PROSITE entry PS51913

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PURL: https://purl.expasy.org/prosite/signature/PS51913

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General information about the entry

Entry name [info]	HTH_HARE
Accession [info]	PS51913
Entry type [info]	MATRIX
Date [info]	22-APR-2020 CREATED; 07-APR-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51913
Associated ProRule [info]	PRU01261

Name and characterization of the entry

Description [info]

HARE-type HTH domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=70;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=65;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1870663; R2=0.0071568; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=9651.2480469; R2=2.2973452; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1162; H_SCORE=12321; N_SCORE=10.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=603; H_SCORE=11037; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-23; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='M';  M= -41, -53, -52, -24,  -8, -17, -58, -21,  31,  20,  87, -15, -19, -44,  12,  -6, -23, -28, -69,  21;
/M: SY='S';  M=  -2, -66, -29, -47, -52, -26, -22, -52, -32, -55, -64,   1, -11,  -9, -18,  70,  68, -60, -83, -66;
/M: SY='W';  M= -24, -73, -55, -19,  55, -76, -43,  -4, -31,  27,  64,  -1, -58, -25, -67, -56, -41,  -1,  76,  33;
/M: SY='I';  M=  -7, -72, -73, -37, -31, -46, -11,  46,  11,  38,  10, -34, -45, -62,   4, -38,  -3,  22, -74, -25;
/M: SY='D';  M= -28, -79,  79,  74, -30, -57, -54, -64, -26, -77, -49,  11, -50,   1, -40, -23, -45, -67, -42, -69;
/M: SY='A';  M=  51, -68, -75, -68, -15, -51, -34,  36, -31,  32,  20, -51, -49, -26, -54, -22, -15,   5,  25, -58;
/M: SY='A';  M=  84, -16, -51, -63, -54, -35, -71,  23, -65, -54, -56, -44, -68, -62, -69, -16, -18,   5, -77, -68;
/M: SY='Y';  M= -33, -78, -49,  35,  25, -76,  21,  21,  12, -29, -52, -28, -49,  -6, -34, -52, -35,  -9,   0,  84;
/M: SY='E';  M=  -1, -43,  24,  55, -56, -61,  18,  -2,  27, -23,   0, -14, -65,  24,  12, -34,  -6, -20, -79, -47;
/M: SY='V';  M= -14, -70, -81, -77,   2, -82, -76,  58, -61,  12, -22, -75, -77, -73, -75, -35, -39,  68, -72,  16;
/M: SY='L';  M= -22, -69, -82, -45, -19, -83, -68,   6, -76,  84,  24, -81, -81, -69, -74, -74, -62, -33, -71, -53;
/M: SY='K';  M=  -4, -75, -25,  45, -75, -53, -27, -35,  54, -38, -63, -16, -65,  28,  38,  13,  -6, -39, -77, -48;
/M: SY='E';  M=   3, -76,  29,  66, -54, -56,  -9, -40,  17, -46, -65,  20, -63,  39,   9, -13, -21, -44, -80, -67;
/M: SY='K';  M=  26, -27, -34,  31, -26, -49,   5, -25,  34, -52, -62,  28, -32,  10,  -4,  23,  -2, -16, -76, -12;
/M: SY='G';  M= -41, -76,   7,  -7,  -8,  54,  -2, -65,  49, -77, -68,  25, -17,  13,   7,  -8, -27, -75, -76, -65;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='K';  M= -45, -34, -25,  45, -43, -10, -10, -75,  48, -73, -26,  14, -34,  37,  38, -29,  18, -42, -78, -46; D=-31;
/I:         I=-31; DM=-79;
/M: SY='P';  M=   7, -82, -49, -18, -43,  -8, -67, -72, -27, -70, -68, -27, 107, -32, -69,   8, -29, -55, -17, -53;
/M: SY='M';  M= -19, -69, -62, -72,  18, -78, -63,   6, -47,  50,  96, -72, -76, -17, -69, -45,  -9,   0, -69,  -9;
/M: SY='H';  M= -38, -71,   1, -10, -69, -54,  91, -72, -17, -58, -62,  29,  -4, -51, -19,  41,  50, -51, -85,   0;
/M: SY='F';  M=   5,   5, -76, -73,  72, -66,   7,  14, -71, -10, -49, -71,   8, -71, -71, -23, -33,  11, -51,  69;
/M: SY='K';  M= -12, -75, -13,  14, -48, -30,  -5, -48,  45, -37, -43,  39, -36,  26,  32,  11, -23, -47, -71,  32;
/M: SY='E';  M= -10, -78,  56,  79, -81, -56, -55, -77,   0, -75, -41, -16, -61,  33, -43, -26, -11, -34, -23, -69;
/M: SY='I';  M= -65, -74, -85, -81, -25, -88, -78,  87, -78,  44,  28, -78, -77, -73, -79, -74, -59,   5, -73, -55;
/M: SY='W';  M=  10, -33, -79, -72,  20, -58, -41,  19, -37,  21,  20, -72, -75, -53, -62, -37,  25,  10, 112,   3;
/M: SY='E';  M=  -4, -76,  48,  55, -79, -34,   6, -78,  32, -63, -68,  29, -64,  37,  -7,  -5, -28, -60, -82, -42;
/M: SY='E';  M=  -4, -51, -32,  45, -66, -72,  13,   8,  34, -16, -10, -27, -67,  32,  34, -34, -38,   1, -74,   6;
/M: SY='I';  M=  35, -45, -78, -74, -46, -20, -77,  66, -72,  -9,  19, -70, -73, -69, -75, -29, -17,  44,  -1, -60;
/M: SY='Q';  M=  13,  15, -63,   9, -26, -53, -41,  13,  20,  12, -19, -12, -70,  47, -44,  -3,  -5,  16,   6, -35;
/M: SY='E';  M=  10, -75,  29,  55, -79, -41, -56, -55,  45, -60, -49,  -6, -45,  27,  20,   0, -16, -52, -79, -68;
/M: SY='K';  M= -14, -45,  -7,  15, -13, -27,  -6,  -9,  30,  21,   8,  15, -70,  11,  25,  -4, -27, -17, -75, -28;
/M: SY='G';  M= -23, -74, -10, -22, -41,  59, -22, -40,  32,   0,  16,  30, -69, -12,  -7, -15, -51, -44, -75, -25;
/M: SY='L';  M= -42, -34, -21, -13,   1,  27,  -3, -27,  -8,  48,   7,   7, -23,  15, -49, -36, -47, -31,  -7,  16;
/M: SY='W';  M= -20, -74,  24, -36,  16, -65,  -8,  12,   7,   9,  -8, -40, -73,  -9,  19, -14,  -1,  14,  57,  30;
/M: SY='S';  M= -32, -21,  34,  16, -36, -49, -26, -37,  27, -43, -65,  16,  14,  14, -10,  41,  33, -42, -82, -66;
/I:         I=-19; MD=-49;
/M: SY='W';  M= -72, -60, -17, -26, -25, -62,  -8, -46,  -3, -39, -45, -37, -24, -27, -23,   9,  -5, -40,  33, -83; D=-19;
/I:         I=-19; MI=0; MD=-49; IM=0; DM=-49;
/M: SY='G';  M= -47,-103, -61, -99, -45,  52, -35,-104, -77, -78, -97, -31, -67, -93, -71, -12, -58, -51,-102, -31; D=-19;
/I:         I=-19; DM=-49;
/M: SY='K';  M=  -3, -75,   3,  24, -23, -47, -10, -40,  63, -27, -24,  -3,  -1,  20, -11,   1,  -4, -33,   9, -36;
/M: SY='T';  M= -13, -69,  30,  36, -74, -24, -10, -55,  -3, -70, -24,  29, -63,  -2, -33,  14,  69, -41, -85, -67;
/M: SY='P';  M= -29, -18,  21,  22, -57, -59, -62, -34, -25, -57, -66, -19,  89,  36, -15,  -2, -11, -29, -25, -32;
/M: SY='W';  M=   4,  -8,   0,  34, -30, -38,  -8,   4,   5,   5, -20, -26, -22,  -4,  10,  -9, -20,  11,  59, -43;
/M: SY='A';  M=  43, -70,   1,  18, -76, -50, -16, -45,  27, -54, -19,  24,  -4,  24,   3,  10,  16, -43, -80, -67;
/M: SY='T';  M=  -7,  14,   8,   7, -69, -53, -22, -14, -15, -31, -17,  -2, -65,  22, -12,  32,  66, -19, -82, -37;
/M: SY='L';  M=   5, -71, -55, -44, -24, -74, -65,   8,   5,  39,  36, -14, -14,  -9,  15, -23, -40,  30,   7, -19;
/M: SY='I';  M=  15, -32, -52, -23, -50,   1, -40,  39, -14,  -2,  18,  33, -71,  16,   3,   2, -25, -13, -22,  11;
/I:         I=-42; MD=-106;
/M: SY='A';  M=  63, -69, -65, -34, -75,  12, -41, -29, -63, -52, -65, -15, -56,  -2, -34,  35,  11, -27, -36, -46; D=-42;
/I:         I=-42; MD=-106;
/M: SY='Q';  M=  -3, -81, -20,  13, -36, -44, -14, -37,  -8, -34,  20, -11, -74,  55,  40,   2,  -8, -33, -81, -29; D=-42;
/I:         I=-42; MI=-106; IM=-106; DM=-106;
/M: SY='L';  M= -51, -71, -84, -78,  53, -85, -18,  48, -77,  62,  -8, -79, -81, -74, -58, -74, -62,   6, -65, -27;
/M: SY='Y';  M= -11, -42, -48, -56,   3, -35,  40, -36, -51, -20, -53,  -3, -76, -37, -46,  19, -20, -46,   2, 106;
/M: SY='T';  M=  -2, -42, -37, -14, -67, -35, -24, -37, -22, -23,  13,  -3, -66,   2,  30,   8,  73,   9, -82, -64;
/M: SY='D';  M= -30, -45,  82,  37, -54, -45,   7, -45, -35, -23, -34,  13, -66,  20,  -2,  -2, -18, -62, -86, -34;
/M: SY='M';  M= -27,  -9, -79, -63, -29, -79, -71,  61, -50,  45,  61, -42, -54, -68, -73,  -1, -14,   1, -75, -56;
/I:         I=-23; MI=0; MD=-58; IM=0; DM=-58;
/M: SY='N';  M= -35, -73, -26, -64, -74,  34, -37, -32, -14, -30,  -8,  72, -30, -26, -12,   5,  24, -12, -23, -70; D=-23;
/I:         I=-23; DM=-58;
/M: SY='E';  M= -13, -76,  11,  25, -67, -16, -13,   2,  -4,  20,  14, -24,  12,  24,  -8, -41,  -4,   0, -81, -65; D=-23;
/I:         I=-23; DM=-58;
/M: SY='D';  M= -20, -40,  92,  13, -65, -26,  -5, -82,  -1, -68, -56,   9, -31, -15, -35,  13, -34, -78, -93, -70; D=-23;
/I:         I=-23; DM=-58;
/M: SY='S';  M=  -1, -44, -13, -59, -58,  43, -36, -63,  -3, -76, -49,  13,  15, -17, -11,  61,  11, -45, -80, -70; D=-23;
/I:         I=-23; DM=-58;
/M: SY='R';  M= -23, -54, -28, -20, -69, -74, -58,  -2,   7,  -7, -34, -27,  13, -16,  88, -23, -10, -33, -22, -44;
/M: SY='F';  M= -73, -71, -87, -81, 117, -70, -68, -36, -77, -17, -28, -76, -85, -37, -75, -73, -66, -13, -43,  -9;
/M: SY='V';  M=   0, -26, -53, -18,   4, -65, -48,  45, -11,  -2,  14, -69, -74, -37, -14, -44,  -8,  52, -21,  26;
/M: SY='R';  M= -25,  15, -63, -55,   3, -71,  13, -34,  49, -13, -26, -22, -18,   1,  59,  10, -18, -36, -69,  25;
/M: SY='V';  M=  -9,   2, -71, -39, -21, -65, -46,  22, -52,  25,   4, -14, -57, -31, -47, -31,  44,  52, -78, -15;
/I:         I=-31; MD=-79;
/M: SY='G';  M=  15, -74,  -3,   6, -65,  70, -10, -50, -18, -79, -71, -10, -25,  -8, -37,  24, -33, -74, -78, -72; D=-31;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='P';  M= -32, -79,  45,  31, -54, -44, -25, -77,  13, -61, -41,  24,  69, -13,  26,   2, -22, -75, -82, -70;
/M: SY='G';  M=  -5, -73,  10, -42, -60,  69, -20, -61, -32, -69, -69,  60, -68,  -1, -32,  -5,  -5, -51, -79, -38;
/M: SY='T';  M= -60, -41, -62,   4, -25, -48,   0, -10,  27,  10,  12, -21, -70,  16,  38, -23,  40,   4,  -7,   8;
/M: SY='W';  M= -60, -84, -89, -79,  73, -77, -70, -40, -72, -46,  -7, -83, -82, -51, -72, -75, -74, -51, 144,  67;
/M: SY='G';  M=  39,  -3,   0, -29,   5,  58, -67, -30, -20, -61, -25, -43, -69, -18, -26,   1,  -5, -65,  43, -25;
/M: SY='L';  M= -50, -26, -83, -76, -42, -84, -41,   9, -77,  85, -30, -81, -82, -70, -75, -45, -40, -12, -72, -38;
/M: SY='R';  M= -24, -43, -27, -50, -51, -69, -56, -52,  62, -56, -43,   3, -69, -16,  77,   8,   0, -35, -75, -28;
/M: SY='E';  M=  15, -72,  22,  56, -76, -12, -32, -33,  13, -61, -66,   1, -39, -17, -11,  39,  -5, -22, -81, -69;
/M: SY='W';  M= -42, -47, -11, -11,   4, -29, -67, -25, -14,  -8,  -5,  17, -20,   0,  21,  -4, -32, -68, 130,   3;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	98 in 98 different sequences
Number of true positive hits	98 in 98 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	HTH HARE-type
Version [info]	2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

98 sequences

ASXL1_HUMAN (Q8IXJ9), ASXL1_MOUSE (P59598), ASXL2_CHICK (Q5ZM88),

ASXL2_HUMAN (Q76L83), ASXL2_MOUSE (Q8BZ32), ASXL3_HUMAN (Q9C0F0), 
ASXL3_MOUSE (Q8C4A5), RLT1_ARATH  (F4HY56), RLT2_ARATH  (Q9FFH1), 
RPOE_BACAH  (A0RLC4), RPOE_BACAN  (Q81JW0), RPOE_BACC1  (Q72XA8), 
RPOE_BACC2  (B7IQZ2), RPOE_BACC4  (B7HFN7), RPOE_BACC7  (B7HY99), 
RPOE_BACCQ  (B9IRX2), RPOE_BACCR  (Q814T1), RPOE_BACCZ  (Q630Q9), 
RPOE_BACHK  (Q6HAU4), RPOE_BACLD  (Q65DT6), RPOE_BACP2  (A8FIE6), 
RPOE_BACSU  (P12464), RPOE_BACVZ  (A7Z9T5), RPOE_HALH5  (Q9K6D6), 
RPOE_LACAC  (Q5FME7), RPOE_LACDA  (Q1GBQ3), RPOE_LACDB  (Q04C52), 
RPOE_LACJO  (Q74LG3), RPOE_LACLA  (Q9CHT4), RPOE_LACLM  (A2RIW1), 
RPOE_LACLS  (Q030Z9), RPOE_LACPL  (Q88Z77), RPOE_LEUCK  (B1MXM6), 
RPOE_LEUMM  (Q03YU3), RPOE_LIGS1  (Q1WV31), RPOE_LIMF3  (B2GA55), 
RPOE_LIMRD  (A5VI25), RPOE_LIMRJ  (B2G5K4), RPOE_LISIN  (Q927T3), 
RPOE_LISMF  (Q71WL9), RPOE_LISMO  (Q8Y494), RPOE_LISW6  (A0ALP6), 
RPOE_MACCJ  (B9E8H2), RPOE_MYCGE  (P47268), RPOE_MYCPN  (P75090), 
RPOE_OCEIH  (Q8EM52), RPOE_OENOB  (Q04D45), RPOE_PEDPA  (Q03DX9), 
RPOE_SHOC1  (Q5WB42), RPOE_STAA1  (A7X4Y0), RPOE_STAA2  (A6U3L3), 
RPOE_STAA3  (Q2FF00), RPOE_STAA8  (Q2FWD0), RPOE_STAA9  (A5IUS3), 
RPOE_STAAB  (Q2YUM5), RPOE_STAAC  (Q5HE72), RPOE_STAAE  (A6QIX2), 
RPOE_STAAM  (P66714), RPOE_STAAN  (P66715), RPOE_STAAR  (Q6GEU7), 
RPOE_STAAS  (Q6G7I2), RPOE_STAAT  (A8YY93), RPOE_STAAW  (P66716), 
RPOE_STACT  (B9DMC7), RPOE_STAEQ  (Q5HM94), RPOE_STAES  (Q8CRM5), 
RPOE_STAS1  (Q49Z74), RPOE_STRA1  (Q3K3S3), RPOE_STRA3  (Q8E7P9), 
RPOE_STRA5  (Q8E291), RPOE_STRE4  (C0M8K7), RPOE_STRGC  (A8AVB9), 
RPOE_STRMU  (Q8DWG2), RPOE_STRP1  (P66719), RPOE_STRP2  (Q04LZ9), 
RPOE_STRP3  (P0DF34), RPOE_STRP4  (B5E1U3), RPOE_STRP6  (Q5XA09), 
RPOE_STRP7  (C1C5L8), RPOE_STRP8  (Q8NZF7), RPOE_STRPG  (A2RCL2), 
RPOE_STRPI  (B1IA31), RPOE_STRPJ  (B8ZLX1), RPOE_STRPN  (P66717), 
RPOE_STRPQ  (P0DF35), RPOE_STRPS  (B2IM97), RPOE_STRR6  (P66718), 
RPOE_STRS2  (A4VZE7), RPOE_STRS7  (C0MFQ8), RPOE_STRSY  (A4VT63), 
RPOE_STRT1  (Q5M1S8), RPOE_STRT2  (Q5M6C1), RPOE_STRTD  (Q03MQ8), 
RPOE_STRU0  (B9DTJ7), RPOE_STRZJ  (C1CCN9), RPOE_STRZP  (C1CIY6), 
RPOE_STRZT  (C1CQ00), RPOE_UREPA  (Q9PPP2)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

13 PDB

2KRC; 2M4K; 4NC7; 4NC8; 6ZCA; 6ZFB; 7F75; 8H1T; 8SVF; 8X6G; 8XA6; 8XA7;
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