The putative ZZ zinc finger, was first identified in the Dystrophin gene, a
427 kDa protein, involved in the Duchenne muscular dystrophy (DMD). This motif
is also present in the adaptor proteins CBP and P300 in a region known to
interact with YY1, E1A and TFIIB, which suggest a possible protein binding
function for this domain . It is closely related to the B-box zinc finger,
(see <PDOC50119>) however B-box do not contain the Asp-Tyr-Asp-Leu motif
present in most of the ZZ zinc fingers .
Some of the proteins containing this domain are listed below:
Mammalian CBP and the related protein p300. Large nuclear proteins that
interact with transcriptional activators and repressors.
Mammalian dystrophin, a multidomain cytoskeletal protein. Its longest
alternatively spliced form consists of an N-terminal actin-binding domain,
followed by 24 spectrin-like repeats, a cysteine-rich calcium-binding
domain and a C-terminal globular domain. Dystrophin form tetramers and is
thought to have multiple functions including involvement in membrane
stability, transduction of contractile forces to the extracellular
environment and organization of membrane specialization. Mutations in the
dystrophin gene lead to muscular dystrophy of Duchenne or Becker type.
Human dystrophin related protein 2. Possibly involved in membrane-
cytosqueleton interactions in the central nervous system.
Utrophin, a dystrophin-like protein of unknown function.
Drosophila Ref(2)P protein. Implicated in sigma rhabdovirus multiplication
and necessary for male fertility.
Prt1 of Arabidopsis thaliana. Encodes a component of the plant N-end rule
The ZZ zinc finger contains 7 positions able to coordinate one zinc atom,
among them only 4 are completely conserved. Our pattern is based on these 4
positions. We have also developed a profile that spans the whole domain.
December 2004 / Pattern and text revised.
PROSITE methods (with tools and information) covered by this documentation:
Giles R.H. Peters D.J. Breuning M.H.
Conjunction dysfunction: CBP/p300 in human disease.
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