,-17,-28,-11, -8,-17, -9,-10, 21, 63,-18;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	40 in 40 different sequences
Number of true positive hits	40 in 40 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	BetaSPN-type CS-alpha/beta
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

40 sequences

KA11N_SCOPC (P0DQN4), KBX11_LYCMC (P0CI49), KBX11_MESEU (A9XE60),

KBX12_MESEU (A9XE59), KBX17_LYCMC (D9U2A7), KBX1_ANDAU  (P69939), 
KBX1_BUTIS  (B8XH40), KBX1_MESGB  (A0A059UI30), KBX1_OLIMR  (Q9N661), 
KBX1_TITCO  (Q5G8A6), KBX1_TITDI  (Q0GY44), KBX1_TITSE  (P69940), 
KBX1_TITST  (P0C2F3), KBX1_TITTR  (Q0GY46), KBX21_LYCMC (P0CJ45), 
KBX22_LYCMC (D9U2B1), KBX23_LYCMC (P0CI42), KBX27_LYCMC (C6ZH27), 
KBX2_HOFGE  (Q0GY41), KBX2_LIOAU  (C7G3K3), KBX2_OLIMR  (Q9NJC6), 
KBX2_TITCO  (Q0GY42), KBX2_TITSE  (P86822), KBX2_TITST  (P0C8W4), 
KBX2_TITTR  (Q0GY45), KBX31_OPICA (Q5WR03), KBX31_UROYA (L0G8Z0), 
KBX32_HOFGE (P0C8W5), KBX32_OPICA (Q5WR01), KBX32_UROYA (L0GCW2), 
KBX33_OPICA (Q5WQZ7), KBX34_OPICA (Q5WQZ9), KBX3_EUSVA  (P0DL47), 
KBX3_HETLA  (P0C2F4), KBX3_HOFGE  (Q0GY40), KBX3_OPICY  (C5J891), 
KBX3_PANIM  (P56972), KIK2_TITDI  (Q0GY43), NDB51_MESEU (P0CH57), 
SMP76_SCOPA (P0DY18)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

6 PDB

5IPO; 5JYH; 7LGL; 7LGV; 7M1D; 7WKF