PROSITE entry PS51913
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General information about the entry
| PURL [info] | https://purl.expasy.org/prosite/signature/PS51913 |
| Entry name [info] | HTH_HARE |
| Accession [info] | PS51913 |
| Entry type [info] | MATRIX |
| Date [info] |
22-APR-2020 CREATED;
07-APR-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51913 |
| Associated ProRule [info] | PRU01261 |
Name and characterization of the entry
| Description [info] | HARE-type HTH domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=70; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=65; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1870663; R2=0.0071568; TEXT='-LogE'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=9651.2480469; R2=2.2973452; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=1162; H_SCORE=12321; N_SCORE=10.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=603; H_SCORE=11037; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-23; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='M'; M= -41, -53, -52, -24, -8, -17, -58, -21, 31, 20, 87, -15, -19, -44, 12, -6, -23, -28, -69, 21; /M: SY='S'; M= -2, -66, -29, -47, -52, -26, -22, -52, -32, -55, -64, 1, -11, -9, -18, 70, 68, -60, -83, -66; /M: SY='W'; M= -24, -73, -55, -19, 55, -76, -43, -4, -31, 27, 64, -1, -58, -25, -67, -56, -41, -1, 76, 33; /M: SY='I'; M= -7, -72, -73, -37, -31, -46, -11, 46, 11, 38, 10, -34, -45, -62, 4, -38, -3, 22, -74, -25; /M: SY='D'; M= -28, -79, 79, 74, -30, -57, -54, -64, -26, -77, -49, 11, -50, 1, -40, -23, -45, -67, -42, -69; /M: SY='A'; M= 51, -68, -75, -68, -15, -51, -34, 36, -31, 32, 20, -51, -49, -26, -54, -22, -15, 5, 25, -58; /M: SY='A'; M= 84, -16, -51, -63, -54, -35, -71, 23, -65, -54, -56, -44, -68, -62, -69, -16, -18, 5, -77, -68; /M: SY='Y'; M= -33, -78, -49, 35, 25, -76, 21, 21, 12, -29, -52, -28, -49, -6, -34, -52, -35, -9, 0, 84; /M: SY='E'; M= -1, -43, 24, 55, -56, -61, 18, -2, 27, -23, 0, -14, -65, 24, 12, -34, -6, -20, -79, -47; /M: SY='V'; M= -14, -70, -81, -77, 2, -82, -76, 58, -61, 12, -22, -75, -77, -73, -75, -35, -39, 68, -72, 16; /M: SY='L'; M= -22, -69, -82, -45, -19, -83, -68, 6, -76, 84, 24, -81, -81, -69, -74, -74, -62, -33, -71, -53; /M: SY='K'; M= -4, -75, -25, 45, -75, -53, -27, -35, 54, -38, -63, -16, -65, 28, 38, 13, -6, -39, -77, -48; /M: SY='E'; M= 3, -76, 29, 66, -54, -56, -9, -40, 17, -46, -65, 20, -63, 39, 9, -13, -21, -44, -80, -67; /M: SY='K'; M= 26, -27, -34, 31, -26, -49, 5, -25, 34, -52, -62, 28, -32, 10, -4, 23, -2, -16, -76, -12; /M: SY='G'; M= -41, -76, 7, -7, -8, 54, -2, -65, 49, -77, -68, 25, -17, 13, 7, -8, -27, -75, -76, -65; /I: I=-31; MI=0; MD=-79; IM=0; DM=-79; /M: SY='K'; M= -45, -34, -25, 45, -43, -10, -10, -75, 48, -73, -26, 14, -34, 37, 38, -29, 18, -42, -78, -46; D=-31; /I: I=-31; DM=-79; /M: SY='P'; M= 7, -82, -49, -18, -43, -8, -67, -72, -27, -70, -68, -27, 107, -32, -69, 8, -29, -55, -17, -53; /M: SY='M'; M= -19, -69, -62, -72, 18, -78, -63, 6, -47, 50, 96, -72, -76, -17, -69, -45, -9, 0, -69, -9; /M: SY='H'; M= -38, -71, 1, -10, -69, -54, 91, -72, -17, -58, -62, 29, -4, -51, -19, 41, 50, -51, -85, 0; /M: SY='F'; M= 5, 5, -76, -73, 72, -66, 7, 14, -71, -10, -49, -71, 8, -71, -71, -23, -33, 11, -51, 69; /M: SY='K'; M= -12, -75, -13, 14, -48, -30, -5, -48, 45, -37, -43, 39, -36, 26, 32, 11, -23, -47, -71, 32; /M: SY='E'; M= -10, -78, 56, 79, -81, -56, -55, -77, 0, -75, -41, -16, -61, 33, -43, -26, -11, -34, -23, -69; /M: SY='I'; M= -65, -74, -85, -81, -25, -88, -78, 87, -78, 44, 28, -78, -77, -73, -79, -74, -59, 5, -73, -55; /M: SY='W'; M= 10, -33, -79, -72, 20, -58, -41, 19, -37, 21, 20, -72, -75, -53, -62, -37, 25, 10, 112, 3; /M: SY='E'; M= -4, -76, 48, 55, -79, -34, 6, -78, 32, -63, -68, 29, -64, 37, -7, -5, -28, -60, -82, -42; /M: SY='E'; M= -4, -51, -32, 45, -66, -72, 13, 8, 34, -16, -10, -27, -67, 32, 34, -34, -38, 1, -74, 6; /M: SY='I'; M= 35, -45, -78, -74, -46, -20, -77, 66, -72, -9, 19, -70, -73, -69, -75, -29, -17, 44, -1, -60; /M: SY='Q'; M= 13, 15, -63, 9, -26, -53, -41, 13, 20, 12, -19, -12, -70, 47, -44, -3, -5, 16, 6, -35; /M: SY='E'; M= 10, -75, 29, 55, -79, -41, -56, -55, 45, -60, -49, -6, -45, 27, 20, 0, -16, -52, -79, -68; /M: SY='K'; M= -14, -45, -7, 15, -13, -27, -6, -9, 30, 21, 8, 15, -70, 11, 25, -4, -27, -17, -75, -28; /M: SY='G'; M= -23, -74, -10, -22, -41, 59, -22, -40, 32, 0, 16, 30, -69, -12, -7, -15, -51, -44, -75, -25; /M: SY='L'; M= -42, -34, -21, -13, 1, 27, -3, -27, -8, 48, 7, 7, -23, 15, -49, -36, -47, -31, -7, 16; /M: SY='W'; M= -20, -74, 24, -36, 16, -65, -8, 12, 7, 9, -8, -40, -73, -9, 19, -14, -1, 14, 57, 30; /M: SY='S'; M= -32, -21, 34, 16, -36, -49, -26, -37, 27, -43, -65, 16, 14, 14, -10, 41, 33, -42, -82, -66; /I: I=-19; MD=-49; /M: SY='W'; M= -72, -60, -17, -26, -25, -62, -8, -46, -3, -39, -45, -37, -24, -27, -23, 9, -5, -40, 33, -83; D=-19; /I: I=-19; MI=0; MD=-49; IM=0; DM=-49; /M: SY='G'; M= -47,-103, -61, -99, -45, 52, -35,-104, -77, -78, -97, -31, -67, -93, -71, -12, -58, -51,-102, -31; D=-19; /I: I=-19; DM=-49; /M: SY='K'; M= -3, -75, 3, 24, -23, -47, -10, -40, 63, -27, -24, -3, -1, 20, -11, 1, -4, -33, 9, -36; /M: SY='T'; M= -13, -69, 30, 36, -74, -24, -10, -55, -3, -70, -24, 29, -63, -2, -33, 14, 69, -41, -85, -67; /M: SY='P'; M= -29, -18, 21, 22, -57, -59, -62, -34, -25, -57, -66, -19, 89, 36, -15, -2, -11, -29, -25, -32; /M: SY='W'; M= 4, -8, 0, 34, -30, -38, -8, 4, 5, 5, -20, -26, -22, -4, 10, -9, -20, 11, 59, -43; /M: SY='A'; M= 43, -70, 1, 18, -76, -50, -16, -45, 27, -54, -19, 24, -4, 24, 3, 10, 16, -43, -80, -67; /M: SY='T'; M= -7, 14, 8, 7, -69, -53, -22, -14, -15, -31, -17, -2, -65, 22, -12, 32, 66, -19, -82, -37; /M: SY='L'; M= 5, -71, -55, -44, -24, -74, -65, 8, 5, 39, 36, -14, -14, -9, 15, -23, -40, 30, 7, -19; /M: SY='I'; M= 15, -32, -52, -23, -50, 1, -40, 39, -14, -2, 18, 33, -71, 16, 3, 2, -25, -13, -22, 11; /I: I=-42; MD=-106; /M: SY='A'; M= 63, -69, -65, -34, -75, 12, -41, -29, -63, -52, -65, -15, -56, -2, -34, 35, 11, -27, -36, -46; D=-42; /I: I=-42; MD=-106; /M: SY='Q'; M= -3, -81, -20, 13, -36, -44, -14, -37, -8, -34, 20, -11, -74, 55, 40, 2, -8, -33, -81, -29; D=-42; /I: I=-42; MI=-106; IM=-106; DM=-106; /M: SY='L'; M= -51, -71, -84, -78, 53, -85, -18, 48, -77, 62, -8, -79, -81, -74, -58, -74, -62, 6, -65, -27; /M: SY='Y'; M= -11, -42, -48, -56, 3, -35, 40, -36, -51, -20, -53, -3, -76, -37, -46, 19, -20, -46, 2, 106; /M: SY='T'; M= -2, -42, -37, -14, -67, -35, -24, -37, -22, -23, 13, -3, -66, 2, 30, 8, 73, 9, -82, -64; /M: SY='D'; M= -30, -45, 82, 37, -54, -45, 7, -45, -35, -23, -34, 13, -66, 20, -2, -2, -18, -62, -86, -34; /M: SY='M'; M= -27, -9, -79, -63, -29, -79, -71, 61, -50, 45, 61, -42, -54, -68, -73, -1, -14, 1, -75, -56; /I: I=-23; MI=0; MD=-58; IM=0; DM=-58; /M: SY='N'; M= -35, -73, -26, -64, -74, 34, -37, -32, -14, -30, -8, 72, -30, -26, -12, 5, 24, -12, -23, -70; D=-23; /I: I=-23; DM=-58; /M: SY='E'; M= -13, -76, 11, 25, -67, -16, -13, 2, -4, 20, 14, -24, 12, 24, -8, -41, -4, 0, -81, -65; D=-23; /I: I=-23; DM=-58; /M: SY='D'; M= -20, -40, 92, 13, -65, -26, -5, -82, -1, -68, -56, 9, -31, -15, -35, 13, -34, -78, -93, -70; D=-23; /I: I=-23; DM=-58; /M: SY='S'; M= -1, -44, -13, -59, -58, 43, -36, -63, -3, -76, -49, 13, 15, -17, -11, 61, 11, -45, -80, -70; D=-23; /I: I=-23; DM=-58; /M: SY='R'; M= -23, -54, -28, -20, -69, -74, -58, -2, 7, -7, -34, -27, 13, -16, 88, -23, -10, -33, -22, -44; /M: SY='F'; M= -73, -71, -87, -81, 117, -70, -68, -36, -77, -17, -28, -76, -85, -37, -75, -73, -66, -13, -43, -9; /M: SY='V'; M= 0, -26, -53, -18, 4, -65, -48, 45, -11, -2, 14, -69, -74, -37, -14, -44, -8, 52, -21, 26; /M: SY='R'; M= -25, 15, -63, -55, 3, -71, 13, -34, 49, -13, -26, -22, -18, 1, 59, 10, -18, -36, -69, 25; /M: SY='V'; M= -9, 2, -71, -39, -21, -65, -46, 22, -52, 25, 4, -14, -57, -31, -47, -31, 44, 52, -78, -15; /I: I=-31; MD=-79; /M: SY='G'; M= 15, -74, -3, 6, -65, 70, -10, -50, -18, -79, -71, -10, -25, -8, -37, 24, -33, -74, -78, -72; D=-31; /I: I=-31; MI=0; MD=-79; IM=0; DM=-79; /M: SY='P'; M= -32, -79, 45, 31, -54, -44, -25, -77, 13, -61, -41, 24, 69, -13, 26, 2, -22, -75, -82, -70; /M: SY='G'; M= -5, -73, 10, -42, -60, 69, -20, -61, -32, -69, -69, 60, -68, -1, -32, -5, -5, -51, -79, -38; /M: SY='T'; M= -60, -41, -62, 4, -25, -48, 0, -10, 27, 10, 12, -21, -70, 16, 38, -23, 40, 4, -7, 8; /M: SY='W'; M= -60, -84, -89, -79, 73, -77, -70, -40, -72, -46, -7, -83, -82, -51, -72, -75, -74, -51, 144, 67; /M: SY='G'; M= 39, -3, 0, -29, 5, 58, -67, -30, -20, -61, -25, -43, -69, -18, -26, 1, -5, -65, 43, -25; /M: SY='L'; M= -50, -26, -83, -76, -42, -84, -41, 9, -77, 85, -30, -81, -82, -70, -75, -45, -40, -12, -72, -38; /M: SY='R'; M= -24, -43, -27, -50, -51, -69, -56, -52, 62, -56, -43, 3, -69, -16, 77, 8, 0, -35, -75, -28; /M: SY='E'; M= 15, -72, 22, 56, -76, -12, -32, -33, 13, -61, -66, 1, -39, -17, -11, 39, -5, -22, -81, -69; /M: SY='W'; M= -42, -47, -11, -11, 4, -29, -67, -25, -14, -8, -5, 17, -20, 0, 21, -4, -32, -68, 130, 3; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 98 in 98 different sequences |
| Number of true positive hits | 98 in 98 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | HTH HARE-type |
| Version [info] | 2 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
98 sequences
ASXL1_HUMAN (Q8IXJ9), ASXL1_MOUSE (P59598), ASXL2_CHICK (Q5ZM88), ASXL2_HUMAN (Q76L83), ASXL2_MOUSE (Q8BZ32), ASXL3_HUMAN (Q9C0F0), ASXL3_MOUSE (Q8C4A5), RLT1_ARATH (F4HY56), RLT2_ARATH (Q9FFH1), RPOE_BACAH (A0RLC4), RPOE_BACAN (Q81JW0), RPOE_BACC1 (Q72XA8), RPOE_BACC2 (B7IQZ2), RPOE_BACC4 (B7HFN7), RPOE_BACC7 (B7HY99), RPOE_BACCQ (B9IRX2), RPOE_BACCR (Q814T1), RPOE_BACCZ (Q630Q9), RPOE_BACHK (Q6HAU4), RPOE_BACLD (Q65DT6), RPOE_BACP2 (A8FIE6), RPOE_BACSU (P12464), RPOE_BACVZ (A7Z9T5), RPOE_HALH5 (Q9K6D6), RPOE_LACAC (Q5FME7), RPOE_LACDA (Q1GBQ3), RPOE_LACDB (Q04C52), RPOE_LACJO (Q74LG3), RPOE_LACLA (Q9CHT4), RPOE_LACLM (A2RIW1), RPOE_LACLS (Q030Z9), RPOE_LACPL (Q88Z77), RPOE_LEUCK (B1MXM6), RPOE_LEUMM (Q03YU3), RPOE_LIGS1 (Q1WV31), RPOE_LIMF3 (B2GA55), RPOE_LIMRD (A5VI25), RPOE_LIMRJ (B2G5K4), RPOE_LISIN (Q927T3), RPOE_LISMF (Q71WL9), RPOE_LISMO (Q8Y494), RPOE_LISW6 (A0ALP6), RPOE_MACCJ (B9E8H2), RPOE_MYCGE (P47268), RPOE_MYCPN (P75090), RPOE_OCEIH (Q8EM52), RPOE_OENOB (Q04D45), RPOE_PEDPA (Q03DX9), RPOE_SHOC1 (Q5WB42), RPOE_STAA1 (A7X4Y0), RPOE_STAA2 (A6U3L3), RPOE_STAA3 (Q2FF00), RPOE_STAA8 (Q2FWD0), RPOE_STAA9 (A5IUS3), RPOE_STAAB (Q2YUM5), RPOE_STAAC (Q5HE72), RPOE_STAAE (A6QIX2), RPOE_STAAM (P66714), RPOE_STAAN (P66715), RPOE_STAAR (Q6GEU7), RPOE_STAAS (Q6G7I2), RPOE_STAAT (A8YY93), RPOE_STAAW (P66716), RPOE_STACT (B9DMC7), RPOE_STAEQ (Q5HM94), RPOE_STAES (Q8CRM5), RPOE_STAS1 (Q49Z74), RPOE_STRA1 (Q3K3S3), RPOE_STRA3 (Q8E7P9), RPOE_STRA5 (Q8E291), RPOE_STRE4 (C0M8K7), RPOE_STRGC (A8AVB9), RPOE_STRMU (Q8DWG2), RPOE_STRP1 (P66719), RPOE_STRP2 (Q04LZ9), RPOE_STRP3 (P0DF34), RPOE_STRP4 (B5E1U3), RPOE_STRP6 (Q5XA09), RPOE_STRP7 (C1C5L8), RPOE_STRP8 (Q8NZF7), RPOE_STRPG (A2RCL2), RPOE_STRPI (B1IA31), RPOE_STRPJ (B8ZLX1), RPOE_STRPN (P66717), RPOE_STRPQ (P0DF35), RPOE_STRPS (B2IM97), RPOE_STRR6 (P66718), RPOE_STRS2 (A4VZE7), RPOE_STRS7 (C0MFQ8), RPOE_STRSY (A4VT63), RPOE_STRT1 (Q5M1S8), RPOE_STRT2 (Q5M6C1), RPOE_STRTD (Q03MQ8), RPOE_STRU0 (B9DTJ7), RPOE_STRZJ (C1CCN9), RPOE_STRZP (C1CIY6), RPOE_STRZT (C1CQ00), RPOE_UREPA (Q9PPP2)» more
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| PDB [Detailed view] |
13 PDB
2KRC; 2M4K; 4NC7; 4NC8; 6ZCA; 6ZFB; 7F75; 8H1T; 8SVF; 8X6G; 8XA6; 8XA7; 8XA8 » more |