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PROSITE documentation PDOC51522 [for PROSITE entry PS51522]

Zinc finger nanos-type profile





Description

Nanos is a highly conserved RNA-binding protein in higher eukaryotes and functions as a key regulatory protein in translational control using a 3' untranslated region during the development and maintenance of germ cells. Nanos comprises a non-conserved amino-terminus and highly conserved carboxy-terminal regions. The C-terminal region has two conserved Cys-Cys-His-Cys (CCHC)-type zinc-finger motifs that are indispensable for nanos function [1,2,3].

The structure of the nanos-type zinc finger is composed of two independent zinc-finger (ZF) lobes, the N-terminal ZF1 and the C-terminal ZF2, which are connected by a linker helix (see <PDB:3ALR>) [3]. These lobes create a large cleft. Zinc ions in ZF1 and ZF2 are bound to the CCHC motif by tetrahedral coordination.

The profile we developed covers the entire nanos-type zinc finger.

Last update:

February 2011 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

ZF_NANOS, PS51522; Zinc finger nanos-type profile  (MATRIX)


References

1AuthorsMosquera L. Forristall C. Zhou Y. King M.L.
TitleA mRNA localized to the vegetal cortex of Xenopus oocytes encodes a protein with a nanos-like zinc finger domain.
SourceDevelopment 117:377-386(1993).
PubMed ID8223259

2AuthorsSubramaniam K. Seydoux G.
Titlenos-1 and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in Caenorhabditis elegans.
SourceDevelopment 126:4861-4871(1999).
PubMed ID10518502

3AuthorsHashimoto H. Hara K. Hishiki A. Kawaguchi S. Shichijo N. Nakamura K. Unzai S. Tamaru Y. Shimizu T. Sato M.
TitleCrystal structure of zinc-finger domain of Nanos and its functional implications.
SourceEMBO. Rep. 11:848-853(2010).
PubMed ID20948543
DOI10.1038/embor.2010.155



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