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PROSITE documentation PDOC51284 [for PROSITE entry PS51284]

DOC domain profile





Description

The anaphase-promoting complex (APC) is a multi-subunit E3 protein ubiquitin ligase that is reponsible for the metaphase to anaphase transition and the exit from mitosis. The subunit APC10 is a one-domain protein homologous to a sequence element, termed the DOC domain, found in several hypothetical proteins that may also mediate ubiquitination reactions, because they contain combinations of either RING finger (see <PDOC00449>), cullin (see <PDOC00967>) or HECT (see <PDOC50237>) domains [1,2,3].

The DOC domain consists of a β-sandwich, in which a five-stranded antiparallel β-sheet is packed on top of a three stranded antiparallel β-sheet, exhibiting a 'jellyroll' fold (see <PDB:1JHJ; A>) [2,3].

Some proteins known to contain a DOC domain are listed below:

  • Eucaryotic Doc1/Apc10.
  • Mammalian protein associated with the transcription factor Myc (PAM).
  • Mouse runty-jerky-sterile (RJS) protein.
  • Human HERC2, the ortholog of RJS.

The profile we developed covers the entire DOC domain.

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html --------------------------------------------------------------------------------.

Last update:

January 2007 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

DOC, PS51284; DOC domain profile  (MATRIX)


References

1AuthorsGrossberger R. Gieffers C. Zachariae W. Podtelejnikov A.V. Schleiffer A. Nasmyth K. Mann M. Peters J.-M.
TitleCharacterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex.
SourceJ. Biol. Chem. 274:14500-14507(1999).
PubMed ID10318877

2AuthorsWendt K.S. Vodermaier H.C. Jacob U. Gieffers C. Gmachl M. Peters J.-M. Huber R. Sondermann P.
TitleCrystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex.
SourceNat. Struct. Biol. 8:784-788(2001).
PubMed ID11524682
DOI10.1038/nsb0901-784

3AuthorsAu S.W.N. Leng X. Harper J.W. Barford D.
TitleImplications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit.
SourceJ. Mol. Biol. 316:955-968(2002).
PubMed ID11884135
DOI10.1006/jmbi.2002.5399



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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