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Entry: PS51926

General information about the entry

Entry name [info] COV_E
Accession [info] PS51926
Entry type [info] MATRIX
Date [info] 07-OCT-2020 CREATED;
07-OCT-2020 DATA UPDATE;
07-OCT-2020 INFO UPDATE.
PROSITE Doc. [info] PDOC51926
Associated ProRule [info] PRU01274

Name and characterization of the entry

Description [info] Coronavirus envelope (CoV E) protein profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=95;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=90;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=4.5550442; R2=0.0058566; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1016; N_SCORE=10.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=333; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-48; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='M';  M=-154,-162,-176,-166,-143,-168,-146,-128,-158,-121,  53,-163,-163,-150,-157,-163,-152,-135,-167,-142;
/M: SY='T';  M=-145,-154,-150,-153,-160,-161,-161,-151,-150,-156,-152,-139,-152,-155,-158,-128,  23,-143,-181,-158;
/M: SY='F';  M=-168,-164,-181,-176,  30,-176,-160,-141,-172,-133,-143,-169,-179,-182,-169,-167,-160,-147,-133,-111;
/M: SY='M';  M= -66, -76, -86, -75, -59, -79, -60, -43, -70, -37, 135, -75,  38, -63, -70, -74, -64, -50, -79, -57;
/M: SY='Y';  M= -68, -74, -78, -72,  52, -80, -53, -46, -62,  35,  75, -73, -80, -63,  28, -70, -64, -52, -49,  82;
/M: SY='N';  M=  15, -72,  19,   7, -80, -56, -55, -75, -53, -78, -69,  68,  49,  31, -59,  50, -48, -72, -84, -71;
/M: SY='F';  M=   7, -71, -82, -74,  69, -78, -70,  12, -75,  60, -40, -78,  25, -74, -75, -70, -62, -44, -61, -43;
/M: SY='V';  M= -58, -68, -80, -76,  25, -83, -78,  42, -74,  24, -40, -73, -76, -75, -76, -64,  28,  70, -76, -54;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='W';  M= -58, -79, -74, -70, -70,   2, -74, -64, -70,  -5, -66, -64, -78,  23, -73,  67, -57,  16,  81, -65; D=-36;
/I:         I=-36; DM=-90;
/M: SY='F';  M= -68, -78, -65,  46,  53, -84, -67,  43, -66,  -2, -53, -69, -73, -64, -71, -65,  35, -49, -65,  32; D=-36;
/I:         I=-36; DM=-90;
/M: SY='E';  M= -64, -77,  55,  71, -69, -66, -48, -79, -46, -76, -70,  66, -65, -44,  12, -54, -57, -76, -76,  39;
/M: SY='D';  M=   9, -70,  67,  14, -72, -66, -62,   4, -57, -65, -63,  23, -65, -57, -65, -48,  64,   7, -89, -67;
/M: SY='N';  M= -54, -68, -47, -62, -74,  40, -54, -67, -56, -76, -67,  95, -70, -55, -63,  32,   9,   5, -87, -71;
/M: SY='G';  M= -54, -75, -69, -75, -66,  78, -74,   7, -69, -10, -61, -57, -70, -68, -75, -53,  34,  -3,  75, -64;
/M: SY='M';  M= -64, -71, -78, -72,  19, -77, -60, -41, -71,  60,  82, -73,  26, -65, -70,   7, -59, -47, -64,  35;
/M: SY='I';  M=   2, -72, -84, -80,  68, -82, -79,  75, -76, -38, -42, -75, -77, -78, -78, -68, -58,  42, -64, -44;
/M: SY='V';  M=   1, -68, -78, -75,  29,   4, -76,  26, -73,  23, -44, -71, -76, -73, -75, -62,   8,  63, -74, -55;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='N';  M= -54, -67, -44, -55, -75, -54, -50, -72, -50, -77, -67,  95, -67,  32, -57,  52,  43, -69, -89, -68;
/M: SY='C';  M=   3,  57, -76, -74,  16,   5, -76,  55, -72, -48, -49, -66, -74, -70, -75,  28, -53,  47, -76, -59;
/M: SY='I';  M= -65, -71, -85, -80,  46, -87, -75,  59, -78,  57, -35, -80, -80, -75, -77, -74, -60,  28, -67, -47;
/M: SY='Y';  M= -68, -73, -81, -78,  58, -83, -59,  10, -74,  52, -39, -78, -83, -72, -72, -72, -63,   7, -49,  80;
/M: SY='W';  M= -68, -79, -90, -80,  19, -83, -82,  56, -76,  42, -42, -84, -79, -74, -77, -76, -66,  11, 125, -42;
/M: SY='F';  M= -65, -70, -83, -79,  77, -84, -73,  37, -76,  41, -40, -76, -80, -77, -76, -69,  10,  30, -61, -40;
/M: SY='L';  M=   3, -70, -83, -77,  24, -82, -74,  50, -76,  59, -36, -78, -79, -73, -76, -70, -59,  31, -70, -52;
/M: SY='G';  M=  35, -70, -74, -74, -61,  49, -76,  35, -72,   9, -49, -66, -73, -69, -75, -57, -58,  46, -77, -65;
/M: SY='C';  M= -65,  92, -82, -79,  73, -80, -72,  23, -76,  39, -46, -73, -83, -77, -77,   0, -61, -47, -64, -44;
/M: SY='I';  M=  -4, -71, -84, -79,  24, -83, -77,  70, -77,  47, -36, -78, -78, -74, -77, -70, -59,  29, -70, -52;
/M: SY='M';  M=  30, -69, -79, -74,  23,   4, -73,  42, -72,  18,  46, -71, -75, -70, -74, -62, -57,  43, -72, -55;
/M: SY='F';  M= -65, -69, -83, -78,  70, -84, -72,  22, -76,  52, -39, -76, -80, -76, -75, -70,  10,  33, -63, -42;
/M: SY='Y';  M= -64, -72, -77, -75, -37, -82, -60,  26, -72,  53, -38, -74, -79, -68, -71, -67,  17,  28, -57,  79;
/M: SY='I';  M= -66, -73, -85, -80, -44, -88, -75,  73, -79,  70, -31, -80, -80, -73, -78, -76, -61, -29, -72, -55;
/M: SY='V';  M= -60, -69, -84, -78,  22, -86, -78,  41, -77,  43, -37, -79, -80, -76, -77, -71, -56,  72, -74, -53;
/M: SY='G';  M= -50,  43, -65, -69, -70,  67, -69, -63, -66,  -7, -62, -53, -69, -64, -72,  44,  35,   6, -80, -70;
/M: SY='C';  M= -63,  71, -75, -67, -57, -81, -70,  57,  41,  16,  38, -67, -75, -62,  16, -67, -59,  12, -77, -61;
/M: SY='A';  M=  81, -63, -69, -64, -71,   8, -72, -53, -65, -61, -58, -62, -68, -63, -69, -45,  17,  35, -78, -69;
/M: SY='F';  M= -69, -71, -86, -80,  76, -86, -70,  31, -78,  67, -35, -80, -83, -77, -76, -76, -64, -40, -59, -39;
/M: SY='L';  M= -63, -70, -76, -69, -43, -81, -63, -37, -70,  74, -35, -73, -79,  28, -69, -66,  22,  10, -67,  34;
/M: SY='T';  M=  43, -66, -61, -58, -66, -63, -63, -53,  10,  15, -53,  37, -68,  30, -59, -48,  51,  13, -80, -65;
/M: SY='C';  M=  35,  72, -78, -74,  67, -70, -72,  42, -72,   0, -50, -69, -77, -72, -74,  11, -57, -45, -65, -47;
/M: SY='I';  M= -59,  48, -79, -76, -52, -83, -78,  56, -73,  32, -40, -71, -76, -73, -76, -63,  40,  51, -80, -60;
/M: SY='Q';  M= -62, -80, -54, -41, -82, -68, -51, -78,  59, -75, -62,  26, -68,  95,  54, -53, -60, -76, -74, -63;
/M: SY='L';  M=  45,  48, -79, -72,  43, -72, -69, -44, -73,  63, -41, -75, -79, -70, -73, -63, -60, -46, -68, -51;
/M: SY='C';  M=  27, 124, -79, -76, -63, -73, -79,  18, -74,  -9, -55, -70, -82, -76, -78, -61, -58,  30, -88, -71;
/M: SY='D';  M=  19, -72,  64, -58,  47, -72, -65,  33, -67,  -1,  56, -59, -73, -66, -70, -62, -58,   4, -72, -51;
/M: SY='Q';  M=   3, -71, -67, -62, -56,  24, -61, -49, -61,  -4, -53, -60, -72,  54, -63,  12,  17,  41, -67,  52;
/M: SY='C';  M=  -5, 137, -78, -77, -66, -75, -78, -61, -74,  -2, -60, -67, -84, -78, -79, -60,  14,   4, -93, -75;
/M: SY='C';  M= -63, 130, -76, -74, -61, -77,  72, -62, -73,  25,  37, -65, -84, -71, -73, -66, -62, -60, -92, -63;
/M: SY='N';  M= -60, -72, -58, -65, -64,  43, -58, -61, -53,  38, -54,  68, -74, -57,  42, -54,  10, -63, -79, -65;
/M: SY='F';  M=   0,  40, -82, -78,  78,  -3, -71,  30, -76,  43, -43, -74, -81, -76, -76, -68, -63, -45, -59, -41;
/M: SY='W';  M= -61,  98, -83, -79,  17,  15, -80, -48, -75,  16, -54, -74, -82, -77, -78, -67, -63,  40, 102, -53;
/M: SY='N';  M=  -6, -72, -49, -58,  19, -60, -47, -70,  20, -70, -62,  93, -74, -52,  30, -52, -54, -70, -65,  60;
/M: SY='T';  M= -52, -65, -58, -61, -68,  11, -66, -55,   9, -64, -60,  17, -64, -60, -61,  14,  88,  24, -85, -66;
/M: SY='W';  M=   3, -74, -79, -72,  21, -70, -77,   5, -69,  19, -52, -71, -74, -67, -72,  28,  14,  18, 123, -45;
/M: SY='V';  M=   9,  50, -82, -76, -52, -79, -78,  27, -75,  44, -40, -77, -79, -73, -76, -66, -56,  65, -80, -61;
/M: SY='C';  M=   3,  72, -79, -76, -47, -78, -70,  26, -73,   2, -45, -74, -80, -72, -74, -65, -56,  65, -68,  59;
/M: SY='K';  M= -58, -72,  26, -51, -67, -70, -63,  10,  57,  -3, -55, -52, -67,  24, -49,  13,  42,  18, -80, -63;
/M: SY='P';  M= -66, -92, -67, -55, -86, -68, -70, -74, -63, -84, -70, -73, 128, -66, -75, -64, -59, -79, -79, -83;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='F';  M=  16, -68, -69, -68,  49, -68, -63,  12, -66,  16, -50, -61, -71, -64, -69,  38,  48, -49, -62,  41;
/M: SY='I';  M=   9, -73, -76, -69,  24,   3, -73,  62, -69,  -3, -44, -69, -74,  41, -71, -62, -58,  42, -72, -55;
/M: SY='Y';  M= -69, -80, -68, -66, -32, -78,  60,   2,  10,  -4, -49, -65, -78, -56,  18, -65, -64, -59, -42, 111;
/M: SY='V';  M=  14, -68, -70, -69,  21,  11, -69, -40,   9,  32, -47,  24, -76, -66, -66, -60, -56,  55, -74, -57;
/M: SY='Y';  M= -68, -79, -67, -72, -24, -75, -40, -52, -64, -53, -50,  24, -82, -61, -63, -64, -62,  12, -34, 126;
/M: SY='N';  M= -59, -70,  32, -54, -70, -63, -54, -68, -46,   0, -62,  65, -70, -51,  56,  30,  43, -65, -85, -65;
/M: SY='Y';  M=  13, -76, -64, -54, -59, -70, -56, -63,  33, -66, -59, -59,  32,  29,  55, -56,  10,   5, -64,  60;
/M: SY='Y';  M= -59, -74, -69, -69,  44,  44, -57, -56,  17, -58, -57, -61, -75, -63, -62,  12, -60,  23, -52,  81;
/M: SY='K';  M= -63, -80, -57, -42, -80, -71, -54, -79,  88, -76, -64, -50, -66,  61,  58, -56, -60, -76, -73, -64;
/M: SY='N';  M= -59, -74, -47,  13, -71, -60, -50, -75,  13, -77, -67,  79,  33,  33,  19,  34, -51, -74, -76,  23;
/M: SY='F';  M= -66, -73, -65,  32,  55, -80, -61, -48,  41,  44, -46, -68, -74, -58, -56, -67, -62,   2, -60,  34;
/M: SY='M';  M= -59, -69, -60, -66, -50, -65, -51, -51, -60,   5,  92,  62, -72, -56, -63,  30,  18, -55, -67,  58;
/I:         I=-25; MD=-63;
/M: SY='N';  M= -70, -80, -62, -65, -64, -74, -58, -64,  14,  13, -60,  70, -82, -58,  50, -64, -63,  -2, -79,  30; D=-25;
/I:         I=-25; MD=-63;
/M: SY='I';  M= -74, -85, -83, -76,  29, -87, -74,  56,   2,  16, -51, -80,  52, -75, -75, -76, -67, -48, -68,  34; D=-25;
/I:         I=-25; MD=-63;
/M: SY='E';  M= -70, -84,  21,  68,  14, -76, -57, -81,  24, -78, -74,  45, -71, -51, -57, -63, -64, -80, -75,  33; D=-25;
/I:         I=-25; MD=-63;
/M: SY='S';  M=  12, -85,  24, -69, -82, -76, -74, -76, -74,  18, -71,  25, -87,  22, -78,  27, -67, -75, -97, -80; D=-25;
/I:         I=-25; MD=-63;
/M: SY='E';  M= -74, -93,  12,  54, -74, -86, -70,  13, -70, -79, -77, -71, -81, -63, -76,  26, -70, -74, -82,  44; D=-25;
/I:         I=-25; MD=-63;
/M: SY='E';  M=  24, -98, -69,  51,-107, -87, -83,-103, -76,-102, -96,  34, -90, -72, -85, -76, -82, -95,-109,-100; D=-25;
/I:         I=-25; MI=-63; MD=-63; IM=-63; DM=-63;
/M: SY='R';  M= -79, -97, -92, -84, -88, -20, -90, -65, -71, -79, -76, -88,  37, -81,  46, -83, -79,  45,-102, -87; D=-25;
/I:         I=-25; DM=-63;
/M: SY='V';  M= -74, -89,  29, -77, -77, -92, -86,  35, -76, -65, -66, -76, -89, -79,  15,   1, -69,  44,-100, -78; D=-25;
/I:         I=-25; DM=-63;
/M: SY='P';  M= -77, -98, -85, -78, -90,  14, -88,   8,   2, -82, -77, -82,  80, -81, -83, -78, -75,   1, -94, -89; D=-25;
/I:         I=-25; DM=-63;
/M: SY='P';  M=  11, -89,  37, -68, -88, -77, -77, -81, -76,  -2, -77,  22,  50, -75, -83,   9, -69, -81, -99, -86; D=-25;
/I:         I=-25; DM=-63;
/M: SY='P';  M= -61, -79, -54,  63, -68, -72, -62, -61, -57,  35, -56, -66,  80, -52, -65,  16, -57, -63, -78, -69;
/M: SY='L';  M= -69, -71, -81, -71,  68, -83, -65, -41, -67,  70, -37, -76, -83,  19,  13, -72, -64, -47, -61, -42;
/M: SY='P';  M= -12, -81, -58,  51, -76, -71, -68, -57, -59, -68, -63, -69,  99, -58, -68, -61, -57,  37, -81, -75;
/I:         I=-31; MD=-79;
/M: SY='R';  M= -99,-116,-102, -90,-109,-112, -98, -95,   7,-103, -96, -97,  16, -86,  46, -98, -96,   1,-114,-102; D=-31;
/I:         I=-31; MD=-79;
/M: SY='N';  M=-101,-108,  42, -82,-117, -91, -83,-116, -87,-120,-111,  69,-107, -88, -95, -84, -87,-116,-135,-108; D=-31;
/I:         I=-31; MD=-79;
/M: SY='G';  M= -88,-111,  17,   2,-118,  28, -97,-121, -94,-118,-112, -82,-101, -89,-102,  13, -91,-114,-118,-109; D=-31;
/I:         I=-31; MD=-79;
/M: SY='W';  M=-105,-124,-113,-100, -93,-111,-115,   6,  13, -99, -97,-108,  23, -98, -94,-106,-103, -96,  98, -85; D=-31;
/I:         I=-31; MD=-79;
/M: SY='N';  M= -99,-108,  23, -92,-104,-101, -94,   7, -95, -95, -94,  49,-109, -95,-102, -91, -88,  -5,-127,-103; D=-31;
/I:         I=-31; MD=-79;
/M: SY='N';  M=-103,-117, -95,-112,-114,   7,-102,   5,-104,-109,-104,  49,-116,-104,-111, -96, -99,-100,-127,-113; D=-31;
/I:         I=-31; MI=-79; IM=-79; DM=-79;
/M: SY='E';  M= -75, -95,  11,  56, -99, -85, -71, -98,  36, -94, -87, -66, -78,  32, -60,   8, -73, -93, -96, -86;
/M: SY='N';  M= -79, -86, -70, -82, -70, -82, -70,  -1, -75, -10, -70,  66, -89, -76, -81, -67,  42, -71, -88,  38;
/M: SY='L';  M= -79, -89, -99, -92, -67,-101, -94,  31, -92,  36, -54, -96,  22, -90, -94, -89, -75,  35, -94, -76;
/I:         I=-23; MD=-58;
/M: SY='C';  M=  22,  44,-132,-126,-135,-116,-133,-129,-127,-128,-124,-124,-133,-126,-132,-107,-115,-116,-143,-135; D=-23;
/I:         I=-23; MI=0; MD=-58; IM=0; DM=-58;
/M: SY='D';  M=-127,-136,  10,-118,-115,-140,-128,   4,-130, -13,-103,-121,-135,-127,-134,-129,-120,-100,-141,-120; D=-23;
/I:         I=-23; DM=-58;
/M: SY='Y';  M=-128,-137,  14,-110,-110,-123,-104,-132,-116,-132,-126,  17,-135,-115,-121,-115,-117,-134,-121,  27; D=-23;
/I:         I=-23; DM=-58;
/M: SY='V';  M=-100,-117,-123,-121,-105,-122,-126,   7,-119, -92, -94,-115,-122,-116,-122,   3, -96,  26,-131,-110;
/I:         I=-23; E1=0; IE=-380; DE=-58;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2020_05 which contains 563'552 sequence entries.


Total number of hits 46 in 46 different sequences
Number of true positive hits 46 in 46 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotic viruses
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
46 sequences

VEMP_BC133  (Q0Q4E8    ), VEMP_BC279  (Q0Q473    ), VEMP_BC512  (Q0Q464    ), 
VEMP_BCHK3  (Q3LZW9    ), VEMP_BCHK4  (A3EX99    ), VEMP_BCHK5  (A3EXD5    ), 
VEMP_BCHK9  (A3EXG8    ), VEMP_BCRP3  (Q3I5J3    ), VEMP_CVBEN  (P0C2Q1    ), 
VEMP_CVBF   (P15775    ), VEMP_CVBLS  (P0C2Q2    ), VEMP_CVBLU  (P0C2Q3    ), 
VEMP_CVBLY  (P0C2Q4    ), VEMP_CVBM   (P15779    ), VEMP_CVBOK  (P0C2Q5    ), 
VEMP_CVBON  (P0C2Q6    ), VEMP_CVBQ   (P0C2Q7    ), VEMP_CVCAI  (P36696    ), 
VEMP_CVCBG  (Q7T6T0    ), VEMP_CVH22  (P19741    ), VEMP_CVHN1  (Q5MQC8    ), 
VEMP_CVHN2  (Q14EA8    ), VEMP_CVHN5  (Q0ZME5    ), VEMP_CVHNL  (Q6Q1S0    ), 
VEMP_CVHOC  (Q04854    ), VEMP_CVMA5  (P0C2R0    ), VEMP_CVMJH  (P06591    ), 
VEMP_CVMS   (P29076    ), VEMP_CVP67  (P0C2Q8    ), VEMP_CVPFS  (P22655    ), 
VEMP_CVPIA  (P0C2Q9    ), VEMP_CVPPU  (P09048    ), VEMP_CVPR8  (P69611    ), 
VEMP_CVPRM  (P69610    ), VEMP_CVRSD  (Q9IKC8    ), VEMP_FIPV   (Q52PA5    ), 
VEMP_IBVB   (Q89894    ), VEMP_IBVK   (P19744    ), VEMP_IBVM   (P05139    ), 
VEMP_IBVP3  (P30246    ), VEMP_IBVU4  (P30247    ), VEMP_IBVU5  (P30248    ), 
VEMP_MERS1  (K9N5R3    ), VEMP_PEDV7  (Q84706    ), VEMP_SARS   (P59637    ), 
VEMP_SARS2  (P0DTC4    )
» more

PDB
[Detailed view]
2 PDB

2MM4; 5X29

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