|PROSITE documentation PDOC51165 [for PROSITE entry PS51165]|
The THUMP (after thiouridine synthases, RNA methylases and pseudouridine synthases) domain is a module of 100-110 amino acid residues which is involved RNA metabolism. It is shared by enzymes that are predicted to carry out at least three unrelated types of RNA-modification, namely methylation, pseudouridylation and thiouridylation. The THUMP domain can occur in stand-alone form or in association with a variety of catalytic domains, like methylase, pseudo U-synthase or rhodanese (see <PDOC00322>). THUMP is an ancient domain with predicted RNA-binding capacity that probably functions by delivering a variety of RNA modification enzymes to their targets. The THUMP domain apparently evolved prior to the divergence of the primary divisions of life .
The THUMP domain has been predicted to adopt an α/β fold similar to that found in the C-terminal domain of translation initiation factor 3 and ribosomal protein S8 .
Some proteins known to contain a THUMP domain are listed below:
The profile we developed covers the entire THUMP domain.Last update:
November 2005 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Aravind L. Koonin E.V.|
|Title||THUMP - a predicted RNA-binding domain shared by 4-thiouridine, pseudouridine synthases and RNA methylases.|
|Source||Trends Biochem. Sci. 26:215-217(2001).|