PRU01308

Accession	PRU01308
Dates	3-MAR-2021 (Created) 3-MAR-2021 (Last updated, Version 1)

Data class

Domain

Predictors

PROSITE; PS51963; BCOV_NSP1_C

Name	Betacoronavirus (BetaCoV) Nsp1 C-terminal domain

Function

The Sarbecovirus Nsp1 C-terminal domain binds to the mRNA channel of the 40S ribosome, where it interferes with mRNA binding and inhibits host protein translation. This inhibition mechanism may be unique to Sarbecoviruses, because the C-terminal region of Nsp1 is shorter in AlphaCoVs and is not highly conserved amongst other BetaCoVs, including MERS-CoV.

Similarity

Belongs to the coronaviruses polyprotein 1ab family.

GO:0039502; Biological process: suppression by virus of host type I interferon-mediated signaling pathway.
GO:0039595; Biological process: induction by virus of catabolism of host mRNA.

Inhibition of host innate immune response by virus
Inhibition of host interferon signaling pathway by virus
Viral immunoevasion
Eukaryotic host translation shutoff by virus
Host mRNA suppression by virus

From: PS51963

Key

From

To

Description

Tag

Condition

FTGroup

DOMAIN

from

to

BetaCoV Nsp1 C-terminal #

Size range	25-40 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	P0C6X7 (R1AB_SARS)
Scope	Viruses; Betacoronavirus
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

• UniProtKB/Swiss-Prot sets
  

  Viruses

  [42]

  
  
• Retrieve set of proteins with 3D structure for this domain