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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00137


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PURL: https://purl.expasy.org/prosite/signature/PS00137

Direct ScanProsite submission
General information about the entry

Entry name [info] SUBTILASE_HIS
Accession [info] PS00137
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00125
Associated ProRule [info] PRU10081

Name and characterization of the entry

Description [info] Serine proteases, subtilase family, histidine active site.
Pattern [info]
H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-[SAGM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 249 in 249 different sequences
Number of true positive hits 234 in 234 different sequences
Number of 'unknown' hits 0
Number of false positive hits 15 in 15 different sequences
Number of false negative sequences 8
Number of 'partial' sequences 7
Precision (true positives / (true positives + false positives)) 93.98 %
Recall (true positives / (true positives + false negatives)) 96.69 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
234 sequences

AEP_YARLI   (P09230), AEX5_CAEEL  (P91863), ALP2_ASPFC  (B0Y473), 
ALP2_ASPFU  (P87184), ALP_CORPA   (Q68GV9), ALP_HAPCH   (P29118), 
ALP_HYPAT   (Q03420), APRX_BACSU  (O31788), AQL1_THEAQ  (P08594), 
ASES_SARSR  (R4IR27), ASP_AERSO   (Q9L5A4), BLI4_CAEEL  (P51559), 
BLI_ONCVO   (A0A044RE18), BPRV_DICNO  (P42779), BPRX_DICNO  (P42780), 
C5AP_STRP1  (P58099), C5AP_STRP3  (P0DD34), C5AP_STRP6  (Q5X9R0), 
C5AP_STRP8  (Q8NZ80), C5AP_STRPQ  (P0DD35), C5AP_STRPY  (P15926), 
CH901_DAVTA (B7ZK61), CL401_COCLU (B3V0K8), CRSP_ARATH  (Q9LNU1), 
CUDP_METAN  (P29138), ELYA_ALKAL  (P27693), ELYA_BACYA  (P20724), 
ELYA_HALH5  (P41363), ELYA_SHOCL  (P41362), EPIP_STAEP  (P30199), 
EXPR_XANCP  (P23314), FKPC1_CAEEL (O17798), FLS_FERPE   (Q93LQ6), 
FUR11_DROME (P26016), FUR1C_DROME (P30430), FUR2_DROME  (P30432), 
FURI1_XENLA (P29119), FURIN_BOVIN (Q28193), FURIN_HUMAN (P09958), 
FURIN_MOUSE (P23188), FURIN_RAT   (P23377), HLY_HALMT   (I3R794), 
HLY_NATA1   (P29143), ISP1_BACSU  (P11018), ISP6_SCHPO  (P40903), 
ISP_PAEPO   (P29139), ISP_SHOCL   (P29140), KEX1A_KLULA (P09231), 
KEX2_CANAW  (O13359), KEX2_YEAST  (P13134), KRP1_SCHPO  (Q09175), 
MBTP1_CRIGR (Q9Z2A8), MBTP1_HUMAN (Q14703), MBTP1_MOUSE (Q9WTZ2), 
MBTP1_RAT   (Q9WTZ3), MYCP2_MYCTU (O05458), MYCP3_MYCTU (O53695), 
MYCP4_MYCTU (I6YC58), MYCP5_MYCTU (O53945), NEC1_BOVIN  (Q9GLR1), 
NEC1_HUMAN  (P29120), NEC1_MOUSE  (P63239), NEC1_MUSCO  (P63240), 
NEC1_RAT(P28840), NEC2_BOVIN  (Q9GLR0), NEC2_CAEEL  (G5ECN9), 
NEC2_DROME  (Q9VBC7), NEC2_HUMAN  (P16519), NEC2_MOUSE  (P21661), 
NEC2_PIG(Q03333), NEC2_PONAB  (Q5REC2), NEC2_RAT(P28841), 
NECA_HYDVU  (P29146), NECB_HYDVU  (P29145), NEP_NATMA   (Q5RLZ1), 
NISP_LACLL  (Q07596), ORYZ_ASPCL  (A1CIA7), ORYZ_ASPFC  (B0Y708), 
ORYZ_ASPFL  (P35211), ORYZ_ASPFN  (B8N106), ORYZ_ASPFU  (P28296), 
ORYZ_ASPOR  (P12547), ORYZ_EMENI  (Q00208), ORYZ_NEOFI  (A1CWF3), 
P1P_LACLC   (P16271), P2P_LACLC   (P15293), P2P_LACPA   (Q02470), 
P3P_LACLS   (P15292), PCH18_PENCH (P9WEW6), PCH18_PENRB (P9WEW5), 
PCSK4_HUMAN (Q6UW60), PCSK4_MOUSE (P29121), PCSK4_RAT   (Q78EH2), 
PCSK5_BRACL (Q9NJ15), PCSK5_HUMAN (Q92824), PCSK5_MOUSE (Q04592), 
PCSK5_RAT   (P41413), PCSK6_HUMAN (P29122), PCSK6_RAT   (Q63415), 
PCSK7_HUMAN (Q16549), PCSK7_MOUSE (Q61139), PCSK7_RAT   (Q62849), 
PEN18_PENRB (Q9P8G3), PENC2_PENCI (Q9Y755), PEPC_ASPNG  (P33295), 
PLS_PYRFU   (P72186), POPC_MYXXD  (Q1DFT5), PRCA_NOSS1  (Q59149), 
PRCA_TRIV2  (P23916), PROA_VIBAL  (P16588), PRTB_YEAST  (P09232), 
PRTK_PARAQ  (P06873), PRTM_SHOC1  (Q99405), PRTR_PARAQ  (P23653), 
PRTS_SERMA  (P09489), PRTT_PARAQ  (P20015), PRTT_SERMA  (P29805), 
PSP3_SCHPO  (Q9UTS0), RM201_RHOMI (Q32ZM1), RRT12_YEAST (P25381), 
SBT24_ARATH (F4HYR6), SBT31_ARATH (F4JJH4), SBT33_ARATH (Q9MAP5), 
SBT34_ARATH (F4HPF1), SBT39_ARATH (Q9ZSB0), SBT3A_ARATH (Q9ZSB1), 
SBT3B_ARATH (Q1PDX5), SBT3C_ARATH (F4JJH5), SBT3G_ARATH (Q8GWX9), 
SBT41_ARATH (F4IG09), SBT51_ARATH (F4HSQ2), SBT61_ARATH (Q0WUG6), 
SEPR_THESR  (P80146), SMP1_MAGPO  (Q9Y778), SPAZ_ARTOA  (G1X8P8), 
SPAZ_ORBOL  (G3FNQ9), SPL1_ENCCU  (Q8SQJ3), SPM1_PYRO7  (P58371), 
SUB10_ARTBC (D4AQG0), SUB10_TRIVH (D4DIS6), SUB1_PLABA  (A0A509AM03), 
SUB1_PLAF7  (Q8I0V0), SUB1_PLAFA  (O61142), SUB1_PLAFO  (W7K9M0), 
SUB1_PLAVI  (E6Y8B9), SUB1_PSED2  (L8G6I7), SUB2A_COCP7 (C5P6D1), 
SUB2C_COCP7 (C5NZ70), SUB2_ARTBC  (D4AZ75), SUB2_ARTBE  (Q64K35), 
SUB2_ARTGP  (E4UZP9), SUB2_ARTOC  (C5G168), SUB2_ARTOT  (Q8J0D8), 
SUB2_DEIRA  (Q9RYM8), SUB2_PLAF7  (Q8IHZ5), SUB2_PLAFA  (O97364), 
SUB2_PLAFP  (Q9Y008), SUB2_PSED2  (L8FSM5), SUB2_TRIEQ  (B6VA85), 
SUB2_TRIRU  (Q69F57), SUB2_TRITO  (B8XGQ5), SUB2_TRIVC  (Q5VJ76), 
SUB2_TRIVH  (D4DLI5), SUB3_PLAF7  (Q8I430), SUB3_PSED2  (L8GD75), 
SUB4B_COCP7 (C5NZT2), SUB5_ARTBC  (D4B194), SUB5_ARTBE  (Q64K32), 
SUB5_ARTGP  (E4V2L6), SUB5_ARTOC  (C5G1D1), SUB5_TRIEQ  (B6VA87), 
SUB5_TRIRU  (Q69F34), SUB5_TRITO  (B8XGQ8), SUB5_TRIVC  (Q5VJ73), 
SUB5_TRIVH  (D4D0F5), SUB6_ARTBC  (D4ALV9), SUB6_ARTBE  (Q64K31), 
SUB6_ARTGP  (E4V4J8), SUB6_ARTOC  (C5FQI3), SUB6_TRIEQ  (A1XIH0), 
SUB6_TRIRU  (Q9UW97), SUB6_TRISD  (A1XIH1), SUB6_TRISH  (Q8J077), 
SUB6_TRITO  (Q3ZEJ8), SUB6_TRIVC  (Q5VJ72), SUB6_TRIVH  (D4D5H3), 
SUB7B_COCP7 (C5PCX1), SUB7C_COCP7 (C5NZ69), SUB7_ARTBC  (D4APA9), 
SUB7_ARTBE  (Q64K36), SUB7_ARTGP  (E4V2V9), SUB7_ARTOC  (C5FJA5), 
SUB7_TRIEQ  (A1XIH3), SUB7_TRIRU  (Q8NID9), SUB7_TRISD  (A1XIH5), 
SUB7_TRITO  (A1XIH4), SUB7_TRIVC  (Q5VJ71), SUB7_TRIVH  (D4CZQ4), 
SUB7_TRIVO  (A1XIH6), SUB8_ARTBC  (D4AX50), SUB8_ARTOC  (C5FII2), 
SUB8_COCP7  (C5P4Z8), SUB8_TRIVH  (D4DKQ4), SUBB_LEDLE  (P29599), 
SUBC_BACLI  (P00780), SUBD_BACLI  (P00781), SUBE_BACSU  (P16396), 
SUBF_BACSU  (P16397), SUBN_BACNA  (P35835), SUBS_LEDLE  (P29600), 
SUBT_BACAM  (P00782), SUBT_BACPU  (P07518), SUBT_BACS9  (P28842), 
SUBT_BACSA  (P00783), SUBT_BACSU  (P04189), SUBT_GEOSE  (P29142), 
SUBV_BACSU  (P29141), TAGB_DICDI  (P54683), TAGC_DICDI  (Q23868), 
TAGD_DICDI  (Q8T9W1), THES_BACSJ  (Q45670), THET_THEVU  (P04072), 
TKSP_THEKO  (Q5JIZ5), TPP2_BOVIN  (A5PK39), TPP2_CAEEL  (Q09541), 
TPP2_DROME  (Q9V6K1), TPP2_HUMAN  (P29144), TPP2_MOUSE  (Q64514), 
TPP2_RAT(Q64560), TPP2_SCHPO  (Q9UT05), TPPII_ARATH (F4JVN6), 
WPRA_BACSU  (P54423), XPR6_YARLI  (P42781), YSP3_YEAST  (P25036)
» more

UniProtKB/Swiss-Prot
False negative sequences
8 sequences

NALP_NEIMB  (Q9JXM7), NALP_NEIMH  (E6MVD9), SBT1_LOTJA  (A9QY40), 
SBT3_LOTJA  (A9QY39), SBT4_LOTJA  (A9QY38), SBTS_LOTJA  (A9JQS7), 
SBT_MEDTR   (G7KEU7), SBT_PETHY   (A0A0M3R8G2)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
7 sequences

ASE2_ACRSP  (P85157), CUDP_METCM  (P80406), NCP3_COPCM  (P83454), 
NVSP_ALIVI  (P83433), PRTE_HALME  (P28308), SP01_SCEBO  (Q10721), 
THEM_MALCI  (P13858)
» more

UniProtKB/Swiss-Prot
False positive sequences
15 sequences

ADCY8_HUMAN (P40145), ADCY8_MOUSE (P97490), ADCY8_RAT   (P40146), 
DGGGP_METTH (O27170), KTNB1_XENTR (Q6NVM2), PSBA3_GLOVI (Q7NH81), 
PSBA_ALETA  (Q9TM69), PSBA_AMPCA  (Q9BBC1), PSBA_AMPOP  (Q7HP56), 
PSBA_HETNI  (Q9MSC0), PSBA_HETPY  (Q9MSC1), PSBA_HETRO  (Q9MSC2), 
PSBA_HETTR  (Q9XQV1), PSBA_PROMC  (Q9TM72), TM241_MOUSE (Q3UME2)
» more

PDB
[Detailed view]
452 PDB

pdb_00001a2q; pdb_00001af4; pdb_00001ah2; pdb_00001ak9; pdb_00001aqn; pdb_00001au9; pdb_00001av7; pdb_00001avt; pdb_00001be6; pdb_00001be8; pdb_00001bfk; pdb_00001bfu; pdb_00001bh6; pdb_00001bjr; pdb_00001c3l; pdb_00001c9j; pdb_00001c9m; pdb_00001c9n; pdb_00001cnm; pdb_00001cse; pdb_00001dbi; pdb_00001dui; pdb_00001egq; pdb_00001gci; pdb_00001gns; pdb_00001gnv; pdb_00001ht3; pdb_00001iav; pdb_00001ic6; pdb_00001jea; pdb_00001lw6; pdb_00001mee; pdb_00001mpt; pdb_00001ndq; pdb_00001ndu; pdb_00001ot5; pdb_00001oyo; pdb_00001oyv; pdb_00001p7v; pdb_00001p7w; pdb_00001p8j; pdb_00001pek; pdb_00001pfg; pdb_00001pj8; pdb_00001ptk; pdb_00001q5p; pdb_00001r0r; pdb_00001r64; pdb_00001s01; pdb_00001s02; pdb_00001sbc; pdb_00001sbh; pdb_00001sbi; pdb_00001sbn; pdb_00001sbt; pdb_00001sca; pdb_00001scb; pdb_00001scd; pdb_00001scj; pdb_00001scn; pdb_00001sel; pdb_00001sib; pdb_00001spb; pdb_00001st2; pdb_00001st3; pdb_00001sua; pdb_00001sub; pdb_00001suc; pdb_00001sud; pdb_00001sue; pdb_00001sup; pdb_00001svn; pdb_00001tec; pdb_00001thm; pdb_00001tk2; pdb_00001tm1; pdb_00001tm3; pdb_00001tm4; pdb_00001tm5; pdb_00001tm7; pdb_00001tmg; pdb_00001to1; pdb_00001to2; pdb_00001ubn; pdb_00001v5i; pdb_00001vsb; pdb_00001wsd; pdb_00001xf1; pdb_00001y1k; pdb_00001y33; pdb_00001y34; pdb_00001y3b; pdb_00001y3c; pdb_00001y3d; pdb_00001y3f; pdb_00001y48; pdb_00001y4a; pdb_00001y4d; pdb_00001yja; pdb_00001yjb; pdb_00001yjc; pdb_00001yu6; pdb_00002dp4; pdb_00002dqk; pdb_00002duj; pdb_00002g4v; pdb_00002hd4; pdb_00002hpz; pdb_00002id4; pdb_00002id8; pdb_00002pkc; pdb_00002pq2; pdb_00002prk; pdb_00002pwa; pdb_00002pwb; pdb_00002pyz; pdb_00002sbt; pdb_00002sec; pdb_00002sic; pdb_00002sni; pdb_00002st1; pdb_00002tec; pdb_00002v8b; pdb_00002wuv; pdb_00002wuw; pdb_00003afg; pdb_00003aj8; pdb_00003aj9; pdb_00003bgo; pdb_00003bx1; pdb_00003cnq; pdb_00003co0; pdb_00003d9q; pdb_00003ddz; pdb_00003de0; pdb_00003de1; pdb_00003de2; pdb_00003de3; pdb_00003de4; pdb_00003de5; pdb_00003de6; pdb_00003de7; pdb_00003dvq; pdb_00003dvr; pdb_00003dvs; pdb_00003dw1; pdb_00003dw3; pdb_00003dwe; pdb_00003dyb; pdb_00003eif; pdb_00003f49; pdb_00003f7m; pdb_00003gt3; pdb_00003gt4; pdb_00003hjr; pdb_00003i2y; pdb_00003i30; pdb_00003i34; pdb_00003i37; pdb_00003l1k; pdb_00003lxu; pdb_00003osz; pdb_00003prk; pdb_00003ptl; pdb_00003q40; pdb_00003q5g; pdb_00003qmp; pdb_00003sic; pdb_00003tec; pdb_00003unx; pdb_00003vsb; pdb_00003vyv; pdb_00003whi; pdb_00003wqb; pdb_00004b5l; pdb_00004c3u; pdb_00004c3v; pdb_00004cfy; pdb_00004cfz; pdb_00004cg0; pdb_00004dj5; pdb_00004dww; pdb_00004dzt; pdb_00004fon; pdb_00004lvn; pdb_00004lvo; pdb_00004mzd; pdb_00004omc; pdb_00004omd; pdb_00004ryd; pdb_00004tr2; pdb_00004wob; pdb_00004woc; pdb_00004z2a; pdb_00004zar; pdb_00005amx; pdb_00005aqe; pdb_00005arb; pdb_00005arc; pdb_00005ard; pdb_00005avj; pdb_00005avk; pdb_00005b1d; pdb_00005b1e; pdb_00005cw1; pdb_00005gl8; pdb_00005i9s; pdb_00005jmo; pdb_00005jxg; pdb_00005jxh; pdb_00005jxi; pdb_00005jxj; pdb_00005k7s; pdb_00005kxu; pdb_00005kxv; pdb_00005mim; pdb_00005mjl; pdb_00005ox2; pdb_00005roc; pdb_00005rod; pdb_00005roe; pdb_00005rof; pdb_00005rog; pdb_00005roh; pdb_00005roi; pdb_00005roj; pdb_00005rok; pdb_00005rol; pdb_00005rom; pdb_00005ron; pdb_00005roo; pdb_00005rop; pdb_00005roq; pdb_00005ror; pdb_00005ros; pdb_00005rot; pdb_00005rou; pdb_00005rov; pdb_00005row; pdb_00005rox; pdb_00005roy; pdb_00005roz; pdb_00005rp0; pdb_00005rp1; pdb_00005rp2; pdb_00005rp3; pdb_00005rp4; pdb_00005rp5; pdb_00005rp6; pdb_00005rp7; pdb_00005rp8; pdb_00005rp9; pdb_00005rpa; pdb_00005rpb; pdb_00005rpc; pdb_00005rpd; pdb_00005rpe; pdb_00005rpf; pdb_00005rpg; pdb_00005rph; pdb_00005rpi; pdb_00005rpj; pdb_00005rpk; pdb_00005rpl; pdb_00005rpm; pdb_00005rpn; pdb_00005rpo; pdb_00005rpp; pdb_00005rpq; pdb_00005rpr; pdb_00005rps; pdb_00005rpt; pdb_00005rpu; pdb_00005rpv; pdb_00005rpw; pdb_00005rpx; pdb_00005rpy; pdb_00005rpz; pdb_00005sic; pdb_00005uvl; pdb_00005whw; pdb_00005wjg; pdb_00005wjh; pdb_00005wrc; pdb_00006cl7; pdb_00006cl8; pdb_00006cl9; pdb_00006cla; pdb_00006clb; pdb_00006dwq; pdb_00006eqv; pdb_00006eqw; pdb_00006eqx; pdb_00006fjs; pdb_00006hlb; pdb_00006hld; pdb_00006hle; pdb_00006hza; pdb_00006hzb; pdb_00006hzc; pdb_00006hzd; pdb_00006j43; pdb_00006k2p; pdb_00006k2r; pdb_00006k2s; pdb_00006k2t; pdb_00006k2v; pdb_00006k2w; pdb_00006k2x; pdb_00006k8m; pdb_00006kkf; pdb_00006law; pdb_00006mh6; pdb_00006n4u; pdb_00006o44; pdb_00006pak; pdb_00006pkj; pdb_00006pkk; pdb_00006pkl; pdb_00006pkm; pdb_00006pkn; pdb_00006pko; pdb_00006pkp; pdb_00006pkq; pdb_00006pkr; pdb_00006pks; pdb_00006pkt; pdb_00006pq0; pdb_00006pq4; pdb_00006pu4; pdb_00006pu5; pdb_00006qf1; pdb_00006qxv; pdb_00006rug; pdb_00006ruh; pdb_00006ruk; pdb_00006run; pdb_00006ruw; pdb_00006rve; pdb_00006rvg; pdb_00006rzp; pdb_00006txg; pdb_00006v8r; pdb_00006y5s; pdb_00006y5t; pdb_00006yd2; pdb_00006yd3; pdb_00006yd4; pdb_00006yd7; pdb_00006zet; pdb_00006zeu; pdb_00006zev; pdb_00007a68; pdb_00007a9f; pdb_00007a9k; pdb_00007a9m; pdb_00007am3; pdb_00007am4; pdb_00007am5; pdb_00007am6; pdb_00007am7; pdb_00007am8; pdb_00007bj3; pdb_00007c0p; pdb_00007jsy; pdb_00007lcu; pdb_00007ln7; pdb_00007lpt; pdb_00007lpu; pdb_00007lpv; pdb_00007lq8; pdb_00007lq9; pdb_00007lqa; pdb_00007lqb; pdb_00007lqc; pdb_00007ltd; pdb_00007lti; pdb_00007ltv; pdb_00007lu0; pdb_00007lu1; pdb_00007lu2; pdb_00007lu3; pdb_00007njj; pdb_00007np7; pdb_00007npr; pdb_00007nps; pdb_00007nuy; pdb_00007nuz; pdb_00007o1u; pdb_00007o1w; pdb_00007o1y; pdb_00007o20; pdb_00007o22; pdb_00007qxy; pdb_00007qxz; pdb_00007qy0; pdb_00007qy1; pdb_00007qy2; pdb_00007s4z; pdb_00007skx; pdb_00007svy; pdb_00007svz; pdb_00007sw0; pdb_00007sw1; pdb_00007sw2; pdb_00007sw3; pdb_00007sw4; pdb_00007sw5; pdb_00007sw6; pdb_00007sw7; pdb_00007sw8; pdb_00007sw9; pdb_00007swa; pdb_00007swb; pdb_00007swc; pdb_00007yzx; pdb_00008b4v; pdb_00008b4w; pdb_00008b4x; pdb_00008coy; pdb_00008coz; pdb_00008cp0; pdb_00008e52; pdb_00008e53; pdb_00008e7f; pdb_00008f05; pdb_00008f06; pdb_00008f07; pdb_00008fyo; pdb_00008fyp; pdb_00008fyq; pdb_00008fyr; pdb_00008fys; pdb_00008oyh; pdb_00008pol; pdb_00008qke; pdb_00008qkg; pdb_00008qkj; pdb_00008rse; pdb_00008rsf; pdb_00008rsg; pdb_00008sdk; pdb_00008sog; pdb_00008sou; pdb_00008sov; pdb_00008spl; pdb_00008sqv; pdb_00008uw8; pdb_00008uwc; pdb_00009ftx; pdb_00009fty; pdb_00009fu1
» more