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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01286


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01286
General rule information [?]

Accession PRU01286
Dates 24-AUG-2020 (Created)
24-AUG-2020 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51937; HNF_P1
Name HNF-1 dimerization (HNF-p1) domain
Function The homeodomain proteins hepatocyte nuclear factor (HNF)-1alpha and HNF-1beta comprise a functionnally important family in which dimerization is essential for DNA binding. HNF-1alpha and HNF-1beta regulate tissue-specific genes in liver, kidney, intestine, and pancreas. These proteins form homo- and heterodimers through an autonomously folded domain encompassing the 32 N- terminal amino acids (HNF-p1). The dimerization domain also binds the transcriptional coactivator DCoH, which stimulates HNF-1alpha activity.
Scope(s) Eukaryota
Metazoa
Example(s) P27889;

Propagated annotation [?]

Features [?]

From: PS51937
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="HNF-p1 #"

Additional information [?]

Size range 30-35 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]