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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01274


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01274
General rule information [?]

Accession PRU01274
Dates 04-JUN-2020 (Created)
01-MAR-2024 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51926; COV_E
Name Coronavirus envelope (CoV E) protein
Function Coronavirus envelope (CoV E) proteins are involved in several aspects of the virus' life cycle, such as assembly, budding, envelope formation, and pathogenesis. They are ~100-residue-long polypeptides that are minor components in virions but are abundantly expressed inside infected cells. They are localized mainly to the endoplasmic reticulum (ER) and Golgi- complex where they participate in the assembly, budding, and intracellular trafficking of infectious virions.
Scope(s) Viruses
Orthocoronavirinae
Example(s) P09048;

Propagated annotation [?]

Comments [?]

FUNCTIONPlays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
SUBUNITHomopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.

Keywords [?]

Host Golgi apparatus
Host membrane
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0016020; Cellular component:membrane
GO:0044178; Cellular component:host cell Golgi membrane
GO:0044694; Biological process:symbiont genome entry into host cell via pore formation in plasma membrane

Features [?]


Additional information [?]

Size range 70-120 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]