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PROSITE documentation PDOC51521 [for PROSITE entry PS51521]

Herpesvirus tegument ubiquitin-specific protease (htUSP) domain profile





Description

All herpesviruses [E1] contain a Ubiquitin (Ub)-specific cysteine protease (USP) domain embedded within their large tegument protein. The herpesvirus tegument ubiquitin (Ub)-specific protease (htUSP) domain of ~200 amino acids adopts an α-β-α sandwich fold that features a central catalytic cleft, ideally suited to accommodate the C-terminal stretch of Ub (see <PDB:2J7Q>). The catalytic triad Cys-His-Asp is strictly conserved, along with a putative oxyanion hole-forming Gln residue. The htUSP domain is a member of peptidase family C76 of clan CA [1,2,3,4,5,E2].

The profile we developed covers the entire htUSP domain.

Last update:

January 2011 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

HTUSP, PS51521; Herpesvirus tegument ubiquitin-specific protease (htUSP) domain profile  (MATRIX)


References

1AuthorsSchlieker C. Korbel G.A. Kattenhorn L.M. Ploegh H.L.
TitleA deubiquitinating activity is conserved in the large tegument protein of the herpesviridae.
SourceJ. Virol. 79:15582-15585(2005).
PubMed ID16306630
DOI10.1128/JVI.79.24.15582-15585.2005

2AuthorsSchlieker C. Weihofen W.A. Frijns E. Kattenhorn L.M. Gaudet R. Ploegh H.L.
TitleStructure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes.
SourceMol. Cell 25:677-687(2007).
PubMed ID17349955
DOI10.1016/j.molcel.2007.01.033

3AuthorsGredmark S. Schlieker C. Quesada V. Spooner E. Ploegh H.L.
TitleA functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection.
SourceJ. Virol. 81:10300-10309(2007).
PubMed ID17634221
DOI10.1128/JVI.01149-07

4AuthorsGonzalez C.M. Wang L. Damania B.
TitleKaposi's sarcoma-associated herpesvirus encodes a viral deubiquitinase.
SourceJ. Virol. 83:10224-10233(2009).
PubMed ID19640989
DOI10.1128/JVI.00589-09

5AuthorsKim E.T. Oh S.E. Lee Y.-O. Gibson W. Ahn J.-H.
TitleCleavage specificity of the UL48 deubiquitinating protease activity of human cytomegalovirus and the growth of an active-site mutant virus in cultured cells.
SourceJ. Virol. 83:12046-12056(2009).
PubMed ID19759126
DOI10.1128/JVI.00411-09

E1Titlehttps://viralzone.expasy.org/176?outline=all_by_species

E2Titlehttps://www.ebi.ac.uk/merops/cgi-bin/famsum?family=c76



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