PROSITE entry PS51888

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General information about the entry

Entry name [info]	CLIP
Accession [info]	PS51888
Entry type [info]	MATRIX
Date [info]	08-MAY-2019 CREATED; 08-MAY-2019 DATA UPDATE; 27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51888
Associated ProRule [info]	PRU01236

Name and characterization of the entry

Description [info]

Clip domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=53;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=53;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.0961080; R2=0.0063122; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1094; N_SCORE=10.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=540; N_SCORE=6.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-41; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='P';  M= -11, -76,   2,  21,   7, -16, -59, -70,  -2, -20, -64, -57,  61, -52,  34,  40, -55, -68, -71,  10;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/M: SY='T';  M= -57, -72, -56, -54, -74,   9, -58, -18,   1, -70, -62,  33, -67,  40,  56,   0,  66, -63, -80, -65;
/I:         I=-33; MD=-84;
/M: SY='T';  M=  13, -67, -60, -63, -71, -67, -67, -58, -58, -66, -62,  33,   4, -62,   2, -45,  87,  15, -88, -69; D=-33;
/I:         I=-33; MD=-84;
/M: SY='P';  M= -14, -84, -66, -58, -84,   9, -66, -78, -54, -81, -70, -64,  95,   8,  43,  -2,   0, -76, -80, -77; D=-33;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='N';  M= -62, -75,  76, -49,   3,  -4, -54, -80, -57, -81, -76,  77, -72, -56, -64,  33, -53, -79, -91, -68; D=-33;
/I:         I=-33; DM=-84;
/M: SY='G';  M= -57, -79,  26,  -7, -84,  71, -63, -84, -58, -81, -72,   2, -69,  51, -10, -51,  24, -79, -81, -74; D=-33;
/I:         I=-33; DM=-84;
/M: SY='E';  M= -59, -75,   4,  53, -70,  25, -59,  -6,  16,  -1,  26,   4, -65,  13,   5, -55,  22, -62, -78, -66;
/M: SY='Q';  M=  21, -74, -55,   1, -79,  -9, -58, -75,  35, -75, -65,  22,  36,  54,  19,  19,   5, -70, -78, -68;
/M: SY='G';  M=  34, -73, -64, -68, -81,  89, -69, -83,  15, -81, -71, -52, -67, -62, -66, -48, -63, -75, -74, -75;
/M: SY='Q';  M= -58, -71, -59, -57, -62, -69, -58,  20,  -9, -24, -54,  43, -69,  52,  20,   2,  52,  11, -75,  18;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/M: SY='I';  M= -61, -73, -74,  -4, -53, -83, -72,  59,  22,  31,  27, -71, -74, -62,   1, -68, -58,  44, -76, -59;
/M: SY='P';  M= -57, -74, -58, -59, -71, -17,  46, -62, -57, -18, -61,  47,  71, -57,  -4,  43,   3,   9, -84, -66;
/M: SY='I';  M=  -9, -71, -78, -75,   8, -77, -70,  59, -73,  30, -41, -72, -76, -69, -74,  18, -55,  38, -66,  38;
/M: SY='Y';  M= -60, -75, -53,  35, -58, -68,  51,  -3,  -1, -18, -58,  29, -69, -48,  35,  34,  -3, -63, -69,  53;
/M: SY='D';  M= -10, -74,  64,  42, -79, -62, -54, -74, -48, -76, -70,  32, -65,  18,  22,  44, -51, -21, -86, -68;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/M: SY='P';  M= -60, -79,  25,  24, -77,   8, -59, -74,  41, -19, -65, -53,  51,  30,  27,  -3,   1, -72, -78, -69;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='Y';  M= -26, -73,   2, -65, -45, -70, -56,  34, -64, -14, -51,   9,  -1, -62, -67,  21,  37,  -3, -58,  81;
/M: SY='L';  M= -63, -72, -83, -76,  11, -84, -75,  48, -76,  56, -37, -79,  30, -74, -77, -72, -59,  42, -73, -55;
/M: SY='W';  M= -18, -76,   2,  33,  29, -77, -60, -53, -55,  47, -48, -68, -75, -56,  42, -66, -64, -57,  59,  34;
/M: SY='E';  M=   6, -77,  43,  61, -83,  26, -56, -81,   0, -77, -70,   6, -63,  55, -54,  -3, -58, -75, -80, -70;
/M: SY='Y';  M= -62, -73, -72, -67, -43, -78, -58,  14,  -4,  33,  19, -68, -76,  13,   0, -11,   5,  27, -59,  72;
/I:         I=-17; MD=-44;
/M: SY='L';  M= -67, -74, -85, -78, -47, -89, -74,  45, -74,  70, -35, -82, -83, -72,   1, -77, -63,  18, -76, -58; D=-17;
/I:         I=-17; MD=-44;
/M: SY='K';  M= -62, -75, -59, -52, -73, -71, -59, -60,  64, -24,  20,  40, -70,  50,   2, -56,  19,  16, -81, -66; D=-17;
/I:         I=-17; MD=-44;
/M: SY='T';  M= -63, -77,   8,  -3, -81, -72,  30, -73,  -8, -76, -70,  24, -72,  38, -63,  17,  62, -17, -94, -71; D=-17;
/I:         I=-17; MD=-44;
/M: SY='P';  M= -16, -91,  -3,  14, -97,  13, -77, -94, -72, -94, -86, -68,  33,  23, -78,  31, -12, -88, -97, -88; D=-17;
/I:         I=-17; MD=-44;
/M: SY='N';  M= -86,-102,   0, -12, -91,   8, -78, -95, -78, -31, -87,  30,  24,   9, -22, -79, -83, -97, -96,  10; D=-17;
/I:         I=-17; MI=0; MD=-44; IM=0; DM=-44;
/M: SY='T';  M= -20, -88,  25, -73, -95, -81, -82, -90, -75, -93, -87, -67,   5, -76, -15,  33,  52, -83,-106, -88; D=-17;
/I:         I=-17; DM=-44;
/M: SY='P';  M= -17, -97,  -9,  16, -95,   7,  66, -94, -72, -92, -81, -70,  70,  -7, -78, -71, -76, -92, -97, -80; D=-17;
/I:         I=-17; DM=-44;
/M: SY='E';  M=  19, -78,   4,  55, -78, -67, -59, -79, -55, -78, -71,   9, -69,  48, -61,  33,  -9, -74, -80,  14; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -21, -82,  72, -56, -74,  38, -64,  -5, -66, -21, -69,   7, -76,   7, -72, -61, -65, -18, -84,  13; D=-17;
/I:         I=-17; DM=-44;
/M: SY='T';  M=   5, -76, -69, -21, -65, -77, -68,  28, -57, -19, -58,  10, -75, -62,  46, -58,  50,  -7, -79,  15; D=-17;
/I:         I=-17; DM=-44;
/M: SY='R';  M= -66, -76,  -7, -66,  26, -75, -66, -10, -19,  15, -58,  32, -78, -63,  36,  19,  24, -13, -80, -60; D=-17;
/I:         I=-17; DM=-44;
/M: SY='F';  M= -73, -79,  22, -71,  68, -81,  23, -58, -74,  18, -55, -69, -84, -72, -73,  -7,  -1, -62, -56,  67; D=-17;
/I:         I=-17; DM=-44;
/M: SY='L';  M= -67, -71, -83, -78, -47, -87, -73,  19, -78,  76, -35, -79, -82, -73, -77, -71,  26,  -4, -77, -58; D=-17;
/I:         I=-17; DM=-44;
/M: SY='R';  M= -59, -77,   5,  -3, -78, -66, -53, -80,   5, -76, -66,  10, -69,  38,  86,  43, -55, -74, -79, -64;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='A';  M=  42, -71, -13,  -1, -73,  27, -65,  -3,  17, -66, -61,   7,  14,   5,  -8, -51,   2,  15, -79, -69;
/M: SY='S';  M=  -9, -68,   6, -58, -67, -58, -61, -59, -60,  16, -59,  30,  35, -55, -65,  77, -45,  -5, -82, -66;
/M: SY='Q';  M= -58, -75, -60,  19, -66, -72,  28,  22,  -2,   6, -50, -58, -69,  82, -54,  19, -56,  28, -77, -60;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/M: SY='G';  M= -52, -75, -59,  17, -78,  80, -65, -79, -11, -24, -68, -52, -67,  11,   3,   2,   2, -75, -75, -72;
/I:         I=-17; MD=-42;
/M: SY='Y';  M= -66, -77,  27,  -5,  48, -14,  31, -63, -66,   2, -58, -61, -76, -64, -69,  14,  13, -65,  61,  61; D=-17;
/I:         I=-17; MD=-42;
/M: SY='R';  M= -73, -89,  -3,  33,   0,  27, -71, -85, -19, -24, -76,  12, -81, -63,  38, -68, -13, -83, -88, -75; D=-17;
/I:         I=-17; MI=0; MD=-42; IM=0; DM=-42;
/M: SY='N';  M=  11, -74,   1, -60, -80,  31, -58, -77,  -3, -23, -70,  82, -74,  17, -62,  -4, -57, -75, -87, -74; D=-17;
/I:         I=-17; DM=-42;
/M: SY='W';  M= -63, -82, -62,  -6, -78,  51, -65, -10, -53, -80, -72,  47,   8, -58,  52, -20, -65, -77,  54, -71; D=-17;
/I:         I=-17; MI=0; MD=-42; IM=0; DM=-42;
/M: SY='Q';  M= -57, -74, -56,   0, -63,  11, -55,  -4, -10, -63, -58,  46, -70,  66,  -2,  -3,   2,  24, -71,  37;
/M: SY='P';  M= -17, -82, -63,  22, -66, -72, -64,  -9, -58,   0, -57, -69,  94,  11,  -2, -62, -59,   6, -73,  18;
/M: SY='I';  M= -26, -74,  23, -61, -54, -76,  26,  46,  19,  34, -44, -62, -73,   8, -61,  -8, -57,  20, -73,  15;
/M: SY='V';  M= -58, -70, -85, -80,  31, -86, -82,  61, -77,  -7, -40, -78, -78, -78, -78, -70, -55,  78, -75, -53;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/I:         E1=0; IE=-380; DE=-380;

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Post-processing [info]

PROMOTED_BY

PS50240

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.

Total number of hits	24 in 23 different sequences
Number of true positive hits	24 in 23 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	4
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	85.71 %

Comments [info]

Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	2
Feature key [info]	DOMAIN
Feature description [info]	Clip
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

23 sequences

CFB_TACTR   (Q27081), CLB10_ANOGA (Q7QBP4), CLB14_ANOGA (Q9NAS8),

CLB15_ANOGA (Q9NAS9), CLB4_ANOGA  (Q7PEV7), CLB9_ANOGA  (F5HKX0), 
CLC9_ANOGA  (A0A1S4GMJ4), EAST_DROME  (P13582), GRASS_DROME (Q9VB68), 
HAYAN_DROME (A8JUP7), HP8_BOMMO   (Q2VG86), MP1_DROME   (A0A126GUP6), 
PCE_TACTR   (P21902), PPAE1_SPOLT (Q49QW1), PPAE_BOMMO  (Q9XXV0), 
PPAF1_HOLDI (O97366), PPAF2_HOLDI (Q9GRW0), PPAF3_HOLDI (Q8I6K0), 
PSH_DROME   (Q9VWU1), SER7_DROME  (Q9V3Z2), SNAK_DROME  (P05049), 
SPE_DROME   (Q9VCJ8), VSP_BOMIG   (B5U2W0)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

4 sequences

CLA28_ANOGA (A0A1S4H5M5), CLA30_ANOGA (A0A1S4HE51), CLA8_ANOGA  (A0A1S4H5S2),

CLB8_ANOGA  (Q8MZM7)

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PDB
[Detailed view]

2 PDB

2B9L; 2XXL