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annotation rule: PRU01308 |
Accession | PRU01308 |
Dates | 3-MAR-2021 (Created) 3-MAR-2021 (Last updated, Version 1) |
Data class | Domain |
Predictors | PROSITE; PS51963; BCOV_NSP1_C |
Name | Betacoronavirus (BetaCoV) Nsp1 C-terminal domain |
Function | The Sarbecovirus Nsp1 C-terminal domain binds to the mRNA channel of the 40S ribosome, where it interferes with mRNA binding and inhibits host protein translation. This inhibition mechanism may be unique to Sarbecoviruses, because the C-terminal region of Nsp1 is shorter in AlphaCoVs and is not highly conserved amongst other BetaCoVs, including MERS-CoV. |
Similarity | Belongs to the coronaviruses polyprotein 1ab family. |
From: PS51963 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | BetaCoV Nsp1 C-terminal # |
Size range | 25-40 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | P0C6X7 (R1AB_SARS) |
Scope | Viruses; Betacoronavirus |
Comments | None |
Viruses | [42] |