We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE entry PS00498
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PURL: https://purl.expasy.org/prosite/signature/PS00498
Direct ScanProsite submission
General information about the entry
| Entry name [info] | TYROSINASE_2 |
| Accession [info] | PS00498 |
| Entry type [info] | PATTERN |
| Date [info] |
01-MAY-1991 CREATED;
01-MAY-1991 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00398 |
Name and characterization of the entry
| Description [info] | Tyrosinase and hemocyanins CuB-binding region signature. |
| Pattern [info] |
D-P-x-F-[LIVMFYW]-x(2)-H-x(3)-D. |
Numerical results [info]
| Total number of hits | 139 in 119 different sequences |
| Number of true positive hits | 133 in 113 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 6 in 6 different sequences |
| Number of false negative sequences | 1 |
| Number of 'partial' sequences | 34 |
| Precision (true positives / (true positives + false positives)) | 95.68 % |
| Recall (true positives / (true positives + false negatives)) | 99.25 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 8 |
| Site [info] | copper at position 7 |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
113 sequences
AS1_ANTMA (Q9FRX6), GRIF_STRGG (B1VTI5), HC2C_MEGCR (P81732), HCY1_MEGCR (Q10583), HCY2A_RAPVE (P80960), HCY2E_RAPVE (P83040), HCY2_CARAE (P84293), HCY2_LIMPO (P04253), HCY2_MEGCR (Q10584), HCY6_ANDAU (P80476), HCYA_APHSP (P14750), HCYA_ENTDO (P12659), HCYA_PANIN (P04254), HCYA_SCUCO (Q95P08), HCYB_APHSP (Q9NFH9), HCYB_ASTLP (P83180), HCYB_HELPO (P12031), HCYB_PANIN (P10787), HCYB_SCUCO (Q8IFJ8), HCYC_APHSP (Q9NFL6), HCYC_PANIN (P80096), HCYC_SCUCO (Q8T115), HCYD_APHSP (P02241), HCYD_SCUCO (Q95P07), HCYE_APHSP (P02242), HCYF_APHSP (Q9NFL5), HCYG_APHSP (Q9NFL4), HCYG_ENTDO (O61363), HCYG_HELPO (P56823), HCYG_SEPOF (P56826), HCYX_SCUCO (Q8T116), HCY_PALVU (P80888), HCY_SCYOL (C0HLU7), HCY_SCYSE (C0HLU8), HKM6_ASPHA (P0DUQ0), IVOB_EMENI (Q5BGU9), LAHY_LARTR (Q6UIL3), ORSC_EMENI (Q5AUW8), PHCY1_HOMAM (Q6KF82), PHCY2_HOMAM (Q6KF81), PHOQ2_DIALO (A0A8J9RRY2), PHQ11_DIALO (A0A8J9R8H5), PHQ12_DIALO (A0A142I737), PPO1_AGABI (Q00024), PPO1_HOLDI (Q8I6K1), PPO1_SPOLT (Q3ZPT5), PPO2_AGABI (O42713), PPO2_DROME (Q9V521), PPO2_HOLDI (Q8I6K2), PPO3_AGABI (C7FF04), PPO3_DROER (Q8I1F6), PPO3_DROME (Q9W1V6), PPO4_AGABI (C7FF05), PPO8_ANOGA (Q8MZM3), PPOA_SOLLC (Q08303), PPOB_SOLLC (Q08304), PPOB_SOLTU (Q06355), PPOC_SOLLC (Q08305), PPOD_SOLLC (Q08306), PPOE_SOLLC (Q08307), PPOF_SOLLC (Q08296), PPO_MALDO (P43309), PPO_PRUAR (O81103), PPO_SPIOL (P43310), PPO_VICFA (Q06215), PPO_VITVI (P43311), PRP1_BOMMO (Q27451), PRP1_MANSE (O44249), PRP1_SIMDA (P85046), PRP2_BOMMO (Q27452), PRP2_GALME (Q6UEH6), PRP2_MANSE (Q25519), TYR1_CAEEL (P34269), TYR1_HAHS4 (A0A261GRE4), TYR2_HAHS4 (A0A261GVB1), TYR3_CAEEL (Q19673), TYRO1_PINMG (H2A0L0), TYRO2_PINMG (H2A0L1), TYRO_ASPFU (Q8J130), TYRO_ASPOR (Q00234), TYRO_BOVIN (Q8MIU0), TYRO_CANLF (P54834), TYRO_CHICK (P55024), TYRO_FELCA (P55033), TYRO_GORGO (Q9BDE0), TYRO_HUMAN (P14679), TYRO_MOUSE (P11344), TYRO_NEUCR (P00440), TYRO_ORYLA (P55025), TYRO_PELLE (Q0MVP0), TYRO_PELNI (Q04604), TYRO_PHONA (A7BHQ9), TYRO_PINMA (P86952), TYRO_PODAS (Q92396), TYRO_RHIML (P33180), TYRO_STRAT (P07524), TYRO_STRGA (P06845), TYRO_STRLN (P55023), TYRP1_AMBME (P55027), TYRP1_BOVIN (Q8WN57), TYRP1_CARAU (P55028), TYRP1_CHICK (O57405), TYRP1_FELCA (Q2VPW6), TYRP1_HUMAN (P17643), TYRP1_MOUSE (P07147), TYRP2_BOVIN (Q95119), TYRP2_CHICK (O93505), TYRP2_HUMAN (P40126), TYRP2_MOUSE (P29812), TYRP2_PIG (Q4R1H1), TYRP_ASPTE (A0A336U966), TYRP_ASPTN (Q0CRX0), USTQ_ASPFN (B8NM74)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
1 sequence
TYRO_STRGB (P55022) |
| UniProtKB/Swiss-Prot 'Partial' sequences |
34 sequences
HCY1_HOMAM (P82296), HCY1_LIODE (P84461), HCY1_MAJSQ (P82302), HCY1_NECPU (P84846), HCY2_HOMAM (P82297), HCY2_LIODE (P84462), HCY2_MAJSQ (P82303), HCY2_PANJA (P82312), HCY3_HOMAM (P82298), HCY3_MAJSQ (P82304), HCY3_PANJA (P82313), HCY4E_MAJSQ (P82306), HCY4_CARMA (P82309), HCY4_HOMAM (P82299), HCY4_MAJSQ (P82305), HCY5_HOMAM (P82300), HCY5_MAJSQ (P82307), HCY6_HOMAM (P82301), HCY6_MAJSQ (P82308), HCYA_CONCC (P84619), HCYB_CONCC (P84620), HCYC_SEPOF (P56824), HCYE_SEPOF (P56825), HCYIA_PANJA (P82310), HCYIB_PANJA (P82311), LEC_PENST (P84821), PHCY_LIODE (P84460), PHCY_LIOHO (P84768), PHCY_LIOMA (P84769), PHCY_NECPU (P84847), PPO3_SARAR (C0HJM0), PPO_ZINOF (P85026), TYRO_COTJA (Q08410), TYRO_PELSI (P55026)» more |
| UniProtKB/Swiss-Prot False positive sequences |
6 sequences
3HID1_ARATH (Q9SZE1), 5053R_ASFB7 (Q89642), 5053R_ASFM2 (Q65129), 5053R_ASFP4 (P0C9T0), 5053R_ASFWA (P0C9T1), LE607_CAEEL (O44743)» more |
| PDB [Detailed view] |
36 PDB
pdb_00001hc1; pdb_00001hcy; pdb_00001js8; pdb_00001ll1; pdb_00001lla; pdb_00001lnl; pdb_00001nol; pdb_00001oxy; pdb_00002p3x; pdb_00002y9w; pdb_00002y9x; pdb_00003hhs; pdb_00003ixv; pdb_00003ixw; pdb_00003l6w; pdb_00003qjo; pdb_00004bed; pdb_00004yzw; pdb_00005m6b; pdb_00005m8l; pdb_00005m8m; pdb_00005m8n; pdb_00005m8o; pdb_00005m8p; pdb_00005m8q; pdb_00005m8r; pdb_00005m8s; pdb_00005m8t; pdb_00006els; pdb_00006hqi; pdb_00006hqj; pdb_00008b74; pdb_00009ey5; pdb_00009ey6; pdb_00009ey7; pdb_00009ey8 » more |