We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS51963

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PURL: https://purl.expasy.org/prosite/signature/PS51963

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General information about the entry

Entry name [info]	BCOV_NSP1_C
Accession [info]	PS51963
Entry type [info]	MATRIX
Date [info]	02-JUN-2021 CREATED; 02-JUN-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51962
Associated ProRule [info]	PRU01308

Name and characterization of the entry

Description [info]

Betacoronavirus (BetaCoV) Nsp1 C-terminal domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=31;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=28;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.6673212; R2=0.0082141; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=954; N_SCORE=10.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=467; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-46; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='F';  M= -65, -74,  68,  52,  72, -73, -60, -66, -57, -62, -65, -52, -67, -57, -64, -56,  41, -65, -68, -47;
/M: SY='P';  M=  -3, -74, -62, -58, -67, -64, -62, -60,  20,  31, -55,  35,  78, -58, -61,  35, -53, -62, -78, -68;
/M: SY='G';  M= -53,  47, -71, -75, -62,  70, -71, -51, -71, -62, -59, -62,  18, -71, -76, -57, -61,  54, -72,  33;
/M: SY='P';  M= -60, -78, -53,  62, -72, -72, -66, -64, -55, -70, -65, -62,  77, -54, -65, -54,  54,   6,  66, -67;
/M: SY='D';  M= -15, -80, 109,  42, -87, -65, -54, -85, -53, -82, -80, -39, -65, -50, -61, -55, -58, -80, -97, -71;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='P';  M=  50, -79, -71, -60, -73, -63, -73,  10, -65, -70, -63, -71, 100, -65, -73, -57, -58, -61,  71, -69;
/M: SY='Y';  M= -68,  61, -76, -76, -30, -80, -49,  34, -70,   2,  42, -73, -81, -65, -68, -68, -63, -48, -43, 110;
/M: SY='E';  M=   3, -75,  66,  68, -69, -69, -58, -65, -54,  30, -59, -53, -65, -49, -61,   5, -57, -64, -83, -67;
/M: SY='D';  M= -66, -80, 104,  47, -82, -68, -54, -79, -52, -14, -73, -41, -65,   5, -60, -57, -58, -77, -93, -69;
/M: SY='F';  M= -65, -71, -83, -79,  82, -83, -65, -35, -75,  22, -44, -78, -83, -77, -73, -71, -61,  55, -52,  59;
/M: SY='H';  M= -64, -83, -48,  65, -76, -72,  99, -76, -52, -69,  36, -55,  64,  27, -56, -59, -62, -76, -85, -58;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='Q';  M=  53, -68,  29,  10, -71, -62, -62, -62, -56,   5, -57, -54, -65,  54, -60, -46,  53, -57, -80, -66;
/M: SY='N';  M= -63, -75,  61,  46, -81, -62, -50, -81,  48, -81, -72,  80, -65, -45, -47, -52, -54, -78, -88, -70;
/M: SY='P';  M= -68, -94, -73, -60, -70, -69, -76, -74, -65, -81, -71, -78, 116, -68, -76, -67, -64, -81, 116, -62;
/M: SY='K';  M= -62,  42, -51, -48, -77, -65, -56, -76,  86, -77, -66,  64, -67, -46,   2, -52,  18, -72, -80, -68;
/M: SY='G';  M=  38, -69, -63, -68, -77,  78, -70, -75, -65, -75, -68, -52, -65, -64, -72, -44,  54, -66, -77, -73;
/M: SY='K';  M= -63, -77, -55, -41, -79, -70, -58, -79, 110, -78, -66, -48, -63, -39, -24, -57, -57, -75, -72, -65;
/I:         I=-23; MD=-58;
/M: SY='Y';  M= -82, -91, -77, -78,  34, -87,  87, -73, -76, -66, -62, -72, -90, -70, -71, -76, -77, -77, -52,  99; D=-23;
/I:         I=-23; MD=-58;
/M: SY='S';  M=   2, -77, -69, -71, -87,  28, -73, -87, -71, -89, -81, -58, -76, -63, -75,  82, -53, -78, -91, -80; D=-23;
/I:         I=-23; MD=-58;
/M: SY='Q';  M= -65,  43, -69, -56, -92, -12, -66, -88,  20, -85, -75, -61, -78,  83,  -8,  37, -65, -84, -88, -76; D=-23;
/I:         I=-23; MD=-58;
/M: SY='K';  M= -67, -84, -63, -65, -90,  42, -68, -92,  60, -92, -81,  51, -77, -60, -55,   4, -66, -88, -89, -81; D=-23;
/I:         I=-23; MD=-58;
/M: SY='A';  M=  58, -75, -86, -79, -68, -75, -83, -52, -80,  33, -55, -82, -85, -77, -82, -65, -66,  30, -87, -74; D=-23;
/I:         I=-23; MI=0; MD=-58; IM=0; DM=-58;
/M: SY='Y';  M= -96,-109, -94, -89, -62,-104, -69, -93, -69, -88, -82, -91,-107, -77,  54, -91, -92, -94, -69,  84; D=-23;
/I:         I=-23; DM=-58;
/M: SY='E';  M=  49, -95, -75,  49,-106, -85, -89, -99, -79, -98, -92, -87, -88, -73, -86, -74, -82, -88,-104, -99; D=-23;
/I:         I=-23; DM=-58;
/M: SY='L';  M= -78, -80, -95, -87, -51, -97, -79, -43, -89,  81, -39, -95, -95, -82, -86, -88, -74, -50, -82, -64; D=-23;
/I:         I=-23; DM=-58;
/M: SY='K';  M= -73, -83, -80, -72, -67, -89, -77,  34,  49,  26,  38, -73, -81, -68, -62, -73,  21, -54, -85, -69; D=-23;
/I:         I=-23; DM=-58;
/M: SY='R';  M= -76, -92, -71, -58, -88, -85, -65, -92,  62, -87, -76, -64, -81, -51,  85, -70, -73, -86, -85, -74; D=-23;
/I:         I=-23; DM=-58;
/M: SY='E';  M= -69, -87, -65,  50, -76,  40, -72, -72, -68,  32, -64, -71, -78,  30, -73, -69, -74, -74, -85, -77; D=-23;
/I:         I=-23; DM=-58;
/M: SY='Y';  M= -67, -77, -75, -70, -39, -82, -55,  37, -56,  34, -43, -71, -80, -60,  53, -68, -63,   4, -54,  85;
/M: SY='G';  M= -57, -76, -55, -62, -79,  71, -57, -85, -46, -82, -70,  64, -71, -53,  67, -51, -61, -80, -79, -71;
/M: SY='G';  M= -49, -77, -64, -76, -83, 103, -71, -91, -70, -86, -75, -50, -68, -67, -77, -49, -68, -84, -74, -78;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	42 in 42 different sequences
Number of true positive hits	42 in 42 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotic viruses
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	BetaCoV Nsp1 C-terminal
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

42 sequences

R1AB_BC133  (P0C6W1), R1AB_BC279  (P0C6V9), R1AB_BCHK3  (P0C6W2),

R1AB_BCHK4  (P0C6W3), R1AB_BCHK5  (P0C6W4), R1AB_BCHK9  (P0C6W5), 
R1AB_BCRP3  (P0C6W6), R1AB_CVBEN  (P0C6W7), R1AB_CVBLU  (P0C6W8), 
R1AB_CVBM   (P0C6W9), R1AB_CVBQ   (P0C6X0), R1AB_CVHN1  (P0C6X2), 
R1AB_CVHN2  (P0C6X3), R1AB_CVHN5  (P0C6X4), R1AB_CVHOC  (P0C6X6), 
R1AB_CVM2   (P0C6X8), R1AB_CVMA5  (P0C6X9), R1AB_CVMJH  (P0C6Y0), 
R1AB_MERS1  (K9N7C7), R1AB_SARS   (P0C6X7), R1AB_SARS2  (P0DTD1), 
R1A_BC133   (P0C6F7), R1A_BC279   (P0C6F5), R1A_BCHK3   (P0C6F8), 
R1A_BCHK4   (P0C6T4), R1A_BCHK5   (P0C6T5), R1A_BCHK9   (P0C6T6), 
R1A_BCRP3   (P0C6T7), R1A_CVBEN   (P0C6T8), R1A_CVBLU   (P0C6T9), 
R1A_CVBM(P0C6U0), R1A_CVBQ(P0C6U1), R1A_CVHN1   (P0C6U3), 
R1A_CVHN2   (P0C6U4), R1A_CVHN5   (P0C6U5), R1A_CVHOC   (P0C6U7), 
R1A_CVM2(P0C6U9), R1A_CVMA5   (P0C6V0), R1A_CVMJH   (P0C6V1), 
R1A_MERS1   (K9N638), R1A_SARS(P0C6U8), R1A_SARS2   (P0DTC1)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

18 PDB

pdb_00006zlw; pdb_00006zm7; pdb_00006zme; pdb_00006zmi; pdb_00006zmo; pdb_00006zmt; pdb_00006zn5; pdb_00006zoj; pdb_00006zok; pdb_00006zon; pdb_00006zp4; pdb_00007jqb; pdb_00007jqc; pdb_00007k3n; pdb_00007k5i; pdb_00008aou; pdb_00008ppl; pdb_00008t4s
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