ProRule PRU01286

General rule information [?]

Accession PRU01286
Dates 24-AUG-2020 (Created)
-- (Last updated, Version 1)
Data class Domain;
Predictors PROSITE; PS51937; HNF_P1
Name HNF-1 dimerization (HNF-p1) domain
Function The homeodomain proteins hepatocyte nuclear factor (HNF)-1alpha and HNF-1beta comprise a functionnally important family in which dimerization is essential for DNA binding. HNF-1alpha and HNF-1beta regulate tissue-specific genes in liver, kidney, intestine, and pancreas. These proteins form homo- and heterodimers through an autonomously folded domain encompassing the 32 N- terminal amino acids (HNF-p1). The dimerization domain also binds the transcriptional coactivator DCoH, which stimulates HNF-1alpha activity.
Scope(s) Eukaryota
Example(s) P27889 (HNF1B_MOUSE);

Propagated annotation [?]

Features [?]

From: PS51937
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="HNF-p1 #"

Additional information [?]

Size range 30-35 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]