PRU01308
General rule information
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Accession | PRU01308 |
Dates | 3-MAR-2021 (Created) 3-MAR-2021 (Last updated, Version 1) |
Data class | Domain |
Predictors | PROSITE; PS51963; BCOV_NSP1_C |
Name | Betacoronavirus (BetaCoV) Nsp1 C-terminal domain |
Function | The Sarbecovirus Nsp1 C-terminal domain binds to the mRNA channel of the 40S ribosome, where it interferes with mRNA binding and inhibits host protein translation. This inhibition mechanism may be unique to Sarbecoviruses, because the C-terminal region of Nsp1 is shorter in AlphaCoVs and is not highly conserved amongst other BetaCoVs, including MERS-CoV. |
Propagated annotation
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Comments
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Similarity | Belongs to the coronaviruses polyprotein 1ab family. |
Gene Ontology
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GO:0039502; Biological process: suppression by virus of host type I interferon-mediated signaling pathway.
GO:0039595; Biological process: induction by virus of catabolism of host mRNA.
GO:0039595; Biological process: induction by virus of catabolism of host mRNA.
Keywords
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Inhibition of host innate immune response by virus
Inhibition of host interferon signaling pathway by virus
Viral immunoevasion
Eukaryotic host translation shutoff by virus
Host mRNA suppression by virus
Inhibition of host interferon signaling pathway by virus
Viral immunoevasion
Eukaryotic host translation shutoff by virus
Host mRNA suppression by virus
Features
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From: PS51963 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | BetaCoV Nsp1 C-terminal # |
Additional information
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Size range | 25-40 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | P0C6X7 (R1AB_SARS) |
Scope | Viruses; Betacoronavirus |
Comments | None |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Viruses [42]
- Retrieve set of proteins with 3D structure for this domain