ProRule PRU01274
General rule information
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| Accession | PRU01274 |
| Dates | 4-JUN-2020 (Created)
1-MAR-2024 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51926; COV_E |
Name | Coronavirus envelope (CoV E) protein |
| Function | Coronavirus envelope (CoV E) proteins are involved in several aspects of the virus' life cycle, such as assembly, budding, envelope formation, and pathogenesis. They are ~100-residue-long polypeptides that are minor components in virions but are abundantly expressed inside infected cells. They are localized mainly to the endoplasmic reticulum (ER) and Golgi- complex where they participate in the assembly, budding, and intracellular trafficking of infectious virions. |
| Scope(s) |
Viruses Orthocoronavirinae |
| Example(s) | P09048 (VEMP_CVPPU); |
Propagated annotation
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Comments
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| FUNCTION | Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. |
| SUBUNIT | Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein. |
Keywords
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Gene Ontology
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| GO:0016020; Cellular component:membrane |
| GO:0044178; Cellular component:host cell Golgi membrane |
| GO:0044694; Biological process:symbiont genome entry into host cell via pore formation in plasma membrane |
Features
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Additional information
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| Size range | 70-120 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [46] All [ 46 ]
- Retrieve set of proteins with 3D structure for this domain