PRU01286
General rule information
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| Accession | PRU01286 |
| Dates | 24-AUG-2020 (Created) 24-AUG-2020 (Last updated, Version 1) |
| Data class | Domain |
| Predictors | PROSITE; PS51937; HNF_P1 |
| Name | HNF-1 dimerization (HNF-p1) domain |
| Function | The homeodomain proteins hepatocyte nuclear factor (HNF)-1alpha and HNF-1beta comprise a functionnally important family in which dimerization is essential for DNA binding. HNF-1alpha and HNF-1beta regulate tissue-specific genes in liver, kidney, intestine, and pancreas. These proteins form homo- and heterodimers through an autonomously folded domain encompassing the 32 N- terminal amino acids (HNF-p1). The dimerization domain also binds the transcriptional coactivator DCoH, which stimulates HNF-1alpha activity. |
Propagated annotation
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Features
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| From: PS51937 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | HNF-p1 # | |||||||||
Additional information
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| Size range | 30-35 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P27889 (HNF1B_MOUSE) |
| Scope | Eukaryota; Metazoa |
| Comments | None |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Eukaryota [18]
- Retrieve set of proteins with 3D structure for this domain