ProRule PRU01380

General rule information [?]

Accession PRU01380
Dates 13-SEP-2023 (Created)
-- (Last updated, Version 1)
Data class Domain;
Predictors PROSITE; PS52036; ZF_RG_N
Name Zinc finger reverse gyrase N-terminal-type
Function Reverse gyrase (RG) is an ATP-dependent topoisomerase that is only found in archaeal and bacterial hyperthermophiles (above 80 degre C) and thermophiles (65-80 degre C). RGs share a modular structure with an N- terminal cysteine-rich region (a zinc finger) preceding a helicase domain that is followed by a C-terminal topoisomerase domain. The helicase domain is subdivided into H1 and H2 domains that are flexibly linked. Some RG topoisomerase domains also include a cysteine-rich region that has been proposed to form a second zinc finger. The two zinc-finger motifs are found to be important to the structure stability maintenance of RG at high temperature. The N-terminal zinc finger firmly attaches the H1 domain to the topoisomerase domain and may contribute to double-strand DNA (dsDNA) binding.
Scope(s) Archaea
Example(s) P0DW67 (RGYR2_SULAC);

Propagated annotation [?]

Comments [?]

case (<Feature:PS52036:11=[CH]> and <Feature:PS52036:14=[CH]> and <Feature:PS52036:29=[CH]> and <Feature:PS52036:32=[CH]>)
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105;

Keywords [?]

Gene Ontology [?]

GO:0046872; Molecular function:metal ion binding
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS52036
Key From To Description Tag Condition FTGroup
case (<Feature:PS52036:11=[C]> and <Feature:PS52036:14=[C]> and <Feature:PS52036:29=[C]> and <Feature:PS52036:32=[C]>)
ZN_FING from to /note="RG N-terminal-type #"
else case (<Feature:PS52036:11=[CH]> and <Feature:PS52036:14=[CH]> and <Feature:PS52036:29=[CH]> and <Feature:PS52036:32=[CH]>)
ZN_FING from to /note="RG N-terminal-type #; atypical"
ZN_FING from to /note="RG N-terminal-type #; degenerate"
end case
BINDING 11 11 /ligand="Zn(2+)"
[CH] 1
BINDING 14 14 /ligand="Zn(2+)"
[CH] 1
BINDING 29 29 /ligand="Zn(2+)"
[CH] 1
BINDING 32 32 /ligand="Zn(2+)"
[CH] 1

Additional information [?]

Size range 37-47 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]