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PROSITE entry PS51937


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General information about the entry

Entry name [info] HNF_P1
Accession [info] PS51937
Entry type [info] MATRIX
Date [info] 02-DEC-2020 CREATED;
02-DEC-2020 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC51937
Associated ProRule [info] PRU01286

Name and characterization of the entry

Description [info] HNF-1 dimerization (HNF-p1) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=32;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=29;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.6413412; R2=0.0088844; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1054; N_SCORE=12.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=435; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-39; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;
...
                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='M';  M=-45,-75, 12, -1,-80,-27,-52,-69,-40,-44, 87,-36,-26,-57, 14,-22,-16,-34,-95,-76;
/M: SY='M';  M= -8,-83,-36, 39,-78,-50,-68,-48,-67,-67, 51,-73, 23,-56,-21,  1,-17, 31,-44,-76;
/M: SY='P';  M=-28,-70,-71,-69,-81,-14,-72,-30,-46,-26,  3,  2, 62,-66, -8, 53,-19,-48,-89,-78;
/M: SY='R';  M=-62,-85,-54,-16,-42,-75,-45,-34, 35, 20,  5,-67,-39, 19, 65,-40,-69,-69,-81,-68;
/M: SY='F';  M=-77,-78,-90,-85, 77,-90,-26,-47,-83, 48,  0,-85,-48,-83,-80,-81,-71,-13,-59, 33;
/M: SY='T';  M=-57,-69,-64,-67,-76,-56,-73,-68,-38,-73,-69,-23,-68,-66,-71, 32, 97,-39,-94,-73;
/M: SY='I';  M= 19,-63,-46,-28,-66,-61,-12, 50,-73,-39,-36,-51, -1, -9,-55, -9,-36, 42,-72,-31;
/M: SY='E';  M=-55,-82,-55, 76,-68,-85,-66,-42,-55, 45,-56,-47,-72, 10,-66,-52,-37,-64,-83,-70;
/M: SY='Q';  M=-66,-91,-61,-41,-96,-74,-54,-83,-14,-78,-65,-57,-73,123,-46,-56,-69,-84,-79,-68;
/M: SY='I';  M=-57,-47,-71, 22,-66,-86,-20, 54,-21, 10,-21,-49,-77, 41,  7,-68,-26,  5,-82,-66;
/M: SY='E';  M=-68,-88, 47, 80,-86,-54,-41,-87,-23,-66,-38,-57,-67, 49,-58,-62,-67,-83,  3,-25;
/M: SY='L';  M=-73,-76,-91,-83,-47,-93,-75,-18,-84, 84,-25,-90,-90,-77,-81,-84,-69,-45,-77,-60;
/M: SY='L';  M=-70,-78,-91,-85,-51,-94,-82, 56,-84, 61,-38,-87,-86,-79,-84,-81,-66, 21,-80,-62;
/M: SY='W';  M=-28,-87,-62,-47,-76,-29,-64,-80,-25,-59,-70,  0,-78, 71, 59,  0,-62,-46, 95,-61;
/M: SY='R';  M= 51,-79,-41,-25,-83,-68,-50,-81,  1,-79,-70,-63,-76,-19, 76, -2,-63,-72,-83,-73;
/M: SY='L';  M=-73,-75,-91,-83,-47,-92,-75,-38,-84, 84,-35,-90,-91,-77,-81,-83,-69,-23,-78,-60;
/M: SY='R';  M=-71,-79,-77,-66,-19,-85,-27,-40,-14, 55, -8,-72,-83,-33, 75,-72,-68,-48,-76,-60;
/M: SY='D';  M=-52,-25, 38, 28,-78, 14, -8,-63,-32,-11,-55, 14,-72, 19, 36,  9,-25,-45,-61,-70;
/M: SY='S';  M=-48,-67,-60,-62,-76,-58,-66,-73,-61,-77,-71,-49,-66,-56,-67, 89, 62,-65,-88,-70;
/M: SY='G';  M=-53,-81,-69,-80,-87, 98,-75,-95,-73,-90,-79,-54,-73,-71,-41,-54,-72,-88,-78,-82;
/M: SY='M';  M=-43,-71,-84,-78,-47,-83,-70, 60,-74, 49, 87,-77,-77,-69,-74,-73,-59, 21,-74,-54;
/M: SY='T';  M=-41,-63,-55,-42,-71,-48,-63,-66,-54,-70,-65, -5,-61,-55,-55, 75, 87,-58,-85,-66;
/M: SY='K';  M=-21,-78,-58,-46,-76,-49,-58,-75, 82,-29,-63,-22, 20, 21, 51,-15,-49,-72,-40,-65;
/M: SY='D';  M=  1,-79, 68, 62,-83,-67,-15,-78,-47,-67,-71,-26, 43, 31,-24,-40, -6,-57,-85,-71;
/M: SY='Q';  M= 21,-73,  5, 42,-71,-41,-61,-18,-53,-18,-55,-34,-67, 74,-57,-53, -3, 38,-79,-65;
/M: SY='L';  M=-62,-71,-84,-78,-46,-86,-76, 59,-77, 60, 11,-79,-79,-73,-77,-51,-58, 44,-75,-56;
/M: SY='I';  M=  0,-70,-82,-76,-44,-82,-78, 65,-47, 38,-12,-76,-76,-72,-75,-55,-31, 54,-77,-58;
/M: SY='H';  M=-26,-60,-34, 42,-78,-69, 90,-65, 12,-56,-38,-50,-65, 87, 11,-30,-62,-76,-80,-56;
/M: SY='A';  M= 91,-63,-69,-62,-24,-16,-70, -2,-64,-62,-12,-63,-67,-61,-51,-31,-48,-33,-25,-67;
/M: SY='L';  M=-58,-38,-83,-75, 47,-83,-65,-15,-74, 69, 48,-79,-21,-41,-49,-74,-63, -9,-62, 21;
/M: SY='D';  M=-33,-38, 66, 56,-82, 40, -8,-83,-23,-79,-67,-12,-39,-21, 11,-30,-10,-77,-84,-71;
/M: SY='E';  M=  1,-72, 56, 56,-77,-64,-58,-58,-47,-73,-33,-34,-37, -9,-16, 33, 50,-66,-23,-68;
/I:         E1=0; IE=-255; DE=-255;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 18 in 18 different sequences
Number of true positive hits 18 in 18 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] HNF-p1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
18 sequences

HMBX1_CAEEL (Q9TYT0), HMBX1_HUMAN (Q6NT76), HMBX1_MOUSE (Q8BJA3), 
HN1BA_DANRE (A1L1N5), HN1BB_DANRE (Q8UW00), HNF1A_CHICK (Q90867), 
HNF1A_HUMAN (P20823), HNF1A_MOUSE (P22361), HNF1A_RAT   (P15257), 
HNF1A_SALSA (Q91474), HNF1B_HUMAN (P35680), HNF1B_MOUSE (P27889), 
HNF1B_PIG   (Q03365), HNF1B_PONAB (Q5RER5), HNF1B_RAT   (P23899), 
HNF1B_XENLA (Q91910), HNFAA_XENLA (Q05041), HNFAB_XENLA (Q91739)
» more

PDB
[Detailed view]
6 PDB

1F93; 1G2Y; 1G2Z; 1G39; 1JB6; 2GYP