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annotation rule: PRU01286

General rule information [?]

Accession PRU01286
Dates 24-AUG-2020 (Created)
24-AUG-2020 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS51937; HNF_P1
Name HNF-1 dimerization (HNF-p1) domain
Function The homeodomain proteins hepatocyte nuclear factor (HNF)-1alpha and HNF-1beta comprise a functionnally important family in which dimerization is essential for DNA binding. HNF-1alpha and HNF-1beta regulate tissue-specific genes in liver, kidney, intestine, and pancreas. These proteins form homo- and heterodimers through an autonomously folded domain encompassing the 32 N- terminal amino acids (HNF-p1). The dimerization domain also binds the transcriptional coactivator DCoH, which stimulates HNF-1alpha activity.

Propagated annotation [?]


Features [?]

From: PS51937
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       HNF-p1 #        

Additional information [?]

Size range 30-35 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P27889 (HNF1B_MOUSE)
Scope
Eukaryota; Metazoa
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]