PROSITE entry PS51963

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General information about the entry

Entry name [info]	BCOV_NSP1_C
Accession [info]	PS51963
Entry type [info]	MATRIX
Date [info]	02-JUN-2021 CREATED; 02-JUN-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51962
Associated ProRule [info]	PRU01308

Name and characterization of the entry

Description [info]

Betacoronavirus (BetaCoV) Nsp1 C-terminal domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=31;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=28;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.6673212; R2=0.0082141; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=954; N_SCORE=10.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=467; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-46; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='F';  M= -65, -74,  68,  52,  72, -73, -60, -66, -57, -62, -65, -52, -67, -57, -64, -56,  41, -65, -68, -47;
/M: SY='P';  M=  -3, -74, -62, -58, -67, -64, -62, -60,  20,  31, -55,  35,  78, -58, -61,  35, -53, -62, -78, -68;
/M: SY='G';  M= -53,  47, -71, -75, -62,  70, -71, -51, -71, -62, -59, -62,  18, -71, -76, -57, -61,  54, -72,  33;
/M: SY='P';  M= -60, -78, -53,  62, -72, -72, -66, -64, -55, -70, -65, -62,  77, -54, -65, -54,  54,   6,  66, -67;
/M: SY='D';  M= -15, -80, 109,  42, -87, -65, -54, -85, -53, -82, -80, -39, -65, -50, -61, -55, -58, -80, -97, -71;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='P';  M=  50, -79, -71, -60, -73, -63, -73,  10, -65, -70, -63, -71, 100, -65, -73, -57, -58, -61,  71, -69;
/M: SY='Y';  M= -68,  61, -76, -76, -30, -80, -49,  34, -70,   2,  42, -73, -81, -65, -68, -68, -63, -48, -43, 110;
/M: SY='E';  M=   3, -75,  66,  68, -69, -69, -58, -65, -54,  30, -59, -53, -65, -49, -61,   5, -57, -64, -83, -67;
/M: SY='D';  M= -66, -80, 104,  47, -82, -68, -54, -79, -52, -14, -73, -41, -65,   5, -60, -57, -58, -77, -93, -69;
/M: SY='F';  M= -65, -71, -83, -79,  82, -83, -65, -35, -75,  22, -44, -78, -83, -77, -73, -71, -61,  55, -52,  59;
/M: SY='H';  M= -64, -83, -48,  65, -76, -72,  99, -76, -52, -69,  36, -55,  64,  27, -56, -59, -62, -76, -85, -58;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='Q';  M=  53, -68,  29,  10, -71, -62, -62, -62, -56,   5, -57, -54, -65,  54, -60, -46,  53, -57, -80, -66;
/M: SY='N';  M= -63, -75,  61,  46, -81, -62, -50, -81,  48, -81, -72,  80, -65, -45, -47, -52, -54, -78, -88, -70;
/M: SY='P';  M= -68, -94, -73, -60, -70, -69, -76, -74, -65, -81, -71, -78, 116, -68, -76, -67, -64, -81, 116, -62;
/M: SY='K';  M= -62,  42, -51, -48, -77, -65, -56, -76,  86, -77, -66,  64, -67, -46,   2, -52,  18, -72, -80, -68;
/M: SY='G';  M=  38, -69, -63, -68, -77,  78, -70, -75, -65, -75, -68, -52, -65, -64, -72, -44,  54, -66, -77, -73;
/M: SY='K';  M= -63, -77, -55, -41, -79, -70, -58, -79, 110, -78, -66, -48, -63, -39, -24, -57, -57, -75, -72, -65;
/I:         I=-23; MD=-58;
/M: SY='Y';  M= -82, -91, -77, -78,  34, -87,  87, -73, -76, -66, -62, -72, -90, -70, -71, -76, -77, -77, -52,  99; D=-23;
/I:         I=-23; MD=-58;
/M: SY='S';  M=   2, -77, -69, -71, -87,  28, -73, -87, -71, -89, -81, -58, -76, -63, -75,  82, -53, -78, -91, -80; D=-23;
/I:         I=-23; MD=-58;
/M: SY='Q';  M= -65,  43, -69, -56, -92, -12, -66, -88,  20, -85, -75, -61, -78,  83,  -8,  37, -65, -84, -88, -76; D=-23;
/I:         I=-23; MD=-58;
/M: SY='K';  M= -67, -84, -63, -65, -90,  42, -68, -92,  60, -92, -81,  51, -77, -60, -55,   4, -66, -88, -89, -81; D=-23;
/I:         I=-23; MD=-58;
/M: SY='A';  M=  58, -75, -86, -79, -68, -75, -83, -52, -80,  33, -55, -82, -85, -77, -82, -65, -66,  30, -87, -74; D=-23;
/I:         I=-23; MI=0; MD=-58; IM=0; DM=-58;
/M: SY='Y';  M= -96,-109, -94, -89, -62,-104, -69, -93, -69, -88, -82, -91,-107, -77,  54, -91, -92, -94, -69,  84; D=-23;
/I:         I=-23; DM=-58;
/M: SY='E';  M=  49, -95, -75,  49,-106, -85, -89, -99, -79, -98, -92, -87, -88, -73, -86, -74, -82, -88,-104, -99; D=-23;
/I:         I=-23; DM=-58;
/M: SY='L';  M= -78, -80, -95, -87, -51, -97, -79, -43, -89,  81, -39, -95, -95, -82, -86, -88, -74, -50, -82, -64; D=-23;
/I:         I=-23; DM=-58;
/M: SY='K';  M= -73, -83, -80, -72, -67, -89, -77,  34,  49,  26,  38, -73, -81, -68, -62, -73,  21, -54, -85, -69; D=-23;
/I:         I=-23; DM=-58;
/M: SY='R';  M= -76, -92, -71, -58, -88, -85, -65, -92,  62, -87, -76, -64, -81, -51,  85, -70, -73, -86, -85, -74; D=-23;
/I:         I=-23; DM=-58;
/M: SY='E';  M= -69, -87, -65,  50, -76,  40, -72, -72, -68,  32, -64, -71, -78,  30, -73, -69, -74, -74, -85, -77; D=-23;
/I:         I=-23; DM=-58;
/M: SY='Y';  M= -67, -77, -75, -70, -39, -82, -55,  37, -56,  34, -43, -71, -80, -60,  53, -68, -63,   4, -54,  85;
/M: SY='G';  M= -57, -76, -55, -62, -79,  71, -57, -85, -46, -82, -70,  64, -71, -53,  67, -51, -61, -80, -79, -71;
/M: SY='G';  M= -49, -77, -64, -76, -83, 103, -71, -91, -70, -86, -75, -50, -68, -67, -77, -49, -68, -84, -74, -78;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.

Total number of hits	42 in 42 different sequences
Number of true positive hits	42 in 42 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotic viruses
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	BetaCoV Nsp1 C-terminal
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

42 sequences

R1AB_BC133  (P0C6W1), R1AB_BC279  (P0C6V9), R1AB_BCHK3  (P0C6W2),

R1AB_BCHK4  (P0C6W3), R1AB_BCHK5  (P0C6W4), R1AB_BCHK9  (P0C6W5), 
R1AB_BCRP3  (P0C6W6), R1AB_CVBEN  (P0C6W7), R1AB_CVBLU  (P0C6W8), 
R1AB_CVBM   (P0C6W9), R1AB_CVBQ   (P0C6X0), R1AB_CVHN1  (P0C6X2), 
R1AB_CVHN2  (P0C6X3), R1AB_CVHN5  (P0C6X4), R1AB_CVHOC  (P0C6X6), 
R1AB_CVM2   (P0C6X8), R1AB_CVMA5  (P0C6X9), R1AB_CVMJH  (P0C6Y0), 
R1AB_MERS1  (K9N7C7), R1AB_SARS   (P0C6X7), R1AB_SARS2  (P0DTD1), 
R1A_BC133   (P0C6F7), R1A_BC279   (P0C6F5), R1A_BCHK3   (P0C6F8), 
R1A_BCHK4   (P0C6T4), R1A_BCHK5   (P0C6T5), R1A_BCHK9   (P0C6T6), 
R1A_BCRP3   (P0C6T7), R1A_CVBEN   (P0C6T8), R1A_CVBLU   (P0C6T9), 
R1A_CVBM(P0C6U0), R1A_CVBQ(P0C6U1), R1A_CVHN1   (P0C6U3), 
R1A_CVHN2   (P0C6U4), R1A_CVHN5   (P0C6U5), R1A_CVHOC   (P0C6U7), 
R1A_CVM2(P0C6U9), R1A_CVMA5   (P0C6V0), R1A_CVMJH   (P0C6V1), 
R1A_MERS1   (K9N638), R1A_SARS(P0C6U8), R1A_SARS2   (P0DTC1)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

18 PDB

6ZLW; 6ZM7; 6ZME; 6ZMI; 6ZMO; 6ZMT; 6ZN5; 6ZOJ; 6ZOK; 6ZON; 6ZP4; 7JQB; 7JQC; 7K3N; 7K5I; 8AOU; 8PPL; 8T4S
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