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The pacifastin family is composed of proteinase inhibitors from arthropods:
Freshwater crayfish pacifastin light chain.
Migratory locust LMPI-1 to -3.
Desert locust SGPI-1 to -5.
Yellowfever mosquito AAPP-1.
African malaria mosquito AGPP-1.
These proteinase inhibitors belong to family I19 [E1] and share a pacifastin
domain of ~35 residues, which contains a characteristic pattern of six
conserved cysteine residues (C-x(9,12)-C-N-x-C-x-C-x(2,3)-G-x(3,6)-C-T-x(3)-C). The pacifastin domain consists of a twisted β-sheet composed of three
antiparallel strands and stabilized by an identical pattern (C1-C4, C2-C6,
C3-C5) of disulfide bridges (see <PDB:1GL1>) [1,2,3,4,5,6].
The profile we developed covers the entire pacifastin domain.
Simonet G. Breugelmans B. Proost P. Claeys I. Van Damme J. De Loof A. Vanden Broeck J.
Title
Characterization of two novel pacifastin-like peptide precursor isoforms in the desert locust (Schistocerca gregaria): cDNA cloning, functional analysis and real-time RT-PCR gene expression studies.
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