|PROSITE documentation PDOC51225 [for PROSITE entry PS51225]|
The ~130-residue MAL and related proteins for vesicle trafficking and membrane link (MARVEL) domain is a module with a four transmembrane-helix architecture that has been identified in proteins of the myelin and lymphocyte (MAL), physins, gyrins and occludin families. All described MARVEL domain-containing proteins are consistent with the M-shaped topology: four transmembrane-helix region architecture with cytoplasmic N- and C-terminal regions. Their function could be related to cholesterol-rich membrane apposition events in a variety of cellular processes, such as biogenesis of vesicular transport carriers or tight junction regulation .
The profile we developed covers the entire MARVEL domain.Last update:
August 2006 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Sanchez-Pulido L. Martin-Belmonte F. Valencia A. Alonso M.A.|
|Title||MARVEL: a conserved domain involved in membrane apposition events.|
|Source||Trends Biochem. Sci. 27:599-601(2002).|