PROSITE documentation PDOC51674 [for PROSITE entry PS51674]4Fe-4S WhiB-like (Wbl)-type iron-sulfur binding domain profile
Description
Members of the WhiB-like (Wbl) family are found exclusively in actinobacteria and are implicated in the regulation of developmental processes. All WhiB-like proteins have four conserved cysteine residues where two of them are in a C-X-X-C motif. The four cysteine residues are proposed to act as the ligands for a [4Fe-4S] cluster. Wbl-mediated transcription regulation is dependent upon the presence or absence and state (nitrosylated or non-nitrosylated) of the [4Fe-4S] cluster [1,2,3].
The profile we developed covers the entire Wbl-type 4Fe-4S domain.
Last update:May 2013 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Garg S.K. Suhail Alam M. Soni V. Radha Kishan K.V. Agrawal P. |
| Title | Characterization of Mycobacterium tuberculosis WhiB1/Rv3219 as a protein disulfide reductase. | |
| Source | Protein Expr. Purif. 52:422-432(2007). | |
| PubMed ID | 17157031 | |
| DOI | 10.1016/j.pep.2006.10.015 |
| 2 | Authors | den Hengst C.D. Buttner M.J. |
| Title | Redox control in actinobacteria. | |
| Source | Biochim. Biophys. Acta 1780:1201-1216(2008). | |
| PubMed ID | 18252205 | |
| DOI | 10.1016/j.bbagen.2008.01.008 |
| 3 | Authors | Smith L.J. Stapleton M.R. Buxton R.S. Green J. |
| Title | Structure-function relationships of the Mycobacterium tuberculosis transcription factor WhiB1. | |
| Source | PLoS ONE 7:E40407-E40407(2012). | |
| PubMed ID | 22792304 | |
| DOI | 10.1371/journal.pone.0040407 |
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