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annotation rule: PRU01308

General rule information [?]

Accession PRU01308
Dates 3-MAR-2021 (Created)
3-MAR-2021 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS51963; BCOV_NSP1_C
Name Betacoronavirus (BetaCoV) Nsp1 C-terminal domain
Function The Sarbecovirus Nsp1 C-terminal domain binds to the mRNA channel of the 40S ribosome, where it interferes with mRNA binding and inhibits host protein translation. This inhibition mechanism may be unique to Sarbecoviruses, because the C-terminal region of Nsp1 is shorter in AlphaCoVs and is not highly conserved amongst other BetaCoVs, including MERS-CoV.

Propagated annotation [?]


Comments [?]

Similarity Belongs to the coronaviruses polyprotein 1ab family.

Gene Ontology [?]

GO:0039502; Biological process: suppression by virus of host type I interferon-mediated signaling pathway.
GO:0039595; Biological process: induction by virus of catabolism of host mRNA.

Keywords [?]

Inhibition of host innate immune response by virus
Inhibition of host interferon signaling pathway by virus
Viral immunoevasion
Eukaryotic host translation shutoff by virus
Host mRNA suppression by virus

Features [?]

From: PS51963
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       BetaCoV Nsp1 C-terminal #        

Additional information [?]

Size range 25-40 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0C6X7 (R1AB_SARS)
Scope
Viruses; Betacoronavirus
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]