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annotation rule: PRU01274

General rule information [?]

Accession PRU01274
Dates 4-JUN-2020 (Created)
4-JUN-2020 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS51926; COV_E
Name Coronavirus envelope (CoV E) protein
Function Coronavirus envelope (CoV E) proteins are involved in several aspects of the virus' life cycle, such as assembly, budding, envelope formation, and pathogenesis. They are ~100-residue-long polypeptides that are minor components in virions but are abundantly expressed inside infected cells. They are localized mainly to the endoplasmic reticulum (ER) and Golgi- complex where they participate in the assembly, budding, and intracellular trafficking of infectious virions.

Propagated annotation [?]

Comments [?]

Function Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.

Gene Ontology [?]

GO:0016021; Cellular component: integral component of membrane.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0039707; Biological process: pore formation by virus in membrane of host cell.

Keywords [?]

Additional information [?]

Size range 70-120 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P09048 (VEMP_CVPPU)
Viruses; Orthocoronavirinae
Comments None


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UniProtKB rule member sequences [?]