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ProRule PRU01308


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01308
Accession PRU01308
Dates 3-MAR-2021 (Created)
1-MAR-2024 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51963; BCOV_NSP1_C
Name Betacoronavirus (BetaCoV) Nsp1 C-terminal domain
Function The Sarbecovirus Nsp1 C-terminal domain binds to the mRNA channel of the 40S ribosome, where it interferes with mRNA binding and inhibits host protein translation. This inhibition mechanism may be unique to Sarbecoviruses, because the C-terminal region of Nsp1 is shorter in AlphaCoVs and is not highly conserved amongst other BetaCoVs, including MERS-CoV.
Scope(s) Viruses
Betacoronavirus
Example(s) P0C6X7 (R1AB_SARS);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the coronaviruses polyprotein 1ab family.

Keywords [?]

Inhibition of host innate immune response by virus
Inhibition of host interferon signaling pathway by virus
Viral immunoevasion
Eukaryotic host translation shutoff by virus
Host mRNA suppression by virus

Gene Ontology [?]

GO:0039502; Biological process:symbiont-mediated suppression of host type I interferon-mediated signaling pathway
GO:0039595; Biological process:symbiont-mediated degradation of host mRNA

Features [?]

From: PS51963
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="BetaCoV Nsp1 C-terminal #"

Additional information [?]

Size range 25-40 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]