PROSITE entry PS52036

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General information about the entry

Entry name [info]	ZF_RG_N
Accession [info]	PS52036
Entry type [info]	MATRIX
Date [info]	24-JAN-2024 CREATED; 24-JAN-2024 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC52036
Associated ProRule [info]	PRU01380

Name and characterization of the entry

Description [info]

Zinc finger reverse gyrase N-terminal-type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=40;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=36;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3040311; R2=0.0087802; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1219; N_SCORE=13.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=478; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-31; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='M';  M= -62, -70, -82, -74, -52, -77, -57,  -3, -67, -18, 138, -18, -72, -60, -66, -71, -60,  -3, -76, -52;
/I:         I=-25; MD=-63;
/M: SY='N';  M=  -2, -90,  19,   2, -86, -20, -36, -78, -77,   0, -77,  25, -89, -75, -48, -13, -23, -20,  -2, -84; D=-25;
/I:         I=-25; DM=-63;
/M: SY='I';  M= -65, -78, -80, -76, -59, -84, -79,  52, -74,  17, -12, -35,  45, -74, -41, -25,   9,  39, -82, -32; D=-25;
/I:         I=-25; MI=-63; IM=-63; DM=-63;
/M: SY='N';  M= -27, -77, -28,  15, -47, -18,  25,   0,   0,  -6,  -8,  48,  40, -54,  38, -58, -17, -17, -80, -32;
/M: SY='P';  M=  49, -70, -71, -66, -33,   5, -70,  11, -67,  -7,  21, -66,  57, -64, -72,   6, -55,  21, -75, -26;
/M: SY='I';  M= -41, -73, -78, -74, -24, -81, -72,  72, -23,  14, -41, -72, -76, -68,  -3,   0, -56,  44, -70,  25;
/M: SY='Y';  M= -71, -80, -73, -75,  31, -79, -42, -10, -68,  -4, -47, -73, -83, -64, -65, -68, -65, -56, -31, 125;
/M: SY='R';  M=  -3, -75, -10,  13, -68, -32,  22, -44,  45,   1,  12,  -1, -69, -23,  57,  -5, -12, -65, -76, -23;
/M: SY='H';  M= -29, -74,  -7, -12, -42,  33,  78, -79,  -3, -76, -65,  62, -69, -24,  18,  21, -56, -77, -80,   8;
/M: SY='L';  M=   9, -16, -72, -70,  -6,  25, -67,   2, -69,  49,  24, -64, -74, -64, -71,  43, -55, -28, -72, -29;
/M: SY='C';  M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82;
/M: SY='P';  M= -66, -87, -70, -60,   8, -72, -72,  12, -66, -68, -62, -74, 117, -69, -76, -65, -59,  -4, -75, -71;
/M: SY='N';  M= -33, -69, -48, -61, -64, -59,  -3,   4, -53, -11, -57,  99, -73, -19,  -5,   3, -20,   9, -84,  -1;
/M: SY='C';  M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82;
/M: SY='G';  M= -52, -75, -24, -67, -33,  89,  -9, -86, -18, -83, -73,  35, -69, -23, -38,  -2, -62, -81, -76, -72;
/M: SY='G';  M= -52, -14, -61, -11, -79,  86, -65, -54, -38, -81, -72,   5, -69, -59,  30,  -6, -46, -79,  19, -72;
/M: SY='D';  M= -32, -76,  68,  42, -75, -42, -12, -27, -24, -47, -19,  16,  29, -51,   1,   5,  16, -44, -85, -27;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='I';  M=  10,   4, -46, -75, -53, -76, -75,  78, -72,  19, -41,  21, -75, -70, -75, -33, -56,  26, -78, -60;
/M: SY='S';  M= -10, -69,  44,  27, -76, -59, -59, -73, -25, -74, -69, -15, -19, -50, -12,  66,  52, -65, -85, -68;
/M: SY='D';  M=  18, -70,  68,   9, -37, -57, -58, -45, -55, -74, -70,  10, -65, -52, -38,  65,  -1, -37, -86, -67;
/M: SY='E';  M= -58, -74,  21,  62, -62, -39, -25, -62, -35,  -4, -60,  11, -66, -16,   7,  21,   1,   6, -73,  35;
/M: SY='R';  M= -32, -80,  23,  50, -78, -71, -53, -82, -17, -76, -68, -15, -68, -41,  92,   0, -60, -75, -79, -66;
/M: SY='L';  M=  -3, -70, -77, -75, -46, -79, -70,  47, -74,  72, -34,  14, -79, -69, -74, -69, -59, -12, -74, -56;
/M: SY='E';  M=   3, -72,  -4,  50, -36, -45, -62,  32, -13,  12,   9,   3, -68, -53, -22,   4,  -7,   0, -77, -23;
/M: SY='K';  M=   2, -73, -54,  21, -67, -15, -21, -17,  40,   2, -21,  34, -68,  25,  13,  23, -23, -63, -75,  -3;
/M: SY='G';  M= -56,  -5, -61, -40, -28,  75,  35, -79,  15, -55, -67,   9, -70, -57,  29, -34, -64, -43, -71,  18;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='G';  M= -35, -77, -72, -77,   2,  45, -10, -59, -74,  44, -16,  37, -81, -71, -77, -15, -46, -44, -80, -65; D=-42;
/I:         I=-42; DM=-106;
/M: SY='P';  M=  20, -11, -69, -61, -16, -68, -24,  15, -14, -46,  -6, -66,  83, -63, -14,   5,   2,  18, -78, -67;
/M: SY='C';  M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='E';  M= -27, -75,  33,  63, -79, -65,   8, -76,   8, -76, -69,  -2,  20, -45,  12,  40,  10, -45, -83, -68;
/M: SY='K';  M= -28, -74, -54,  24, -71, -68, -57,  -5,  57, -24, -59,  36, -68,  -5,  45,  14, -55,   2, -78, -65;
/M: SY='C';  M= -61, 149,  15, -73, -73, -75, -77, -79, -74, -70, -70, -63, -89, -80, -81, -32, -60, -67,-101, -81;
/M: SY='M';  M= -14, -71, -75, -40, -17, -77, -15,  16, -65,  52,  56, -34, -77, -32,   6,  -6, -34,   9, -68,  29;
/I:         I=-22; MD=-55;
/M: SY='H';  M= -41,-101,  -7, -38, -19, -92,  14, -95, -46, -66, -90,   2,  -4, -39,  12,   9, -16, -46,-107, -87; D=-22;
/I:         I=-22; MI=0; MD=-55; IM=0; DM=-55;
/M: SY='P';  M= -37, -78,  26,  40, -19, -25, -59, -74, -11, -77, -69,   6,  75,  -1, -11,  39, -53, -40, -80, -70;
/M: SY='E';  M= -59, -76,  16,  76, -75, -13, -55, -74,  12, -28, -66,  17, -62,   0,   8,   7,   4, -43, -79, -20;
/M: SY='D';  M= -42, -78,  64,  55, -30, -15,  -4, -19,   0, -22, -66,   1,  11, -24,   8, -15, -58, -36, -83, -66;
/M: SY='I';  M= -42, -72, -23, -19, -22, -12,  -8,  32,  28,  -5, -53,  13, -36, -16,   3,  24,   9,  24, -78, -61;
/M: SY='E';  M= -18,  -2,  14,  45, -23, -16, -30,  -1,   1,   9, -57,  13, -31, -27,   1,   5,  14, -11, -79, -64;
/M: SY='L';  M=   2, -22, -29,  20,   6, -14, -62,  11, -11,  21, -19,   4,  14, -57,   4,  11, -26,  -8, -71,   8;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.

Total number of hits	22 in 22 different sequences
Number of true positive hits	22 in 22 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Archaea, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	ZN_FING
Feature description [info]	RG N-terminal-type
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

22 sequences

RGYR1_AERPE (Q9YCB6), RGYR1_AQUAE (O67037), RGYR1_SACS2 (Q97ZZ8),

RGYR1_SULAC (Q08582), RGYR1_SULTO (Q971T7), RGYR2_AERPE (Q9YC75), 
RGYR2_AQUAE (O67226), RGYR2_SACS2 (Q97ZF5), RGYR2_SULAC (P0DW67), 
RGYR2_SULTO (Q975P6), RGYRB_METKA (F1SVH1), RGYRB_NANEQ (Q74M79), 
RGYR_ARCFU  (O29238), RGYR_CALS4  (Q8R979), RGYR_METJA  (Q58907), 
RGYR_PYRAB  (Q9UZ86), RGYR_PYRAE  (Q8ZXT5), RGYR_PYRFU  (P95479), 
RGYR_PYRHO  (O58530), RGYR_SACSH  (P74759), RGYR_THEKO  (Q6F598), 
RGYR_THEMA  (O51934)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

9 PDB

1GL9; 4DDT; 4DDU; 4DDV; 4DDW; 4DDX; 7FSE; 7FSF; 8OFB